Anders A. Jensen
Professor
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
- Published
Allosteric modulation of an excitatory amino acid transporter: The subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain
Abrahamsen, B., Schneider, N., Erichsen, M. N., Huynh, Tri Hien Viet, Fahlke, C., Bunch, Lennart & Jensen, Anders A., 2013, In: Journal of Neuroscience. 33, 3, p. 1068-1087Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization
Adelfinger, L., Turecek, R., Ivankova, K., Jensen, Anders A., Moss, S. J., Gassmann, M. & Bettler, B., 2014, In: Biochemical Pharmacology. 91, 3, p. 369-379 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemoenzymatic synthesis of a series of 4-substituted glutamate analogues and pharmacological characterization at human glutamate transporters subtypes 1-3
Alaux, S., Kusk, M., Sagot, E., Bolte, J., Jensen, Anders A., Bräuner, Hans, Gefflaut, T. & Bunch, Lennart, 2005, In: Journal of Medicinal Chemistry. 48, 25, p. 7980-92 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Concise Guide to PHARMACOLOGY 2023/24: Ion channels
Alexander, S. P. H., Mathie, A. A., Peters, J. A., Veale, E. L., Striessnig, J., Kelly, E., Armstrong, J. F., Faccenda, E., Harding, S. D., Davies, J. A., Aldrich, R. W., Attali, B., Baggetta, A. M., Becirovic, E., Biel, M., Bill, R. M., Caceres, A. I., Catterall, W. A., Conner, A. C., Davies, P. & 53 others, , 2023, In: British Journal of Pharmacology. 180 , Suppl 2, p. S145-S222Research output: Contribution to journal › Journal article › Research › peer-review
- Published
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels
CGTP Collaborators, C. C., Dec 2019, In: British Journal of Pharmacology. 176, Suppl 1, p. S142-S228Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The concise guide to pharmacology 2021/22: Ion channels
Alexander, S. P., Mathie, A., Peters, J. A., Veale, E. L., Striessnig, J., Kelly, E., Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., Southan, C., Davies, J. A., Aldrich, R. W., Attali, B., Baggetta, A. M., Becirovic, E., Biel, M., Bill, R. M., Catterall, W. A., Conner, A. C. & 38 others, , 2021, In: British Journal of Pharmacology. 178 , Suppl. 1, p. S157-S245Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modulation of thalamo-cortical activity by the NMDA receptor antagonists ketamine and phencyclidine in the awake freely-moving rat
Amat-Foraster, M., Celada, P., Richter, U., Jensen, Anders A., Plath, N., Artigas, F. & Herrik, K. F., 2019, In: Neuropharmacology. 158, 14 p., 107745.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Temporally dissociable effects of ketamine on neuronal discharge and gamma oscillations in rat thalamo-cortical networks
Amat-Foraster, M., Jensen, Anders A., Plath, N., Herrik, K. F., Celada, P. & Artigas, F., 2018, In: Neuropharmacology. 137, p. 13-23Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rational design of a-conotoxin analogues targeting a7 nicotinic acetylcholine receptors: Improved antagonistic activity by incorporation of proline derivatives
Armishaw, C., Jensen, Anders A., Balle, T., Clark, R. J., Harpsøe, Kasper, Skonberg, C., Liljefors, T. & Strømgaard, Kristian, 2009, In: Journal of Biological Chemistry. 284, 14, p. 9498-9512Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and biological activity of novel a-conotoxin analogues incorporating substituted proline derivatives
Armishaw, C., Jensen, Anders A., Skonberg, C., Liljefors, T. & Strømgaard, Kristian, 2009, Peptides for youth: The proceedings of the 20th American peptide symposium. Del Valle, S., Escher, E. & Lubell, W. D. (eds.). Springer, Vol. 611. p. 179-180 (Advances in Experimental Medicine and Biology, Vol. 611).Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
- Published
A synthetic combinatorial strategy for developing a-conotoxin analogs as potent a7 nicotinic acetylcholine receptor antagonists
Armishaw, C. J., Singh, N., Medina-Franco, J. L., Clark, R. J., Scott, K. C. M., Houghten, R. A. & Jensen, Anders A., 2010, In: Journal of Biological Chemistry. 285, 3, p. 1809-1821Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Improving the stability of alpha-conotoxin AuIB through N-to-C cyclization: The effect of linker length on stability and activity at nicotinic acetylcholine receptors
Armishaw, C. J., Jensen, Anders A., Balle, L. D., Scott, K. C. M., Sørensen, L. & Strømgaard, Kristian, 2011, In: Antioxidants & Redox Signaling. 14, 1, p. 65-76Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters
Assaf, Z., Larsen, A. P., Venskutonyte, R., Han, L., Abrahamsen, B., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Jensen, Anders A., Pickering, Darryl S, Frydenvang, Karla Andrea, Gefflaut, T. & Bunch, Lennart, 2013, In: Journal of Medicinal Chemistry. 56, 4, p. 1614-1628Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exploration of the molecular architecture of the orthosteric binding site in the α4β2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane.
