Complexity of the influence of gangliosides on histamine release from human basophils and rat mast cells

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Complexity of the influence of gangliosides on histamine release from human basophils and rat mast cells. / Jensen, C; Svendsen, U G; Thastrup, Ole; Stahl Skov, P; Leon, A; Norn, S.

In: Agents and Actions, Vol. 21, No. 1-2, 1987, p. 79-82.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jensen, C, Svendsen, UG, Thastrup, O, Stahl Skov, P, Leon, A & Norn, S 1987, 'Complexity of the influence of gangliosides on histamine release from human basophils and rat mast cells', Agents and Actions, vol. 21, no. 1-2, pp. 79-82.

APA

Jensen, C., Svendsen, U. G., Thastrup, O., Stahl Skov, P., Leon, A., & Norn, S. (1987). Complexity of the influence of gangliosides on histamine release from human basophils and rat mast cells. Agents and Actions, 21(1-2), 79-82.

Vancouver

Jensen C, Svendsen UG, Thastrup O, Stahl Skov P, Leon A, Norn S. Complexity of the influence of gangliosides on histamine release from human basophils and rat mast cells. Agents and Actions. 1987;21(1-2):79-82.

Author

Jensen, C ; Svendsen, U G ; Thastrup, Ole ; Stahl Skov, P ; Leon, A ; Norn, S. / Complexity of the influence of gangliosides on histamine release from human basophils and rat mast cells. In: Agents and Actions. 1987 ; Vol. 21, No. 1-2. pp. 79-82.

Bibtex

@article{4eab520ad6474e109de601915d67aeb8,
title = "Complexity of the influence of gangliosides on histamine release from human basophils and rat mast cells",
abstract = "The influence of exogenous addition of gangliosides on histamine release from human basophils and rat mast cells was examined in vitro. Gangliosides dose-dependently inhibited histamine release, and this inhibition was dependent on the ganglioside sialic acid content, since GT1b, having 3 sialic acid moieties, was more potent than gangliosides with 2 moieties (GD1a and GD1b), which again were more potent inhibitors than GM1 with one moiety. Asialo-GM1 was without effect. In high concentrations the gangliosides potentiated basophil histamine release. The modulation of histamine release was reflected in the sensitivity of the cells to extracellular calcium, since inhibition of the release could be counteracted by increasing the extracellular concentration of calcium.",
keywords = "Animals, Asthma, Basophils, Calcium, Drug Interactions, Gangliosides, Histamine Release, Humans, Male, Mast Cells, N-Acetylneuraminic Acid, Rats, Rhinitis, Allergic, Seasonal, Sialic Acids, Structure-Activity Relationship",
author = "C Jensen and Svendsen, {U G} and Ole Thastrup and {Stahl Skov}, P and A Leon and S Norn",
year = "1987",
language = "English",
volume = "21",
pages = "79--82",
journal = "Agents and Actions",
issn = "0065-4299",
publisher = "Birkhauser Verlag Basel",
number = "1-2",

}

RIS

TY - JOUR

T1 - Complexity of the influence of gangliosides on histamine release from human basophils and rat mast cells

AU - Jensen, C

AU - Svendsen, U G

AU - Thastrup, Ole

AU - Stahl Skov, P

AU - Leon, A

AU - Norn, S

PY - 1987

Y1 - 1987

N2 - The influence of exogenous addition of gangliosides on histamine release from human basophils and rat mast cells was examined in vitro. Gangliosides dose-dependently inhibited histamine release, and this inhibition was dependent on the ganglioside sialic acid content, since GT1b, having 3 sialic acid moieties, was more potent than gangliosides with 2 moieties (GD1a and GD1b), which again were more potent inhibitors than GM1 with one moiety. Asialo-GM1 was without effect. In high concentrations the gangliosides potentiated basophil histamine release. The modulation of histamine release was reflected in the sensitivity of the cells to extracellular calcium, since inhibition of the release could be counteracted by increasing the extracellular concentration of calcium.

AB - The influence of exogenous addition of gangliosides on histamine release from human basophils and rat mast cells was examined in vitro. Gangliosides dose-dependently inhibited histamine release, and this inhibition was dependent on the ganglioside sialic acid content, since GT1b, having 3 sialic acid moieties, was more potent than gangliosides with 2 moieties (GD1a and GD1b), which again were more potent inhibitors than GM1 with one moiety. Asialo-GM1 was without effect. In high concentrations the gangliosides potentiated basophil histamine release. The modulation of histamine release was reflected in the sensitivity of the cells to extracellular calcium, since inhibition of the release could be counteracted by increasing the extracellular concentration of calcium.

KW - Animals

KW - Asthma

KW - Basophils

KW - Calcium

KW - Drug Interactions

KW - Gangliosides

KW - Histamine Release

KW - Humans

KW - Male

KW - Mast Cells

KW - N-Acetylneuraminic Acid

KW - Rats

KW - Rhinitis, Allergic, Seasonal

KW - Sialic Acids

KW - Structure-Activity Relationship

M3 - Journal article

C2 - 2442983

VL - 21

SP - 79

EP - 82

JO - Agents and Actions

JF - Agents and Actions

SN - 0065-4299

IS - 1-2

ER -

ID: 43350423