Morten Grunnet
Affiliate Professor
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
- 2024
- E-pub ahead of print
A phase 1 trial of AP30663, a KCa2 channel inhibitor in development for conversion of atrial fibrillation
Yfanti, C., Vestbjerg, B., van't Westende, J., Edvardsson, N., Monfort, L. M., Olesen, Morten Steen Salling, Bentzen, Bo Hjorth, Grunnet, Morten, Eveleens Maarse, B. C., Diness, Jonas Goldin, Kemme, M. J. B., Sørensen, U., Moerland, M., van Esdonk, M. J., Klaassen, E. S., Gal, P. & Holst, A. G., 2024, (E-pub ahead of print) In: British Journal of Clinical Pharmacology.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Characterization of Atrial and Ventricular Structural Remodeling in a Porcine Model of Atrial Fibrillation Induced by Atrial Tachypacing
Citerni, C., Kirchhoff, J., Olsen, Lisbeth Høier, Sattler, Stefan M, Gentilini, F., Forni, M., Zannoni, A., Grunnet, Morten, Edvardsson, N., Bentzen, Bo Hjorth & Diness, J. G., 2020, In: Frontiers in Veterinary Science. 7, 12 p., 179.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of KCa2 and Kv11.1 Channels in Pigs With Left Ventricular Dysfunction
Citerni, C., Kirchhoff, J., Olsen, Lisbeth Høier, Sattler, Stefan M, Grunnet, Morten, Edvardsson, N., Bentzen, Bo Hjorth & Diness, J. G., 2020, In: Frontiers in Pharmacology. 11, 11 p., 556.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The KCa2 Channel Inhibitor AP30663 Selectively Increases Atrial Refractoriness, Converts Vernakalant-Resistant Atrial Fibrillation and Prevents Its Reinduction in Conscious Pigs
Diness, J. G., Kirchhoff, J. E., Speerschneider, T., Abildgaard, L., Edvardsson, N., Sorensen, U. S., Grunnet, Morten & Bentzen, Bo Hjorth, 2020, In: Frontiers in Pharmacology. 11, 9 p., 159.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Arrhythmia development during inhibition of small-conductance calcium-activated potassium channels in acute myocardial infarction in a porcine model
Lubberding, Anniek Frederike, Sattler, Stefan M, Grunnet, Morten, Sørensen, U. S., Tfelt-Hansen, Jacob & Jespersen, Thomas, Oct 2019, In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 21, 10, p. 1584–1593Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of arrhythmogenic calmodulin variants on small conductance Ca2+-activated K+ (SK3) channels
Saljic, Arnela, Muthukumarasamy, K. M., la Cour, J. M., Boddum, K., Grunnet, Morten, Berchtold, Martin Werner & Jespersen, Thomas, 2019, In: Physiological Reports. 7, 19, 13 p., e14210.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The KCa2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts
Kirchhoff, J. E., Skarsfeldt, M., Muthukumarasamy, K. M., Simó-Vicens, R., Bomholtz, Sofia Hammami, Abildgaard, L., Jespersen, Thomas, Sørensen, U. S., Grunnet, Morten, Bentzen, Bo Hjorth & Diness, Jonas Goldin, 2019, In: Frontiers in Pharmacology. 10, 13 p., 668.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Selective Na V 1.1 activation rescues Dravet syndrome mice from seizures and premature death
Richards, K. L., Milligan, C. J., Richardson, R. J., Jancovski, N., Grunnet, Morten, Jacobson, L. H., Undheim, E. A. B., Mobli, M., Chow, C. Y., Herzig, V., Csoti, A., Panyi, G., Reid, C. A., King, G. F. & Petrou, S., 21 Aug 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 34, p. E8077-E8085Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacological rescue of mutated K(v)3.1 ion-channel linked to progressive myoclonus epilepsies
Munch, A. S., Saljic, Arnela, Boddum, K., Grunnet, Morten, Hougaard, C. & Jespersen, Thomas, 2018, In: European Journal of Pharmacology. 833, p. 255-262Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
A New Negative Allosteric Modulator AP14145 for the Study of Small Conductance Calcium-Activated Potassium Channels
Simo Vicens, R., Kirchhoff, J. E., Dolce , B., Abildgaard, L., Speerschneider, T., Sørensen, U. S., Grunnet, Morten, Diness, Jonas Goldin & Bentzen, Bo Hjorth, 5 Dec 2017, In: British Journal of Pharmacology. 174, 23, p. 4396-4408 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phosphodiesterase 1a inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries
