Anders A. Jensen
Professor
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
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11-Aminostrychnine and N-(Strychnine-11-yl)propionamide: Synthesis, Configuration, and Pharmacological Evaluation at Glycine Receptors
Zlotos, D. P., Mohsen, A. M. Y., Mandour, Y. M., Marzouk, M. A., Breitinger, U., Villmann, C., Breitinger, H., Sotriffer, C., Jensen, Anders A. & Holzgrabe, U., 6 Aug 2019, In: Journal of Natural Products. 82, p. 2332-2336Research output: Contribution to journal › Journal article › Research › peer-review
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18F-Labelling of electron rich iodonium ylides: application to the radiosynthesis of potential 5-HT2A receptor PET ligands
Petersen, I. N., Villadsen, J., Hansen, H. D., Madsen, J., Jensen, Anders A., Gillings, N., Lehel, S., Herth, Matthias Manfred, Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, Apr 2017, In: Organic & Biomolecular Chemistry. 15, p. 4351-4358Research output: Contribution to journal › Journal article › Research › peer-review
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25CN-NBOH: A selective agonist for in vitro and in vivo investigations of the serotonin 2A receptor
Marcher, Emil, Jensen, Anders A. & Kristensen, Jesper Langgaard, 2021, In: ChemMedChem. 16, 21, p. 3263-3270Research output: Contribution to journal › Review › Research › peer-review
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3B but which 3B? And that's just one of the questions: the heterogeneity of human 5-HT3 receptors
Jensen, Anders A., Davies, P. A., Bräuner, Hans & Krzywkowski, K., 2008, In: TIPS - Trends in Pharmacological Sciences. 29, 9, p. 437-444Research output: Contribution to journal › Journal article › Research › peer-review
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4,4-Dimethyl- and diastereomeric 4-hydroxy-4-methyl-(2S)-glutamate analogues display distinct pharmacological profiles at ionotropic glutamate receptors and excitatory amino acid transporters
Bunch, Lennart, Pickering, Darryl S, Gefflaut, T., Vinatier, V., Helaine, V., Amir, A., Nielsen, Birgitte & Jensen, Anders A., 2009, In: ChemMedChem. 4, 11, p. 1925-1929Research output: Contribution to journal › Journal article › Research › peer-review
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5-(Piperidin-4-yl)-3-Hydroxypyrazole: A Novel Scaffold for Probing the Orthosteric γ-Aminobutyric Acid Type A Receptor Binding Site
Krall, J., Kongstad, Kenneth Thermann, Nielsen, Birgitte, Sørensen, T. E., Balle, T., Jensen, Anders A. & Frølund, Bente, 2014, In: ChemMedChem. 9, 11, p. 2475-2485 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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5-HT2A/5-HT2C receptor pharmacology and intrinsic clearance of N-benzylphenethylamines modified at the primary site of metabolism
Leth-Petersen, S., Petersen, I. N., Jensen, Anders A., Bundgaard, C., Bæk, M., Kehler, J. & Kristensen, Jesper Langgaard, 26 Aug 2016, In: A C S Chemical Neuroscience. p. 1-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology
Peng, Y., McCorvy, J. D., Harpsøe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajsen, L. F., Huang, X., Wu, Y., Shen, L., Bjørn-Yoshimoto, W. E., Ding, K., Wacker, D., Han, G. W., Cheng, J., Katritch, V., Jensen, A. A. & 6 others, , 2018, In: Cell. 172, 4, p. 719-730 P719-730.E14.Research output: Contribution to journal › Journal article › Research › peer-review
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5-Substituted imidazole-4-acetic acid analogues: Synthesis, modeling, and pharmacological characterization of a series of novel γ-aminobutyric acidC receptor agonists
Madsen, C., Jensen, Anders A., Liljefors, T., Kristiansen, Uffe, Nielsen, Birgitte, Hansen, C. P., Larsen, M., Ebert, B., Bang-Andersen, B., Krogsgaard-Larsen, Povl & Frølund, Bente, 2007, In: Journal of Medicinal Chemistry. 50, p. 4147-4161Research output: Contribution to journal › Journal article › Research › peer-review
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Beta-Sulfonamido Functionalized Aspartate Analogs as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype-Selectivity Profiles Arising from Subtle Structural Differences
Hansen, J. C., Bjørn-Yoshimoto, Walden, Bisballe, N., Nielsen, Birgitte, Jensen, Anders A. & Bunch, Lennart, 2016, In: Journal of Medicinal Chemistry. 59, p. 8771-8786 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A multifaceted GABAA receptor modulator: Functional properties and mechanism of action of the sedative-hypnotic and recreational drug methaqualone (Quaalude)
