Jan Stenvang
Associate Professor
Translational and Clinical Pharmacology
Jagtvej 160
2100 København Ø
- Published
A Comprehensive RNA Study to Identify circRNA and miRNA Biomarkers for Docetaxel Resistance in Breast Cancer
Huang, P., Li, F., Mo, Z., Geng, C., Wen, F., Zhang, C., Guo, J., Wu, S., Li, L., Brunner, N. & Stenvang, Jan, 2021, In: Frontiers in Oncology. 11, 14 p., 669270.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A novel dual-target steroid sulfatase inhibitor and antiestrogen: SR 16157, a promising agent for the therapy of breast cancer
Rasmussen, L. M., Zaveri, N. T., Stenvang, Jan, Peters, R. H. & Lykkesfeldt, A. E., 2007, In: Breast Cancer Research and Treatment. 106, 2, p. 191-203 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A phase II study of Epirubicin in oxaliplatin-resistant patients with metastatic colorectal cancer and TOP2A gene amplification
Tarpgaard, L. S., Qvortrup, C., Nygård, S. B., Nielsen, Signe Lykke, Andersen, D. R., Jensen, N. F., Stenvang, Jan, Detlefsen, S., Brünner, N. & Pfeiffer, P., 2016, In: B M C Cancer. 16, 5 p., 91.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A phase II study of weekly irinotecan in patients with locally advanced or metastatic HER2- negative breast cancer and increased copy numbers of the topoisomerase 1 (TOP1) gene: a study protocol
Kümler, Iben, Balslev, E., Stenvang, Jan, Brünner, N. & Nielsen, D., 2015, In: B M C Cancer. 15, 5 p., 78.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A systematic review on topoisomerase 1 inhibition in the treatment of metastatic breast cancer
Kümler, I., Brünner, N., Stenvang, Jan, Balslev, E. & Nielsen, D. L., 2013, In: Breast Cancer Research and Treatment. 138, 2, p. 347-358 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ABCG2 Protein Levels and Association to Response to First-Line Irinotecan-Based Therapy for Patients with Metastatic Colorectal Cancer
Palshof, J. A., Cederbye, C. N., Hgdall, E. V. S., Poulsen, T. S., Linnemann, D., Nygaard, S. B., Stenvang, Jan, Christensen, I. J., Jensen, B. V., Pfeiffer, P., Brunner, N., Yilmaz, M., Viuff, B. M. & Nielsen, Dorte Lisbet, 2020, In: International Journal of Molecular Sciences. 21, 14, 13 p., 5027.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acquisition of docetaxel resistance in breast cancer cells reveals upregulation of ABCB1 expression as a key mediator of resistance accompanied by discrete upregulation of other specific genes and pathways
Hansen, S. N., Westergaard, David, Thomsen, M. B. H., Vistesen, M. V., Do, K. N., Fogh, L., Belling, K. G., Wang, J., Yang, H., Gupta, R., Ditzel, H. J., Moreira, José, Brünner, N., Stenvang, Jan & Rasmussen, A. S., 2015, In: Tumor Biology. 36, 6, p. 4327-4338 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An Explorative Analysis of ABCG2/TOP-1 mRNA Expression as a Biomarker Test for FOLFIRI Treatment in Stage III Colon Cancer Patients: Results from Retrospective Analyses of the PETACC-3 Trial
Stenvang, Jan, Budinská, E., van Cutsem, E., Bosman, F., Popovici, V. & Brünner, N., 2020, In: Cancers. 12, 4, 12 p., 977.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antibody validation and scoring guidelines for ABCG2 immunohistochemical staining in formalin-fixed paraffin-embedded colon cancer tissue
Karlsson, Camilla Cederbye, Palshof, J. A., Kuhlmann, Tine Plato, Duun-Henriksen, A. K., Linnemann, D., Stenvang, Jan, Nielsen, Dorte Lisbet, Brunner, N. & Viuff, B. M., 3 Jun 2016, In: Scientific Reports. 6, 16 p., 26997.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antibody-drug conjugates (ADCs) targeting trophoblast cell surface antigen 2 (Trop-2) and precision treatment of breast cancer
