Morten Grunnet
Affiliate Professor
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
- Published
5-HT1A receptors modulate small-conductance Ca2+-activated K+ channels.
Grunnet, Morten, Jespersen, Thomas & Perrier, J., 2004, In: Journal of Neuroscience Research. 78, 6, p. 845-54 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A New Negative Allosteric Modulator AP14145 for the Study of Small Conductance Calcium-Activated Potassium Channels
Simo Vicens, R., Kirchhoff, J. E., Dolce , B., Abildgaard, L., Speerschneider, T., Sørensen, U. S., Grunnet, Morten, Diness, Jonas Goldin & Bentzen, Bo Hjorth, 5 Dec 2017, In: British Journal of Pharmacology. 174, 23, p. 4396-4408 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- E-pub ahead of print
A phase 1 trial of AP30663, a KCa2 channel inhibitor in development for conversion of atrial fibrillation
Yfanti, C., Vestbjerg, B., van't Westende, J., Edvardsson, N., Monfort, L. M., Olesen, Morten Steen Salling, Bentzen, Bo Hjorth, Grunnet, Morten, Eveleens Maarse, B. C., Diness, Jonas Goldin, Kemme, M. J. B., Sørensen, U., Moerland, M., van Esdonk, M. J., Klaassen, E. S., Gal, P. & Holst, A. G., 2024, (E-pub ahead of print) In: British Journal of Clinical Pharmacology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A radiolabeled peptide ligand of the hERG channel, [125I]-BeKm-1.
Angelo, K., Korolkova, Y. V., Grunnet, Morten, Grishin, E. V., Pluzhnikov, K. A., Klærke, Dan Arne, Knaus, H., Møller, Morten & Olesen, Søren-Peter, 2003, In: Pflügers Archiv: European Journal of Physiology. 447, 1, p. 55-63 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome
Callø, Kirstine, Cordeiro, J. M., Di Diego, J. M., Hansen, R. S., Grunnet, Morten, Olesen, Søren-Peter & Antzelevitch, C., 2008, In: Cardiovascular Research. 81, 4, p. 686-94 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activation of ERG2 potassium channels by the diphenylurea NS1643.
Elmedyb, P., Olesen, Søren-Peter & Grunnet, Morten, 2007, In: Neuropharmacology. 53, 2, p. 283-94 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activation of big conductance Ca(2+)-activated K (+) channels (BK) protects the heart against ischemia-reperfusion injury
Bentzen, Bo Hjorth, Osadchii, O., Jespersen, Thomas, Hansen, R. S., Olesen, Søren-Peter & Grunnet, Morten, 2009, In: Pflügers Archiv: European Journal of Physiology. 457, 5, p. 979-88 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).
Hansen, R. S., Diness, T. G., Christ, T., Demnitz, J., Ravens, U., Olesen, Søren-Peter & Grunnet, Morten, 2005, In: Molecular Pharmacology. 69, 1, p. 266-77 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Anti-hypertensive treatment preserves appetite suppression while preventing cardiovascular adverse effects of tesofensine in rats
Bentzen, Bo Hjorth, Grunnet, Morten, Hyveled-Nielsen, L., Sundgreen, C., lassen, J. B. & Hansen, H. H., 2012, In: Obesity.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium
Skibsbye, L., Wang, X., Axelsen, L. N., Bomholtz, Sofia Hammami, Nielsen, Morten Schak, Grunnet, Morten, Bentzen, Bo Hjorth & Jespersen, Thomas, Aug 2015, In: Journal of Cardiovascular Pharmacology. 66, 2, p. 165-176 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antiarrhythmic effect of IKr activation in a cellular model of LQT3
Diness, Jonas Goldin, Hansen, R. S., Nissen, J. D., Jespersen, Thomas & Grunnet, Morten, 2008, In: Heart Rhythm. 6, 1, p. 100-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antiarrhythmic effect of the Ca(2+)-activated K(+) (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation
Kirchhoff, J. E., Diness, Jonas Goldin, Abildgaard, L., Sheykhzade, Majid, Grunnet, Morten & Jespersen, Thomas, 8 Oct 2016, In: Pfluegers Archiv. 468, 11, p. 1853–1863 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome.
