Christian Adam Olsen

Christian Adam Olsen

Professor

ORCID: 0000-0002-2953-8942

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  1. Published

    5,6-Dihydropyrrolo[2,1-b]isoquinolines as scaffolds for synthesis of lamellarin analogues

    Olsen, Christian Adam, Parera, N., Albericio, F. & Álvarez, M., 21 Mar 2005, In: Tetrahedron Letters. 46, 12, p. 2041-2044 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    A Continuous, Fluorogenic Sirtuin 2 Deacylase Assay: Substrate Screening and Inhibitor Evaluation

    Galleano, I., Schiedel, M., Jung, M., Madsen, A. S. & Olsen, Christian Adam, 11 Feb 2016, In: Journal of Medicinal Chemistry. 59, 3, p. 1021-31 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    A Robust Proton Flux (pHlux) Assay for Studying the Function and Inhibition of the Influenza A M2 Proton Channel

    Santner, P., Martins, J. M. D. S., Laursen, J. S., Behrendt, L., Riber, Leise, Olsen, Christian Adam, Arkin, I. T., Winther, Jakob R., Willemoës, Martin & Lindorff-Larsen, Kresten, 2018, In: Biochemistry. 57, 41, p. 5949-5956

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    A potent trifluoromethyl ketone histone deacetylase inhibitor exhibits class-dependent mechanism of action

    Madsen, A. S. & Olsen, Christian Adam, 2016, In: MedChemComm. 7, p. 464-470 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids

    Olsen, Christian Adam, Christensen, C., Nielsen, Birgitte, Farah, M. M., Mohamed, F. M., Witt, M., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard, Franzyk, Henrik & Jaroszewski, J. W., 2006, In: Organic Letters. 8, 15, p. 3371-4 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    An NAD+-Dependent Sirtuin Depropionylase and Deacetylase (Sir2La) from the Probiotic Bacterium Lactobacillus acidophilus NCFM

    Olesen, S., Rajabi, N., Svensson, B., Olsen, Christian Adam & Madsen, A. S., 4 Jun 2018, In: Biochemistry. 57, 26, p. 3903-3915

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    An Update on Lysine Deacylases Targeting the Expanding "Acylome"

    Olsen, Christian Adam, Mar 2014, In: ChemMedChem. 9, 3, p. 434-437 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    An azumamide C analogue without the zinc-binding functionality

    Villadsen, J. S., Kitir, B., Wich, K., Friis, T., Madsen, A. S. & Olsen, Christian Adam, 12 Aug 2014, In: MedChemComm. 5, p. 1849-1855

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Antimicrobial, hemolytic, and cytotoxic activities of ß-peptoid-peptide hybrid oligomers: Improved properties compared to natural AMPs

    Olsen, Christian Adam, Ziegler, H. L., Nielsen, Hanne Mørck, Frimodt-Møller, N., Jaroszewski, J. W. & Franzyk, Henrik, 2010, In: ChemBioChem. 11, 10, p. 1356-1360

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Antimicrobial, hemolytic, and cytotoxic activities of β-peptoid- peptide hybrid oligomers: Improved properties compared to natural AMPs (ChemBioChem (2010) 11, (152-160))

    Olsen, Christian Adam, Ziegler, H. L., Nielsen, Hanne Mørck, Frimodt-Møller, N., Jaroszewski, J. W. & Franzyk, Henrik, 16 Aug 2010, In: ChemBioChem. 11, 12, 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  11. Published

    Antiplasmodial and prehemolytic activities of alpha-peptide-beta-peptoid chimeras

    Vedel, L., Bonke, G., Foged, Camilla, Ziegler, H. L., Franzyk, Henrik, Jaroszewski, J. W. & Olsen, Christian Adam, 2007, In: ChemBioChem. 8, 15, p. 1781-1784 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Aryl Fluorosulfate Based Inhibitors That Covalently Target the SIRT5 Lysine Deacylase**

    Bolding, J. E., Martín-Gago, P., Rajabi, N., Gamon, Luke Francis, Hansen, T. N., Bartling, Christian Reinhard Otto, Strømgaard, Kristian, Davies, Michael J. & Olsen, Christian Adam, 2022, In: Angewandte Chemie - International Edition. 61, 47, 11 p., e202204565.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Arylfluorosulfate-Based Electrophiles for Covalent Protein Labeling: A New Addition to the Arsenal

    Martín-Gago, P. & Olsen, Christian Adam, 21 Jan 2019, In: Angewandte Chemie - International Edition. 58, 4, p. 957-966 10 p.