Stenvang, Jan, Vestlev, P. M., Jensen, B. V. & Pfeiffer, P., 2022, In: Annals of Translational Medicine. 10, 21, 4 p., 1184.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
BMP-2 induces EMT and breast cancer stemness through Rb and CD44
Huang, P., Chen, A., He, W., Li, Z., Zhang, G., Liu, Z., Liu, G., Liu, X., He, S., Xiao, G., Huang, F., Stenvang, Jan, Brünner, N., Hong, A. & Wang, J., 2017, In: Cell Death Discovery. 3, 12 p., 17039.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biomarker-guided repurposing of chemotherapeutic drugs for cancer therapy: a novel strategy in drug development
Stenvang, Jan, Kümler, I., Nygård, S. B., Smith, D. H., Nielsen, D., Brünner, N. & Moreira, José, 2013, In: Frontiers in Oncology. 3, 9 p., 313.Research output: Contribution to journal › Review › Research › peer-review
- Published
Breast cancer cells with acquired antiestrogen resistance are sensitized to cisplatin-induced cell death
Yde, C. W., Gyrd-Hansen, Mads, Lykkesfeldt, A. E., Issinger, O. & Stenvang, Jan, Jun 2007, In: Molecular Cancer Therapeutics. 6, 6, p. 1869-1876 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations
Jensen, N. F., Agama, K., Roy, A., Smith, D. H., Pfister, T. D., Rømer, M. U., Zhang, H., Doroshow, J. H., Knudsen, B. R., Stenvang, Jan, Brünner, N. & Pommier, Y., 2016, In: Journal of Experimental and Clinical Cancer Research (Online). 35, 14 p., 56.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of resistance to a recombinant hexameric Fas-ligand (APO010) in human cancer cell lines
Jandu, H., Nielsen, A., Brunner, N., Hansen, A., Knudsen, S., Stenvang, Jan & Jensen, P. B., 2020, In: Experimental Hematology. 87, p. 33-41Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comprehensive genomic analysis of Oesophageal Squamous Cell Carcinoma reveals clinical relevance
Du, P., Huang, P., Huang, X., Li, X., Feng, Z., Li, F., Liang, S., Song, Y., Stenvang, Jan, Brünner, N., Yang, H., Ou, Y., Gao, Q. & Li, L., Dec 2017, In: Scientific Reports. 7, 9 p., 15324.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conserved residues and their role in the structure, function, and stability of acyl-coenzyme A binding protein
Kragelund, B. B., Poulsen, K., Andersen, K. V., Baldursson, T., Krøll, J. B., Neergård, T. B., Jepsen, J., Roepstorff, P., Kristiansen, Karsten, Poulsen, F. M., Knudsen, J. & Stenvang, Jan, 1999, In: Biochemistry. 38, 8, p. 2386-94 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Downregulation of p21(WAF1/CIP1) and estrogen receptor alpha in MCF-7 cells by antisense oligonucleotides containing locked nucleic acid (LNA)
Stenvang, Jan, Pfundheller, H. M. & Lykkesfeldt, A. E., 2004, In: Oligonucleotides. 14, 2, p. 147-56 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Drug resistance in colorectal cancer cell lines is partially associated with aneuploidy status in light of profiling gene expression
Guo, J., Xu, S., Huang, X., Li, L., Zhang, C., Pan, Q., Ren, Z., Zhou, R., Ren, Y., Zi, J., Wu, L., Stenvang, Jan, Brünner, N., Wen, B. & Liu, S., 2016, In: Journal of Proteome Research. 15, 11, p. 4047–4059 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Drug transporters in breast cancer: response to anthracyclines and taxanes
Kümler, I., Stenvang, Jan, Moreira, José, Brünner, N. & Nielsen, Dorte Lisbet, Sep 2015, In: Expert Review of Anticancer Therapy. 15, 9, p. 1075-1092 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Establishment and characterization of models of chemotherapy resistance in colorectal cancer: towards a predictive signature of chemoresistance
