The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses
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The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses. / Moreira, José Manuel Alfonso; Scheipers, Peter; Sørensen, Poul.
In: B M C Cancer, Vol. 3, 2003, p. 30.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses
AU - Moreira, José Manuel Alfonso
AU - Scheipers, Peter
AU - Sørensen, Poul
PY - 2003
Y1 - 2003
N2 - Histone deacetylase inhibitors (HDACIs) induce hyperacetylation of core histones modulating chromatin structure and affecting gene expression. These compounds are also able to induce growth arrest, cell differentiation, and apoptotic cell death of tumor cells in vitro as well as in vivo. Even though several genes modulated by HDAC inhibition have been identified, those genes clearly responsible for the biological effects of these drugs have remained elusive. We investigated the pharmacological effect of the HDACI and potential anti-cancer agent Trichostatin A (TSA) on primary T cells.
AB - Histone deacetylase inhibitors (HDACIs) induce hyperacetylation of core histones modulating chromatin structure and affecting gene expression. These compounds are also able to induce growth arrest, cell differentiation, and apoptotic cell death of tumor cells in vitro as well as in vivo. Even though several genes modulated by HDAC inhibition have been identified, those genes clearly responsible for the biological effects of these drugs have remained elusive. We investigated the pharmacological effect of the HDACI and potential anti-cancer agent Trichostatin A (TSA) on primary T cells.
KW - Animals
KW - Antigens, CD
KW - Apoptosis
KW - CD4-Positive T-Lymphocytes
KW - Caspases
KW - Enzyme Inhibitors
KW - Female
KW - Gene Expression Regulation
KW - Histone Deacetylase Inhibitors
KW - Hydroxamic Acids
KW - Interleukin-2
KW - Lymphocyte Activation
KW - Mice
KW - Mice, Inbred C57BL
KW - NF-kappa B
KW - Reactive Oxygen Species
KW - Signal Transduction
KW - Transcriptional Activation
U2 - 10.1186/1471-2407-3-30
DO - 10.1186/1471-2407-3-30
M3 - Journal article
C2 - 14606959
VL - 3
SP - 30
JO - B M C Cancer
JF - B M C Cancer
SN - 1471-2407
ER -
ID: 41043584