Anders A. Jensen

Discovery and Structure-Activity Relationships of 2,5-Dimethoxyphenylpiperidines as Selective Serotonin 5-HT2A Receptor Agonists

Rørsted, E. M., Jensen, Anders A., Smits, G., Frydenvang, Karla Andrea & Kristensen, Jesper Langgaard, 22 Apr 2024, (E-pub ahead of print) In: Journal of Medicinal Chemistry.

Research output: Contribution to journal › Journal article › Research › peer-review

Discovery of a Novel Class of Benzimidazole-Based Nicotinic Acetylcholine Receptor Modulators: Positive and Negative Modulation Arising from Overlapping Allosteric Sites

Zhou, L., Dau, V. & Jensen, Anders A., 2023, In: Journal of Medicinal Chemistry. 66, 17, p. 12586–12601

Research output: Contribution to journal › Journal article › Research › peer-review

Evolutionary conservation of Zinc-Activated Channel (ZAC) functionality in mammals: a range of mammalian ZACs assemble into cell surface-expressed functional receptors

Jensen, Anders A., 2023, In: Frontiers in Molecular Biosciences. 10, 11 p., 1265429.

Research output: Contribution to journal › Journal article › Research › peer-review

Identification of 5-HT2 Serotonin Receptor Modulators through the Synthesis of a Diverse, Tropane- and Quinuclidine-alkaloid-Inspired Compound Library

Yao, R., Jensen, Anders A., Bryce-Rogers, H. P., Schultz-Knudsen, Katrine, Zhou, L., Hovendal, N. P., Pedersen, H., Kubus, M., Ulven, Trond & Laraia, L., 2023, In: Journal of Medicinal Chemistry. 66, 16, p. 11536-11554

Research output: Contribution to journal › Journal article › Research › peer-review

In Vitro and In Vivo Evaluation of Pellotine: A Hypnotic Lophophora Alkaloid

Poulie, C. B. M., Chan, C. B., Parka, A., Lettorp, M., Vos, J., Raaschou, A., Pottie, E., Bundgaard, M. S., Sørensen, L. M. E., Cecchi, C. R., Märcher-Rørsted, E., Bach, A., Herth, M. M., Decker, A., Jensen, A. A., Elfving, B., Kretschmann, A. C., Stove, C. P., Kohlmeier, K. A., Cornett, C. & 3 others, Janfelt, Christian, Kornum, Birgitte Rahbek & Kristensen, Jesper Langgaard, 2023, In: ACS Pharmacology & Translational Science. 6, 10, p. 1492-1507

Research output: Contribution to journal › Journal article › Research › peer-review

Introducing Conformational Restraints on 25CN-NBOH: A Selective 5-HT_2A Receptor Agonist

Marcher, Emil, Nykodemová, J., Harpsøe, Kasper, Jensen, Anders A. & Kristensen, Jesper Langgaard, 2023, In: ACS Medicinal Chemistry Letters. 14, 3, p. 319–325

Research output: Contribution to journal › Journal article › Research › peer-review

Ligand selectivity hotspots in serotonin GPCRs

Simon, Ícaro Ariel, Bjørn-Yoshimoto, Walden, Harpsøe, Kasper, Iliadis, S., Svensson, B., Jensen, Anders A. & Gloriam, David E., 2023, In: Trends in Pharmacological Sciences. 44, 12, p. 978-990

Research output: Contribution to journal › Review › Research › peer-review

Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats

Kiilerich, K. F., Lorenz, J., Scharff, M. B., Speth, N., Brandt, T. G., Czurylo, J., Xiong, M., Jessen, N. S., Casado-Sainz, A., Shalgunov, Vladimir, Kjærby, Celia, Satała, G., Bojarski, A. J., Jensen, Anders A., Herth, Matthias Manfred, Cumming, P., Overgaard, A. & Palner, M., 2023, In: Molecular Psychiatry. 28, 9, p. 3829-3841

Research output: Contribution to journal › Journal article › Research › peer-review

Structure–Activity Assessment and In-Depth Analysis of Biased Agonism in a Set of Phenylalkylamine 5-HT2A Receptor Agonists

Pottie, E., Poulie, Christian Bernard Matthijs, Simon, Ícaro Ariel, Harpsøe, Kasper, D’Andrea, L., Komarov, I. V., Gloriam, David E., Jensen, Anders A., Kristensen, Jesper Langgaard & Stove, C. P., 2023, In: ACS Chemical Neuroscience. 14, 15, p. 2727–2742

Research output: Contribution to journal › Journal article › Research › peer-review

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels

Alexander, S. P. H., Mathie, A. A., Peters, J. A., Veale, E. L., Striessnig, J., Kelly, E., Armstrong, J. F., Faccenda, E., Harding, S. D., Davies, J. A., Aldrich, R. W., Attali, B., Baggetta, A. M., Becirovic, E., Biel, M., Bill, R. M., Caceres, A. I., Catterall, W. A., Conner, A. C., Davies, P. & 53 others, De Clerq, K., Delling, M., Di Virgilio, F., Falzoni, S., Fenske, S., Fortuny-Gomez, A., Fountain, S., George, C., Goldstein, S. A. N., Grimm, C., Grissmer, S., Ha, K., Hammelmann, V., Hanukoglu, I., Hu, M., Ijzerman, A. P., Jabba, S. V., Jarvis, M., Jensen, Anders A., Jordt, S. E., Kaczmarek, L. K., Kellenberger, S., Kennedy, C., King, B., Kitchen, P., Liu, Q., Lynch, J. W., Meades, J., Mehlfeld, V., Nicke, A., Offermanns, S., Perez-Reyes, E., Plant, L. D., Rash, L., Ren, D., Salman, M. M., Sieghart, W., Sivilotti, L. G., Smart, T. G., Snutch, T. P., Tian, J., Trimmer, J. S., Van den Eynde, C., Vriens, J., Wei, A. D., Winn, B. T., Wulff, H., Xu, H., Yang, F., Fang, W., Yue, L., Zhang, X. & Zhu, M., 2023, In: British Journal of Pharmacology. 180 , Suppl 2, p. S145-S222

Research output: Contribution to journal › Journal article › Research › peer-review

Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype

Chałupnik, P., Vialko, A., Pickering, Darryl S, Hinkkanen, M., Donbosco, S., Møller, T. C., Jensen, Anders A., Nielsen, Birgitte, Bay, Yasmin, Kristensen, Anders Skov, Johansen, Tommy Nørskov, Łątka, K., Bajda, M. & Szymańska, E., 2022, In: International Journal of Molecular Sciences. 23, 15, 16 p., 8797.

Research output: Contribution to journal › Journal article › Research › peer-review

Discovery of β-Arrestin-Biased 25CN-NBOH-Derived 5-HT_2A Receptor Agonists

Poulie, Christian Bernard Matthijs, Pottie, E., Simon, I. A., Harpsøe, Kasper, D’andrea, L., Komarov, I. V., Gloriam, David E., Jensen, Anders A., Stove, C. P. & Kristensen, Jesper Langgaard, 2022, In: Journal of Medicinal Chemistry. 65, 18, p. 12031–12043

Research output: Contribution to journal › Journal article › Research › peer-review

Strychnine and its mono- and dimeric analogues: a pharmaco-chemical perspective

Zlotos, D. P., Mandour, Y. M. & Jensen, Anders A., 2022, In: Natural Product Reports. 39, 10, p. 1910-1937

Research output: Contribution to journal › Review › Research › peer-review

25CN-NBOH: A selective agonist for in vitro and in vivo investigations of the serotonin 2A receptor

Marcher, Emil, Jensen, Anders A. & Kristensen, Jesper Langgaard, 2021, In: ChemMedChem. 16, 21, p. 3263-3270

Research output: Contribution to journal › Review › Research › peer-review

C-2-Linked Dimeric Strychnine Analogues as Bivalent Ligands Targeting Glycine Receptors

Zlotos, D. P., Abdelmalek, C. M., Botros, L. S., Banoub, M. M., Mandour, Y. M., Breitinger, U., El Nady, A., Breitinger, H., Sotriffer, C., Villmann, C., Jensen, Anders A. & Holzgrabe, U., 2021, In: Journal of Natural Products. 84, 2, p. 382-394

Research output: Contribution to journal › Journal article › Research › peer-review

Delineation of the functional properties exhibited by the Zinc-Activated Channel (ZAC) and its high-frequency Thr¹²⁸Ala variant (rs2257020) in Xenopus oocytes

Madjroh, Nawid, Davies, P. A., Smalley, J. L., Kristiansen, Uffe, Söderhielm, P. C. & Jensen, Anders A., 2021, In: Pharmacological Research. 169, 18 p., 105653.