Jensen, N. F., Stenvang, J., Beck, M. K., Hanáková, B., Belling, K. C., Do, K. N., Viuff, B. M., Nygård, S. B., Gupta, R., Rasmussen, M. H., Tarpgaard, L. S., Hansen, T. P., Budinská, E., Pfeiffer, P., Bosman, F., Tejpar, S., Roth, A., Delorenzi, M., Andersen, C. L., Rømer, M. U. K. & 2 others, , 24 Feb 2015, In: Molecular Oncology. 9, 6, p. 1169-1185 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Four phase 1 trials to evaluate the safety and pharmacokinetic profile of single and repeated dosing of SCO-101 in adult male and female volunteers
Bergmann, T. K., Stage, T. B., Stenvang, Jan, Christophersen, P., Jacobsen, T. A., Roest, N. L., Vestlev, P. M. & Brunner, N., 2020, In: Basic & Clinical Pharmacology & Toxicology. 127, 4, p. 329-337Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gel-Based Proteomics of Clinical Samples Identifies Potential Serological Biomarkers for Early Detection of Colorectal Cancer
Thorsen, S. F., Gromova, I., Christensen, I. J., Fredriksson, S., Andersen, C. L., Nielsen, H. J., Stenvang, Jan & Moreira, José, Dec 2019, In: International Journal of Molecular Sciences (Online). 20, 19 p., 6082.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High expression of microRNA-625-3p is associated with poor response to first-line oxaliplatin based treatment of metastatic colorectal cancer
Rasmussen, M. H., Jensen, N. F., Tarpgaard, L. S., Qvortrup, C., Rømer, M. U. K., Stenvang, Jan, Hansen, T. P., Christensen, L. L., Lindebjerg, J., Hansen, F., Jensen, B. V., Hansen, T. F., Pfeiffer, P., Brünner, N., Ørntoft, T. F. & Andersen, C. L., 2013, In: Molecular Oncology. 7, 3, p. 637-646 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability
Assarsson, E., Lundberg, M., Holmquist, G., Björkesten, J., Thorsen, S. B., Ekman, D., Eriksson, A., Rennel Dickens, E., Ohlsson, S., Edfeldt, G., Andersson, A., Lindstedt, P., Stenvang, Jan, Gullberg, M. & Fredriksson, S., 2014, In: PLOS ONE. 9, 4, 11 p., e95192.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification and characterization of a new TIMP-1 binding protein
Moreira, José, Høeberg, M., Lademann, U. A., Viuff, B. M., Jensen, L. V., Stenvang, Jan, Nygård, S. B., Ørum-Madsen, M. S., Vistesen, M. V., Fuglsang, Anja Thoe, Liu, S. & Brünner, N., 2015, In: Cancer Research. 75, 9 suppl., 1 p., Abstract P5-07-08.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Implications of ABCG2 Expression on Irinotecan Treatment of Colorectal Cancer Patients: A Review
Nielsen, Dorte Lisbet, Palshof, J. A., Bruenner, N., Stenvang, Jan & Viuff, B. M., Sep 2017, In: International Journal of Molecular Sciences (Online). 18, 9, 16 p., 1926.Research output: Contribution to journal › Review › Research › peer-review
Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT
Yde, C. W., Frogne, T., Lykkesfeldt, A. E., Fichtner, I., Issinger, O. G. & Stenvang, Jan, 2007, In: Cancer Letters. 256, 2, p. 229-237 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of microRNA function by antimiR oligonucleotides
Stenvang, Jan, Petri, A., Lindow, M., Obad, S. & Kauppinen, S., 2012, In: Silence. 3, 1, 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insulin-like growth factor binding protein 2 is a marker for antiestrogen resistant human breast cancer cell lines but is not a major growth regulator
Juncker-Jensen, A., Lykkesfeldt, A. E., Worm, J., Ralfkiær, U., Espelund, U. & Stenvang, Jan, 1 Aug 2006, In: Growth Hormone and IGF Research. 16, 4, p. 224-239 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Integrative analyses of gene expression and DNA methylation profiles in breast cancer cell line models of tamoxifen-resistance indicate a potential role of cells with stem-like properties
Lin, X., Li, J., Yin, G., Zhao, Q., Elias, D., Lykkesfeldt, A., Stenvang, Jan, Brünner, N., Wang, J., Yang, H., Bolund, L. & Ditzel, H. J., 2013, In: Breast cancer research : BCR. 15, 6, 17 p., R119.Research output: Contribution to journal › Journal article › Research › peer-review