Diness, T. G., Yeh, Y., Qi, X. Y., Chartier, D., Tsuji, Y., Hansen, R. S., Olesen, Søren-Peter, Grunnet, Morten & Nattel, S., 2008, In: Cardiovascular Research. 79, 1, p. 61-69 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Apamin interacts with all subtypes of cloned small-conductance Ca2+-activated K+ channels
Grunnet, Morten, Jensen, B. S., Olesen, Søren-Peter & Klærke, Dan Arne, 2001, In: Pflügers Archiv: European Journal of Physiology. 441, p. 544-550Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Arrhythmia development during inhibition of small-conductance calcium-activated potassium channels in acute myocardial infarction in a porcine model
Lubberding, Anniek Frederike, Sattler, Stefan M, Grunnet, Morten, Sørensen, U. S., Tfelt-Hansen, Jacob & Jespersen, Thomas, Oct 2019, In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 21, 10, p. 1584–1593Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Attenuated ventricular β-adrenergic response and reduced repolarization reserve in a rabbit model of chronic heart failure
Nissen, J. D., Thomsen, Morten Bækgaard, Bentzen, Bo Hjorth, Diness, Jonas Goldin, Diness, T. G., Jespersen, Thomas & Grunnet, Morten, 2012, In: Journal of Cardiovascular Pharmacology. 59, 2, p. 142-150 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
BK channel activators and their therapeutic perspectives
Bentzen, Bo Hjorth, Olesen, Søren-Peter, Rønn, L. C. B. & Grunnet, Morten, 2014, In: Frontiers in Physiology. 5, p. 1-12 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Basolateral localisation of KCNQ1 potassium channels in MDCK cells: molecular identification of an N-terminal targeting motif.
Jespersen, Thomas, Rasmussen, Hanne Borger, Grunnet, Morten, Jensen, H. S., Angelo, K., Dupuis, D. S., Vogel, L. K., Jorgensen, N. K., Klærke, Dan Arne & Olesen, Søren-Peter, 2004, In: Journal of Cell Science. 117, Pt 19, p. 4517-26 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Benzimidazolyl-acetamide derivatives useful as potassium channel modulators
SØRENSEN, U. S., Grunnet, Morten, Bentzen, Bo Hjorth, Christophersen, P., Diness, Jonas Goldin, SKIBSBYE, L. & Strøbæk, D., 7 Jan 2013Research output: Other contribution › Research
- Published
Bevacizumab plus irinotecan in the treatment patients with progressive recurrent malignant brain tumours
Poulsen, H. S., Grunnet, Morten, Sorensen, M., Olsen, P., Hasselbalch, B., Nelausen, K., Kosteljanetz, M. & Lassen, U., 2009, In: Acta Oncologica. 48, 1, p. 52-58 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623[N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N '-(3 '-trifluoromethylphenyl)urea]
Hansen, R. S., Diness, T. G., Christ, T., Wettwer, E., Ravens, U., Olesen, Søren-Peter & Grunnet, Morten, 2006, In: Molecular Pharmacology. 70, 4, p. 1319-1329 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biophysical characterization of the short QT mutation hERG-N588K reveals a mixed gain-and loss-of-function
Grunnet, Morten, Diness, T. G., Hansen, R. S. & Olesen, Søren-Peter, 2008, In: Cellular Physiology and Biochemistry. 22, 5-6, p. 611-624 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cardiac channelopathies and sudden infant death syndrome
Tfelt-Hansen, J., Winkel, B. G., Grunnet, Morten & Jespersen, Thomas, 2011, In: The Cardiology. 119, 1, p. 21-33 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cardiac ion channels and mechanisms for protection against atrial fibrillation.
Grunnet, Morten, Bentzen, Bo Hjorth, Sørensen, U. S. & Diness, Jonas Goldin, 2011, In: Reviews of Physiology, Biochemistry and Pharmacology. 162, p. 1-58 59 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia
Schmitt, Nicole, Grunnet, Morten & Olesen, Søren-Peter, Apr 2014, In: Physiological Reviews. 94, 2, p. 609-53 45 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell swelling activates cloned Ca(2+)-activated K(+) channels: a role for the F-actin cytoskeleton.