Research output: Contribution to journal › Journal article › Research › peer-review

Discovery and functional characterization of N-(thiazol-2-yl)-benzamide analogs as the first class of selective antagonists of the Zinc-Activated Channel (ZAC)

Madjroh, Nawid, Mellou, E., Davies, P. A., Söderhielm, P. C. & Jensen, Anders A., 2021, In: Biochemical Pharmacology. 193, 16 p., 114782.

Research output: Contribution to journal › Journal article › Research › peer-review

Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery

Clementson, S., Matheu, S. A., Marcher, Emil, Pedersen, H., Jensen, Anders A., Clausen, Rasmus Prætorius, Vital, P., Glibstrup, E., Jessing, M. & Kristensen, Jesper Langgaard, 2021, In: The Journal of Organic Chemistry. 86, 12, p. 8248-8262

Research output: Contribution to journal › Journal article › Research › peer-review

Probing the molecular basis for signal transduction through the Zinc-Activated Channel (ZAC)

Madjroh, Nawid, Mellou, E., Æbelø, L., Davies, P. A., Söderhielm, P. C. & Jensen, Anders A., 2021, In: Biochemical Pharmacology. 193, 18 p., 114781.

Research output: Contribution to journal › Journal article › Research › peer-review

The concise guide to pharmacology 2021/22: Ion channels

Alexander, S. P., Mathie, A., Peters, J. A., Veale, E. L., Striessnig, J., Kelly, E., Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., Southan, C., Davies, J. A., Aldrich, R. W., Attali, B., Baggetta, A. M., Becirovic, E., Biel, M., Bill, R. M., Catterall, W. A., Conner, A. C. & 38 others, Davies, P., Delling, M., Virgilio, F. D., Falzoni, S., Fenske, S., George, C., Goldstein, S. A. N., Grissmer, S., Ha, K., Hammelmann, V., Hanukoglu, I., Jarvis, M., Jensen, Anders A., Kaczmarek, L. K., Kellenberger, S., Kennedy, C., King, B., Kitchen, P., Lynch, J. W., Perez-Reyes, E., Plant, L. D., Rash, L., Ren, D., Salman, M. M., Sivilotti, L. G., Smart, T. G., Snutch, T. P., Tian, J., Trimmer, J. S., Van den Eynde, C., Vriens, J., Wei, A. D., Winn, B. T., Wulff, H., Xu, H., Yue, L., Zhang, X. & Zhu, M., 2021, In: British Journal of Pharmacology. 178 , Suppl. 1, p. S157-S245

Research output: Contribution to journal › Journal article › Research › peer-review

Characterization of AN317, a novel selective agonist of α6β2-containing nicotinic acetylcholine receptors

Sandager-Nielsen, K., Ahring, P. K., Klein, J., van Hout, M., Thaneshwaran, S., Brito dos Santos, Altair, Jacobsen, T. A., Amrutkar, D. V., Peters, D., Jensen, Anders A., Kohlmeier, Kristi Anne, Christophersen, P. & Dyhring, T., 2020, In: Biochemical Pharmacology. 174, 13 p., 113786.

Research output: Contribution to journal › Journal article › Research › peer-review

Characterization of AN6001, the first positive allosteric modulator of α6β2-containing nicotinic acetylcholine receptors

van Hout, M., Klein, J., Ahring, P. K., Brown, D. T., Thaneshwaran, S., Brito dos Santos, Altair, Jensen, Anders A., Kohlmeier, Kristi Anne, Christophersen, P. & Dyhring, T., 2020, In: Biochemical Pharmacology. 174, 113788.

Research output: Contribution to journal › Journal article › Research › peer-review

Comparison of biophysical properties of α1β2 and α3β2 GABAA receptors in whole-cell patch-clamp electrophysiological recordings

Olander, E. R., Janzen , D., Villmann , C. & Jensen, Anders A., 2020, In: P L o S One. 15, 6, 13 p., e0234080.

Research output: Contribution to journal › Journal article › Research › peer-review

Dark Classics in Chemical Neuroscience: NBOMes

Poulie, Christian Bernard Matthijs, Jensen, Anders A., Halberstadt, A. & Kristensen, Jesper Langgaard, 2020, In: ACS Chemical Neuroscience. p. 3860–3869 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Design, Synthesis, and Pharmacological Characterization of Heterobivalent Ligands for the Putative 5-HT_2A/mGlu₂ Receptor Complex

Poulie, Christian Bernard Matthijs, Liu, N., Jensen, Anders A. & Bunch, Lennart, 2020, In: Journal of Medicinal Chemistry. 63, 17, p. 9928-9949 22 p.

Research output: Contribution to journal › Journal article › Research › peer-review

From Methaqualone and Beyond: Structure-Activity Relationship of 6-, 7-, and 8-Substituted 2,3-Diphenyl-quinazolin-4(3H)-ones and in Silico Prediction of Putative Binding Modes of Quinazolin-4(3H)-ones as Positive Allosteric Modulators of GABAA Receptors

Wang, P., Jensen, Anders A. & Bunch, Lennart, 2020, In: ACS Chemical Neuroscience. 11, 24, p. 4362-4375

Research output: Contribution to journal › Journal article › Research › peer-review

Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay

Gadgaard, C. & Jensen, Anders A., 2020, In: Biochemical Pharmacology. 175, 13 p., 113870.

Research output: Contribution to journal › Journal article › Research › peer-review

Investigation of the 2,5-dimethoxy motif in phenethylamine Serotonin 2A receptor agonists

Marcher, Emil, Halberstadt, A. L., Klein, A. K., Chatha, M., Jademyr, S., Jensen, Anders A. & Kristensen, Jesper Langgaard, 2020, In: ACS Chemical Neuroscience. 11, p. 1238-1244

Research output: Contribution to journal › Letter › Research › peer-review

The selective 5-HT2A receptor agonist 25CN-NBOH: structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics of [3H]25CN-NBOH

Jensen, Anders A., Halberstadt, A. L., Marcher, Emil, Odland, Anna Ulstein, Chatha, M., Speth, N., Liebscher, G., Hansen, M., Bräuner, Hans, Palner, M., Andreasen T., Jesper & Kristensen, Jesper Langgaard, 2020, In: Biochemical Pharmacology. 177, 16 p., 113979.

Research output: Contribution to journal › Journal article › Research › peer-review

β-Indolyloxy Functionalized Aspartate Analogs as Inhibitors of the Excitatory Amino Acid Transporters (EAATs)

Liu, N., Jensen, Anders A. & Bunch, Lennart, 2020, In: ACS Medicinal Chemistry Letters. 11, 11, p. 2212-2220 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels

CGTP Collaborators, C. C., Dec 2019, In: British Journal of Pharmacology. 176, Suppl 1, p. S142-S228

Research output: Contribution to journal › Journal article › Research › peer-review

11-Aminostrychnine and N-(Strychnine-11-yl)propionamide: Synthesis, Configuration, and Pharmacological Evaluation at Glycine Receptors

Zlotos, D. P., Mohsen, A. M. Y., Mandour, Y. M., Marzouk, M. A., Breitinger, U., Villmann, C., Breitinger, H., Sotriffer, C., Jensen, Anders A. & Holzgrabe, U., 6 Aug 2019, In: Journal of Natural Products. 82, p. 2332-2336

Research output: Contribution to journal › Journal article › Research › peer-review

Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

Giraudo, A., Krall, J., Bavo, Francesco, Nielsen, Birgitte, Kongstad, Kenneth Thermann, Rolando, B., De Blasio, R., Gloriam, David E., Löffler, R., Thiesen, L., Harpsøe, Kasper, Frydenvang, Karla Andrea, Boschi, D., Wellendorph, Petrine, Lolli, M. L., Jensen, Anders A. & Frølund, Bente, 27 Jun 2019, In: Journal of Medicinal Chemistry. 62, 12, p. 5797-5809

Research output: Contribution to journal › Journal article › Research › peer-review

Design and Synthesis of 2,3-trans-Proline Analogs as Ligands for the Ionotropic Glutamate Receptors and the Excitatory Amino Acid Transporters

Poulie, Christian Bernard Matthijs, Alcaide Lopez, A., Krell-Jørgensen, M. P., Larsen, Y., Astier, E., Bjørn-Yoshimoto, Walden, Yi, F., Syrenne, J. T., Storgaard, M., Nielsen, Birgitte, Frydenvang, Karla Andrea, Jensen, Anders A., Hansen, K. B., Pickering, Darryl S & Bunch, Lennart, 19 Jun 2019, In: A C S Chemical Neuroscience. 10, 6, p. 2989-3007 19 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Discovery of 2-(Imidazo[1,2-b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites

Krall, J., Bavo, Francesco, Falk-Petersen, C. B., Jensen, C. H., Nielsen, J. O., Tian, Yongsong, Anglani, V., Kongstad, Kenneth Thermann, Petersen, Louise Piilgaard, Nielsen, Birgitte, Gloriam, David E., Kehler, J., Jensen, Anders A., Harpsøe, Kasper, Wellendorph, Petrine & Frølund, Bente, 14 Mar 2019, In: Journal of Medicinal Chemistry. 62, 5, p. 2798-2813

Research output: Contribution to journal › Journal article › Research › peer-review

Developing New 4-PIOL and 4-PHP Analogues for Photoinactivation of γ-Aminobutyric Acid Type A Receptors

Mortensen, M., Krall, J., Kongstad, Kenneth Thermann, Brygger, B. M., Lenzi, O., Francotte, P., Sørensen, T. E., Nielsen, Birgitte, Jensen, Anders A., Smart, T. G. & Frølund, Bente, 2019, In: ACS Chemical Neuroscience. 10, 11, p. 4669-4684

Research output: Contribution to journal › Journal article › Research › peer-review

Identification and Structure-Activity Relationship Study of Imidazo[1,2-a]pyridine-3-amines as First Selective Inhibitors of Excitatory Amino Acid Transporter Subtype 3 (EAAT3)

Wu, P., Bjørn-Yoshimoto, Walden, Staudt, Markus, Jensen, Anders A. & Bunch, Lennart, 2019, In: ACS Chemical Neuroscience. 10, p. 4414-4429

Research output: Contribution to journal › Journal article › Research › peer-review

Modulation of thalamo-cortical activity by the NMDA receptor antagonists ketamine and phencyclidine in the awake freely-moving rat

Amat-Foraster, M., Celada, P., Richter, U., Jensen, Anders A., Plath, N., Artigas, F. & Herrik, K. F., 2019, In: Neuropharmacology. 158, 14 p., 107745.

Research output: Contribution to journal › Journal article › Research › peer-review

Use of the 4-Hydroxy-Triazole Moiety as a Bioisosteric Tool for the Development of Ionotropic Glutamate Receptor Ligands

Sainas, S., Temperini, P., Farnsworth, J. C., Yi, F., Møllerud, S., Jensen, Anders A., Nielsen, Birgitte, Kastrup, Jette Sandholm Jensen, Hansen, K. B., Boschi, D., Pickering, Darryl S, Clausen, Rasmus Prætorius & Lolli, M., 2019, In: Journal of Medicinal Chemistry. 62, p. 4467-4482

Research output: Contribution to journal › Journal article › Research › peer-review

α-Conotoxin VnIB from Conus ventricosus is a potent and selective antagonist of α6β4* nicotinic acetylcholine receptors

van Hout, M., Valdes, A., Christensen, S. B., Tran, P. T., Watkins, M., Gajewiak, J., Jensen, Anders A., Olivera, B. M. & McIntosh, J. M., 2019, In: Neuropharmacology. 157, 107691.

Research output: Contribution to journal › Journal article › Research › peer-review

Conformational transitions of the serotonin 5-HT3 receptor

Polovinkin, L., Hassaine, G., Perot, J., Neumann, E., Jensen, Anders A., Lefebvre, S. N., Corringer, P., Neyton, J., Chipot, C., Dehez, F., Schoehn, G. & Nury, H., Nov 2018, In: Nature. 563, 7730, p. 275-279 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Chemoenzymatic synthesis and pharmacological characterization of functionalized aspartate analogues as novel excitatory amino acid transporter inhibitors

Fu, H., Zhang, J., Tepper, P. G., Bunch, Lennart, Jensen, Anders A. & Poelarends, G. J., 13 Sep 2018, In: Journal of Medicinal Chemistry. 61, 17, p. 7741-7753

Research output: Contribution to journal › Journal article › Research › peer-review

Probing the molecular basis for affinity/potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABAA receptors

Söderhielm, P. C., Balle, T., Bak-Nyhus, S., Zhang, M., Hansen, K. M., Ahring, P. K. & Jensen, Anders A., Aug 2018, In: Biochemical Pharmacology. 158, p. 339-358

Research output: Contribution to journal › Journal article › Research › peer-review

5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

Peng, Y., McCorvy, J. D., Harpsøe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajsen, L. F., Huang, X., Wu, Y., Shen, L., Bjørn-Yoshimoto, W. E., Ding, K., Wacker, D., Han, G. W., Cheng, J., Katritch, V., Jensen, A. A. & 6 others, Hanson, M. A., Zhao, S., Gloriam, David E., Roth, B. L., Stevens, R. C. & Liu, Z., 2018, In: Cell. 172, 4, p. 719-730 P719-730.E14.

Research output: Contribution to journal › Journal article › Research › peer-review

Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors

Olander, E. R., Madjroh, Nawid, Bunch, Lennart, Söderhielm, P. C. & Jensen, Anders A., 2018, In: Biochemical Pharmacology. 150, p. 305-319

Research output: Contribution to journal › Journal article › Research › peer-review

Dual Nicotinic Acetylcholine Receptor α4β2 Antagonists/α7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts

Crestey, F., Jensen, Anders A., Soerensen, C., Magnus, C. B., Andreasen T., Jesper, Peters, G. H. J. & Kristensen, Jesper Langgaard, 2018, In: Journal of Medicinal Chemistry. 61, p. 1719-1729

Research output: Contribution to journal › Journal article › Research › peer-review

Functional Properties and Mechanism of Action of PPTQ, an Allosteric Agonist and Low Nanomolar Positive Allosteric Modulator at GABAA Receptors

Madjroh, Nawid, Olander, E. R., Bundgaard, C., Söderhielm, P. C. & Jensen, Anders A., 2018, In: Biochemical Pharmacology. 147, p. 153-169

Research output: Contribution to journal › Journal article › Research › peer-review

Functional characterization of alpha7 nicotinic acetylcholine and NMDA receptor signaling in SH-SY5Y neuroblastoma cells in an ERK phosphorylation assay

Elnagar, M. R., Walls, Anne Byriel, Helal, G. K., Hamada, F. M., Thomsen, M. S. & Jensen, Anders A., 2018, In: European Journal of Pharmacology. 826, p. 106-113

Research output: Contribution to journal › Journal article › Research › peer-review

Profiling of GABAA and GABAB receptor expression in the myometrium of the human uterus

Söderhielm, P. C., Klein, A. B., Bomholtz, Sofia Hammami & Jensen, Anders A., 2018, In: Life Sciences. 214, p. 145-152

Research output: Contribution to journal › Journal article › Research › peer-review

Temporally dissociable effects of ketamine on neuronal discharge and gamma oscillations in rat thalamo-cortical networks

Amat-Foraster, M., Jensen, Anders A., Plath, N., Herrik, K. F., Celada, P. & Artigas, F., 2018, In: Neuropharmacology. 137, p. 13-23

Research output: Contribution to journal › Journal article › Research › peer-review

18F-Labelling of electron rich iodonium ylides: application to the radiosynthesis of potential 5-HT2A receptor PET ligands

Petersen, I. N., Villadsen, J., Hansen, H. D., Madsen, J., Jensen, Anders A., Gillings, N., Lehel, S., Herth, Matthias Manfred, Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, Apr 2017, In: Organic & Biomolecular Chemistry. 15, p. 4351-4358

Research output: Contribution to journal › Journal article › Research › peer-review

A strategic approach to [6,6]-bicyclic lactones: application towards the CD fragment of DHβE

Jepsen, T. H., Glibstrup, E., Crestey, F. L. J., Jensen, Anders A. & Kristensen, Jesper Langgaard, 2017, In: Beilstein Journal of Organic Chemistry. 13, p. 988-994 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Detailed characterization of the in vitro pharmacological and pharmacokinetic properties of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (25CN-NBOH), a highly selective and brain-penetrant 5-HT2A receptor agonist

Jensen, Anders A., McCorvy, J. D., Petersen, S. L., Bundgaard, C., Liebscher, G., Kenakin, T. P., Bräuner, Hans, Kehler, J. & Kristensen, Jesper Langgaard, 2017, In: Journal of Pharmacology and Experimental Therapeutics. 361, 3, p. 441-453

Research output: Contribution to journal › Journal article › Research › peer-review

Functional characterization of GABAA receptor-mediated modulation of cortical neuron network activity in microelectrode array recordings

Bader, B. M., Steder, A., Klein, A. B., Frølund, Bente, Schroeder, O. H. U. & Jensen, Anders A., 2017, In: PloS One. 12, 10, 32 p., e0186147.