Bach, T. B., Jensen, Anders A., Petersen, J. G., Sørensen, T. E., Volpe, S. D., Liu, J., Blaazer, A. R., van Muijlwijk-Koezen, J. E., Balle, T. & Frølund, Bente, 2015, In: European Journal of Medicinal Chemistry. 102, p. 425-444 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional characterization of GABAA receptor-mediated modulation of cortical neuron network activity in microelectrode array recordings
Bader, B. M., Steder, A., Klein, A. B., Frølund, Bente, Schroeder, O. H. U. & Jensen, Anders A., 2017, In: PloS One. 12, 10, 32 p., e0186147.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and nicotinic receptor activity of a hydroxylated tropane
Bremner, J. B., Godfrey, C. A., Jensen, Anders A. & Smith, R. J., 2004, In: Bioorganic & Medicinal Chemistry Letters. 14, 1, p. 271-3 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain
Bräuner, Hans, Jensen, Anders A., Sheppard, P. O., O'Hara, P. & Krogsgaard-Larsen, Povl, 1999, In: Journal of Biological Chemistry. 274, 26, p. 18382-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D
Bräuner, Hans, Jensen, Anders A., Sheppard, P. O., Larsen, Birger Brodin, Krogsgaard-Larsen, Povl & O'Hara, P., 2001, In: BBA General Subjects. 1518, 3, p. 237-48 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interaction of CPCCOEt with a chimeric mGlu1b and calcium sensing receptor
Bräuner, Hans, Jensen, Anders A. & Krogsgaard-Larsen, Povl, 1999, In: NeuroReport. 10, 18, p. 3923-5 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors
Bräuner, Hans, Wellendorph, Petrine & Jensen, Anders A., 2007, In: Current Drug Targets. 8, 1, p. 169-184Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Azetidinic amino acids: stereocontrolled synthesis and pharmacological characterization as ligands for glutamate receptors and transporters
Bräuner, Hans, Bunch, Lennart, Chopin, N., Couty, F., Evano, G., Jensen, Anders A., Kusk, M. L., Nielsen, Birgitte & Rabasso, N., 2005, In: Organic & Biomolecular Chemistry. 3, 21, p. 3926-36 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
4,4-Dimethyl- and diastereomeric 4-hydroxy-4-methyl-(2S)-glutamate analogues display distinct pharmacological profiles at ionotropic glutamate receptors and excitatory amino acid transporters
Bunch, Lennart, Pickering, Darryl S, Gefflaut, T., Vinatier, V., Helaine, V., Amir, A., Nielsen, Birgitte & Jensen, Anders A., 2009, In: ChemMedChem. 4, 11, p. 1925-1929Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Excitatory amino acid transporters as potential drug targets
Bunch, Lennart, Erichsen, M. N. & Jensen, Anders A., 2009, In: Expert Opinion On Therapeutic Targets. 13, 6, p. 719-731Research output: Contribution to journal › Journal article › Research › peer-review
- Published
- Published
Rational design and enantioselective synthesis of (1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarboxylic acid - a novel inhibitor at human glutamate transporter subtypes 1, 2, and 3
Bunch, Lennart, Nielsen, Birgitte, Jensen, Anders A. & Bräuner, Hans, 2006, In: Journal of Medicinal Chemistry. 49, 1, p. 172-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype
Chałupnik, P., Vialko, A., Pickering, Darryl S, Hinkkanen, M., Donbosco, S., Møller, T. C., Jensen, Anders A., Nielsen, Birgitte, Bay, Y., Kristensen, Anders Skov, Johansen, Tommy Nørskov, Łątka, K., Bajda, M. & Szymańska, E., 2022, In: International Journal of Molecular Sciences. 23, 15, 16 p., 8797.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The human GABA transporter GAT-2: From cloning to high throughput screening
Christiansen, B., Kvist, T., Jensen, Anders A. & Bräuner, Hans, 2008, Innovative drug development for headache disorders. Olesen, J. & Ramadan, N. (eds.). Oxford, Storbritannien: Oxford University Press, Vol. 16. p. 3-15 (Frontiers in headache research series, Vol. 16).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Cloning and characterization of a functional human ¿-aminobutyric acid (GABA) transporter, human GAT-2
Christiansen, B., Meinild, A., Jensen, Anders A. & Bräuner, Hans, 2007, In: Journal of Biological Chemistry. 282, 27, p. 19331-19341 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ny human GABA-transportør: et muligt mål for behandling af epilepsi
Christiansen, B., Kvist, T., Jensen, Anders A. & Bräuner, Hans, 2008, In: Lægemiddelforskning. p. 25-27Research output: Contribution to journal › Journal article › Communication
- Published
The human γ-aminobutyric acid transporter GAT-2: from cloning to high throughput screening
Christiansen, B., Kvist, T., Jensen, Anders A. & Bräuner, Hans, 2008, Innovative Drug Development for Headache Disorders. Frontiers in Headache Research. Olesen, J. & Ramadan, N. (eds.). Oxford, UK: Oxford University Press, Vol. 16. p. 3-15Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism
Chua, H. C., Christensen, E. H. T., Hoestgaard-Jensen, K., Hartiadi, L. Y., Ramzan, I., Jensen, Anders A., Absalom, N. L. & Chebib, M., 23 Jun 2016, In: P L o S One. 11, 6, p. 1-17 17 p., e0157700.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A parallel panning scheme used for selection of a GluA4-specific Fab targeting the ligand-binding domain
Clausen, Rasmus Prætorius, Mohr, A. Ø., Riise, E., Jensen, Anders A., Gill, A., Madden, D. R., Kastrup, Jette Sandholm Jensen & Skottrup, P. D., 8 Jul 2016, In: International Journal of Biological Macromolecules. 92, p. 779-787 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization
Clausen, Rasmus Prætorius, Naur, P., Kristensen, Anders Skov, Greenwood, J. R., Strange, M., Bräuner, Hans, Jensen, Anders A., Nielsen, A. S. T., Geneser, U., Ringgaard, L. M., Nielsen, Birgitte, Pickering, Darryl S, Brehm, L., Gajhede, Michael, Krogsgaard-Larsen, Povl & Kastrup, Jette Sandholm Jensen, 2009, In: Journal of Medicinal Chemistry. 52, 15, p. 4911-4922Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery
Clementson, S., Matheu, S. A., Marcher, Emil, Pedersen, H., Jensen, Anders A., Clausen, Rasmus Prætorius, Vital, P., Glibstrup, E., Jessing, M. & Kristensen, Jesper Langgaard, 2021, In: The Journal of Organic Chemistry. 86, 12, p. 8248-8262Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neuroprotective effects of the novel glutamate transporter inhibitor (-)-3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]-isoxazole-4-carboxylic acid, which preferentially inhibits reverse transport (glutamate release) compared with glutamate reuptake
