Christian Adam Olsen
Professor
Biopharmaceuticals
Jagtvej 162
2100 København Ø
- 2024
- Accepted/In press
Sulfur(VI) Fluoride Exchange Chemistry in Solid-Phase Synthesis of Compound Arrays: Discovery of Histone Deacetylase Inhibitors
Hansen, T. N., Danková, D., Bæk, M., Grlaš, L. & Olsen, Christian Adam, 2024, (Accepted/In press) In: JACS Au.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Contemporary Applications of Thioamides and Methods for their Synthesis
Hansen, T. N. & Olsen, Christian Adam, 2024, In: Chemistry: A European Journal. 30, 9, e202303770.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide-Activated Sirtuin 7**
Bolding, J. E., Nielsen, A. L., Jensen, Iben, Hansen, T. N., Ryberg, Line Abildgaard, Jameson, S. T., Harris, Pernille, Peters, G. H. J., Denu, J. M., Rogers, Joseph Matthew & Olsen, Christian Adam, 2023, In: Angewandte Chemie - International Edition. 62, 49, e202314597.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Förster Resonance Energy Transfer Assay for Investigating the Reactivity of Thioesters in Biochemistry and Native Chemical Ligation
Gless, B. H., Schmied, S. H., Bejder, Benjamin Svejdal & Olsen, Christian Adam, 2023, In: JACS Au. 3, 5, p. 1443–1451Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Aryl Fluorosulfate Based Inhibitors That Covalently Target the SIRT5 Lysine Deacylase**
Bolding, J. E., Martín-Gago, P., Rajabi, N., Gamon, Luke Francis, Hansen, T. N., Bartling, Christian Reinhard Otto, Strømgaard, Kristian, Davies, Michael J. & Olsen, Christian Adam, 2022, In: Angewandte Chemie - International Edition. 61, 47, 11 p., e202204565.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
On-Resin Peptide Cyclization Using the 3-Amino-4-(Methylamino)Benzoic Acid MeDbz Linker
Gless, B. H. & Olsen, Christian Adam, 2022, Methods in Molecular Biology. Humana Press, p. 101-115 (Methods in Molecular Biology, Vol. 2371).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Chiral Posttranslational Modification to Lysine ε-Amino Groups
Moreno Yruela, Carlos, Baek, M., Monda, F. & Olsen, Christian Adam, 2022, In: Accounts of Chemical Research. 55, 10, p. 1456-1466Research output: Contribution to journal › Review › Research › peer-review
- Published
Class I histone deacetylases (HDAC1-3) are histone lysine delactylases
Moreno Yruela, Carlos, Zhang, D., Wei, W., Bæk, M., Liu, W., Gao, J., Danková, D., Nielsen, A. L., Bolding, J. E., Yang, L., Jameson, S. T., Wong, J., Olsen, Christian Adam & Zhao, Y., 2022, In: Science Advances. 8, 3, eabi6696.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Determination of Slow-Binding HDAC Inhibitor Potency and Subclass Selectivity
Moreno Yruela, Carlos & Olsen, Christian Adam, 2022, In: ACS Medicinal Chemistry Letters. 13, 5, p. 779-785Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Investigation of Carboxylic Acid Isosteres and Prodrugs for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme**
Rajabi, N., Hansen, T. N., Nielsen, A. L., Nguyen, H. T., Bæk, M., Bolding, J. E., Bahlke, O., Petersen, S. E. G., Bartling, Christian Reinhard Otto, Strømgaard, Kristian & Olsen, Christian Adam, 2022, In: Angewandte Chemie - International Edition. 61, 22, 9 p., e202115805.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
The Chemical Biology-Medicinal Chemistry Continuum: EFMC's Vision
Duca, M., Gillingham, D., Olsen, Christian Adam, Sbardella, G., Skaanderup, P. R., van der Stelt, M., Vauzeilles, B., Vazquez, O. & Auberson, Y. P., 2021, In: ChemBioChem. 22, 19, p. 2823-2825Research output: Contribution to journal › Editorial › Research › peer-review
- Published
Rearrangement of Thiodepsipeptides by S → N Acyl Shift Delivers Homodetic Autoinducing Peptides
Gless, B. H., Bejder, Benjamin Svejdal, Monda, F., Bojer, Martin Saxtorph, Ingmer, Hanne & Olsen, Christian Adam, 2021, In: Journal of the American Chemical Society. 143, 28, p. 10514–10518Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High-throughput screening of histone deacetylases and determination of kinetic parameters using fluorogenic assays