Hammer, H., Bader, B. M., Ehnert, C., Bundgaard, C., Bunch, Lennart, Hoestgaard-Jensen, K., Schroeder, O. H., Bastlund, J. F., Gramowski-Voß, A. & Jensen, Anders A., 2015, In: Molecular Pharmacology. 88, 2, p. 401-420 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A parallel panning scheme used for selection of a GluA4-specific Fab targeting the ligand-binding domain
Clausen, Rasmus Prætorius, Mohr, A. Ø., Riise, E., Jensen, Anders A., Gill, A., Madden, D. R., Kastrup, Jette Sandholm Jensen & Skottrup, P. D., 8 Jul 2016, In: International Journal of Biological Macromolecules. 92, p. 779-787 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A strategic approach to [6,6]-bicyclic lactones: application towards the CD fragment of DHβE
Jepsen, T. H., Glibstrup, E., Crestey, F. L. J., Jensen, Anders A. & Kristensen, Jesper Langgaard, 2017, In: Beilstein Journal of Organic Chemistry. 13, p. 988-994 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A synthetic combinatorial strategy for developing a-conotoxin analogs as potent a7 nicotinic acetylcholine receptor antagonists
Armishaw, C. J., Singh, N., Medina-Franco, J. L., Clark, R. J., Scott, K. C. M., Houghten, R. A. & Jensen, Anders A., 2010, In: Journal of Biological Chemistry. 285, 3, p. 1809-1821Research output: Contribution to journal › Journal article › Research › peer-review
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Acetylcholine
Jensen, Anders A., 2016, Textbook of drug design and discovery. Strømgaard, K., Krogsgaard-Larsen, P. & Madsen, U. (eds.). 5 ed. Taylor & FrancisResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
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Acetylcholine
Jensen, Anders A. & Krogsgaard-Larsen, Povl, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 263-281Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
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Allosteric modulation of G-protein coupled receptors
Jensen, Anders A. & Spalding, T. A., 2004, In: European Journal of Pharmaceutical Sciences. 21, 4, p. 407-20 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Allosteric modulation of an excitatory amino acid transporter: The subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain
Abrahamsen, B., Schneider, N., Erichsen, M. N., Huynh, Tri Hien Viet, Fahlke, C., Bunch, Lennart & Jensen, Anders A., 2013, In: Journal of Neuroscience. 33, 3, p. 1068-1087Research output: Contribution to journal › Journal article › Research › peer-review
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Allosteric modulation of the calcium-sensing receptor
Jensen, Anders A. & Bräuner, Hans, 2007, In: Current Neuropharmacology. 5, 3, p. 180-186Research output: Contribution to journal › Journal article › Research › peer-review
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Azetidinic amino acids: stereocontrolled synthesis and pharmacological characterization as ligands for glutamate receptors and transporters
Bräuner, Hans, Bunch, Lennart, Chopin, N., Couty, F., Evano, G., Jensen, Anders A., Kusk, M. L., Nielsen, Birgitte & Rabasso, N., 2005, In: Organic & Biomolecular Chemistry. 3, 21, p. 3926-36 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bioavailability studies and in vitro profiling of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor 2-amino-4-(4-methyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-102)
Haym, I., Huynh, Tri Hien Viet, Hansen, S. W., Pedersen, M. H. F., Ruiz, J. A., Erichsen, M. N., Gynther, M., Bjørn-Yoshimoto, Walden, Abrahamsen, B., Bastlund, J. F., Bundgaard, C., Eriksen, A. L., Jensen, Anders A. & Bunch, Lennart, 2016, In: ChemMedChem. 11, 4, p. 403-419 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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C-2-Linked Dimeric Strychnine Analogues as Bivalent Ligands Targeting Glycine Receptors
Zlotos, D. P., Abdelmalek, C. M., Botros, L. S., Banoub, M. M., Mandour, Y. M., Breitinger, U., El Nady, A., Breitinger, H., Sotriffer, C., Villmann, C., Jensen, Anders A. & Holzgrabe, U., 2021, In: Journal of Natural Products. 84, 2, p. 382-394Research output: Contribution to journal › Journal article › Research › peer-review
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Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists--structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC)
Hansen, C. P., Jensen, Anders A., Balle, T., Bitsch-Jensen, K., Hassan, M. M., Liljefors, T. & Frølund, Bente, 2009, In: Bioorganic & Medicinal Chemistry Letters. 19, 1, p. 87-91Research output: Contribution to journal › Journal article › Research › peer-review