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Integrative analysis of miRNA and gene expression reveals regulatory networks in tamoxifen-resistant breast cancer
Joshi, T., Elias, D., Stenvang, Jan, Alves, C. M. L., Teng, F., Lyng, M. B., Lykkesfeldt, A. E., Brünner, N., Wang, J., Gupta, R., Workman, C. T. & Ditzel, H. J., 2016, In: OncoTarget. 7, 35, p. 57239-57253 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
LNA-antisense rivals siRNA for gene silencing
Stenvang, Jan & Wengel, J., Mar 2004, In: Current Opinion in Drug Discovery & Development. 7, 2, p. 188-94 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Locked nucleic acid: a potent nucleic acid analog in therapeutics and biotechnology
Stenvang, Jan, Sørensen, M. D. & Wengel, J., 2004, In: Oligonucleotides. 14, 2, p. 130-46 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Measuring ERCC1 protein expression in cancer specimens: validation of a novel antibody
Smith, D. H., Fiehn, A. K., Fogh, L., Christensen, I. J., Hansen, T. P., Stenvang, Jan, Nielsen, H. J., Nielsen, K. V., Hasselby, J. P., Brünner, N. & Jensen, S. S., 2014, In: Scientific Reports. 4, p. 1-8 8 p., 4313.Research output: Contribution to journal › Journal article › Research › peer-review
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Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer
Yu, J., Feng, Q., Wong, S. H., Zhang, D., Liang, Q. Y., Qin, Y., Tang, L., Zhao, H., Stenvang, J., Li, Y., Wang, X., Xu, X., Chen, N., Wu, W. K. K., Al-Aama, J., Nielsen, H. J., Kiilerich, P., Jensen, B. A. H., Yau, T. O., Lan, Z. & 19 others, , 2017, In: Gut. 66, p. 70-78 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Metallopeptidase Inhibitor 1 (TIMP-1) promotes receptor tyrosine kinase c-Kit signaling in colorectal cancer
Nordgaard, C., Doll, S., Matos, A. L. D. S. A., Høeberg, M., Kazi, J. U., Friis, S., Stenvang, Jan, Rönnstrand, L., Mann, Matthias & Moreira, José, 2019, In: Molecular Oncology. 13, 12, p. 2646-2662Research output: Contribution to journal › Journal article › Research › peer-review
MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte–associated antigen 4
Sonkoly , E., Janson , P., Majuri , M., Savinko , T., Fyhrquist , N., Eidsmo , L., Xu , N., Meisgen , F., Wei , T., Bradley , M., Stenvang, Jan, Kauppinen , S., Alenius, H., Lauerma , A., Homey , B., Winqvist , O., Ståhle , M. & Pivarcsi , A., 2010, In: Journal of Allergy and Clinical Immunology. 126, 3, p. 581-589.e20 29 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Submitted
MicroRNA profiling in generated oxaliplatin- and SN-38-resistant colorectal cancer cell lines
Jensen, N. F., Søkilde, R., Stenvang, Jan, Litman, T., Brunner, N. & Rømer, M. U. K., 2011, (Submitted). 1 p.Research output: Contribution to conference › Conference abstract for conference › Research
- Published
MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo
Eskildsen, T., Taipaleenmäki, H., Stenvang, Jan, Abdallah, B., Ditzel, N., Nossent, Anne Yaël, Bak, M., Kauppinen, S. & Kassem, M., 12 Apr 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 15, p. 6139-44 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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MicroRNAs as targets for antisense-based therapeutics
Stenvang, Jan & Kauppinen, M. S., 2008, In: Expert Opinion on Biological Therapy. 8, 1, p. 59-81 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
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MicroRNAs, epigenetics and disease
Silahtaroglu, Asli & Stenvang, Jan, 2010, In: Essays in Biochemistry. 48, 1, p. 165-185 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