Colleoni, S., Jensen, Anders A., Landucci, E., Fumagalli, E., Conti, P., Pinto, A., De Amici, M., Pellegrini-Giampietro, D. E., De Micheli, C., Mennini, T. & Gobbi, M., 2008, In: Journal of Pharmacology and Experimental Therapeutics. 326, 2, p. 646-656 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dual Nicotinic Acetylcholine Receptor α4β2 Antagonists/α7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts
Crestey, F., Jensen, Anders A., Soerensen, C., Magnus, C. B., Andreasen T., Jesper, Peters, G. H. J. & Kristensen, Jesper Langgaard, 2018, In: Journal of Medicinal Chemistry. 61, p. 1719-1729Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design, synthesis and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists
Crestey, F., Jensen, Anders A., Borch, M., Andreasen T., Jesper, Andersen, J., Balle, T. & Kristensen, Jesper Langgaard, 2013, In: Journal of Medicinal Chemistry. 56, 23, p. 9673-9682Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells
Cuesta, E. P., Christensen, S., Jensen, Anders A., Jensen, N. F., Bunch, Lennart, Rømer, M. U. K., Brünner, N., Stenvang, Jan & Pedersen, Stine Helene Falsig, 2015, In: B M C Cancer. 15, 1, 17 p., 411.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of the first highly selective inhibitor of human GABA transporter GAT3
Damgaard, M., Al-Khawaja, A., Vogensen, S. B., Jurik, A., Sijm, M., Lie, M., Bæk, M. I., Rosenthal, E., Jensen, Anders A., Ecker, G. F., Frølund, Bente, Wellendorph, Petrine & Clausen, Rasmus Prætorius, 2015, In: A C S Chemical Neuroscience. 6, p. 1591-1599 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional characterization of alpha7 nicotinic acetylcholine and NMDA receptor signaling in SH-SY5Y neuroblastoma cells in an ERK phosphorylation assay
Elnagar, M. R., Walls, Anne Byriel, Helal, G. K., Hamada, F. M., Thomsen, M. S. & Jensen, Anders A., 2018, In: European Journal of Pharmacology. 826, p. 106-113Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probing the putative α7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue
Elnagar, M. R., Walls, Anne Byriel, Helal, G. K., Hamada, F. M., Thomsen, M. S. & Jensen, Anders A., 2017, In: PLOS ONE. 12, 21 p., e0189513.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probing for improved potency and in vivo bioavailability of excitatory amino acid transporter subtype 1 inhibitors UCPH-101 and UCPH-102: Design, synthesis and pharmacological evaluation of substituted 7-biphenyl analogs
Erichsen, M. N., Hansen, J., Artacho Ruiz, J., Demmer, C. S., Abrahamsen, B., Bastlund, J. F., Bundgaard, C., Jensen, Anders A. & Bunch, Lennart, 2014, In: Neurochemical Research. 39, 10, p. 1964-1979 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101)
Erichsen, M. N., Huynh, Tri Hien Viet, Abrahamsen, B., Bastlund, J. F., Bundgaard, C., Monrad, O., Bekker-Jensen, A., Nielsen, C. W., Frydenvang, Karla Andrea, Jensen, Anders A. & Bunch, Lennart, 2010, In: Journal of Medicinal Chemistry. 53, 19, p. 7180–7191Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stereoselective chemoenzymatic synthesis of the four stereoisomers of l-2-(2-carboxycyclobutyl)glycine and pharmacological characterization at human excitatory amino acid transporter subtypes 1, 2, and 3
Faure, S., Jensen, Anders A., Maurat, V., Gu, X., Sagot, E., Aitken, D. J., Bolte, J., Gefflaut, T. & Bunch, Lennart, 2006, In: Journal of Medicinal Chemistry. 49, 22, p. 6532-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effekt og bivirkninger: GABA fra A til C.