    Research output: Contribution to journal › Review › Research › peer-review

  14. Published

    Aziridines in parallel- and solid-phase synthesis

    Olsen, Christian Adam, Bonke, G., Vedel, L., Franzyk, Henrik & Jaroszewski, J. W., 2007, In: European Journal of Organic Chemistry. 2007, 11, p. 1717-1724

    Research output: Contribution to journal › Review › Research › peer-review

  15. Published

    Backbone-Fluorinated 1,2,3-Triazole-Containing Dipeptide Surrogates

    Engel-Andreasen, J., Wellhöfer, I., Wich, K. & Olsen, Christian Adam, 16 Oct 2017, In: Journal of Organic Chemistry. 82, 21, p. 11613-11619

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Cellular uptake and membrane-destabilising properties of a-peptide/ß-peptoid chimeras: lessons for the design of new cell-penetrating peptides

    Foged, Camilla, Franzyk, Henrik, Bahrami, S., Frøkjær, Sven, Jaroszewski, J. W., Nielsen, Hanne Mørck & Olsen, Christian Adam, 2008, In: BBA General Subjects. 1778, 11, p. 2487-2495

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Chemical Editing of Macrocyclic Natural Products and Kinetic Profiling Reveal Slow, Tight-Binding Histone Deacetylase Inhibitors with Picomolar Affinities

    Kitir, B., Maolanon, A. R., Ohm, R. G., Colaço, A. R., Fristrup, P., Madsen, A. S. & Olsen, Christian Adam, 26 Sep 2017, In: Biochemistry. 56, 38, p. 5134-5146 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Chiral Posttranslational Modification to Lysine ε-Amino Groups

    Moreno Yruela, Carlos, Baek, M., Monda, F. & Olsen, Christian Adam, 2022, In: Accounts of Chemical Research. 55, 10, p. 1456-1466

    Research output: Contribution to journal › Review › Research › peer-review

  19. Published

    Cis-Trans Amide Bond Rotamers in beta-Peptoids and Peptoids: Evaluation of Stereoelectronic Effects in Backbone and Side Chains

    Laursen, J. S., Engel-Andreasen, J., Fristrup, P., Harris, Pernille & Olsen, Christian Adam, 20 Feb 2013, In: Journal of the American Chemical Society. 135, 7, p. 2835-2844

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Class I histone deacetylases (HDAC1-3) are histone lysine delactylases

    Moreno Yruela, Carlos, Zhang, D., Wei, W., Bæk, M., Liu, W., Gao, J., Danková, D., Nielsen, A. L., Bolding, J. E., Yang, L., Jameson, S. T., Wong, J., Olsen, Christian Adam & Zhao, Y., 2022, In: Science Advances. 8, 3, eabi6696.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Conformationally rigid histone deacetylase inhibitors correct DF508-CFTR protein function

    Vickers, C. J., Olsen, Christian Adam, Hutt, D. M., Montero, A., Leman, L. J., Maryanoff, B. E., Balch, W. E. & Ghadiri, M. R., 28 Aug 2011, In: American Chemical Society. Abstracts of Papers (at the National Meeting). 242

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Contemporary Applications of Thioamides and Methods for their Synthesis

    Hansen, T. N. & Olsen, Christian Adam, 2024, In: Chemistry: A European Journal. 30, 9, e202303770.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Cross-Talk between Staphylococcus aureus and Other Staphylococcal Species via the agr Quorum Sensing System

    Canovas de la Nuez, J., Baldry, M., Bojer, Martin Saxtorph, Andersen, P. S., Grzeskowiak, P. K., Stegger, M., Damborg, Peter Panduro, Olsen, Christian Adam & Ingmer, Hanne, 2016, In: Frontiers in Microbiology. 7, 1733.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Cyclic tetrapeptide HDAC inhibitors as potential therapeutics for spinal muscular atrophy: Screening with iPSC-derived neuronal cells