Moreno Yruela, Carlos & Olsen, Christian Adam, 2021, In: STAR Protocols. 2, 1, 14 p., 100313.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hydroxamic acid-modified peptide microarrays for profiling isozyme-selective interactions and inhibition of histone deacetylases
Moreno Yruela, Carlos, Bæk, M., Vrsanova, A., Schulte, C., Maric, H. M. & Olsen, Christian Adam, 4 Jan 2021, In: Nature Communications. 12, 1Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration
Nielsen, A. L., Rajabi, N., Kudo, N., Jørgensen, Kathrine Lundø, Moreno Yruela, Carlos, Bæk, M., Fontenas, M., Lucidi, A., Madsen, A. S., Yoshida, M. & Olsen, Christian Adam, 2021, In: RSC Chemical Biology. 2, p. 612-626Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mitochondria-targeted inhibitors of the human SIRT3 lysine deacetylase
Troelsen, K. S., Bæk, M., Nielsen, A. L., Madsen, A. S., Rajabi, N. & Olsen, Christian Adam, 2021, In: RSC Chemical Biology. 2, p. 627-635Research output: Contribution to journal › Journal article › Research › peer-review
- Published
SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia
Yan, D., Franzini, A., Pomicter, A. D., Halverson, B. J., Antelope, O., Mason, C. C., Ahmann, J. M., Senina, A. V., Vellore, N. A., Jones, C. L., Zabriskie, M. S., Than, H., Xiao, M. J., van Scoyk, A., Patel, A. B., Clair, P. M., Heaton, W. L., Owen, S. C., Andersen, J. L., Egbert, C. M. & 11 others, , 2021, In: Cancer Discovery. 2, 3, p. 266-287Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Zn2+-Dependent Histone Deacetylases in Plants: Structure and Evolution
Yruela, I., Moreno Yruela, Carlos & Olsen, Christian Adam, 2021, In: Trends in Plant Science. 26, 7, p. 741-757Research output: Contribution to journal › Review › Research › peer-review
- 2020
- Published
Photo Cross-Linking Probes Containing ϵ-N-Thioacyllysine and ϵ-N-Acyl-(δ-aza)lysine Residues
Bæk, M., Martín-Gago, P., Laursen, J. S., Madsen, J. L. H., Chakladar, S. & Olsen, Christian Adam, 23 Mar 2020, In: Chemistry - A European Journal. 26, 17, p. 3862-3869 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction
Lynagh, T., Kiontke, S., Meyhoff-Madsen, M., Gless, B. H., Johannesen, J., Kattelmann, S., Christiansen, A., Dufva, M., Laustsen, A. H., Devkota, K., Olsen, Christian Adam, Kuemmel, D., Pless, Stephan & Lohse, B., 2020, In: Journal of Medicinal Chemistry. 63, 22, p. 13709-13718 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hydroxamic Acid-Containing Peptides in the Study of Histone Deacetylases
Moreno Yruela, Carlos & Olsen, Christian Adam, 2020, Topics in Medicinal Chemistry. A. M. (ed.). Springer, p. 29-54 26 p. (Topics in Medicinal Chemistry, Vol. 33).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Selective inhibitors of SIRT2 regulate perinuclear α-tubulin acetylation, migration, and invasion of breast cancer cells
Nielsen, A. L., Rajabi, N., Kudo, N., Jørgensen, Kathrine Lundø, Fontenas, M., Lucidi, A., Madsen, A. S., Yoshida, M. & Olsen, Christian Adam, 2020, In: bioRxiv. 26 p.Research output: Contribution to journal › Journal article › Research
- Published
Finding the gas pedal on a slow sirtuin
Nielsen, A. L. & Olsen, Christian Adam, 31 Jan 2020, In: Journal of Biological Chemistry. 295, p. 400-401Research output: Contribution to journal › Literature review › Research › peer-review
- Published
Dethioacylation by sirtuins 1–3: Considerations for drug design using mechanism-based sirtuin inhibition
Rajabi, N., Nielsen, A. L. & Olsen, Christian Adam, 2020, In: A C S Medicinal Chemistry Letters. 11, 10, p. 1886-1892Research output: Contribution to journal › Letter › Research › peer-review
- Published
Increasing the Functional Group Diversity in Helical beta-Peptoids: Achievement of Solvent- and pH-Dependent Folding
Wellhofer, I., Beck, J., Frydenvang, Karla Andrea, Brase, S. & Olsen, Christian Adam, 2020, In: Journal of Organic Chemistry. 85, 16, p. 10466-10478 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Identification of autoinducing thiodepsipeptides from staphylococci enabled by native chemical ligation