Jorgensen, N. K., Pedersen, Stine Helene Falsig, Rasmussen, Hanne Borger, Grunnet, Morten, Klærke, Dan Arne & Olesen, Søren-Peter, 2003, In: BBA General Subjects. 1615, 1-2, p. 115-25 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cells exposed to a huntingtin fragment containing an expanded polyglutamine tract show no sign of ion channel formation: results arguing against the ion channel hypothesis.
Nørremølle, Anne, Grunnet, Morten, Hasholt, Lis Frydenreich & Sørensen, S. A., 2003, In: Journal of Neuroscience Research. 71, 1, p. 132-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Central and Peripheral GABA(A) Receptor Regulation of the Heart Rate Depends on the Conscious State of the Animal
Bentzen, Bo Hjorth & Grunnet, Morten, 2011, In: Advances in Pharmacological Sciences. 2011, 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of Atrial and Ventricular Structural Remodeling in a Porcine Model of Atrial Fibrillation Induced by Atrial Tachypacing
Citerni, C., Kirchhoff, J., Olsen, Lisbeth Høier, Sattler, Stefan M, Gentilini, F., Forni, M., Zannoni, A., Grunnet, Morten, Edvardsson, N., Bentzen, Bo Hjorth & Diness, J. G., 2020, In: Frontiers in Veterinary Science. 7, 12 p., 179.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of cardiac repolarization in the Göttingen minipig
Laursen, M., Olesen, Søren-Peter, Grunnet, Morten, Mow, T., Jespersen, T. & Jespersen, Thomas, 2011, In: Journal of Pharmacological and Toxicological Methods. 63, 2, p. 186-95 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of hERG1a and hERG1b potassium channels-a possible role for hERG1b in the I (Kr) current.
Larsen, A. P., Olesen, Søren-Peter, Grunnet, Morten & Jespersen, Thomas, 2008, In: Pflügers Archiv: European Journal of Physiology. 456, 6, p. 1137-48 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2.
Bøttger, P., Hede, S. E., Grunnet, Morten, Høyer, B., Klærke, Dan Arne & Pedersen, L., 2006, In: American Journal of Physiology: Cell Physiology. 291, 6, p. C1377-87Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of two new dominant ClC-1 channel mutations associated with myotonia.
Grunnet, Morten, Jespersen, Thomas, Colding-Jørgensen, E., Schwartz, M., Klærke, Dan Arne, Vissing, John, Olesen, Søren-Peter & Dunø, M., 2003, In: Muscle & Nerve. 28, 6, p. 722-32 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterizations of a loss-of-function mutation in the Kir3.4 channel subunit.
Callø, Kirstine, Ravn, L. S., Schmitt, Nicole, Sui, J. L., Duno, M., Haunso, S., Grunnet, Morten, Svendsen, J. H. & Olesen, Søren-Peter, 2007, In: Biochemical and Biophysical Research Communications. 364, 4, p. 889-95 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Coassembly of big conductance Ca2+-activated K+ channels and L-type voltage-gated Ca2+ channels in rat brain.
Grunnet, Morten & Kaufmann, W. A., 2004, In: Journal of Biological Chemistry. 279, 35, p. 36445-53 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Combined gating and trafficking defect in Kv11.1 manifests as a malignant long QT syndrome phenotype in a large Danish p.F29L founder family
Kanters, Jørgen K., Skibsbye, L., Hedley, P. L., Dembic, M., Liang, B., Hagen, C. M., Eschen, O., Grunnet, Morten, Christiansen, M. & Jespersen, Thomas, 2015, In: Scandinavian Journal of Clinical & Laboratory Investigation. 75, 8, p. 699-709 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Common and rare variants in SCN10A modulate the risk of atrial fibrillation.
Jabbari, J., Olesen, Morten Steen Salling, Yuan, L., Nielsen, J. B., Liang, B., Macri, V., Christophersen, I. E., Nielsen, N., Sajadieh, Ahmad, Ellinor, P. T., Grunnet, Morten, Haunsø, Stig, Holst, A. G., Svendsen, Jesper Hastrup & Jespersen, Thomas, 2015, In: Circulation: Cardiovascular Genetics. 8, 1, p. 64-73 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Computational analysis of the effects of the hERG channel opener NS1643 in a human ventricular cell model.
