Synthesis of (3-hydroxy-pyrazolin-5-yl)glycine based ligands interacting with ionotropic glutamate receptors

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Synthesis of (3-hydroxy-pyrazolin-5-yl)glycine based ligands interacting with ionotropic glutamate receptors. / Pinto, A; Tamborini, L; Mastronardi, F; Ettari, R; Safoz, Y; Bunch, Lennart; Nielsen, Birgitte; Jensen, Anders A.; De Micheli, C; Conti, P.

In: European Journal of Medicinal Chemistry, Vol. 75, 2014, p. 151-158.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Pinto, A, Tamborini, L, Mastronardi, F, Ettari, R, Safoz, Y, Bunch, L, Nielsen, B, Jensen, AA, De Micheli, C & Conti, P 2014, 'Synthesis of (3-hydroxy-pyrazolin-5-yl)glycine based ligands interacting with ionotropic glutamate receptors', European Journal of Medicinal Chemistry, vol. 75, pp. 151-158. https://doi.org/10.1016/j.ejmech.2014.01.029

APA

Pinto, A., Tamborini, L., Mastronardi, F., Ettari, R., Safoz, Y., Bunch, L., Nielsen, B., Jensen, A. A., De Micheli, C., & Conti, P. (2014). Synthesis of (3-hydroxy-pyrazolin-5-yl)glycine based ligands interacting with ionotropic glutamate receptors. European Journal of Medicinal Chemistry, 75, 151-158. https://doi.org/10.1016/j.ejmech.2014.01.029

Vancouver

Pinto A, Tamborini L, Mastronardi F, Ettari R, Safoz Y, Bunch L et al. Synthesis of (3-hydroxy-pyrazolin-5-yl)glycine based ligands interacting with ionotropic glutamate receptors. European Journal of Medicinal Chemistry. 2014;75:151-158. https://doi.org/10.1016/j.ejmech.2014.01.029

Author

Pinto, A ; Tamborini, L ; Mastronardi, F ; Ettari, R ; Safoz, Y ; Bunch, Lennart ; Nielsen, Birgitte ; Jensen, Anders A. ; De Micheli, C ; Conti, P. / Synthesis of (3-hydroxy-pyrazolin-5-yl)glycine based ligands interacting with ionotropic glutamate receptors. In: European Journal of Medicinal Chemistry. 2014 ; Vol. 75. pp. 151-158.

Bibtex

@article{ba6ea50c8c5e43aca46b8dd73cc6d661,
title = "Synthesis of (3-hydroxy-pyrazolin-5-yl)glycine based ligands interacting with ionotropic glutamate receptors",
abstract = "Following the concept that increasing the molecular complexity may enhance the receptor selectivity, we replaced the 3-hydroxy-isoxazoline ring of model compound tricholomic acid with a 3-hydroxy-pyrazoline ring, which could be variously decorated at the N1 position, inserting groups characterized by different electronic and steric properties. Binding assays on rat brain synaptic membranes showed that, depending on the nature of the substituent, some of the new synthesized ligands interacted with either AMPA or KA receptors, with affinities in the mid-micromolar range.",
author = "A Pinto and L Tamborini and F Mastronardi and R Ettari and Y Safoz and Lennart Bunch and Birgitte Nielsen and Jensen, {Anders A.} and {De Micheli}, C and P Conti",
year = "2014",
doi = "10.1016/j.ejmech.2014.01.029",
language = "English",
volume = "75",
pages = "151--158",
journal = "European Journal of Medicinal Chemistry",
issn = "0223-5234",
publisher = "Elsevier Masson",

}

RIS

TY - JOUR

T1 - Synthesis of (3-hydroxy-pyrazolin-5-yl)glycine based ligands interacting with ionotropic glutamate receptors

AU - Pinto, A

AU - Tamborini, L

AU - Mastronardi, F

AU - Ettari, R

AU - Safoz, Y

AU - Bunch, Lennart

AU - Nielsen, Birgitte

AU - Jensen, Anders A.

AU - De Micheli, C

AU - Conti, P

PY - 2014

Y1 - 2014

N2 - Following the concept that increasing the molecular complexity may enhance the receptor selectivity, we replaced the 3-hydroxy-isoxazoline ring of model compound tricholomic acid with a 3-hydroxy-pyrazoline ring, which could be variously decorated at the N1 position, inserting groups characterized by different electronic and steric properties. Binding assays on rat brain synaptic membranes showed that, depending on the nature of the substituent, some of the new synthesized ligands interacted with either AMPA or KA receptors, with affinities in the mid-micromolar range.

AB - Following the concept that increasing the molecular complexity may enhance the receptor selectivity, we replaced the 3-hydroxy-isoxazoline ring of model compound tricholomic acid with a 3-hydroxy-pyrazoline ring, which could be variously decorated at the N1 position, inserting groups characterized by different electronic and steric properties. Binding assays on rat brain synaptic membranes showed that, depending on the nature of the substituent, some of the new synthesized ligands interacted with either AMPA or KA receptors, with affinities in the mid-micromolar range.

U2 - 10.1016/j.ejmech.2014.01.029

DO - 10.1016/j.ejmech.2014.01.029

M3 - Journal article

VL - 75

SP - 151

EP - 158

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

SN - 0223-5234

ER -

ID: 98587296