Frølund, Bente, Madsen, C., Jensen, Anders A., Kristiansen, Uffe & Liljefors, T., 2006, In: Lægemiddelforskning. p. 32-33Research output: Contribution to journal › Journal article › Communication
- Published
Chemoenzymatic synthesis and pharmacological characterization of functionalized aspartate analogues as novel excitatory amino acid transporter inhibitors
Fu, H., Zhang, J., Tepper, P. G., Bunch, Lennart, Jensen, Anders A. & Poelarends, G. J., 13 Sep 2018, In: Journal of Medicinal Chemistry. 61, 17, p. 7741-7753Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay
Gadgaard, C. & Jensen, Anders A., 2020, In: Biochemical Pharmacology. 175, 13 p., 113870.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Delineation of the functional properties and the mechanism of action of TMPPAA, an allosteric agonist and positive allosteric modulator of 5-HT3 Receptors
Gasiorek, A., Trattnig, S. M., Ahring, P. K., Kristiansen, Uffe, Frølund, Bente, Frederiksen, K. & Jensen, Anders A., 2016, In: Biochemical Pharmacology. 110-111, p. 92-108 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters
Giraudo, A., Krall, J., Bavo, Francesco, Nielsen, Birgitte, Kongstad, Kenneth Thermann, Rolando, B., De Blasio, R., Gloriam, David E., Löffler, R., Thiesen, L., Harpsøe, Kasper, Frydenvang, Karla Andrea, Boschi, D., Wellendorph, Petrine, Lolli, M. L., Jensen, Anders A. & Frølund, Bente, 27 Jun 2019, In: Journal of Medicinal Chemistry. 62, 12, p. 5797-5809Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting α4β2 nAChRs in CNS disorders: Perspectives on positive allosteric modulation as a therapeutic approach
Grupe, M., Grunnet, M., Bastlund, J. F. & Jensen, Anders A., 2015, In: Basic & Clinical Pharmacology & Toxicology. 116, 3, p. 187-200 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Selective potentiation of (α4)3(β2)2 nicotinic acetylcholine receptors augments amplitudes of prefrontal nicotine-evoked glutamatergic transients in rats
Grupe, M., Paolone, G., Jensen, Anders A., Sandager-Nielsen, K., Sarter, M. & Grunnet, M., 2013, In: Biochemical Pharmacology. 86, 10, p. 1487-1496Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Unraveling the mechanism of action of NS9283, a positive allosteric modulator of (a4)3(ß2)2 nicotinic ACh receptors
Grupe, M., Jensen, Anders A., Ahring, P. K., Christensen, J. K. & Grunnet, M., 2013, In: British Journal of Pharmacology. 168, 8, p. 2000-2010Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional characterization of the 1,5-benzodiazepine clobazam and its major active metabolite N-desmethylclobazam at human GABAA receptors expressed in Xenopus laevis oocytes
Hammer, H., Ebert, B., Jensen, H. S. & Jensen, Anders A., 2015, In: P L o S One. 10, p. 1-21 21 p., e0120239.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A multifaceted GABAA receptor modulator: Functional properties and mechanism of action of the sedative-hypnotic and recreational drug methaqualone (Quaalude)
Hammer, H., Bader, B. M., Ehnert, C., Bundgaard, C., Bunch, Lennart, Hoestgaard-Jensen, K., Schroeder, O. H., Bastlund, J. F., Gramowski-Voß, A. & Jensen, Anders A., 2015, In: Molecular Pharmacology. 88, 2, p. 401-420 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel acetylcholine and carbamoylcholine analogues: Development of a functionally selective a4ß2 nicotinic acetylcholine receptor agonist
Hansen, C. P., Jensen, Anders A., Christensen, J. K., Balle, T., Liljefors, T. & Frølund, Bente, 2008, In: Journal of Medicinal Chemistry. 51, 23, p. 7380-7395Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists--structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC)
Hansen, C. P., Jensen, Anders A., Balle, T., Bitsch-Jensen, K., Hassan, M. M., Liljefors, T. & Frølund, Bente, 2009, In: Bioorganic & Medicinal Chemistry Letters. 19, 1, p. 87-91Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Beta-Sulfonamido Functionalized Aspartate Analogs as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype-Selectivity Profiles Arising from Subtle Structural Differences
Hansen, J. C., Bjørn-Yoshimoto, Walden, Bisballe, N., Nielsen, Birgitte, Jensen, Anders A. & Bunch, Lennart, 2016, In: Journal of Medicinal Chemistry. 59, p. 8771-8786 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New insights into the structure-activity-relationship of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitors UCPH-101 and UCPH-102