Peitersen, T., Grunnet, Morten, Benson, A. P., Holden, A. V., von Holstein-Rathlou, Niels-Henrik & Olesen, Søren-Peter, 2008, In: Heart Rhythm. 5, 5, p. 734-41 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels
Krzystanek, K., Rasmussen, Hanne Borger, Grunnet, Morten, Staub, O., Olesen, Søren-Peter, Abriel, H. & Jespersen, Thomas, 2012, In: Heart Rhythm. 9, 3, p. 440-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Difference in allelic expression of the CLCN1 gene and the possible influence on the myotonia congenita phenotype.
Dunø, M., Colding-Jørgensen, E., Grunnet, Morten, Jespersen, Thomas, Vissing, John & Schwartz, M., 2004, In: European Journal of Human Genetics. 12, 9, p. 738-43 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels
Larsen, A. P., Bentzen, Bo Hjorth & Grunnet, Morten, Oct 2010, In: British Journal of Pharmacology. 161, 3, p. 614-28 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Does KCNE5 play a role in long QT syndrome?
Hofman-Bang, J., Jespersen, Thomas, Grunnet, Morten, Larsen, Lars Allan, Andersen, P. S., Kanters, Jørgen K., Kjeldsen, K. & Christiansen, M., 2004, In: Clinica Chimica Acta. 345, 1-2, p. 49-53 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dual-function vector for protein expression in both mammalian cells and Xenopus laevis oocytes
Jespersen, Thomas, Grunnet, Morten, Angelo, K., Klærke, Dan Arne & Olesen, Poul, 1 Mar 2002, In: BioTechniques. 32, 3, p. 536-8, 540Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of antiarrhythmic drugs on small conductance calcium –activated potassium channels
Simo Vicens, R., Sauter, D. R. P., Grunnet, Morten, Diness, Jonas Goldin & Bentzen, Bo Hjorth, 15 May 2017, In: European Journal of Pharmacology. 803, p. 118-123 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects on atrial fibrillation in aged hypertensive rats by Ca(2+)-activated K(+) channel inhibition
Diness, Jonas Goldin, Skibsbye, L., Jespersen, Thomas, Bartels, Emil Daniel, Sørensen, U. S., Hansen, R. S. & Grunnet, Morten, 2011, In: Hypertension. 57, 6, p. 1129-35 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Energetic performance is improved by specific activation of K+ fluxes through K(Ca) channels in heart mitochondria
Aon, M. A., Cortassa, S., Wei, A., Grunnet, Morten & O'Rourke, B., 2009, In: BBA General Subjects. 1797, 1, p. 71-80 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extracellular potassium inhibits Kv7.1 potassium channels by stabilizing an inactivated state
Larsen, A. P., Steffensen, Annette Buur, Grunnet, Morten & Olesen, Søren-Peter, 2011, In: Biophysical Journal. 101, 4, p. 818-27 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fetal arrhythmia caused by dysregulation of HERG channels.
Grunnet, Morten, 2008, In: Heart Rhythm. 5, 4, p. 562-4 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Flecainide provocation reveals concealed brugada syndrome in a long QT syndrome family with a novel L1786Q mutation in SCN5A. SCN5A mutations associated with overlap phenotype of long QT syndrome type 3 and Brugada syndrome.
Kanters, Jørgen K., Yuan, L., Hedley, P. L., Stoevring, B., Jons, C., Bloch Thomsen, P. E., Grunnet, Morten, Christiansen, M. & Jespersen, Thomas, 6 Mar 2014, In: Circulation Journal. 78, 5, p. 1136-43 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Frequency-dependent modulation of KCNQ1 and HERG1 potassium channels.
Diness, T. G., Hansen, R. S., Olesen, Søren-Peter & Grunnet, Morten, 2006, In: Biochemical and Biophysical Research Communications. 343, 4, p. 1224-33 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 182570346
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Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
343
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Effect of antiarrhythmic drugs on small conductance calcium –activated potassium channels
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
286
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Antiarrhythmic effect of the Ca(2+)-activated K(+) (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation
Research output: Contribution to journal › Journal article › Research › peer-review
Published