Khammy, M. M., Dalsgaard, T., Larsen, P. H., Christoffersen, C. T., Clausen, D., Rasmussen, L. K., Folkersen, L., Grunnet, Morten, Kehler, J., Aalkjær, Christian & Nielsen, J., Nov 2017, In: British Journal of Pharmacology. 174, 22, p. 4186-4198 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs
Diness, Jonas Goldin, Skibsbye, L., Simó-Vicens, R., Louro Larupa dos Santos, J., Lundegaard, Pia Rengtved, Citerni, C., Sauter, D. R. P., Bomholtz, Sofia Hammami, Svendsen, Jesper Hastrup, Olesen, Søren-Peter, Sørensen, U. S., Jespersen, Thomas, Grunnet, Morten & Bentzen, Bo Hjorth, 10 Oct 2017, In: Circulation: Arrhythmia and Electrophysiology. 10, 19 p., e005125.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel selective PDE type 1 inhibitors cause vasodilatation and lower blood pressure in rats
Laursen, M., Beck, L., Kehler, J., Christoffersen, C. T., Bundgaard, C., Mogensen, S., Mow, T. J., Pinilla, E., Knudsen, J. S., Hedegaard, E. R., Grunnet, Morten & Simonsen, U., Aug 2017, In: British Journal of Pharmacology. 174, 15, p. 2563-2575 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of antiarrhythmic drugs on small conductance calcium –activated potassium channels
Simo Vicens, R., Sauter, D. R. P., Grunnet, Morten, Diness, Jonas Goldin & Bentzen, Bo Hjorth, 15 May 2017, In: European Journal of Pharmacology. 803, p. 118-123 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel negative allosteric modulator inhibits small conductance calcium-activated potassium channels and selectively prolongs atrial refractoriness in conscious pigs
Simó-Vicens, R., Citerni, C., Edvardsson, N. G., Sørensen, U. S., Grunnet, Morten, Diness, Jonas Goldin & Bentzen, Bo Hjorth, 11 May 2017, In: Heart Rhythm. 14, 5 suppl., p. S149-S150 P-PO02-15.Research output: Contribution to journal › Conference abstract in journal › Research
- 2016
- Published
Antiarrhythmic effect of the Ca(2+)-activated K(+) (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation
Kirchhoff, J. E., Diness, Jonas Goldin, Abildgaard, L., Sheykhzade, Majid, Grunnet, Morten & Jespersen, Thomas, 8 Oct 2016, In: Pfluegers Archiv. 468, 11, p. 1853–1863 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Role of calcium activated potassium channels in atrial fibrillation pathophysiology and therapy
Diness, Jonas Goldin, Bentzen, Bo Hjorth, S. Sørensen, U. & Grunnet, Morten, Nov 2015, In: Journal of Cardiovascular Pharmacology. 66, 5, p. 441-448 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium
Skibsbye, L., Wang, X., Axelsen, L. N., Bomholtz, Sofia Hammami, Nielsen, Morten Schak, Grunnet, Morten, Bentzen, Bo Hjorth & Jespersen, Thomas, Aug 2015, In: Journal of Cardiovascular Pharmacology. 66, 2, p. 165-176 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Late Sodium Current in Human Atrial Cardiomyocytes from Patients in Sinus Rhythm and Atrial Fibrillation
Poulet, C., Wettwer, E., Grunnet, Morten, Jespersen, Thomas, Fabritz, L., Matschke, K., Knaut, M. & Ravens, U., 29 Jun 2015, In: PLOS ONE. 10, 6, p. 1-19 19 p., e0131432.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Combined gating and trafficking defect in Kv11.1 manifests as a malignant long QT syndrome phenotype in a large Danish p.F29L founder family
Kanters, Jørgen K., Skibsbye, L., Hedley, P. L., Dembic, M., Liang, B., Hagen, C. M., Eschen, O., Grunnet, Morten, Christiansen, M. & Jespersen, Thomas, 2015, In: Scandinavian Journal of Clinical & Laboratory Investigation. 75, 8, p. 699-709 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Common and rare variants in SCN10A modulate the risk of atrial fibrillation.
Jabbari, J., Olesen, Morten Steen Salling, Yuan, L., Nielsen, J. B., Liang, B., Macri, V., Christophersen, I. E., Nielsen, N., Sajadieh, Ahmad, Ellinor, P. T., Grunnet, Morten, Haunsø, Stig, Holst, A. G., Svendsen, Jesper Hastrup & Jespersen, Thomas, 2015, In: Circulation: Cardiovascular Genetics. 8, 1, p. 64-73 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia
Schmitt, Nicole, Grunnet, Morten & Olesen, Søren-Peter, Apr 2014, In: Physiological Reviews. 94, 2, p. 609-53 45 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Flecainide provocation reveals concealed brugada syndrome in a long QT syndrome family with a novel L1786Q mutation in SCN5A. SCN5A mutations associated with overlap phenotype of long QT syndrome type 3 and Brugada syndrome.