Research output: Contribution to journal › Journal article › Research › peer-review

Probing the putative α7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue

Elnagar, M. R., Walls, Anne Byriel, Helal, G. K., Hamada, F. M., Thomsen, M. S. & Jensen, Anders A., 2017, In: PLOS ONE. 12, 21 p., e0189513.

Research output: Contribution to journal › Journal article › Research › peer-review

Oxime Ethers of (E)-11-Isonitrosostrychnine as Highly Potent Glycine Receptor Antagonists

Mohsen, A. M. Y., Mandour, Y. M., Sarukhanyan, E., Breitinger, U., Villmann, C., Banoub, M. M., Breitinger, H., Dandekar, T., Holzgrabe, U., Sotriffer, C., Jensen, Anders A. & Zlotos, D. P., 14 Dec 2016, In: Journal of Natural Products. 79, 12, p. 2997–3005 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

γ-Glutamyl-dipeptides: Easy tools to rapidly probe the stereoelectronic properties of ionotropic glutamate receptor binding pocket

Tamborini, L., Nicosia, V., Conti, P., Dall'Oglio, F., De Micheli, C., Nielsen, Birgitte, Jensen, Anders A., Pickering, Darryl S & Pinto, A., 1 Dec 2016, In: Tetrahedron. 72, 51, p. 8586-8492 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Discovery of α-Substituted Imidazole-4-acetic Acid Analogues as a Novel Class of ρ1 γ-Aminobutyric Acid Type A Receptor Antagonists with Effect on Retinal Vascular Tone

Krall, J., Brygger, B. M., Sigurðardóttir, S. B., Ng, C. K. L., Bundgaard, C., Kehler, J., Nielsen, Birgitte, Bek, T., Jensen, Anders A. & Frølund, Bente, 13 Sep 2016, In: ChemMedChem. 11, 20, p. 2299-2310 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5-HT2A/5-HT2C receptor pharmacology and intrinsic clearance of N-benzylphenethylamines modified at the primary site of metabolism

Leth-Petersen, S., Petersen, I. N., Jensen, Anders A., Bundgaard, C., Bæk, M., Kehler, J. & Kristensen, Jesper Langgaard, 26 Aug 2016, In: A C S Chemical Neuroscience. p. 1-6 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

A parallel panning scheme used for selection of a GluA4-specific Fab targeting the ligand-binding domain

Clausen, Rasmus Prætorius, Mohr, A. Ø., Riise, E., Jensen, Anders A., Gill, A., Madden, D. R., Kastrup, Jette Sandholm Jensen & Skottrup, P. D., 8 Jul 2016, In: International Journal of Biological Macromolecules. 92, p. 779-787 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism

Chua, H. C., Christensen, E. H. T., Hoestgaard-Jensen, K., Hartiadi, L. Y., Ramzan, I., Jensen, Anders A., Absalom, N. L. & Chebib, M., 23 Jun 2016, In: P L o S One. 11, 6, p. 1-17 17 p., e0157700.

Research output: Contribution to journal › Journal article › Research › peer-review

Synthesis and evaluation of 18F-labeled 5-HT2A receptor agonists as PET ligands

Herth, Matthias Manfred, Petersen, I. N., Hansen, H. D., Hansen, M., Ettrup, A., Jensen, Anders A., Lehel, S., Dyssegaard, A., Gillings, N., Knudsen, G. M. & Kristensen, Jesper Langgaard, 19 Apr 2016, In: Nuclear Medicine and Biology. 43, 8, p. 455-462 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Beta-Sulfonamido Functionalized Aspartate Analogs as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype-Selectivity Profiles Arising from Subtle Structural Differences

Hansen, J. C., Bjørn-Yoshimoto, Walden, Bisballe, N., Nielsen, Birgitte, Jensen, Anders A. & Bunch, Lennart, 2016, In: Journal of Medicinal Chemistry. 59, p. 8771-8786 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Bioavailability studies and in vitro profiling of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor 2-amino-4-(4-methyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-102)

Haym, I., Huynh, Tri Hien Viet, Hansen, S. W., Pedersen, M. H. F., Ruiz, J. A., Erichsen, M. N., Gynther, M., Bjørn-Yoshimoto, Walden, Abrahamsen, B., Bastlund, J. F., Bundgaard, C., Eriksen, A. L., Jensen, Anders A. & Bunch, Lennart, 2016, In: ChemMedChem. 11, 4, p. 403-419 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Convergent [18]F-labeling and evaluation of N-benzyl-phenethylamines as 5-HT2A receptor PET ligands

Petersen, I. N., Villadsen, J., Hansen, H. D., Jensen, Anders A., Lehel, S., Gillings, N., Herth, Matthias Manfred, Knudsen, G. M. & Kristensen, Jesper Langgaard, 2016, In: Bioorganic & Medicinal Chemistry. 24, p. 5353-5356 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Copper and protons directly activate the zinc-activated channel

Trattnig, S. M., Gasiorek, A., Deeb, T. Z., Comenencia Ortiz, E. J., Moss, S. J., Jensen, Anders A. & Davies, P. A., 2016, In: Biochemical Pharmacology. 103, p. 109-117 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Delineation of the functional properties and the mechanism of action of TMPPAA, an allosteric agonist and positive allosteric modulator of 5-HT3 Receptors

Gasiorek, A., Trattnig, S. M., Ahring, P. K., Kristiansen, Uffe, Frølund, Bente, Frederiksen, K. & Jensen, Anders A., 2016, In: Biochemical Pharmacology. 110-111, p. 92-108 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Identification of a New Class of Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitors Followed by a Structure-Activity-Relationship Study

Hansen, S. W., Erichsen, M. N., Fu, B., Bjørn-Yoshimoto, Walden, Abrahamsen, B., Hansen, J. C., Jensen, Anders A. & Bunch, Lennart, 2016, In: Journal of Medicinal Chemistry. 59, 19, p. 8757-8770 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

New insights into the structure-activity-relationship of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitors UCPH-101 and UCPH-102

Hansen, S. W., Erichsen, M. N., Huynh, Tri Hien Viet, Ruiz, J. A., Haym, I., Bjørn-Yoshimoto, Walden, Abrahamsen, B., Hansen, Jeanette Venla, Storgaard, M., Eriksen, A. L., Jensen, Anders A. & Bunch, Lennart, 2016, In: ChemMedChem. 11, 4, p. 382-402 21 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Tweaking subtype-selectivity and agonist efficacy at (S)-2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) receptors in a small series of BnTetAMPA analogues

Wang, S., Larsen, Y., Navarrete, C. V., Jensen, Anders A., Nielsen, Birgitte, Al-Musaed, A., Frydenvang, Karla Andrea, Kastrup, Jette Sandholm Jensen, Pickering, Darryl S & Clausen, Rasmus Prætorius, 2016, In: Journal of Medicinal Chemistry. 59, 5, p. 2244-2254 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors

Petersen, I. N., Crestey, F., Jensen, Anders A., Indurthi, D. C., Pedersen, H., Andreasen T., Jesper, Balle, T. & Kristensen, Jesper Langgaard, 9 Apr 2015, In: A C S Medicinal Chemistry Letters. 6, 4, p. 472-475 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

A multifaceted GABAA receptor modulator: Functional properties and mechanism of action of the sedative-hypnotic and recreational drug methaqualone (Quaalude)

Hammer, H., Bader, B. M., Ehnert, C., Bundgaard, C., Bunch, Lennart, Hoestgaard-Jensen, K., Schroeder, O. H., Bastlund, J. F., Gramowski-Voß, A. & Jensen, Anders A., 2015, In: Molecular Pharmacology. 88, 2, p. 401-420 20 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Conformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerations

de la Fuente Revenga, M., Balle, T., Jensen, Anders A. & Frølund, Bente, 2015, In: European Journal of Medicinal Chemistry. 102, p. 352-362 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities

Jensen, Anders A., Fahlke, C., Bjørn-Yoshimoto, Walden & Bunch, Lennart, 2015, In: Current Opinion in Pharmacology. 20, p. 116-123 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Exploration of the molecular architecture of the orthosteric binding site in the α4β2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane.