Gless, B. H., Bojer, Martin Saxtorph, Peng, P., Baldry, M., Ingmer, Hanne & Olsen, Christian Adam, 22 Apr 2019, In: Nature Chemistry. 11, p. 463–469Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Arylfluorosulfate-Based Electrophiles for Covalent Protein Labeling: A New Addition to the Arsenal
Martín-Gago, P. & Olsen, Christian Adam, 21 Jan 2019, In: Angewandte Chemie - International Edition. 58, 4, p. 957-966 10 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
- Published
Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression
Moreno Yruela, Carlos, Fass, D. M., Cheng, C., Herz, J., Olsen, Christian Adam & Haggarty, S. J., 22 Jul 2019, In: A C S Chemical Neuroscience. 10, 8, p. 3769-3777Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of co-inhabiting coagulase negative staphylococci on S. Aureus agr quorum sensing, host factor binding, and biofilm formation
Peng, P., Baldry, M., Gless, B. H., Bojer, Martin Saxtorph, Espinosa-Gongora, C., Baig, S. J., Andersen, P. S., Olsen, Christian Adam & Ingmer, Hanne, 2019, In: Frontiers in Microbiology. 10, SEP, 14 p., 2212.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functionalized Helical beta-Peptoids
Wellhofer, I., Frydenvang, Karla Andrea, Kotesova, S., Christiansen, A. M., Laursen, J. S. & Olsen, Christian Adam, 5 Apr 2019, In: Journal of Organic Chemistry. 84, 7, p. 3762-3779Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Direct Peptide Cyclization and One-Pot Modification Using the MeDbz Linker
Gless, B. H. & Olsen, Christian Adam, 6 Aug 2018, In: Journal of Organic Chemistry. 83, 17, p. 10525-10534Research output: Contribution to journal › Letter › Research › peer-review
- Published
Elucidating the Enzymatic Activity of HDAC11
Moreno Yruela, Carlos, Galleano, I., Madsen, A. S. & Olsen, Christian Adam, 19 Aug 2018.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Histone Deacetylase 11 Is an ε- N -Myristoyllysine Hydrolase
Moreno Yruela, Carlos, Galleano, I., Madsen, A. S. & Olsen, Christian Adam, 3 May 2018, In: Cell Chemical Biology. 25, 7, p. 849-856Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis of Trifluoromethyl Ketone Containing Amino Acid Building Blocks for the Preparation of Peptide-Based Histone Deacetylase (HDAC) Inhibitors
Moreno Yruela, Carlos & Olsen, Christian Adam, 2018, In: Synthesis. 50, 20, p. 4037-4046Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Potent and selective inhibition of sirtuin 2 deacylation
Nielsen, A. L., Rajabi, N., Madsen, A. & Olsen, Christian Adam, 19 Aug 2018.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
An NAD+-Dependent Sirtuin Depropionylase and Deacetylase (Sir2La) from the Probiotic Bacterium Lactobacillus acidophilus NCFM
Olesen, S., Rajabi, N., Svensson, B., Olsen, Christian Adam & Madsen, A. S., 4 Jun 2018, In: Biochemistry. 57, 26, p. 3903-3915Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting Sirtuins: Substrate Specificity and Inhibitor Design
Rajabi, N., Galleano, I., Madsen, A. S. & Olsen, Christian Adam, 3 Feb 2018, Progress in Molecular Biology and Translational Science: Sirtuins in Health and Disease. Elsevier, p. 25-69 (Progress in Molecular Biology and Translational Science, Vol. 154).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
A Robust Proton Flux (pHlux) Assay for Studying the Function and Inhibition of the Influenza A M2 Proton Channel
Santner, P., Martins, J. M. D. S., Laursen, J. S., Behrendt, L., Riber, Leise, Olsen, Christian Adam, Arkin, I. T., Winther, Jakob R., Willemoës, Martin & Lindorff-Larsen, Kresten, 2018, In: Biochemistry. 57, 41, p. 5949-5956Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Random mutagenesis analysis of the Influenza A M2 proton channel reveals novel resistance mutants
Santner, P., Martins, J. M. D. S., Kampmeyer, Caroline, Hartmann-Petersen, Rasmus, Laursen, J. S., Stein, Amelie, Olsen, Christian Adam, Arkin, I. T., Winther, Jakob R., Willemoës, Martin & Lindorff-Larsen, Kresten, 2018, In: Biochemistry. 57, 41, p. 5957-5968Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Metabolic control by sirtuins and other enzymes that sense NAD(+), NADH, or their ratio