Kanters, Jørgen K., Yuan, L., Hedley, P. L., Stoevring, B., Jons, C., Bloch Thomsen, P. E., Grunnet, Morten, Christiansen, M. & Jespersen, Thomas, 6 Mar 2014, In: Circulation Journal. 78, 5, p. 1136-43 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
G-protein-coupled inward rectifier potassium current contributes to ventricular repolarization
Liang, B., Nissen, J. D., Laursen, M., Wang, X., Skibsbye, L., Hearing, M. C., Andersen, M. N., Rasmussen, Hanne Borger, Wickman, K., Grunnet, Morten, Olesen, Søren-Peter & Jespersen, Thomas, 1 Jan 2014, In: Cardiovascular Research. 101, 1, p. 175-84 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
BK channel activators and their therapeutic perspectives
Bentzen, Bo Hjorth, Olesen, Søren-Peter, Rønn, L. C. B. & Grunnet, Morten, 2014, In: Frontiers in Physiology. 5, p. 1-12 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
GIRK channel activation via adenosine or muscarinic receptors has similar effects on rat atrial electrophysiology
Wang, X., Liang, B., Skibsbye, L., Olesen, Søren-Peter, Grunnet, Morten & Jespersen, Thomas, Aug 2013, In: Journal of Cardiovascular Pharmacology. 62, 2, p. 192-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Benzimidazolyl-acetamide derivatives useful as potassium channel modulators
SØRENSEN, U. S., Grunnet, Morten, Bentzen, Bo Hjorth, Christophersen, P., Diness, Jonas Goldin, SKIBSBYE, L. & Strøbæk, D., 7 Jan 2013Research output: Other contribution › Research
- 2012
- Published
Functionally Selective AT(1) Receptor Activation Reduces Ischemia Reperfusion Injury
Hostrup, A., Christensen, G. L., Bentzen, Bo Hjorth, Liang, B., Aplin, M., Grunnet, Morten, Hansen, J. L. & Jespersen, Thomas, 30 Jul 2012, In: Cellular Physiology and Biochemistry. 30, 3, p. 642-652 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Anti-hypertensive treatment preserves appetite suppression while preventing cardiovascular adverse effects of tesofensine in rats
Bentzen, Bo Hjorth, Grunnet, Morten, Hyveled-Nielsen, L., Sundgreen, C., lassen, J. B. & Hansen, H. H., 2012, In: Obesity.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Attenuated ventricular β-adrenergic response and reduced repolarization reserve in a rabbit model of chronic heart failure
Nissen, J. D., Thomsen, Morten Bækgaard, Bentzen, Bo Hjorth, Diness, Jonas Goldin, Diness, T. G., Jespersen, Thomas & Grunnet, Morten, 2012, In: Journal of Cardiovascular Pharmacology. 59, 2, p. 142-150 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels
Krzystanek, K., Rasmussen, Hanne Borger, Grunnet, Morten, Staub, O., Olesen, Søren-Peter, Abriel, H. & Jespersen, Thomas, 2012, In: Heart Rhythm. 9, 3, p. 440-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Keeping the rhythm -- pro-arrhythmic investigations in isolated Göttingen minipig hearts
Laursen, M., Grunnet, Morten, Olesen, Søren-Peter, Jespersen, Thomas & Mow, T., 2012, In: Journal of Pharmacological and Toxicological Methods. 64, 2, p. 134-44 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Pharmacological activation of Kv11.1 in transgenic long QT-1 rabbits
Bentzen, Bo Hjorth, Bahrke, S., Wu, K., Larsen, A. P., Odening, K. E., Franke, G., Storm vans Gravesande, K., Biermann, J., Peng, X., Koren, G., Zehender, M., Bode, C., Grunnet, Morten & Brunner, M., Feb 2011, In: Journal of Cardiovascular Pharmacology. 57, 2, p. 223-30 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cardiac channelopathies and sudden infant death syndrome
Tfelt-Hansen, J., Winkel, B. G., Grunnet, Morten & Jespersen, Thomas, 2011, In: The Cardiology. 119, 1, p. 21-33 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cardiac ion channels and mechanisms for protection against atrial fibrillation.