Bach, T. B., Jensen, Anders A., Petersen, J. G., Sørensen, T. E., Volpe, S. D., Liu, J., Blaazer, A. R., van Muijlwijk-Koezen, J. E., Balle, T. & Frølund, Bente, 2015, In: European Journal of Medicinal Chemistry. 102, p. 425-444 20 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Functional characterization of the 1,5-benzodiazepine clobazam and its major active metabolite N-desmethylclobazam at human GABAA receptors expressed in Xenopus laevis oocytes

Hammer, H., Ebert, B., Jensen, H. S. & Jensen, Anders A., 2015, In: P L o S One. 10, p. 1-21 21 p., e0120239.

Research output: Contribution to journal › Journal article › Research › peer-review

Identification of the first highly selective inhibitor of human GABA transporter GAT3

Damgaard, M., Al-Khawaja, A., Vogensen, S. B., Jurik, A., Sijm, M., Lie, M., Bæk, M. I., Rosenthal, E., Jensen, Anders A., Ecker, G. F., Frølund, Bente, Wellendorph, Petrine & Clausen, Rasmus Prætorius, 2015, In: A C S Chemical Neuroscience. 6, p. 1591-1599 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Targeting α4β2 nAChRs in CNS disorders: Perspectives on positive allosteric modulation as a therapeutic approach

Grupe, M., Grunnet, M., Bastlund, J. F. & Jensen, Anders A., 2015, In: Basic & Clinical Pharmacology & Toxicology. 116, 3, p. 187-200 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells

Cuesta, E. P., Christensen, S., Jensen, Anders A., Jensen, N. F., Bunch, Lennart, Rømer, M. U. K., Brünner, N., Stenvang, Jan & Pedersen, Stine Helene Falsig, 2015, In: B M C Cancer. 15, 1, 17 p., 411.

Research output: Contribution to journal › Journal article › Research › peer-review

The metabolic impact of β-hydroxybutyrate on neurotransmission: Reduced glycolysis mediates changes in calcium responses and KATP channel receptor sensitivity

Lund, Trine Meldgaard, Ploug, K. B., Iversen, A., Jensen, Anders A. & Jansen-Olesen, I., 2015, In: Journal of Neurochemistry. 132, 5, p. 520-531 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5-(Piperidin-4-yl)-3-Hydroxypyrazole: A Novel Scaffold for Probing the Orthosteric γ-Aminobutyric Acid Type A Receptor Binding Site

Krall, J., Kongstad, Kenneth Thermann, Nielsen, Birgitte, Sørensen, T. E., Balle, T., Jensen, Anders A. & Frølund, Bente, 2014, In: ChemMedChem. 9, 11, p. 2475-2485 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization

Adelfinger, L., Turecek, R., Ivankova, K., Jensen, Anders A., Moss, S. J., Gassmann, M. & Bettler, B., 2014, In: Biochemical Pharmacology. 91, 3, p. 369-379 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT6 and dopamine D2 receptor ligands

Krogsgaard-Larsen, N., Jensen, Anders A., Schrøder, T. J., Christoffersen, C. T. & Kehler, J., 2014, In: Journal of Medicinal Chemistry. 57, 13, p. 5823-5828 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Pharmacological characterisation of α6β4* nicotinic acetylcholine receptors assembled from three different α6/α3 subunit chimeras in tsA201 cells

Jensen, A. B., Hoestgaard-Jensen, K. & Jensen, Anders A., 2014, In: European Journal of Pharmacology. 740, p. 703-713 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Probing for improved potency and in vivo bioavailability of excitatory amino acid transporter subtype 1 inhibitors UCPH-101 and UCPH-102: Design, synthesis and pharmacological evaluation of substituted 7-biphenyl analogs

Erichsen, M. N., Hansen, J., Artacho Ruiz, J., Demmer, C. S., Abrahamsen, B., Bastlund, J. F., Bundgaard, C., Jensen, Anders A. & Bunch, Lennart, 2014, In: Neurochemical Research. 39, 10, p. 1964-1979 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Probing α4βδ GABAA Receptor Heterogeneity: Differential Regional Effects of a Functionally Selective α4β1δ/α4β3δ Receptor Agonist on Tonic and Phasic Inhibition in Rat Brain

Hoestgaard-Jensen, K., Dalby, N. O., Krall, J., Hammer, H., Krogsgaard-Larsen, Povl, Frølund, Bente & Jensen, Anders A., 2014, In: Journal of Neuroscience. 34, 49, p. 16256-16272 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Semisynthetic analogues of toxiferine I and their pharmacological properties at α7 nAChRs, muscle-type nAChRs, and the allosteric binding site of muscarinic M2 receptors

Zlotos, D. P., Tränkle, C., Holzgrabe, U., Gündisch, D. & Jensen, Anders A., 2014, In: Journal of Natural Products. 77, 9, p. 2006-2013 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Structure-activity relationships of strychnine analogues at glycine receptors

Mohsen, A. M. Y., Heller, E., Holzgrabe, U., Jensen, Anders A. & Zlotos, D. P., 2014, In: Chemistry & Biodiversity. 11, 8, p. 1256-1262 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel γ-aminobutyric acidA receptor agonists

Petersen, J. G., Sørensen, T. E., Damgaard, M., Nielsen, Birgitte, Jensen, Anders A., Balle, T., Bergmann, R. & Frølund, Bente, 2014, In: European Journal of Medicinal Chemistry. 84, p. 404-416 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Synthesis and pharmacological evaluation of DHβE analogs as neuronal nicotinic acetylcholine receptor antagonists

Jepsen, T. H., Jensen, Anders A., Lund, M. H., Glibstrup, E. & Kristensen, Jesper Langgaard, 2014, In: A C S Medicinal Chemistry Letters. 5, 7, p. 766-770 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Synthesis of (3-hydroxy-pyrazolin-5-yl)glycine based ligands interacting with ionotropic glutamate receptors

Pinto, A., Tamborini, L., Mastronardi, F., Ettari, R., Safoz, Y., Bunch, Lennart, Nielsen, Birgitte, Jensen, Anders A., De Micheli, C. & Conti, P., 2014, In: European Journal of Medicinal Chemistry. 75, p. 151-158 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors

Hoestgaard-Jensen, K., O'Connor, R. M., Dalby, N. O., Simonsen, C., Finger, B. C., Golubeva, A., Hammer, H., Bergmann, M. L., Kristiansen, Uffe, Krogsgaard-Larsen, Povl, Bräuner, Hans, Ebert, B., Frølund, Bente, Cryan, J. F. & Jensen, Anders A., Oct 2013, In: British Journal of Pharmacology. 170, 4, p. 919-32 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Exploring the orthosteric binding site of the γ-aminobutyric acid type A receptor using 4-(piperidin-4-yl)-1-hydroxypyrazoles 3- or 5-imidazolyl substituted: design, synthesis, and pharmacological evaluation

Krall, J., Jensen, C. H., Sørensen, T. E., Nielsen, Birgitte, Jensen, Anders A., Sander, T., Balle, T. & Frølund, Bente, 15 Jul 2013, In: Journal of Medicinal Chemistry. 56, 16, p. 6536−6540 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties

Jensen, Anders A., Plath, N., Pedersen, M. H. F., Isberg, V., Krall, J., Wellendorph, Petrine, Stensbøl, T. B., Gloriam, David E., Krogsgaard-Larsen, Povl & Frølund, Bente, 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 1211-27 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Allosteric modulation of an excitatory amino acid transporter: The subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain

Abrahamsen, B., Schneider, N., Erichsen, M. N., Huynh, Tri Hien Viet, Fahlke, C., Bunch, Lennart & Jensen, Anders A., 2013, In: Journal of Neuroscience. 33, 3, p. 1068-1087

Research output: Contribution to journal › Journal article › Research › peer-review

Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters

Assaf, Z., Larsen, A. P., Venskutonyte, R., Han, L., Abrahamsen, B., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Jensen, Anders A., Pickering, Darryl S, Frydenvang, Karla Andrea, Gefflaut, T. & Bunch, Lennart, 2013, In: Journal of Medicinal Chemistry. 56, 4, p. 1614-1628

Research output: Contribution to journal › Journal article › Research › peer-review

Design, synthesis and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists

Crestey, F., Jensen, Anders A., Borch, M., Andreasen T., Jesper, Andersen, J., Balle, T. & Kristensen, Jesper Langgaard, 2013, In: Journal of Medicinal Chemistry. 56, 23, p. 9673-9682

Research output: Contribution to journal › Journal article › Research › peer-review