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Carbamoylcholine homologs: synthesis and pharmacology at nicotinic acetylcholine receptors
Jensen, Anders A., Mikkelsen, I. B., Frølund, Bente, Frydenvang, Karla Andrea, Brehm, L., Jaroszewski, J. W., Bräuner, Hans, Falch, E. & Krogsgaard-Larsen, Povl, 2004, In: European Journal of Pharmacology. 497, 2, p. 125-37 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors
Jensen, Anders A., Frølund, Bente, Bräuner, Hans, Falch, E. & Krogsgaard-Larsen, Povl, 2003, In: Molecular Pharmacology. 64, 4, p. 865-75 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characteristics of stably expressed human dopamine D1a and D1b receptors: atypical behavior of the dopamine D1b receptor
Pedersen, U. B., Norby, B., Jensen, Anders A., Schiødt, M., Hansen, A., Suhr-Jessen, P., Scheideler, M., Thastrup, Ole & Andersen, P. H., 1994, In: European Journal of Pharmacology. 267, 1, p. 85-93 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of AN317, a novel selective agonist of α6β2-containing nicotinic acetylcholine receptors
Sandager-Nielsen, K., Ahring, P. K., Klein, J., van Hout, M., Thaneshwaran, S., Brito dos Santos, Altair, Jacobsen, T. A., Amrutkar, D. V., Peters, D., Jensen, Anders A., Kohlmeier, Kristi Anne, Christophersen, P. & Dyhring, T., 2020, In: Biochemical Pharmacology. 174, 13 p., 113786.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of AN6001, the first positive allosteric modulator of α6β2-containing nicotinic acetylcholine receptors
van Hout, M., Klein, J., Ahring, P. K., Brown, D. T., Thaneshwaran, S., Brito dos Santos, Altair, Jensen, Anders A., Kohlmeier, Kristi Anne, Christophersen, P. & Dyhring, T., 2020, In: Biochemical Pharmacology. 174, 113788.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling
Krzywkowski, K. M., Davies, P. A., Irving, A. J., Bräuner, Hans & Jensen, Anders A., 2008, In: Pharmacogenetics and Genomics (Print Edition). 18, 12, p. 1027-1040Research output: Contribution to journal › Journal article › Research › peer-review
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Chemo-enzymatic synthesis of (2S,4R)-2-amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic acid: a novel selective inhibitor of human excitatory amino acid transporter subtype 2
Sagot, E., Jensen, Anders A., Pickering, Darryl S, Pu, X., Umberti, M., Stensbøl, T. B., Nielsen, Birgitte, Assaf, Z., Aboab, B., Bolte, J., Gefflaut, T. & Bunch, Lennart, 2008, In: Journal of Medicinal Chemistry. 51, 14, p. 4085-4092 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters
Assaf, Z., Larsen, A. P., Venskutonyte, R., Han, L., Abrahamsen, B., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Jensen, Anders A., Pickering, Darryl S, Frydenvang, Karla Andrea, Gefflaut, T. & Bunch, Lennart, 2013, In: Journal of Medicinal Chemistry. 56, 4, p. 1614-1628Research output: Contribution to journal › Journal article › Research › peer-review
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Chemoenzymatic synthesis and pharmacological characterization of functionalized aspartate analogues as novel excitatory amino acid transporter inhibitors
Fu, H., Zhang, J., Tepper, P. G., Bunch, Lennart, Jensen, Anders A. & Poelarends, G. J., 13 Sep 2018, In: Journal of Medicinal Chemistry. 61, 17, p. 7741-7753Research output: Contribution to journal › Journal article › Research › peer-review
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Chemoenzymatic synthesis of a series of 4-substituted glutamate analogues and pharmacological characterization at human glutamate transporters subtypes 1-3
Alaux, S., Kusk, M., Sagot, E., Bolte, J., Jensen, Anders A., Bräuner, Hans, Gefflaut, T. & Bunch, Lennart, 2005, In: Journal of Medicinal Chemistry. 48, 25, p. 7980-92 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cloning and characterization of a functional human ¿-aminobutyric acid (GABA) transporter, human GAT-2
Christiansen, B., Meinild, A., Jensen, Anders A. & Bräuner, Hans, 2007, In: Journal of Biological Chemistry. 282, 27, p. 19331-19341 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D
Bräuner, Hans, Jensen, Anders A., Sheppard, P. O., Larsen, Birger Brodin, Krogsgaard-Larsen, Povl & O'Hara, P., 2001, In: BBA General Subjects. 1518, 3, p. 237-48 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparison of biophysical properties of α1β2 and α3β2 GABAA receptors in whole-cell patch-clamp electrophysiological recordings
Olander, E. R., Janzen , D., Villmann , C. & Jensen, Anders A., 2020, In: P L o S One. 15, 6, 13 p., e0234080.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational transitions of the serotonin 5-HT3 receptor