Grunnet, Morten, Bentzen, Bo Hjorth, Sørensen, U. S. & Diness, Jonas Goldin, 2011, In: Reviews of Physiology, Biochemistry and Pharmacology. 162, p. 1-58 59 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Central and Peripheral GABA(A) Receptor Regulation of the Heart Rate Depends on the Conscious State of the Animal
Bentzen, Bo Hjorth & Grunnet, Morten, 2011, In: Advances in Pharmacological Sciences. 2011, 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of cardiac repolarization in the Göttingen minipig
Laursen, M., Olesen, Søren-Peter, Grunnet, Morten, Mow, T., Jespersen, T. & Jespersen, Thomas, 2011, In: Journal of Pharmacological and Toxicological Methods. 63, 2, p. 186-95 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects on atrial fibrillation in aged hypertensive rats by Ca(2+)-activated K(+) channel inhibition
Diness, Jonas Goldin, Skibsbye, L., Jespersen, Thomas, Bartels, Emil Daniel, Sørensen, U. S., Hansen, R. S. & Grunnet, Morten, 2011, In: Hypertension. 57, 6, p. 1129-35 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extracellular potassium inhibits Kv7.1 potassium channels by stabilizing an inactivated state
Larsen, A. P., Steffensen, Annette Buur, Grunnet, Morten & Olesen, Søren-Peter, 2011, In: Biophysical Journal. 101, 4, p. 818-27 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The cardioprotective effect of brief acidic reperfusion after ischemia in perfused rat hearts is not mimicked by inhibition of the Na+/H+ exchanger NHE1
Andersen, A., Bentzen, Bo Hjorth, Salling, H., Klingberg, H., Kanneworff, M., Grunnet, Morten & Pedersen, Stine Helene Falsig, 2011, In: Cellular Physiology and Biochemistry. 28, 1, p. 13-24 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The duration of pacing-induced atrial fibrillation is reduced in vivo by inhibition of small conductance Ca2+-activated K+ channels.
Skibsbye, L., Diness, Jonas Goldin, Sørensen, U. S., Hansen, R. S. & Grunnet, Morten, 2011, In: Journal of Cardiovascular Pharmacology. 57, 6, p. 672-681Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels
Larsen, A. P., Bentzen, Bo Hjorth & Grunnet, Morten, Oct 2010, In: British Journal of Pharmacology. 161, 3, p. 614-28 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation
Diness, Jonas Goldin, Sørensen, U. S., Nissen, J. D., Al-Shahib, B., Jespersen, T., Grunnet, Morten, Hansen, R. S. & Jespersen, Thomas, Aug 2010, In: Circulation. Arrhythmia and electrophysiology. 3, 4, p. 380-90 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of a Kir3.4 Mutation in Congenital Long QT Syndrome
Yang, Y., Yang, Y., Liang, B., Liu, J., Li, J., Grunnet, M., Olesen, S-P., Rasmussen, H. B., Ellinor, P. T., Gao, L., Lin, X., Li, L., Wang, L., Xiao, J., Liu, Y., Liu, Y., Zhang, S., Liang, D., Peng, L., Jespersen, T. & 1 others, , 2010, In: American Journal of Human Genetics. 86, 6, p. 872-80 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Inherited cardiac diseases caused by mutations in the Nav1.5 sodium channel.
Tfelt-Hansen, Jacob, Winkel, B., Grunnet, Morten & Jespersen, Thomas, Oct 2009, In: Journal of Cardiovascular Electrophysiology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activation of big conductance Ca(2+)-activated K (+) channels (BK) protects the heart against ischemia-reperfusion injury
Bentzen, Bo Hjorth, Osadchii, O., Jespersen, Thomas, Hansen, R. S., Olesen, Søren-Peter & Grunnet, Morten, 2009, In: Pflügers Archiv: European Journal of Physiology. 457, 5, p. 979-88 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bevacizumab plus irinotecan in the treatment patients with progressive recurrent malignant brain tumours
Poulsen, H. S., Grunnet, Morten, Sorensen, M., Olsen, P., Hasselbalch, B., Nelausen, K., Kosteljanetz, M. & Lassen, U., 2009, In: Acta Oncologica. 48, 1, p. 52-58 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Energetic performance is improved by specific activation of K+ fluxes through K(Ca) channels in heart mitochondria
Aon, M. A., Cortassa, S., Wei, A., Grunnet, Morten & O'Rourke, B., 2009, In: BBA General Subjects. 1797, 1, p. 71-80 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional properties of human neuronal Kv11 channels
Einarsen, K., Callø, Kirstine, Grunnet, Morten, Olesen, Søren-Peter & Schmitt, Nicole, 2009, In: Pflügers Archiv: European Journal of Physiology. 458, 4, p. 689-700 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inherited Cardiac Diseases Caused by Mutations in the Nav1.5 Sodium Channel
