Medicinal Chemistry in the Frølund Group

We are aiming for development of molecular probes and novel methodologies to obtain insight into identity, localization, function, therapeutic potential of target receptors/transporters, and to match orphan ligands and binding sites with neuroprotection in focus

chemical synthesis

 

 

 

 

 

 

 

 

The main focus of the current research in the Frølund group is on GHB/CaMK2 pharmacology and the ionotropic GABAA receptors but also covers nACh receptors and the GABA relevant transporters GAT and TauT.

The overall goal of the research is to develop molecular probes and novel methodologies to obtain insight into identity, localization, function, therapeutic potential of target receptors/transporters, and to match orphan ligands and binding sites with neuroprotection in focus.

The approaches comprise structure-activity studies, development of imaging ligands for determination of localization, mobility and activation of target proteins, and engineered molecular probes for ligand-protein crystallization, identification and probing of binding sites, bioorthogonal chemistry, targeted delivery and rewiring cell signaling.

All projects are interdisciplinary, building on international and national collaborations. With a platform in medicinal chemistry, our projects bridges with molecular pharmacology, computational and biostructural chemistry.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Group leader Bente Frølund

Group Leader

Bente Frølund
Professor

Phone +45 3533 6495
bfr@sund.ku.dk

Group members

Name Title Phone E-mail
Christos Avgerinos PhD Fellow E-mail
Francesco Bavo Assistant Professor +4535327264 E-mail
Ioannis Panagiotis Avgeris PhD Fellow E-mail
Kirsten Braad Iskov Laboratory Technician E-mail
Nicoline Ninn Jensen PhD Fellow E-mail