    Lai, J. I., Leman, L. J., Ku, S., Vickers, C. J., Olsen, Christian Adam, Montero, A., Ghadiri, M. R. & Gottesfeld, J. M., 2017, In: Bioorganic and Medicinal Chemistry Letters. 27, 15, p. 3289-3293 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Design, Synthesis, Biological Evaluation, and Structural Characterization of Potent Histone Deacetylase Inhibitors Based on Cyclic alpha/beta-Tetrapeptide Architectures

    Montero, A., Beierle, J. M., Olsen, Christian Adam & Ghadiri, M. R., 4 Mar 2009, In: Journal of the American Chemical Society. 131, 8, p. 3033-3041

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Determination of Slow-Binding HDAC Inhibitor Potency and Subclass Selectivity

    Moreno Yruela, Carlos & Olsen, Christian Adam, 2022, In: ACS Medicinal Chemistry Letters. 13, 5, p. 779-785

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Dethioacylation by sirtuins 1–3: Considerations for drug design using mechanism-based sirtuin inhibition

    Rajabi, N., Nielsen, A. L. & Olsen, Christian Adam, 2020, In: A C S Medicinal Chemistry Letters. 11, 10, p. 1886-1892

    Research output: Contribution to journal › Letter › Research › peer-review

  28. Published

    Dimeric Building Blocks for Solid-Phase Synthesis of α-Peptide-β-Peptoid Chimeras

    Seigan, G. B., Vedel, L., Matthias, W., Jaroszewski, J. W., Olsen, Christian Adam & Franzyk, Henrik, 2008, In: Synthesis. 2008, 15, p. 2381-2390 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Diols as Building Blocks in Solid-Phase Synthesis of Polyamine Toxins by Fukuyama-Mitsunobu Alkylation

    Olsen, Christian Adam, Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2004, In: Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. p. 473-476 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Direct Peptide Cyclization and One-Pot Modification Using the MeDbz Linker

    Gless, B. H. & Olsen, Christian Adam, 6 Aug 2018, In: Journal of Organic Chemistry. 83, 17, p. 10525-10534

    Research output: Contribution to journal › Letter › Research › peer-review

  31. Published

    Discovery of HDAC Inhibitors That Lack an Active Site Zn2+-Binding Functional Group

    Vickers, C. J., Olsen, Christian Adam, Leman, L. J. & Ghadiri, M. R., Jun 2012, In: ACS Medicinal Chemistry Letters. 3, 6, p. 505-508

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Discovery of Potent and Selective Histone Deacetylase Inhibitors via Focused Combinatorial Libraries of Cyclic alpha(3)beta-Tetrapeptides

    Olsen, Christian Adam & Ghadiri, M. R., 10 Dec 2009, In: Journal of Medicinal Chemistry. 52, 23, p. 7836-7846

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Effect of co-inhabiting coagulase negative staphylococci on S. Aureus agr quorum sensing, host factor binding, and biofilm formation

    Peng, P., Baldry, M., Gless, B. H., Bojer, Martin Saxtorph, Espinosa-Gongora, C., Baig, S. J., Andersen, P. S., Olsen, Christian Adam & Ingmer, Hanne, 2019, In: Frontiers in Microbiology. 10, SEP, 14 p., 2212.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Effects of Thionation and Fluorination on Cis-Trans Isomerization in Tertiary Amides: An Investigation of N-Alkylglycine (Peptoid) Rotamers

    Engel-Andreasen, J., Wich, K., Laursen, J. S., Harris, P. & Olsen, Christian Adam, 4 Mar 2015, In: Journal of Organic Chemistry. 80, 11, p. 5415–5427 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Elucidating the Enzymatic Activity of HDAC11

    Moreno Yruela, Carlos, Galleano, I., Madsen, A. S. & Olsen, Christian Adam, 19 Aug 2018.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  36. Published

    Erratum: Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids (Organic Letters (2006) 8 (3371))

    Olsen, Christian Adam, Christensen, C., Nielsen, Birgitte, Farah, M. M., Witt, M., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard, Franzyk, Henrik & Jaroszewski, J. W., 15 Oct 2010, In: Organic Letters. 12, 20, p. 4708 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  37. Published