Tfelt-Hansen, J., Winkel, B. G., Grunnet, Morten & Jespersen, Thomas, 2009, In: Cardiovascular Electrophysiology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Negative Modulation of SK Channels Terminates and Protects Against Atrial Fibrillation in Rat and Guinea Pig Ex Vivo and in vivo Models
Diness, Jonas Goldin, Schultz Hansen, R., Sørensen, U. S. & Grunnet, Morten, 2009, In: Circulation. Supplement. 2009;120 (18): S712-S712 Suppl. 2.Research output: Contribution to journal › Conference article › Research › peer-review
- Published
Pharmacologically induced long QT type 2 can be rescued by activation of IKs with benzodiazepine R-L3 in isolated guinea pig cardiomyocytes
Nissen, J. D., Diness, Jonas Goldin, Diness, T. G., Hansen, R. S., Grunnet, Morten & Jespersen, Thomas, 2009, In: Journal of Cardiovascular Pharmacology. 54, 2, p. 169-77 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and characterisation of NS13558: a new important tool for addressing KCa1.1 channel function ex vivo
Bentzen, Bo Hjorth, Andersen, R. W., Olesen, Søren-Peter, Grunnet, Morten & Nardi, A., 2009, In: NAUNYN-SCHMIEDEBERGS ARCHIV FUR EXPERIMENTELLE PATHOLOGIE UND PHARMAKOLOGIE.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transmural expression of ion channels and transporters in human nondiseased and end-stage failing hearts
Soltysinska, E., Olesen, Søren-Peter, Christ, T., Wettwer, E., Varró, A., Grunnet, Morten & Jespersen, Thomas, 2009, In: Pflügers Archiv: European Journal of Physiology. 459, 1, p. 11-23 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome
Callø, Kirstine, Cordeiro, J. M., Di Diego, J. M., Hansen, R. S., Grunnet, Morten, Olesen, Søren-Peter & Antzelevitch, C., 2008, In: Cardiovascular Research. 81, 4, p. 686-94 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antiarrhythmic effect of IKr activation in a cellular model of LQT3
Diness, Jonas Goldin, Hansen, R. S., Nissen, J. D., Jespersen, Thomas & Grunnet, Morten, 2008, In: Heart Rhythm. 6, 1, p. 100-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome.
Diness, T. G., Yeh, Y., Qi, X. Y., Chartier, D., Tsuji, Y., Hansen, R. S., Olesen, Søren-Peter, Grunnet, Morten & Nattel, S., 2008, In: Cardiovascular Research. 79, 1, p. 61-69 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biophysical characterization of the short QT mutation hERG-N588K reveals a mixed gain-and loss-of-function
Grunnet, Morten, Diness, T. G., Hansen, R. S. & Olesen, Søren-Peter, 2008, In: Cellular Physiology and Biochemistry. 22, 5-6, p. 611-624 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of hERG1a and hERG1b potassium channels-a possible role for hERG1b in the I (Kr) current.
Larsen, A. P., Olesen, Søren-Peter, Grunnet, Morten & Jespersen, Thomas, 2008, In: Pflügers Archiv: European Journal of Physiology. 456, 6, p. 1137-48 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Computational analysis of the effects of the hERG channel opener NS1643 in a human ventricular cell model.
Peitersen, T., Grunnet, Morten, Benson, A. P., Holden, A. V., von Holstein-Rathlou, Niels-Henrik & Olesen, Søren-Peter, 2008, In: Heart Rhythm. 5, 5, p. 734-41 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fetal arrhythmia caused by dysregulation of HERG channels.
Grunnet, Morten, 2008, In: Heart Rhythm. 5, 4, p. 562-4 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vivo effects of the IKr agonist NS3623 on cardiac electrophysiology of the guinea pig.
Hansen, R. S., Olesen, Søren-Peter, Rønn, L. C. B. & Grunnet, Morten, 2008, In: Journal of Cardiovascular Pharmacology. 52, 1, p. 35-41 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oxycodone is associated with dose-dependent QTc prolongation in patients and low-affinity inhibiting of hERG activity in vitro
Fanoe, S., Jensen, G. B., Sjøgren, P., Korsgaard, M. P. G., Grunnet, Morten, Fanoe, S., Jensen, G. B., Sjøgren, P., Korsgaard, M. P. G. & Grunnet, M., 2008, In: British Journal of Clinical Pharmacology. 67, 2, p. 172-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Single-copy insertion of transgenes in Caenorhabditis elegans.
Frøkjær-Jensen, Christian, Davis, M. W., Hopkins, C. E., Newman, B. J., Thummel, J. M., Olesen, Søren-Peter, Grunnet, Morten & Jorgensen, E. M., 2008, In: Nature Genetics. 40, 11, p. 1375-83 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Activation of ERG2 potassium channels by the diphenylurea NS1643.
Elmedyb, P., Olesen, Søren-Peter & Grunnet, Morten, 2007, In: Neuropharmacology. 53, 2, p. 283-94 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterizations of a loss-of-function mutation in the Kir3.4 channel subunit.
