The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses
Research output: Contribution to journal › Journal article › Research › peer-review
Histone deacetylase inhibitors (HDACIs) induce hyperacetylation of core histones modulating chromatin structure and affecting gene expression. These compounds are also able to induce growth arrest, cell differentiation, and apoptotic cell death of tumor cells in vitro as well as in vivo. Even though several genes modulated by HDAC inhibition have been identified, those genes clearly responsible for the biological effects of these drugs have remained elusive. We investigated the pharmacological effect of the HDACI and potential anti-cancer agent Trichostatin A (TSA) on primary T cells.
| Original language | English |
|---|---|
| Journal | B M C Cancer |
| Volume | 3 |
| Pages (from-to) | 30 |
| ISSN | 1471-2407 |
| DOIs | |
| Publication status | Published - 2003 |
- Animals, Antigens, CD, Apoptosis, CD4-Positive T-Lymphocytes, Caspases, Enzyme Inhibitors, Female, Gene Expression Regulation, Histone Deacetylase Inhibitors, Hydroxamic Acids, Interleukin-2, Lymphocyte Activation, Mice, Mice, Inbred C57BL, NF-kappa B, Reactive Oxygen Species, Signal Transduction, Transcriptional Activation
Research areas
ID: 41043584