Discovery of a subtype-selective of the human betaine/GABA transporter 1 (BGT-1) with a non-competitive pharmacological profile

Kragholm, B., Kvist, T., Madsen, K. K., Jørgensen, L., Vogensen, S. B., Schousboe, Arne, Clausen, Rasmus Prætorius, Jensen, Anders A. & Bräuner, Hans, 2013, In: Biochemical Pharmacology. 86, p. 521-528

Research output: Contribution to journal › Journal article › Research › peer-review

Elucidation of molecular impediments in the α6 subunit for in vitro expression of functional α6β4* nicotinic acetylcholine receptors

Jensen, A. B., Hoestgaard-Jensen, K. & Jensen, Anders A., 2013, In: Journal of Biological Chemistry. 288, 47, p. 33708-33721

Research output: Contribution to journal › Journal article › Research › peer-review

Selective potentiation of (α4)3(β2)2 nicotinic acetylcholine receptors augments amplitudes of prefrontal nicotine-evoked glutamatergic transients in rats

Grupe, M., Paolone, G., Jensen, Anders A., Sandager-Nielsen, K., Sarter, M. & Grunnet, M., 2013, In: Biochemical Pharmacology. 86, 10, p. 1487-1496

Research output: Contribution to journal › Journal article › Research › peer-review

Structure-activity-relationship study of N-acyl-N-phenylpiperazines as potential inhibitors of the excitatory amino acid transporters (EAATs): Improving the potency of a micromolar screening hit is not truism

Huynh, Tri Hien Viet, Demmer, C. S., Abrahamsen, B., Marcher, Emil, Frykman, M., Jensen, Anders A. & Bunch, Lennart, 2013, In: SpringerPlus. 2, p. 112

Research output: Contribution to journal › Journal article › Research › peer-review

Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as ¿-aminobutyric acid_A receptor agonists

Petersen, J. G., Bergmann, R., Møller, H. A., Jørgensen, Charlotte Grube, Nielsen, Birgitte, Kehler, J., Frydenvang, Karla Andrea, Kristensen, Jesper Langgaard, Balle, T., Jensen, Anders A., Kristiansen, Uffe & Frølund, Bente, 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 993-1006

Research output: Contribution to journal › Journal article › Research › peer-review

Synthesis, pharmacology and biostructural characterization of novel a4ß2 nicotinic acetylcholine receptor agonists

Ussing, C. A., Hansen, C. P., Petersen, J. G., Jensen, Anders A., Rohde, L. A. H., Ahring, P. K., Nielsen, E. Ø., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Frølund, Bente & Balle, T., 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 940-951

Research output: Contribution to journal › Journal article › Research › peer-review

Unraveling the mechanism of action of NS9283, a positive allosteric modulator of (a4)₃(ß2)₂ nicotinic ACh receptors

Grupe, M., Jensen, Anders A., Ahring, P. K., Christensen, J. K. & Grunnet, M., 2013, In: British Journal of Pharmacology. 168, 8, p. 2000-2010

Research output: Contribution to journal › Journal article › Research › peer-review

Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102

Huynh, Tri Hien Viet, Abrahamsen, B., Madsen, K. K., Gonzalez-Franquesa, A., Jensen, Anders A. & Bunch, Lennart, 2012, In: Bioorganic & Medicinal Chemistry. 20, 23, p. 6831-6839

Research output: Contribution to journal › Journal article › Research › peer-review

Discovery of a novel allosteric modulator of 5-HT3 receptor: Inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site

Trattnig, S. M., Harpsøe, Kasper, Thygesen, S. B., Rahr, L. M., Ahring, P. K., Balle, T. & Jensen, Anders A., 2012, In: Journal of Biological Chemistry. 287, 30, p. 25241-25254

Research output: Contribution to journal › Journal article › Research › peer-review

Structure-activity relationship study of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101) and absolute configurational assignment using infrared and vibrational circular dichroism spectroscopy in combination with ab initio hartree-fock calculations

Huynh, Tri Hien Viet, Shim, I., Bohr, H., Abrahamsen, B., Nielsen, Birgitte, Jensen, Anders A. & Bunch, Lennart, 2012, In: Journal of Medicinal Chemistry. 55, 11, p. 5403-12 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Discovery of benzamide analogues as a novel class of 5-HT₃ receptor agonists

Jørgensen, Charlotte Grube, Frølund, Bente, Kehler, J. & Jensen, Anders A., 4 Apr 2011, In: ChemMedChem. 6, 4, p. 725-736

Research output: Contribution to journal › Journal article › Research › peer-review

Improving the stability of alpha-conotoxin AuIB through N-to-C cyclization: The effect of linker length on stability and activity at nicotinic acetylcholine receptors

Armishaw, C. J., Jensen, Anders A., Balle, L. D., Scott, K. C. M., Sørensen, L. & Strømgaard, Kristian, 2011, In: Antioxidants & Redox Signaling. 14, 1, p. 65-76

Research output: Contribution to journal › Journal article › Research › peer-review

Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands

Krogsgaard-Larsen, N., Jensen, Anders A. & Kehler, J., 15 Sep 2010, In: Bioorganic & Medicinal Chemistry Letters. 20, 18, p. 5431-5433

Research output: Contribution to journal › Journal article › Research › peer-review

A synthetic combinatorial strategy for developing a-conotoxin analogs as potent a₇ nicotinic acetylcholine receptor antagonists

Armishaw, C. J., Singh, N., Medina-Franco, J. L., Clark, R. J., Scott, K. C. M., Houghten, R. A. & Jensen, Anders A., 2010, In: Journal of Biological Chemistry. 285, 3, p. 1809-1821

Research output: Contribution to journal › Journal article › Research › peer-review

Ginkgolide X is a potent antagonist of anionic Cys-loop receptors with a unique selectivity profile at glycine receptors

Jensen, Anders A., Bergmann, M. L., Sander, T. & Balle, T., 2010, In: Journal of Biological Chemistry. 285, 13, p. 10141-10153

Research output: Contribution to journal › Journal article › Research › peer-review

Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acid_A receptor ligands: synthesis, pharmacology, and structure-activity relationships

Møller, H. A., Sander, T., Kristensen, Jesper Langgaard, Nielsen, Birgitte, Krall, J., Bergmann, M. L., Christiansen, B., Balle, T., Jensen, Anders A. & Frølund, Bente, 2010, In: Journal of Medicinal Chemistry. 53, 8, p. 3417-3421

Research output: Contribution to journal › Journal article › Research › peer-review

Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101)

Erichsen, M. N., Huynh, Tri Hien Viet, Abrahamsen, B., Bastlund, J. F., Bundgaard, C., Monrad, O., Bekker-Jensen, A., Nielsen, C. W., Frydenvang, Karla Andrea, Jensen, Anders A. & Bunch, Lennart, 2010, In: Journal of Medicinal Chemistry. 53, 19, p. 7180–7191

Research output: Contribution to journal › Journal article › Research › peer-review

4,4-Dimethyl- and diastereomeric 4-hydroxy-4-methyl-(2S)-glutamate analogues display distinct pharmacological profiles at ionotropic glutamate receptors and excitatory amino acid transporters

Bunch, Lennart, Pickering, Darryl S, Gefflaut, T., Vinatier, V., Helaine, V., Amir, A., Nielsen, Birgitte & Jensen, Anders A., 2009, In: ChemMedChem. 4, 11, p. 1925-1929

Research output: Contribution to journal › Journal article › Research › peer-review

Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists--structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC)

Hansen, C. P., Jensen, Anders A., Balle, T., Bitsch-Jensen, K., Hassan, M. M., Liljefors, T. & Frølund, Bente, 2009, In: Bioorganic & Medicinal Chemistry Letters. 19, 1, p. 87-91

Research output: Contribution to journal › Journal article › Research › peer-review

Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1

Jensen, Anders A., Erichsen, M. N., Nielsen, C. W., Stensbøl, T. B., Kehler, J. & Bunch, Lennart, 2009, In: Journal of Medicinal Chemistry. 52, 4, p. 912-915

Research output: Contribution to journal › Journal article › Research › peer-review

Excitatory amino acid transporters as potential drug targets

Bunch, Lennart, Erichsen, M. N. & Jensen, Anders A., 2009, In: Expert Opinion On Therapeutic Targets. 13, 6, p. 719-731

Research output: Contribution to journal › Journal article › Research › peer-review

No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions

Wellendorph, Petrine, Johansen, L. D., Jensen, Anders A., Casanova, E., Gassmann, M., Deprez, P., Clément-Lacroix, P., Bettler, B. & Bräuner, Hans, 2009, In: Journal of Molecular Endocrinology. 42, 3, p. 215-223