Callø, Kirstine, Ravn, L. S., Schmitt, Nicole, Sui, J. L., Duno, M., Haunso, S., Grunnet, Morten, Svendsen, J. H. & Olesen, Søren-Peter, 2007, In: Biochemical and Biophysical Research Communications. 364, 4, p. 889-95 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inactivation as a new regulatory mechanism for neuronal Kv7 channels.
Jensen, H. S., Grunnet, Morten & Olesen, Søren-Peter, 2007, In: Biophysical Journal. 92, 8, p. 2747-56 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KCNQ channels are involved in the regulatory volume decrease response in primary neonatal rat cardiomyocytes.
Callø, Kirstine, Nielsen, Morten Schak, Grunnet, Morten, Schmitt, Nicole & Jorgensen, N. K., 2007, In: BBA General Subjects. 1773, 6, p. 764-73 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modulation of ERG channels by XE991.
Elmedyb, P., Callø, Kirstine, Schmitt, Nicole, Hansen, R. S., Grunnet, Morten & Olesen, Søren-Peter, 2007, In: Basic & Clinical Pharmacology & Toxicology. 100, 5, p. 316-22 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutations in the Kv1.5 channel gene KCNA5 in cardiac arrest patients.
Nielsen, N. H., Winkel, B. G., Kanters, Jørgen K., Schmitt, Nicole, Hofman-Bang, J., Jensen, H. S., Bentzen, Bo Hjorth, Sigurd, B., Larsen, Lars Allan, Andersen, P. S., Kjeldsen, K., Grunnet, Morten, Christiansen, M., Olesen, Søren-Peter & Haunsø, Stig, 2007, In: Biochemical and Biophysical Research Communications. 354, 3, p. 776-82 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart.
Hansen, R. S., Olesen, Søren-Peter & Grunnet, Morten, 2007, In: Journal of Pharmacology and Experimental Therapeutics. 321, 3, p. 996-1002 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels.
Bentzen, Bo Hjorth, Nardi, A., Callø, Kirstine, Madsen, L. S., Olesen, Søren-Peter & Grunnet, Morten, 2007, In: Molecular Pharmacology. 72, 4, p. 1033-44 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623[N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N '-(3 '-trifluoromethylphenyl)urea]
Hansen, R. S., Diness, T. G., Christ, T., Wettwer, E., Ravens, U., Olesen, Søren-Peter & Grunnet, Morten, 2006, In: Molecular Pharmacology. 70, 4, p. 1319-1329 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2.
Bøttger, P., Hede, S. E., Grunnet, Morten, Høyer, B., Klærke, Dan Arne & Pedersen, L., 2006, In: American Journal of Physiology: Cell Physiology. 291, 6, p. C1377-87Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Frequency-dependent modulation of KCNQ1 and HERG1 potassium channels.
Diness, T. G., Hansen, R. S., Olesen, Søren-Peter & Grunnet, Morten, 2006, In: Biochemical and Biophysical Research Communications. 343, 4, p. 1224-33 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Subtype-specific, bi-component inhibition of SK channels by low internal pH.
Peitersen, T., Jespersen, Thomas, Jorgensen, N. K., Olesen, Søren-Peter & Grunnet, Morten, 2006, In: Biochemical and Biophysical Research Communications. 343, 3, p. 943-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels.
Bentzen, Bo Hjorth, Schmitt, Nicole, Callø, Kirstine, Dalby Brown, W., Grunnet, Morten & Olesen, Søren-Peter, 2006, In: Neuropharmacology. 51, 6, p. 1068-77 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The corticosteroid hormone induced factor: a new modulator of KCNQ1 channels?
Jespersen, Thomas, Grunnet, Morten, Rasmussen, Hanne Borger, Jørgensen, N. B., Jensen, H., Angelo, K., Olesen, Søren-Peter & Klærke, Dan Arne, 2006, In: Biochemical and Biophysical Research Communications. 341, 4, p. 979-88 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).
Hansen, R. S., Diness, T. G., Christ, T., Demnitz, J., Ravens, U., Olesen, Søren-Peter & Grunnet, Morten, 2005, In: Molecular Pharmacology. 69, 1, p. 266-77 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional assessment of compound mutations in the KCNQ1 and KCNH2 genes associated with long QT syndrome.
Grunnet, Morten, Behr, E. R., Callø, Kirstine, Hofman-Bang, J., Till, J., Christiansen, M., McKenna, W. J., Olesen, Søren-Peter & Schmitt, Nicole, 2005, In: Heart Rhythm. 2, 11, p. 1238-49 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hypoosmotic cell swelling as a novel mechanism for modulation of cloned HCN2 channels.