Polovinkin, L., Hassaine, G., Perot, J., Neumann, E., Jensen, Anders A., Lefebvre, S. N., Corringer, P., Neyton, J., Chipot, C., Dehez, F., Schoehn, G. & Nury, H., Nov 2018, In: Nature. 563, 7730, p. 275-279 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerations
de la Fuente Revenga, M., Balle, T., Jensen, Anders A. & Frølund, Bente, 2015, In: European Journal of Medicinal Chemistry. 102, p. 352-362 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Construction of a high affinity zinc binding site in the metabotropic glutamate receptor mGluR1: noncompetitive antagonism originating from the amino-terminal domain of a family C G-protein-coupled receptor
Jensen, Anders A., Sheppard, P. O., Jensen, L. B., O'Hara, P. J. & Bräuner, Hans, 2001, In: Journal of Biological Chemistry. 276, 13, p. 10110-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Convergent [18]F-labeling and evaluation of N-benzyl-phenethylamines as 5-HT2A receptor PET ligands
Petersen, I. N., Villadsen, J., Hansen, H. D., Jensen, Anders A., Lehel, S., Gillings, N., Herth, Matthias Manfred, Knudsen, G. M. & Kristensen, Jesper Langgaard, 2016, In: Bioorganic & Medicinal Chemistry. 24, p. 5353-5356 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Copper and protons directly activate the zinc-activated channel
Trattnig, S. M., Gasiorek, A., Deeb, T. Z., Comenencia Ortiz, E. J., Moss, S. J., Jensen, Anders A. & Davies, P. A., 2016, In: Biochemical Pharmacology. 103, p. 109-117 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dark Classics in Chemical Neuroscience: NBOMes
Poulie, Christian Bernard Matthijs, Jensen, Anders A., Halberstadt, A. & Kristensen, Jesper Langgaard, 2020, In: ACS Chemical Neuroscience. p. 3860–3869 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors
Olander, E. R., Madjroh, Nawid, Bunch, Lennart, Söderhielm, P. C. & Jensen, Anders A., 2018, In: Biochemical Pharmacology. 150, p. 305-319Research output: Contribution to journal › Journal article › Research › peer-review
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Delineation of the functional properties and the mechanism of action of TMPPAA, an allosteric agonist and positive allosteric modulator of 5-HT3 Receptors
Gasiorek, A., Trattnig, S. M., Ahring, P. K., Kristiansen, Uffe, Frølund, Bente, Frederiksen, K. & Jensen, Anders A., 2016, In: Biochemical Pharmacology. 110-111, p. 92-108 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Delineation of the functional properties exhibited by the Zinc-Activated Channel (ZAC) and its high-frequency Thr128Ala variant (rs2257020) in Xenopus oocytes
Madjroh, Nawid, Davies, P. A., Smalley, J. L., Kristiansen, Uffe, Söderhielm, P. C. & Jensen, Anders A., 2021, In: Pharmacological Research. 169, 18 p., 105653.Research output: Contribution to journal › Journal article › Research › peer-review
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Design and Synthesis of 2,3-trans-Proline Analogs as Ligands for the Ionotropic Glutamate Receptors and the Excitatory Amino Acid Transporters
Poulie, Christian Bernard Matthijs, Alcaide Lopez, A., Krell-Jørgensen, M. P., Larsen, Y., Astier, E., Bjørn-Yoshimoto, Walden, Yi, F., Syrenne, J. T., Storgaard, M., Nielsen, Birgitte, Frydenvang, Karla Andrea, Jensen, Anders A., Hansen, K. B., Pickering, Darryl S & Bunch, Lennart, 19 Jun 2019, In: A C S Chemical Neuroscience. 10, 6, p. 2989-3007 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Design, Synthesis, and Pharmacological Characterization of Heterobivalent Ligands for the Putative 5-HT2A/mGlu2 Receptor Complex
Poulie, Christian Bernard Matthijs, Liu, N., Jensen, Anders A. & Bunch, Lennart, 2020, In: Journal of Medicinal Chemistry. 63, 17, p. 9928-9949 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Design, synthesis and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists
Crestey, F., Jensen, Anders A., Borch, M., Andreasen T., Jesper, Andersen, J., Balle, T. & Kristensen, Jesper Langgaard, 2013, In: Journal of Medicinal Chemistry. 56, 23, p. 9673-9682Research output: Contribution to journal › Journal article › Research › peer-review
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Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102
Huynh, Tri Hien Viet, Abrahamsen, B., Madsen, K. K., Gonzalez-Franquesa, A., Jensen, Anders A. & Bunch, Lennart, 2012, In: Bioorganic & Medicinal Chemistry. 20, 23, p. 6831-6839Research output: Contribution to journal › Journal article › Research › peer-review
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Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties
Jensen, Anders A., Plath, N., Pedersen, M. H. F., Isberg, V., Krall, J., Wellendorph, Petrine, Stensbøl, T. B., Gloriam, David E., Krogsgaard-Larsen, Povl & Frølund, Bente, 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 1211-27 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Detailed characterization of the in vitro pharmacological and pharmacokinetic properties of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (25CN-NBOH), a highly selective and brain-penetrant 5-HT2A receptor agonist
Jensen, Anders A., McCorvy, J. D., Petersen, S. L., Bundgaard, C., Liebscher, G., Kenakin, T. P., Bräuner, Hans, Kehler, J. & Kristensen, Jesper Langgaard, 2017, In: Journal of Pharmacology and Experimental Therapeutics. 361, 3, p. 441-453Research output: Contribution to journal › Journal article › Research › peer-review
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Developing New 4-PIOL and 4-PHP Analogues for Photoinactivation of γ-Aminobutyric Acid Type A Receptors
Mortensen, M., Krall, J., Kongstad, Kenneth Thermann, Brygger, B. M., Lenzi, O., Francotte, P., Sørensen, T. E., Nielsen, Birgitte, Jensen, Anders A., Smart, T. G. & Frølund, Bente, 2019, In: ACS Chemical Neuroscience. 10, 11, p. 4669-4684Research output: Contribution to journal › Journal article › Research › peer-review
- E-pub ahead of print
Discovery and Structure-Activity Relationships of 2,5-Dimethoxyphenylpiperidines as Selective Serotonin 5-HT2A Receptor Agonists
Marcher, Emil, Jensen, Anders A., Smits, G., Frydenvang, Karla Andrea & Kristensen, Jesper Langgaard, 2024, (E-pub ahead of print) In: Journal of Medicinal Chemistry.Research output: Contribution to journal › Journal article › Research › peer-review
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Discovery and functional characterization of N-(thiazol-2-yl)-benzamide analogs as the first class of selective antagonists of the Zinc-Activated Channel (ZAC)
Madjroh, Nawid, Mellou, E., Davies, P. A., Söderhielm, P. C. & Jensen, Anders A., 2021, In: Biochemical Pharmacology. 193, 16 p., 114782.Research output: Contribution to journal › Journal article › Research › peer-review
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Discovery of 2-(Imidazo[1,2-b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites
Krall, J., Bavo, Francesco, Falk-Petersen, C. B., Jensen, C. H., Nielsen, J. O., Tian, Yongsong, Anglani, V., Kongstad, Kenneth Thermann, Petersen, Louise Piilgaard, Nielsen, Birgitte, Gloriam, David E., Kehler, J., Jensen, Anders A., Harpsøe, Kasper, Wellendorph, Petrine & Frølund, Bente, 14 Mar 2019, In: Journal of Medicinal Chemistry. 62, 5, p. 2798-2813Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of a Novel Class of Benzimidazole-Based Nicotinic Acetylcholine Receptor Modulators: Positive and Negative Modulation Arising from Overlapping Allosteric Sites
Zhou, L., Dau, V. & Jensen, Anders A., 2023, In: Journal of Medicinal Chemistry. 66, 17, p. 12586–12601Research output: Contribution to journal › Journal article › Research › peer-review
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Discovery of a novel allosteric modulator of 5-HT3 receptor: Inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site
Trattnig, S. M., Harpsøe, Kasper, Thygesen, S. B., Rahr, L. M., Ahring, P. K., Balle, T. & Jensen, Anders A., 2012, In: Journal of Biological Chemistry. 287, 30, p. 25241-25254Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of a subtype-selective of the human betaine/GABA transporter 1 (BGT-1) with a non-competitive pharmacological profile
Kragholm, B., Kvist, T., Madsen, K. K., Jørgensen, L., Vogensen, S. B., Schousboe, Arne, Clausen, Rasmus Prætorius, Jensen, Anders A. & Bräuner, Hans, 2013, In: Biochemical Pharmacology. 86, p. 521-528Research output: Contribution to journal › Journal article › Research › peer-review
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Discovery of benzamide analogues as a novel class of 5-HT3 receptor agonists
Jørgensen, Charlotte Grube, Frølund, Bente, Kehler, J. & Jensen, Anders A., 4 Apr 2011, In: ChemMedChem. 6, 4, p. 725-736Research output: Contribution to journal › Journal article › Research › peer-review
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Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype
Chałupnik, P., Vialko, A., Pickering, Darryl S, Hinkkanen, M., Donbosco, S., Møller, T. C., Jensen, Anders A., Nielsen, Birgitte, Bay, Y., Kristensen, Anders Skov, Johansen, Tommy Nørskov, Łątka, K., Bajda, M. & Szymańska, E., 2022, In: International Journal of Molecular Sciences. 23, 15, 16 p., 8797.Research output: Contribution to journal › Journal article › Research › peer-review