Anderson, K. A., Madsen, A. S., Olsen, Christian Adam & Hirschey, M. D., Dec 2017, In: B B A - Reviews on Cancer. 1858, 12, p. 991-998 8 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion
Anderson, K. A., Huynh, F. K., Fisher-Wellman, K., Stuart, J. D., Peterson, B. S., Douros, J. D., Wagner, G. R., Thompson, J. W., Madsen, A. S., Green, M. F., Sivley, R. M., Ilkayeva, O. R., Stevens, R. D., Backos, D. S., Capra, J. A., Olsen, Christian Adam, Campbell, J. E., Muoio, D. M., Grimsrud, P. A. & Hirschey, M. D., 4 Apr 2017, In: Cell Metabolism. 25, 4, p. 838-855.e15Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Backbone-Fluorinated 1,2,3-Triazole-Containing Dipeptide Surrogates
Engel-Andreasen, J., Wellhöfer, I., Wich, K. & Olsen, Christian Adam, 16 Oct 2017, In: Journal of Organic Chemistry. 82, 21, p. 11613-11619Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Scalable and Purification-Free Synthesis of a Myristoylated Fluorogenic Sirtuin Substrate
Galleano, I., Nielsen, J., Stahl Madsen, A. & Olsen, Christian Adam, 2017, In: SYNLETT: Accounts and Rapid Communications in Chemical Synthesis. 28, 16, p. 2169-2173Research output: Contribution to journal › Letter › Research › peer-review
- Published
Structure-activity relationship study based on Autoinducing Peptide (AIP) from dog pathogen S. schleiferi
Gless, B. H., Peng, P., Pedersen, K. D., Gotfredsen, C. H., Ingmer, Hanne & Olsen, Christian Adam, 2017, In: Organic Letters. 19, 19, p. 5276–5279Research output: Contribution to journal › Letter › Research › peer-review
- Published
Chemical Editing of Macrocyclic Natural Products and Kinetic Profiling Reveal Slow, Tight-Binding Histone Deacetylase Inhibitors with Picomolar Affinities
Kitir, B., Maolanon, A. R., Ohm, R. G., Colaço, A. R., Fristrup, P., Madsen, A. S. & Olsen, Christian Adam, 26 Sep 2017, In: Biochemistry. 56, 38, p. 5134-5146 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cyclic tetrapeptide HDAC inhibitors as potential therapeutics for spinal muscular atrophy: Screening with iPSC-derived neuronal cells
Lai, J. I., Leman, L. J., Ku, S., Vickers, C. J., Olsen, Christian Adam, Montero, A., Ghadiri, M. R. & Gottesfeld, J. M., 2017, In: Bioorganic and Medicinal Chemistry Letters. 27, 15, p. 3289-3293 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes
Maolanon, A., Kristensen, H., Leman, L., Ghadiri, R. & Olsen, Christian Adam, 2017, In: ChemBioChem. 18, 1, p. 5-49 45 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanism-based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight
Rajabi, N., Auth, M., Troelsen, K. R., Pannek, M., Bhatt, D., Fontenas, M., Hirschey, M., Steegborn, C., Madsen, A. S. & Olsen, Christian Adam, 20 Nov 2017, In: Angewandte Chemie, Int. Ed.. 56, 47, p. 14836-14841Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
The agr inhibitors solonamide B and analogues alter immune responses to Staphylococccus aureus but do not exhibit adverse effects on immune cell functions
Baldry, M., Kitir, B., Frøkiær, Hanne, Christensen, S. B., Taverne, N., Meijerink, M., Franzyk, Henrik, Olsen, Christian Adam, Wells, J. M. & Ingmer, Hanne, 2016, In: P L o S One. 11, 1, 17 p., e0145618.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 101364066
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2040
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Synthesis and antiangiogenic activity of N-alkylated levamisole derivatives
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
390
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Cross-Talk between Staphylococcus aureus and Other Staphylococcal Species via the agr Quorum Sensing System
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
359
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The agr inhibitors solonamide B and analogues alter immune responses to Staphylococccus aureus but do not exhibit adverse effects on immune cell functions
Research output: Contribution to journal › Journal article › Research › peer-review
Published