Modulation of CpG oligodeoxynucleotide-mediated immune stimulation by locked nucleic acid (LNA)
Vollmer, J., Uhlmann, E., Stenvang, Jan, Schetter, C., Jurk, M., Wader, T., Wüllner, M. & Krieg, A. M., 2004, In: Oligonucleotides. 14, 1, p. 23-31 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular Profiling of Docetaxel-Resistant Prostate Cancer Cells Identifies Multiple Mechanisms of Therapeutic Resistance
Lima, T. S., Iglesias Gato, Diego, De Oliveira Souza, Luciano, Stenvang, Jan, Lima, D. S., Røder, Andreas, Brasso, K. & Moreira, José, 2021, In: Cancers. 13, 19 p.Research output: Contribution to journal › Journal article › Research
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Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines
Jandu, H., Aluzaité, K., Fogh, L., Thrane, S. W., Noer, J. B., Proszek, J., Nguyen Do, K., Hansen, S. N., Damsgaard-Hansen, B., Nielsen, S. L., Stougaard, M., Knudsen, B. R., Moreira, J., Hamerlik, P., Gajjar, M., Smid, M., Martens, J., Foekens, J., Pommier, Y., Brünner, N. & 2 others, , 22 Jan 2016, In: B M C Cancer. 16, 13 p., 34.Research output: Contribution to journal › Journal article › Research › peer-review
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Multiplexed homogeneous proximity ligation assays for high throughput protein biomarker research in serological material
Lundberg, M., Thorsen, S. B., Assarsson, E., Villablanca, A., Tran, B., Gee, N., Knowles, M., Nielsen, B. E. S., Couto, E. G., Martin, R., Nilsson, O., Fermer, C., Schlingemann, J., Christensen, I. J., Nielsen, H. J., Ekstrom, B., Andersson, C., Gustafsson, M., Brünner, N., Stenvang, J. & 1 others, , Apr 2011, In: Molecular and Cellular Proteomics. 10Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New use for old drugs: Epirubicin in colorectal cancer
Tarpgaard, L. S., Qvortrup, C., Nielsen, S. L., Stenvang, Jan, Detlefsen, S., Brunner, N. & Pfeiffer, P., 2021, In: Acta Oncologica. 60, 7, p. 954-956 3 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
No effect of ablation of surfactant protein-D on acute cerebral infarction in mice
Lambertsen, K. L., Østergaard, K., Clausen, B. H., Hansen, S., Stenvang, Jan, Thorsen, S. B., Meldgaard, M., Kristensen, B. W., Hansen, P. B. L., Sørensen, G. L. & Finsen, B., 2014, In: Journal of Neuroinflammation. 11, 13 p., 123.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacodynamic modelling reveals synergistic interaction between docetaxel and SCO-101 in a docetaxel-resistant triple negative breast cancer cell line
Nøhr-Nielsen, A., Bagger, Sofie Morsing, Brünner, N., Stenvang, Jan & Lund, Trine Meldgaard, 2020, In: European Journal of Pharmaceutical Sciences. 148, 10 p., 105315.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Plasma levels of the MMP-9:TIMP-1 complex as prognostic biomarker in breast cancer: a retrospective study
Thorsen, S. B., Christensen, Sarah Louise T, Würtz, S. Ø., Lundberg, M., Nielsen, B. E. S., Jensen, L. V., Knowles, M., Gee, N., Fredriksson, S., Møller, S., Brünner, N., Rasmussen, A. S. & Stenvang, Jan, 2013, In: B M C Cancer. 13, 12 p., 598.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 12922
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MicroRNAs, epigenetics and disease
Research output: Contribution to journal › Journal article › Research › peer-review
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Measuring ERCC1 protein expression in cancer specimens: validation of a novel antibody
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Progesterone receptor isoform A may regulate the effects of neoadjuvant aglepristone in canine mammary carcinoma
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