Research output: Contribution to journal › Journal article › Research › peer-review

Rational design of a-conotoxin analogues targeting a7 nicotinic acetylcholine receptors: Improved antagonistic activity by incorporation of proline derivatives

Armishaw, C., Jensen, Anders A., Balle, T., Clark, R. J., Harpsøe, Kasper, Skonberg, C., Liljefors, T. & Strømgaard, Kristian, 2009, In: Journal of Biological Chemistry. 284, 14, p. 9498-9512

Research output: Contribution to journal › Journal article › Research › peer-review

The four human ¿-aminobutyric acid (GABA) transporters: pharmacological characterization and validation of a highly efficient screening assay

Kvist, T., Christiansen, B., Jensen, Anders A. & Bräuner, Hans, 2009, In: Combinatorial Chemistry & High Throughput Screening. 12, 3, p. 241-249

Research output: Contribution to journal › Journal article › Research › peer-review

The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization

Clausen, Rasmus Prætorius, Naur, P., Kristensen, Anders Skov, Greenwood, J. R., Strange, M., Bräuner, Hans, Jensen, Anders A., Nielsen, A. S. T., Geneser, U., Ringgaard, L. M., Nielsen, Birgitte, Pickering, Darryl S, Brehm, L., Gajhede, Michael, Krogsgaard-Larsen, Povl & Kastrup, Jette Sandholm Jensen, 2009, In: Journal of Medicinal Chemistry. 52, 15, p. 4911-4922

Research output: Contribution to journal › Journal article › Research › peer-review

3B but which 3B? And that's just one of the questions: the heterogeneity of human 5-HT3 receptors

Jensen, Anders A., Davies, P. A., Bräuner, Hans & Krzywkowski, K., 2008, In: TIPS - Trends in Pharmacological Sciences. 29, 9, p. 437-444

Research output: Contribution to journal › Journal article › Research › peer-review

Characterization of the effects of four HTR3B polymorphisms on human 5-HT_3AB receptor expression and signalling

Krzywkowski, K. M., Davies, P. A., Irving, A. J., Bräuner, Hans & Jensen, Anders A., 2008, In: Pharmacogenetics and Genomics (Print Edition). 18, 12, p. 1027-1040

Research output: Contribution to journal › Journal article › Research › peer-review

Chemo-enzymatic synthesis of (2S,4R)-2-amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic acid: a novel selective inhibitor of human excitatory amino acid transporter subtype 2

Sagot, E., Jensen, Anders A., Pickering, Darryl S, Pu, X., Umberti, M., Stensbøl, T. B., Nielsen, Birgitte, Assaf, Z., Aboab, B., Bolte, J., Gefflaut, T. & Bunch, Lennart, 2008, In: Journal of Medicinal Chemistry. 51, 14, p. 4085-4092 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

En genetisk variation i en serotonin–receptor – et muligt link til depression?

Krzywkowski, K. M., Feinberg-Zadek, P., Davies, P. A., Jensen, Anders A. & Bräuner, Hans, 2008, In: Dansk Kemi 83. 89, 6/7

Research output: Contribution to journal › Journal article › Communication

High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT_3AB receptor

Krzywkowski, K. M., Davies, P. A., Feinberg-Zadek, P. L., Bräuner, Hans & Jensen, Anders A., 2008, In: Proceedings of the National Academy of Science of the United States of America. 105, 2, p. 722-727

Research output: Contribution to journal › Journal article › Research › peer-review

Neuroprotective effects of the novel glutamate transporter inhibitor (-)-3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]-isoxazole-4-carboxylic acid, which preferentially inhibits reverse transport (glutamate release) compared with glutamate reuptake

Colleoni, S., Jensen, Anders A., Landucci, E., Fumagalli, E., Conti, P., Pinto, A., De Amici, M., Pellegrini-Giampietro, D. E., De Micheli, C., Mennini, T. & Gobbi, M., 2008, In: Journal of Pharmacology and Experimental Therapeutics. 326, 2, p. 646-656 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Novel acetylcholine and carbamoylcholine analogues: Development of a functionally selective a₄ß₂ nicotinic acetylcholine receptor agonist

Hansen, C. P., Jensen, Anders A., Christensen, J. K., Balle, T., Liljefors, T. & Frølund, Bente, 2008, In: Journal of Medicinal Chemistry. 51, 23, p. 7380-7395

Research output: Contribution to journal › Journal article › Research › peer-review

Ny human GABA-transportør: et muligt mål for behandling af epilepsi

Christiansen, B., Kvist, T., Jensen, Anders A. & Bräuner, Hans, 2008, In: Lægemiddelforskning. p. 25-27

Research output: Contribution to journal › Journal article › Communication

5-Substituted imidazole-4-acetic acid analogues: Synthesis, modeling, and pharmacological characterization of a series of novel γ-aminobutyric acidC receptor agonists

Madsen, C., Jensen, Anders A., Liljefors, T., Kristiansen, Uffe, Nielsen, Birgitte, Hansen, C. P., Larsen, M., Ebert, B., Bang-Andersen, B., Krogsgaard-Larsen, Povl & Frølund, Bente, 2007, In: Journal of Medicinal Chemistry. 50, p. 4147-4161

Research output: Contribution to journal › Journal article › Research › peer-review

Allosteric modulation of the calcium-sensing receptor

Jensen, Anders A. & Bräuner, Hans, 2007, In: Current Neuropharmacology. 5, 3, p. 180-186

Research output: Contribution to journal › Journal article › Research › peer-review

Cloning and characterization of a functional human ¿-aminobutyric acid (GABA) transporter, human GAT-2

Christiansen, B., Meinild, A., Jensen, Anders A. & Bräuner, Hans, 2007, In: Journal of Biological Chemistry. 282, 27, p. 19331-19341 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

En genetisk variation i en serotonin-receptor: et muligt link til depression?

Krzywkowski, K. M., Davies, P. A., Feinberg-Zadek, P. L., Jensen, Anders A. & Bräuner, Hans, 2007, In: Lægemiddelforskning. p. 30-31

Research output: Contribution to journal › Journal article › Communication

Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA

Jensen, Anders A., Christesen, T., Bølcho, U., Greenwood, J. R., Postorino, G., Vogensen, S. B., Johansen, Tommy Nørskov, Egebjerg, J., Bräuner, Hans & Clausen, Rasmus Prætorius, 2007, In: Journal of Medicinal Chemistry. 50, 17, p. 4177-4185 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Naturally occurring variations in the human 5-HT_3A gene profoundly impact 5-HT₃ receptor function and expression

Krzywkowski, K. M., Jensen, Anders A., Connolly, C. N. & Bräuner, Hans, 2007, In: Pharmacogenetics and Genomics (Print Edition). 17, 4, p. 255-266

Research output: Contribution to journal › Journal article › Research › peer-review

Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal a7 nicotinic acetylcholine receptor

Jensen, Anders A., Zlotos, D. P. & Liljefors, T., 2007, In: Journal of Medicinal Chemistry. 50, 19, p. 4616-4629

Research output: Contribution to journal › Journal article › Research › peer-review

Probing the pharmacophore of ginkgolides as glycine receptor antagonists

Jensen, Anders A., Begum, N., Vogensen, S. B., Knapp, K. M., Gundertofte, K., Dzyuba, S. V., Ishii, H., Nakanishi, K., Kristiansen, Uffe & Strømgaard, Kristian, 2007, In: Journal of Medicinal Chemistry. 50, 7, p. 1610-1617

Research output: Contribution to journal › Journal article › Research › peer-review

Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors

Bräuner, Hans, Wellendorph, Petrine & Jensen, Anders A., 2007, In: Current Drug Targets. 8, 1, p. 169-184

Research output: Contribution to journal › Journal article › Research › peer-review

Effekt og bivirkninger: GABA fra A til C.

Frølund, Bente, Madsen, C., Jensen, Anders A., Kristiansen, Uffe & Liljefors, T., 2006, In: Lægemiddelforskning. p. 32-33

Research output: Contribution to journal › Journal article › Communication

Functional characterisation of homomeric ionotropic glutamate receptors GluR1-GluR6 in a fluorescence-based high throughput screening assay

Strange, M., Bräuner, Hans & Jensen, Anders A., 2006, In: Combinatorial Chemistry & High Throughput Screening. 9, 2, p. 147-58 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Neurotransmitter transporters

Jensen, Anders A., 2006, In: Current Topics in Medicinal Chemistry. 6, 17, p. 1799-1800 2 p.

