An expedient synthesis of the fibril binding compound FSB via sequential Pd-catalyzed coupling reactions
Research output: Contribution to journal › Journal article › Research › peer-review
The styryl benzene derivative (E, E)-1-fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (FSB), well-known for its binding to beta-amyloid peptide fibrils, was synthesized in an efficient manner exploiting two sequential palladium(0)-catalyzed coupling reactions in a 34% overall yield. This is a substantial improvement to the previously reported synthesis of FSB in 1.1%.
Original language | English |
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Journal | The Journal of Organic Chemistry |
Volume | 73 |
Issue number | 9 |
Pages (from-to) | 3570-3 |
Number of pages | 4 |
ISSN | 0022-3263 |
DOIs | |
Publication status | Published - 2 May 2008 |
- Catalysis, Molecular Structure, Palladium/chemistry, Styrenes/chemical synthesis
Research areas
ID: 325013938