Hansen, S. W., Erichsen, M. N., Huynh, Tri Hien Viet, Ruiz, J. A., Haym, I., Bjørn-Yoshimoto, Walden, Abrahamsen, B., Hansen, Jeanette Venla, Storgaard, M., Eriksen, A. L., Jensen, Anders A. & Bunch, Lennart, 2016, In: ChemMedChem. 11, 4, p. 382-402 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of a New Class of Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitors Followed by a Structure-Activity-Relationship Study
Hansen, S. W., Erichsen, M. N., Fu, B., Bjørn-Yoshimoto, Walden, Abrahamsen, B., Hansen, J. C., Jensen, Anders A. & Bunch, Lennart, 2016, In: Journal of Medicinal Chemistry. 59, 19, p. 8757-8770 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bioavailability studies and in vitro profiling of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor 2-amino-4-(4-methyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-102)
Haym, I., Huynh, Tri Hien Viet, Hansen, S. W., Pedersen, M. H. F., Ruiz, J. A., Erichsen, M. N., Gynther, M., Bjørn-Yoshimoto, Walden, Abrahamsen, B., Bastlund, J. F., Bundgaard, C., Eriksen, A. L., Jensen, Anders A. & Bunch, Lennart, 2016, In: ChemMedChem. 11, 4, p. 403-419 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and evaluation of 18F-labeled 5-HT2A receptor agonists as PET ligands
Herth, Matthias Manfred, Petersen, I. N., Hansen, H. D., Hansen, M., Ettrup, A., Jensen, Anders A., Lehel, S., Dyssegaard, A., Gillings, N., Knudsen, G. M. & Kristensen, Jesper Langgaard, 19 Apr 2016, In: Nuclear Medicine and Biology. 43, 8, p. 455-462 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors
Hoestgaard-Jensen, K., O'Connor, R. M., Dalby, N. O., Simonsen, C., Finger, B. C., Golubeva, A., Hammer, H., Bergmann, M. L., Kristiansen, Uffe, Krogsgaard-Larsen, Povl, Bräuner, Hans, Ebert, B., Frølund, Bente, Cryan, J. F. & Jensen, Anders A., Oct 2013, In: British Journal of Pharmacology. 170, 4, p. 919-32 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probing α4βδ GABAA Receptor Heterogeneity: Differential Regional Effects of a Functionally Selective α4β1δ/α4β3δ Receptor Agonist on Tonic and Phasic Inhibition in Rat Brain
Hoestgaard-Jensen, K., Dalby, N. O., Krall, J., Hammer, H., Krogsgaard-Larsen, Povl, Frølund, Bente & Jensen, Anders A., 2014, In: Journal of Neuroscience. 34, 49, p. 16256-16272 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-activity relationship study of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101) and absolute configurational assignment using infrared and vibrational circular dichroism spectroscopy in combination with ab initio hartree-fock calculations
Huynh, Tri Hien Viet, Shim, I., Bohr, H., Abrahamsen, B., Nielsen, Birgitte, Jensen, Anders A. & Bunch, Lennart, 2012, In: Journal of Medicinal Chemistry. 55, 11, p. 5403-12 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-activity-relationship study of N-acyl-N-phenylpiperazines as potential inhibitors of the excitatory amino acid transporters (EAATs): Improving the potency of a micromolar screening hit is not truism
Huynh, Tri Hien Viet, Demmer, C. S., Abrahamsen, B., Marcher, Emil, Frykman, M., Jensen, Anders A. & Bunch, Lennart, 2013, In: SpringerPlus. 2, p. 112Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102
Huynh, Tri Hien Viet, Abrahamsen, B., Madsen, K. K., Gonzalez-Franquesa, A., Jensen, Anders A. & Bunch, Lennart, 2012, In: Bioorganic & Medicinal Chemistry. 20, 23, p. 6831-6839Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ginkgolides and glycine receptors: a structure-activity relationship study
Jaracz, S., Nakanishi, K., Jensen, Anders A. & Strømgaard, Kristian, 2004, In: Chemistry: A European Journal. 10, 6, p. 1507-18 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties
Jensen, Anders A., Plath, N., Pedersen, M. H. F., Isberg, V., Krall, J., Wellendorph, Petrine, Stensbøl, T. B., Gloriam, David E., Krogsgaard-Larsen, Povl & Frølund, Bente, 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 1211-27 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The selective 5-HT2A receptor agonist 25CN-NBOH: structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics of [3H]25CN-NBOH
Jensen, Anders A., Halberstadt, A. L., Marcher, Emil, Odland, Anna Ulstein, Chatha, M., Speth, N., Liebscher, G., Hansen, M., Bräuner, Hans, Palner, M., Andreasen T., Jesper & Kristensen, Jesper Langgaard, 2020, In: Biochemical Pharmacology. 177, 16 p., 113979.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Detailed characterization of the in vitro pharmacological and pharmacokinetic properties of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (25CN-NBOH), a highly selective and brain-penetrant 5-HT2A receptor agonist