Research output: Contribution to journal › Journal article › Research

Pharmacological characterisation of strychnine and brucine analogues at glycine and alpha7 nicotinic acetylcholine receptors

Jensen, Anders A., Gharagozloo, P., Birdsall, N. J. M. & Zlotos, D. P., 2006, In: European Journal of Pharmacology. 539, 1-2, p. 27-33 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Rational design and enantioselective synthesis of (1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarboxylic acid - a novel inhibitor at human glutamate transporter subtypes 1, 2, and 3

Bunch, Lennart, Nielsen, Birgitte, Jensen, Anders A. & Bräuner, Hans, 2006, In: Journal of Medicinal Chemistry. 49, 1, p. 172-8 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Stereoselective chemoenzymatic synthesis of the four stereoisomers of l-2-(2-carboxycyclobutyl)glycine and pharmacological characterization at human excitatory amino acid transporter subtypes 1, 2, and 3

Faure, S., Jensen, Anders A., Maurat, V., Gu, X., Sagot, E., Aitken, D. J., Bolte, J., Gefflaut, T. & Bunch, Lennart, 2006, In: Journal of Medicinal Chemistry. 49, 22, p. 6532-8 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Stoffer fra Tempeltæet (Ginkgo biloba) som redskaber for studier af hjernens funktion

Jensen, Anders A. & Strømgaard, Kristian, 2006, In: Dansk Kemi 83. 87, 1, p. 16-18

Research output: Contribution to journal › Journal article › Communication

Unaturlige aminosyrer skaber ny viden om proteiner

Rannes, J., Andersen, J., Jensen, Anders A., Christensen, L. & Strømgaard, Kristian, 2006, In: Lægemiddelforskning. p. 28-29

Research output: Contribution to journal › Journal article › Communication

Azetidinic amino acids: stereocontrolled synthesis and pharmacological characterization as ligands for glutamate receptors and transporters

Bräuner, Hans, Bunch, Lennart, Chopin, N., Couty, F., Evano, G., Jensen, Anders A., Kusk, M. L., Nielsen, Birgitte & Rabasso, N., 2005, In: Organic & Biomolecular Chemistry. 3, 21, p. 3926-36 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Chemoenzymatic synthesis of a series of 4-substituted glutamate analogues and pharmacological characterization at human glutamate transporters subtypes 1-3

Alaux, S., Kusk, M., Sagot, E., Bolte, J., Jensen, Anders A., Bräuner, Hans, Gefflaut, T. & Bunch, Lennart, 2005, In: Journal of Medicinal Chemistry. 48, 25, p. 7980-92 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Functional characterisation of human glycine receptors in a fluorescence-based high throughput screening assay

Jensen, Anders A., 2005, In: European Journal of Pharmacology. 521, 1-3, p. 39-42 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations

Jensen, Anders A., Frølund, Bente, Liljefors, T. & Krogsgaard-Larsen, Povl, 2005, In: Journal of Medicinal Chemistry. 48, 15, p. 4705-45 41 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Allosteric modulation of G-protein coupled receptors

Jensen, Anders A. & Spalding, T. A., 2004, In: European Journal of Pharmaceutical Sciences. 21, 4, p. 407-20 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Carbamoylcholine homologs: synthesis and pharmacology at nicotinic acetylcholine receptors

Jensen, Anders A., Mikkelsen, I. B., Frølund, Bente, Frydenvang, Karla Andrea, Brehm, L., Jaroszewski, J. W., Bräuner, Hans, Falch, E. & Krogsgaard-Larsen, Povl, 2004, In: European Journal of Pharmacology. 497, 2, p. 125-37 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Fluorescensbaseret farmakologi

Jensen, Anders A., Strange, M. & Bräuner, Hans, 2004, In: Dansk Kemi 83. p. 29 31 p.

Research output: Contribution to journal › Journal article › Communication

Functional characterisation of the human alpha1 glycine receptor in a fluorescence-based membrane potential assay

Jensen, Anders A. & Kristiansen, Uffe, 2004, In: Biochemical Pharmacology. 67, 9, p. 1789-99 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Ginkgolides and glycine receptors: a structure-activity relationship study

Jaracz, S., Nakanishi, K., Jensen, Anders A. & Strømgaard, Kristian, 2004, In: Chemistry: A European Journal. 10, 6, p. 1507-18 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay

Jensen, Anders A. & Bräuner, Hans, 2004, In: Biochemical Pharmacology. 67, 11, p. 2115-27 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Site-specific incorporation of unnatural amino acids into proteins

Strømgaard, A., Jensen, Anders A. & Strømgaard, Kristian, 2004, In: ChemBioChem. 5, 7, p. 909-16 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Synthesis and nicotinic receptor activity of a hydroxylated tropane

Bremner, J. B., Godfrey, C. A., Jensen, Anders A. & Smith, R. J., 2004, In: Bioorganic & Medicinal Chemistry Letters. 14, 1, p. 271-3 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors

Jensen, Anders A., Frølund, Bente, Bräuner, Hans, Falch, E. & Krogsgaard-Larsen, Povl, 2003, In: Molecular Pharmacology. 64, 4, p. 865-75 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET)

Jensen, Anders A., Hansen, J. L., Sheikh, S. P. & Bräuner, Hans, 2002, In: European Journal of Biochemistry. 269, 20, p. 5076-87 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors

Jensen, Anders A., Mosbacher, J., Elg, S., Lingenhoehl, K., Lohmann, T., Johansen, Tommy Nørskov, Abrahamsen, B., Mattsson, J., Lehmann, A., Bettler, B. & Bräuner, Hans, 2002, In: Molecular Pharmacology. 61, 6, p. 1377-84 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The dance of the clams: twists and turns in the family C GPCR homodimer

Jensen, Anders A., Greenwood, J. R. & Bräuner, Hans, 2002, In: Trends in Pharmacological Sciences. 23, 11, p. 491-3 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D

Bräuner, Hans, Jensen, Anders A., Sheppard, P. O., Larsen, Birger Brodin, Krogsgaard-Larsen, Povl & O'Hara, P., 2001, In: BBA General Subjects. 1518, 3, p. 237-48 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Construction of a high affinity zinc binding site in the metabotropic glutamate receptor mGluR1: noncompetitive antagonism originating from the amino-terminal domain of a family C G-protein-coupled receptor

Jensen, Anders A., Sheppard, P. O., Jensen, L. B., O'Hara, P. J. & Bräuner, Hans, 2001, In: Journal of Biological Chemistry. 276, 13, p. 10110-8 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Pharmacological characterization of homobaclofen on wild type and mutant GABA(B)1b receptors coexpressed with the GABA(B)2 receptor

Jensen, Anders A., Madsen, B. E., Krogsgaard-Larsen, Povl & Bräuner, Hans, 2001, In: European Journal of Pharmacology. 417, 3, p. 177-80 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Functional importance of the Ala(116)-Pro(136) region in the calcium-sensing receptor. Constitutive activity and inverse agonism in a family C G-protein-coupled receptor

Jensen, Anders A., Spalding, T. A., Burstein, E. S., Sheppard, P. O., O'Hara, P. J., Brann, M. R., Krogsgaard-Larsen, Povl & Bräuner, Hans, 2000, In: Journal of Biological Chemistry. 275, 38, p. 29547-55 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The role of Arg(78) in the metabotropic glutamate receptor mGlu(1) for agonist binding and selectivity

Jensen, Anders A., Sheppard, P. O., O'Hara, P. J., Krogsgaard-Larsen, Povl & Bräuner, Hans, 2000, In: European Journal of Pharmacology. 397, 2-3, p. 247-53 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Øget forståelse af vigtig receptor i hjernen

Jensen, Anders A. & Bräuner, Hans, 2000, In: Lægemiddelforskning. p. 28-29

Research output: Contribution to journal › Journal article › Communication

Interaction of CPCCOEt with a chimeric mGlu1b and calcium sensing receptor

Bräuner, Hans, Jensen, Anders A. & Krogsgaard-Larsen, Povl, 1999, In: NeuroReport. 10, 18, p. 3923-5 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain

Bräuner, Hans, Jensen, Anders A., Sheppard, P. O., O'Hara, P. & Krogsgaard-Larsen, Povl, 1999, In: Journal of Biological Chemistry. 274, 26, p. 18382-6 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The dopamine D1 receptor family: structural and functional aspects

Jensen, Anders A., Pedersen, U. B., Din, N. & Andersen, P. H., 1996, In: Biochemical Society Transactions. 24, 1, p. 163-9 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review