Callø, Kirstine, Elmedyb, P., Olesen, Søren-Peter, Jorgensen, N. K. & Grunnet, Morten, 2005, In: Biophysical Journal. 89, 3, p. 2159-69 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Quantification and distribution of big conductance Ca2+-activated K+ channels in kidney epithelia.
Grunnet, Morten, Hay-Schmidt, Anders & Klærke, Dan Arne, 2005, In: BBA General Subjects. 1714, 2, p. 114-24 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The KCNQ1 potassium channel: from gene to physiological function.
Jespersen, Thomas, Grunnet, Morten & Olesen, Søren-Peter, 2005, In: Physiology. 20, p. 408-16 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
hKCNE4 inhibits the hKCNQ1 potassium current without affecting the activation kinetics.
Grunnet, Morten, Olesen, Søren-Peter, Klærke, Dan Arne & Jespersen, Thomas, 2005, In: Biochemical and Biophysical Research Communications. 328, 4, p. 1146-53 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
5-HT1A receptors modulate small-conductance Ca2+-activated K+ channels.
Grunnet, Morten, Jespersen, Thomas & Perrier, J., 2004, In: Journal of Neuroscience Research. 78, 6, p. 845-54 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Basolateral localisation of KCNQ1 potassium channels in MDCK cells: molecular identification of an N-terminal targeting motif.
Jespersen, Thomas, Rasmussen, Hanne Borger, Grunnet, Morten, Jensen, H. S., Angelo, K., Dupuis, D. S., Vogel, L. K., Jorgensen, N. K., Klærke, Dan Arne & Olesen, Søren-Peter, 2004, In: Journal of Cell Science. 117, Pt 19, p. 4517-26 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Coassembly of big conductance Ca2+-activated K+ channels and L-type voltage-gated Ca2+ channels in rat brain.
Grunnet, Morten & Kaufmann, W. A., 2004, In: Journal of Biological Chemistry. 279, 35, p. 36445-53 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Difference in allelic expression of the CLCN1 gene and the possible influence on the myotonia congenita phenotype.
Dunø, M., Colding-Jørgensen, E., Grunnet, Morten, Jespersen, Thomas, Vissing, John & Schwartz, M., 2004, In: European Journal of Human Genetics. 12, 9, p. 738-43 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Does KCNE5 play a role in long QT syndrome?
Hofman-Bang, J., Jespersen, Thomas, Grunnet, Morten, Larsen, Lars Allan, Andersen, P. S., Kanters, Jørgen K., Kjeldsen, K. & Christiansen, M., 2004, In: Clinica Chimica Acta. 345, 1-2, p. 49-53 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Recruitment of motor neuronal persistent inward currents shapes withdrawal reflexes in the frog
Grunnet, Morten, Jespersen, Thomas & Perrier, Jean-Francois Marie, 2004, In: Journal of Neuroscience Research. 78, p. 845-854Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
A radiolabeled peptide ligand of the hERG channel, [125I]-BeKm-1.
Angelo, K., Korolkova, Y. V., Grunnet, Morten, Grishin, E. V., Pluzhnikov, K. A., Klærke, Dan Arne, Knaus, H., Møller, Morten & Olesen, Søren-Peter, 2003, In: Pflügers Archiv: European Journal of Physiology. 447, 1, p. 55-63 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell swelling activates cloned Ca(2+)-activated K(+) channels: a role for the F-actin cytoskeleton.
Jorgensen, N. K., Pedersen, Stine Helene Falsig, Rasmussen, Hanne Borger, Grunnet, Morten, Klærke, Dan Arne & Olesen, Søren-Peter, 2003, In: BBA General Subjects. 1615, 1-2, p. 115-25 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cells exposed to a huntingtin fragment containing an expanded polyglutamine tract show no sign of ion channel formation: results arguing against the ion channel hypothesis.
Nørremølle, Anne, Grunnet, Morten, Hasholt, Lis Frydenreich & Sørensen, S. A., 2003, In: Journal of Neuroscience Research. 71, 1, p. 132-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of two new dominant ClC-1 channel mutations associated with myotonia.
Grunnet, Morten, Jespersen, Thomas, Colding-Jørgensen, E., Schwartz, M., Klærke, Dan Arne, Vissing, John, Olesen, Søren-Peter & Dunø, M., 2003, In: Muscle & Nerve. 28, 6, p. 722-32 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional coupling between heterologously expressed dopamine D(2) receptors and KCNQ channels.
Ljungstrom, T., Grunnet, Morten, Jensen, B. S. & Olesen, Søren-Peter, 2003, In: Pflügers Archiv: European Journal of Physiology. 446, 6, p. 684-94 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium channels.