Jensen, Anders A., McCorvy, J. D., Petersen, S. L., Bundgaard, C., Liebscher, G., Kenakin, T. P., Bräuner, Hans, Kehler, J. & Kristensen, Jesper Langgaard, 2017, In: Journal of Pharmacology and Experimental Therapeutics. 361, 3, p. 441-453Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evolutionary conservation of Zinc-Activated Channel (ZAC) functionality in mammals: a range of mammalian ZACs assemble into cell surface-expressed functional receptors
Jensen, Anders A., 2023, In: Frontiers in Molecular Biosciences. 10, 11 p., 1265429.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Carbamoylcholine homologs: synthesis and pharmacology at nicotinic acetylcholine receptors
Jensen, Anders A., Mikkelsen, I. B., Frølund, Bente, Frydenvang, Karla Andrea, Brehm, L., Jaroszewski, J. W., Bräuner, Hans, Falch, E. & Krogsgaard-Larsen, Povl, 2004, In: European Journal of Pharmacology. 497, 2, p. 125-37 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Construction of a high affinity zinc binding site in the metabotropic glutamate receptor mGluR1: noncompetitive antagonism originating from the amino-terminal domain of a family C G-protein-coupled receptor
Jensen, Anders A., Sheppard, P. O., Jensen, L. B., O'Hara, P. J. & Bräuner, Hans, 2001, In: Journal of Biological Chemistry. 276, 13, p. 10110-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacological characterisation of strychnine and brucine analogues at glycine and alpha7 nicotinic acetylcholine receptors
Jensen, Anders A., Gharagozloo, P., Birdsall, N. J. M. & Zlotos, D. P., 2006, In: European Journal of Pharmacology. 539, 1-2, p. 27-33 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Functional importance of the carboxyl tail cysteine residues in the human D1 dopamine receptor
Jensen, Anders A., Pedersen, U. B., Kiemer, A., Din, N. & Andersen, P. H., 1995, In: Journal of Neurochemistry. 65, 3, p. 1325-31 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
3B but which 3B? And that's just one of the questions: the heterogeneity of human 5-HT3 receptors
Jensen, Anders A., Davies, P. A., Bräuner, Hans & Krzywkowski, K., 2008, In: TIPS - Trends in Pharmacological Sciences. 29, 9, p. 437-444Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The dopamine D1 receptor family: structural and functional aspects
Jensen, Anders A., Pedersen, U. B., Din, N. & Andersen, P. H., 1996, In: Biochemical Society Transactions. 24, 1, p. 163-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Øget forståelse af vigtig receptor i hjernen
Jensen, Anders A. & Bräuner, Hans, 2000, In: Lægemiddelforskning. p. 28-29Research output: Contribution to journal › Journal article › Communication
- Published
Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA
Jensen, Anders A., Christesen, T., Bølcho, U., Greenwood, J. R., Postorino, G., Vogensen, S. B., Johansen, Tommy Nørskov, Egebjerg, J., Bräuner, Hans & Clausen, Rasmus Prætorius, 2007, In: Journal of Medicinal Chemistry. 50, 17, p. 4177-4185 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities
Jensen, Anders A., Fahlke, C., Bjørn-Yoshimoto, Walden & Bunch, Lennart, 2015, In: Current Opinion in Pharmacology. 20, p. 116-123 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacological characterization of homobaclofen on wild type and mutant GABA(B)1b receptors coexpressed with the GABA(B)2 receptor
Jensen, Anders A., Madsen, B. E., Krogsgaard-Larsen, Povl & Bräuner, Hans, 2001, In: European Journal of Pharmacology. 417, 3, p. 177-80 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of Arg(78) in the metabotropic glutamate receptor mGlu(1) for agonist binding and selectivity
Jensen, Anders A., Sheppard, P. O., O'Hara, P. J., Krogsgaard-Larsen, Povl & Bräuner, Hans, 2000, In: European Journal of Pharmacology. 397, 2-3, p. 247-53 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stoffer fra Tempeltæet (Ginkgo biloba) som redskaber for studier af hjernens funktion
Jensen, Anders A. & Strømgaard, Kristian, 2006, In: Dansk Kemi 83. 87, 1, p. 16-18Research output: Contribution to journal › Journal article › Communication
- Published
Fluorescensbaseret farmakologi
Jensen, Anders A., Strange, M. & Bräuner, Hans, 2004, In: Dansk Kemi 83. p. 29 31 p.Research output: Contribution to journal › Journal article › Communication