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Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1
Jensen, Anders A., Erichsen, M. N., Nielsen, C. W., Stensbøl, T. B., Kehler, J. & Bunch, Lennart, 2009, In: Journal of Medicinal Chemistry. 52, 4, p. 912-915Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of α-Substituted Imidazole-4-acetic Acid Analogues as a Novel Class of ρ1 γ-Aminobutyric Acid Type A Receptor Antagonists with Effect on Retinal Vascular Tone
Krall, J., Brygger, B. M., Sigurðardóttir, S. B., Ng, C. K. L., Bundgaard, C., Kehler, J., Nielsen, Birgitte, Bek, T., Jensen, Anders A. & Frølund, Bente, 13 Sep 2016, In: ChemMedChem. 11, 20, p. 2299-2310 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of β-Arrestin-Biased 25CN-NBOH-Derived 5-HT2A Receptor Agonists
Poulie, Christian Bernard Matthijs, Pottie, E., Simon, Icaro A, Harpsøe, Kasper, D'Andrea, L., Komarov, I. V., Gloriam, David E., Jensen, Anders A., Stove, C. P. & Kristensen, Jesper Langgaard, 2022, In: Journal of Medicinal Chemistry. 65, 18, p. 12031–12043Research output: Contribution to journal › Journal article › Research › peer-review
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Dual Nicotinic Acetylcholine Receptor α4β2 Antagonists/α7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts
Crestey, F., Jensen, Anders A., Soerensen, C., Magnus, C. B., Andreasen T., Jesper, Peters, G. H. J. & Kristensen, Jesper Langgaard, 2018, In: Journal of Medicinal Chemistry. 61, p. 1719-1729Research output: Contribution to journal › Journal article › Research › peer-review
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Effekt og bivirkninger: GABA fra A til C.
Frølund, Bente, Madsen, C., Jensen, Anders A., Kristiansen, Uffe & Liljefors, T., 2006, In: Lægemiddelforskning. p. 32-33Research output: Contribution to journal › Journal article › Communication
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Elucidation of molecular impediments in the α6 subunit for in vitro expression of functional α6β4* nicotinic acetylcholine receptors
Jensen, A. B., Hoestgaard-Jensen, K. & Jensen, Anders A., 2013, In: Journal of Biological Chemistry. 288, 47, p. 33708-33721Research output: Contribution to journal › Journal article › Research › peer-review
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En genetisk variation i en serotonin-receptor: et muligt link til depression?
Krzywkowski, K. M., Davies, P. A., Feinberg-Zadek, P. L., Jensen, Anders A. & Bräuner, Hans, 2007, In: Lægemiddelforskning. p. 30-31Research output: Contribution to journal › Journal article › Communication
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En genetisk variation i en serotonin–receptor – et muligt link til depression?
Krzywkowski, K. M., Feinberg-Zadek, P., Davies, P. A., Jensen, Anders A. & Bräuner, Hans, 2008, In: Dansk Kemi 83. 89, 6/7Research output: Contribution to journal › Journal article › Communication
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Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery
Clementson, S., Matheu, S. A., Marcher, Emil, Pedersen, H., Jensen, Anders A., Clausen, Rasmus Prætorius, Vital, P., Glibstrup, E., Jessing, M. & Kristensen, Jesper Langgaard, 2021, In: The Journal of Organic Chemistry. 86, 12, p. 8248-8262Research output: Contribution to journal › Journal article › Research › peer-review
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Evolutionary conservation of Zinc-Activated Channel (ZAC) functionality in mammals: a range of mammalian ZACs assemble into cell surface-expressed functional receptors
Jensen, Anders A., 2023, In: Frontiers in Molecular Biosciences. 10, 11 p., 1265429.Research output: Contribution to journal › Journal article › Research › peer-review
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Excitatory amino acid transporters as potential drug targets
Bunch, Lennart, Erichsen, M. N. & Jensen, Anders A., 2009, In: Expert Opinion On Therapeutic Targets. 13, 6, p. 719-731Research output: Contribution to journal › Journal article › Research › peer-review
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Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities
Jensen, Anders A., Fahlke, C., Bjørn-Yoshimoto, Walden & Bunch, Lennart, 2015, In: Current Opinion in Pharmacology. 20, p. 116-123 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Exploration of the molecular architecture of the orthosteric binding site in the α4β2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane.