Grunnet, Morten, Rasmussen, H. B., Hay-Schmidt, Anders, Rosenstierne, M., Klærke, Dan Arne, Olesen, Søren-Peter & Jespersen, Thomas, 2003, In: Biophysical Journal. 85, 3, p. 1525-37 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KCNQ1 channels sense small changes in cell volume.
Grunnet, Morten, Jespersen, Thomas, MacAulay, Nanna, Jørgensen, N. K., Schmitt, Nicole, Pongs, O., Olesen, Søren-Peter & Klærke, Dan Arne, 2003, In: Journal of Physiology. 549, Pt 2, p. 419-27 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Localization of Ca2+ -activated big-conductance K+ channels in rabbit distal colon.
Hay-Schmidt, Anders, Grunnet, Morten, Abrahamse, S. L., Knaus, H. & Klærke, Dan Arne, 2003, In: Pflügers Archiv: European Journal of Physiology. 446, 1, p. 61-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacological investigation of the role of ion channels in salivary secretion.
Stummann, T. C., Poulsen, J. H., Hay-Schmidt, Anders, Grunnet, Morten, Klærke, Dan Arne, Rasmussen, Hanne Borger, Olesen, Søren-Peter & Jorgensen, N. K., 2003, In: Pflügers Archiv: European Journal of Physiology. 446, 1, p. 78-87 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solid-phase synthesis and biological activity of a thioether analogue of conotoxin G1.
Bondebjerg, J., Grunnet, Morten, Jespersen, Thomas & Meldal, Morten Peter, 2003, In: ChemBioChem. 4, 2-3, p. 186-94 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role og K+ and C1- channels in salivary secretion
Stummann, T. C., Poulsen, J. H., Hay-Schmidt, Anders, Grunnet, Morten, Klærke, Dan Arne, Olesen, Søren-Peter & Jørgensen, N. K., 2003, In: Pflügers Archiv: European Journal of Physiology. 446, p. 78-87Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The voltage-gated potassium channel subunit, Kv1.3, is expressed in epithelia.
Grunnet, Morten, Rasmussen, Hanne Borger, Hay-Schmidt, Anders & Klærke, Dan Arne, 2003, In: BBA General Subjects. 1616, 1, p. 85-94 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
- Published
Dual-function vector for protein expression in both mammalian cells and Xenopus laevis oocytes
Jespersen, Thomas, Grunnet, Morten, Angelo, K., Klærke, Dan Arne & Olesen, Poul, 1 Mar 2002, In: BioTechniques. 32, 3, p. 536-8, 540Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KCNE4 is an inhibitory subunit to the KCNQ1 channel.
Grunnet, Morten, Jespersen, Thomas, Rasmussen, Hanne Borger, Ljungstrøm, T., Jorgensen, N. K., Olesen, Søren-Peter & Klærke, Dan Arne, 2002, In: Journal of Physiology. 542, Pt 1, p. 119-30 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current.
Angelo, K., Jespersen, Thomas, Grunnet, Morten, Nielsen, Morten Schak, Klærke, Dan Arne & Olesen, Søren-Peter, 2002, In: Biophysical Journal. 83, 4, p. 1997-2006 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of cloned, Ca2+-activated K+ channels by cell volume changes.
Grunnet, Morten, MacAulay, Nanna, Jorgensen, N. K., Jensen, S., Olesen, Søren-Peter & Klærke, Dan Arne, 2002, In: Pflügers Archiv: European Journal of Physiology. 444, 1-2, p. 167-77 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
- Published
Pharmacological modulation of SK3 channels
Grunnet, Morten, Jespersen, Thomas, Angelo, K., Frøkjær-Jensen, Christian, Klærke, Dan Arne, Olesen, Poul & Jensen, B. S., 1 Jun 2001, In: Neuropharmacology. 40, 7, p. 879-887 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Apamin interacts with all subtypes of cloned small-conductance Ca2+-activated K+ channels
Grunnet, Morten, Jensen, B. S., Olesen, Søren-Peter & Klærke, Dan Arne, 2001, In: Pflügers Archiv: European Journal of Physiology. 441, p. 544-550Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of a novel voltage-gated Na+ channel rNav 1.5a in the rat hippocampal progenitor stem cell line HiB5
Korsgaard, M., Grunnet, Morten, Christophersen, P., Ahring, P. K. & Olesen, Søren-Peter, 2001, In: Pflügers Archiv: European Journal of Physiology. 443, p. 18-30Research output: Contribution to journal › Journal article › Research › peer-review
ID: 182570346
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Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
343
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Effect of antiarrhythmic drugs on small conductance calcium –activated potassium channels
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
286
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Antiarrhythmic effect of the Ca(2+)-activated K(+) (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation
Research output: Contribution to journal › Journal article › Research › peer-review
Published