    Expansion of the Lysine Acylation Landscape

    Olsen, Christian Adam, 2012, In: Angewandte Chemie International Edition. 51, 16, p. 3755-3756

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Expedient protocol for solid-phase synthesis of secondary and tertiary amines

    Olsen, Christian Adam, Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2004, In: Organic Letters. 6, 12, p. 1935-8 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Finding the gas pedal on a slow sirtuin

    Nielsen, A. L. & Olsen, Christian Adam, 31 Jan 2020, In: Journal of Biological Chemistry. 295, p. 400-401

    Research output: Contribution to journal › Literature review › Research › peer-review

  40. Published

    Fukuyama-Mitsunobu Alkylation in Amine Synthesis on Solid Phase Revisited: N-Alkylation with Secondary Alcohols and Synthesis of Curtatoxins

    Olsen, Christian Adam, Witt, M., Hansen, S. H., Jaroszewski, J. W. & Franzyk, Henrik, 2005, In: Tetrahedron. 61, p. 6046-6055 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Functionalized Helical beta-Peptoids

    Wellhofer, I., Frydenvang, Karla Andrea, Kotesova, S., Christiansen, A. M., Laursen, J. S. & Olsen, Christian Adam, 5 Apr 2019, In: Journal of Organic Chemistry. 84, 7, p. 3762-3779

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Förster Resonance Energy Transfer Assay for Investigating the Reactivity of Thioesters in Biochemistry and Native Chemical Ligation

    Gless, B. H., Schmied, S. H., Bejder, Benjamin Svejdal & Olsen, Christian Adam, 2023, In: JACS Au. 3, 5, p. 1443–1451

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Guanidino groups greatly enhance the action of antimicrobial peptidomimetics against bacterial cytoplasmic membranes

    Andreev, K., Bianchi, C., Laursen, J. S., Citterio, L., Hein-Kristensen, L., Gram, L., Kuzmenko, I., Olsen, Christian Adam & Gidalevitz, D., 2014, In: B B A - Biomembranes. 1838, 10, p. 2492-502 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    High-throughput screening of histone deacetylases and determination of kinetic parameters using fluorogenic assays

    Moreno Yruela, Carlos & Olsen, Christian Adam, 2021, In: STAR Protocols. 2, 1, 14 p., 100313.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Histone Deacetylase 11 Is an ε- N -Myristoyllysine Hydrolase

    Moreno Yruela, Carlos, Galleano, I., Madsen, A. S. & Olsen, Christian Adam, 3 May 2018, In: Cell Chemical Biology. 25, 7, p. 849-856

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Hurtige genveje til nye lægemidler

    Olsen, Christian Adam, Franzyk, Henrik & Jaroszewski, J. W., 2003, In: Lægemiddelforskning. 2003, p. 8-9 2 p.

    Research output: Contribution to journal › Journal article › Communication

  47. Published

    Hydroxamic Acid-Containing Peptides in the Study of Histone Deacetylases

    Moreno Yruela, Carlos & Olsen, Christian Adam, 2020, Topics in Medicinal Chemistry. A. M. (ed.). Springer, p. 29-54 26 p. (Topics in Medicinal Chemistry, Vol. 33).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  48. Published

    Hydroxamic acid-modified peptide microarrays for profiling isozyme-selective interactions and inhibition of histone deacetylases

    Moreno Yruela, Carlos, Bæk, M., Vrsanova, A., Schulte, C., Maric, H. M. & Olsen, Christian Adam, 4 Jan 2021, In: Nature Communications. 12, 1

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Identification of autoinducing thiodepsipeptides from staphylococci enabled by native chemical ligation

    Gless, B. H., Bojer, Martin Saxtorph, Peng, P., Baldry, M., Ingmer, Hanne & Olsen, Christian Adam, 22 Apr 2019, In: Nature Chemistry. 11, p. 463–469

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Increasing the Functional Group Diversity in Helical beta-Peptoids: Achievement of Solvent- and pH-Dependent Folding

    Wellhofer, I., Beck, J., Frydenvang, Karla Andrea, Brase, S. & Olsen, Christian Adam, 2020, In: Journal of Organic Chemistry. 85, 16, p. 10466-10478 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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