Bach, T. B., Jensen, Anders A., Petersen, J. G., Sørensen, T. E., Volpe, S. D., Liu, J., Blaazer, A. R., van Muijlwijk-Koezen, J. E., Balle, T. & Frølund, Bente, 2015, In: European Journal of Medicinal Chemistry. 102, p. 425-444 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Exploring the orthosteric binding site of the γ-aminobutyric acid type A receptor using 4-(piperidin-4-yl)-1-hydroxypyrazoles 3- or 5-imidazolyl substituted: design, synthesis, and pharmacological evaluation
Krall, J., Jensen, C. H., Sørensen, T. E., Nielsen, Birgitte, Jensen, Anders A., Sander, T., Balle, T. & Frølund, Bente, 15 Jul 2013, In: Journal of Medicinal Chemistry. 56, 16, p. 6536−6540 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters
Giraudo, A., Krall, J., Bavo, Francesco, Nielsen, Birgitte, Kongstad, Kenneth Thermann, Rolando, B., De Blasio, R., Gloriam, David E., Löffler, R., Thiesen, L., Harpsøe, Kasper, Frydenvang, Karla Andrea, Boschi, D., Wellendorph, Petrine, Lolli, M. L., Jensen, Anders A. & Frølund, Bente, 27 Jun 2019, In: Journal of Medicinal Chemistry. 62, 12, p. 5797-5809Research output: Contribution to journal › Journal article › Research › peer-review
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Fluorescensbaseret farmakologi
Jensen, Anders A., Strange, M. & Bräuner, Hans, 2004, In: Dansk Kemi 83. p. 29 31 p.Research output: Contribution to journal › Journal article › Communication
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From Methaqualone and Beyond: Structure-Activity Relationship of 6-, 7-, and 8-Substituted 2,3-Diphenyl-quinazolin-4(3H)-ones and in Silico Prediction of Putative Binding Modes of Quinazolin-4(3H)-ones as Positive Allosteric Modulators of GABAA Receptors
Wang, P., Jensen, Anders A. & Bunch, Lennart, 2020, In: ACS Chemical Neuroscience. 11, 24, p. 4362-4375Research output: Contribution to journal › Journal article › Research › peer-review
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Functional Properties and Mechanism of Action of PPTQ, an Allosteric Agonist and Low Nanomolar Positive Allosteric Modulator at GABAA Receptors
Madjroh, Nawid, Olander, E. R., Bundgaard, C., Söderhielm, P. C. & Jensen, Anders A., 2018, In: Biochemical Pharmacology. 147, p. 153-169Research output: Contribution to journal › Journal article › Research › peer-review
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Functional characterisation of homomeric ionotropic glutamate receptors GluR1-GluR6 in a fluorescence-based high throughput screening assay
Strange, M., Bräuner, Hans & Jensen, Anders A., 2006, In: Combinatorial Chemistry & High Throughput Screening. 9, 2, p. 147-58 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional characterisation of human glycine receptors in a fluorescence-based high throughput screening assay
Jensen, Anders A., 2005, In: European Journal of Pharmacology. 521, 1-3, p. 39-42 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional characterisation of the human alpha1 glycine receptor in a fluorescence-based membrane potential assay
Jensen, Anders A. & Kristiansen, Uffe, 2004, In: Biochemical Pharmacology. 67, 9, p. 1789-99 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay
Gadgaard, C. & Jensen, Anders A., 2020, In: Biochemical Pharmacology. 175, 13 p., 113870.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional characterization of GABAA receptor-mediated modulation of cortical neuron network activity in microelectrode array recordings
Bader, B. M., Steder, A., Klein, A. B., Frølund, Bente, Schroeder, O. H. U. & Jensen, Anders A., 2017, In: PloS One. 12, 10, 32 p., e0186147.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA
Jensen, Anders A., Christesen, T., Bølcho, U., Greenwood, J. R., Postorino, G., Vogensen, S. B., Johansen, Tommy Nørskov, Egebjerg, J., Bräuner, Hans & Clausen, Rasmus Prætorius, 2007, In: Journal of Medicinal Chemistry. 50, 17, p. 4177-4185 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional characterization of alpha7 nicotinic acetylcholine and NMDA receptor signaling in SH-SY5Y neuroblastoma cells in an ERK phosphorylation assay
Elnagar, M. R., Walls, Anne Byriel, Helal, G. K., Hamada, F. M., Thomsen, M. S. & Jensen, Anders A., 2018, In: European Journal of Pharmacology. 826, p. 106-113Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional characterization of the 1,5-benzodiazepine clobazam and its major active metabolite N-desmethylclobazam at human GABAA receptors expressed in Xenopus laevis oocytes
Hammer, H., Ebert, B., Jensen, H. S. & Jensen, Anders A., 2015, In: P L o S One. 10, p. 1-21 21 p., e0120239.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional importance of the Ala(116)-Pro(136) region in the calcium-sensing receptor. Constitutive activity and inverse agonism in a family C G-protein-coupled receptor