- Published
Allosteric modulation of G-protein coupled receptors
Jensen, Anders A. & Spalding, T. A., 2004, In: European Journal of Pharmaceutical Sciences. 21, 4, p. 407-20 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors
Jensen, Anders A., Mosbacher, J., Elg, S., Lingenhoehl, K., Lohmann, T., Johansen, Tommy Nørskov, Abrahamsen, B., Mattsson, J., Lehmann, A., Bettler, B. & Bräuner, Hans, 2002, In: Molecular Pharmacology. 61, 6, p. 1377-84 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The dance of the clams: twists and turns in the family C GPCR homodimer
Jensen, Anders A., Greenwood, J. R. & Bräuner, Hans, 2002, In: Trends in Pharmacological Sciences. 23, 11, p. 491-3 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional characterisation of human glycine receptors in a fluorescence-based high throughput screening assay
Jensen, Anders A., 2005, In: European Journal of Pharmacology. 521, 1-3, p. 39-42 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional importance of the Ala(116)-Pro(136) region in the calcium-sensing receptor. Constitutive activity and inverse agonism in a family C G-protein-coupled receptor
Jensen, Anders A., Spalding, T. A., Burstein, E. S., Sheppard, P. O., O'Hara, P. J., Brann, M. R., Krogsgaard-Larsen, Povl & Bräuner, Hans, 2000, In: Journal of Biological Chemistry. 275, 38, p. 29547-55 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neurotransmitter transporters
Jensen, Anders A., 2006, In: Current Topics in Medicinal Chemistry. 6, 17, p. 1799-1800 2 p.Research output: Contribution to journal › Journal article › Research
- Published
Molecular pharmacology of the metabotropic glutamate receptors
Jensen, Anders A., 2004, Molecular Neuropharmacology. Strategies and Methods . Schousboe, A. & Bräuner-Osborne, H. (eds.). Humana Press, p. 47-82Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
The dopamine D1 receptor family: Pharmacology and signal transduction
Jensen, Anders A., Pedersen, U. B., Din, N. & Andersen, P. H., 1995, Alfred Benzon Symposium. Fog, R., Gerlach, J. & Hemmingsen, R. (eds.). Vol. 38. p. 236-246Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations
Jensen, Anders A., Frølund, Bente, Liljefors, T. & Krogsgaard-Larsen, Povl, 2005, In: Journal of Medicinal Chemistry. 48, 15, p. 4705-45 41 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional characterisation of the human alpha1 glycine receptor in a fluorescence-based membrane potential assay
Jensen, Anders A. & Kristiansen, Uffe, 2004, In: Biochemical Pharmacology. 67, 9, p. 1789-99 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acetylcholine
Jensen, Anders A., 2016, Textbook of drug design and discovery. Strømgaard, K., Krogsgaard-Larsen, P. & Madsen, U. (eds.). 5 ed. Taylor & FrancisResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
- Published
Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors
Jensen, Anders A., Frølund, Bente, Bräuner, Hans, Falch, E. & Krogsgaard-Larsen, Povl, 2003, In: Molecular Pharmacology. 64, 4, p. 865-75 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET)
Jensen, Anders A., Hansen, J. L., Sheikh, S. P. & Bräuner, Hans, 2002, In: European Journal of Biochemistry. 269, 20, p. 5076-87 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay
Jensen, Anders A. & Bräuner, Hans, 2004, In: Biochemical Pharmacology. 67, 11, p. 2115-27 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acetylcholine
Jensen, Anders A. & Krogsgaard-Larsen, Povl, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 263-281Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
- Published
Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1
Jensen, Anders A., Erichsen, M. N., Nielsen, C. W., Stensbøl, T. B., Kehler, J. & Bunch, Lennart, 2009, In: Journal of Medicinal Chemistry. 52, 4, p. 912-915Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1298436
Most downloads
-
331
downloads
A strategic approach to [6,6]-bicyclic lactones: application towards the CD fragment of DHβE
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
328
downloads
The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
268
downloads
Functional characterization of GABAA receptor-mediated modulation of cortical neuron network activity in microelectrode array recordings
Research output: Contribution to journal › Journal article › Research › peer-review
Published