Jensen, Anders A., Spalding, T. A., Burstein, E. S., Sheppard, P. O., O'Hara, P. J., Brann, M. R., Krogsgaard-Larsen, Povl & Bräuner, Hans, 2000, In: Journal of Biological Chemistry. 275, 38, p. 29547-55 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Functional importance of the carboxyl tail cysteine residues in the human D1 dopamine receptor
Jensen, Anders A., Pedersen, U. B., Kiemer, A., Din, N. & Andersen, P. H., 1995, In: Journal of Neurochemistry. 65, 3, p. 1325-31 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization
Adelfinger, L., Turecek, R., Ivankova, K., Jensen, Anders A., Moss, S. J., Gassmann, M. & Bettler, B., 2014, In: Biochemical Pharmacology. 91, 3, p. 369-379 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ginkgolide X is a potent antagonist of anionic Cys-loop receptors with a unique selectivity profile at glycine receptors
Jensen, Anders A., Bergmann, M. L., Sander, T. & Balle, T., 2010, In: Journal of Biological Chemistry. 285, 13, p. 10141-10153Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ginkgolides and glycine receptors: a structure-activity relationship study
Jaracz, S., Nakanishi, K., Jensen, Anders A. & Strømgaard, Kristian, 2004, In: Chemistry: A European Journal. 10, 6, p. 1507-18 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor
Krzywkowski, K. M., Davies, P. A., Feinberg-Zadek, P. L., Bräuner, Hans & Jensen, Anders A., 2008, In: Proceedings of the National Academy of Science of the United States of America. 105, 2, p. 722-727Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification and Structure-Activity Relationship Study of Imidazo[1,2-a]pyridine-3-amines as First Selective Inhibitors of Excitatory Amino Acid Transporter Subtype 3 (EAAT3)
Wu, P., Bjørn-Yoshimoto, Walden, Staudt, Markus, Jensen, Anders A. & Bunch, Lennart, 2019, In: ACS Chemical Neuroscience. 10, p. 4414-4429Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of 5-HT2 Serotonin Receptor Modulators through the Synthesis of a Diverse, Tropane- and Quinuclidine-alkaloid-Inspired Compound Library
Yao, R., Jensen, Anders A., Bryce-Rogers, H. P., Schultz-Knudsen, Katrine, Zhou, L., Hovendal, N. P., Pedersen, H., Kubus, M., Ulven, Trond & Laraia, L., 2023, In: Journal of Medicinal Chemistry. 66, 16, p. 11536-11554Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of a New Class of Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitors Followed by a Structure-Activity-Relationship Study
Hansen, S. W., Erichsen, M. N., Fu, B., Bjørn-Yoshimoto, Walden, Abrahamsen, B., Hansen, J. C., Jensen, Anders A. & Bunch, Lennart, 2016, In: Journal of Medicinal Chemistry. 59, 19, p. 8757-8770 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of the first highly selective inhibitor of human GABA transporter GAT3
Damgaard, M., Al-Khawaja, A., Vogensen, S. B., Jurik, A., Sijm, M., Lie, M., Bæk, M. I., Rosenthal, E., Jensen, Anders A., Ecker, G. F., Frølund, Bente, Wellendorph, Petrine & Clausen, Rasmus Prætorius, 2015, In: A C S Chemical Neuroscience. 6, p. 1591-1599 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Improving the stability of alpha-conotoxin AuIB through N-to-C cyclization: The effect of linker length on stability and activity at nicotinic acetylcholine receptors
Armishaw, C. J., Jensen, Anders A., Balle, L. D., Scott, K. C. M., Sørensen, L. & Strømgaard, Kristian, 2011, In: Antioxidants & Redox Signaling. 14, 1, p. 65-76Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In Vitro and In Vivo Evaluation of Pellotine: A Hypnotic Lophophora Alkaloid
Poulie, C. B. M., Chan, C. B., Parka, A., Lettorp, M., Vos, J., Raaschou, A., Pottie, E., Bundgaard, M. S., Sørensen, L. M. E., Cecchi, C. R., Märcher-Rørsted, E., Bach, A., Herth, M. M., Decker, A., Jensen, A. A., Elfving, B., Kretschmann, A. C., Stove, C. P., Kohlmeier, K. A., Cornett, C. & 3 others, , 2023, In: ACS Pharmacology & Translational Science. 6, 10, p. 1492-1507Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interaction of CPCCOEt with a chimeric mGlu1b and calcium sensing receptor
Bräuner, Hans, Jensen, Anders A. & Krogsgaard-Larsen, Povl, 1999, In: NeuroReport. 10, 18, p. 3923-5 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Introducing Conformational Restraints on 25CN-NBOH: A Selective 5-HT2A Receptor Agonist
Marcher, Emil, Nykodemová, J., Harpsøe, Kasper, Jensen, Anders A. & Kristensen, Jesper Langgaard, 2023, In: ACS Medicinal Chemistry Letters. 14, 3, p. 319–325Research output: Contribution to journal › Journal article › Research › peer-review
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A strategic approach to [6,6]-bicyclic lactones: application towards the CD fragment of DHβE
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The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells
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Functional characterization of GABAA receptor-mediated modulation of cortical neuron network activity in microelectrode array recordings
Research output: Contribution to journal › Journal article › Research › peer-review
Published