Bladder contractility is modulated by Kv7 channels in pig detrusor

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Bladder contractility is modulated by Kv7 channels in pig detrusor. / Svalø, Julie; Bille, Michala; Parameswaran Theepakaran, Neeraja; Sheykhzade, Majid; Nordling, Jørgen; Bouchelouche, Pierre.

In: European Journal of Pharmacology, Vol. 715, No. 1-3, 21.05.2013, p. 312-320.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Svalø, J, Bille, M, Parameswaran Theepakaran, N, Sheykhzade, M, Nordling, J & Bouchelouche, P 2013, 'Bladder contractility is modulated by Kv7 channels in pig detrusor', European Journal of Pharmacology, vol. 715, no. 1-3, pp. 312-320. https://doi.org/10.1016/j.ejphar.2013.05.005

APA

Svalø, J., Bille, M., Parameswaran Theepakaran, N., Sheykhzade, M., Nordling, J., & Bouchelouche, P. (2013). Bladder contractility is modulated by Kv7 channels in pig detrusor. European Journal of Pharmacology, 715(1-3), 312-320. https://doi.org/10.1016/j.ejphar.2013.05.005

Vancouver

Svalø J, Bille M, Parameswaran Theepakaran N, Sheykhzade M, Nordling J, Bouchelouche P. Bladder contractility is modulated by Kv7 channels in pig detrusor. European Journal of Pharmacology. 2013 May 21;715(1-3):312-320. https://doi.org/10.1016/j.ejphar.2013.05.005

Author

Svalø, Julie ; Bille, Michala ; Parameswaran Theepakaran, Neeraja ; Sheykhzade, Majid ; Nordling, Jørgen ; Bouchelouche, Pierre. / Bladder contractility is modulated by Kv7 channels in pig detrusor. In: European Journal of Pharmacology. 2013 ; Vol. 715, No. 1-3. pp. 312-320.

Bibtex

@article{1092944bb38b44df9445c78233531277,
title = "Bladder contractility is modulated by Kv7 channels in pig detrusor",
abstract = "Kv7 channels are involved in smooth muscle relaxation, and accordingly we believe that they constitute potential targets for the treatment of overactive bladder syndrome. We have therefore used myography to examine the function of Kv7 channels in detrusor, i.e. pig bladder, with a view to determining the effects of the following potassium channel activators: ML213 (Kv7.2/Kv7.4 channels) and retigabine (Kv7.2-7.5 channels). Retigabine produced a concentration-dependent relaxation of carbachol- and electric field-induced contractions. The potency was similar in magnitude to that of ML213-induced relaxation, suggesting that Kv7.2 and/or Kv7.4 channels constitute the subtypes that are relevant to bladder contractility. The effects of retigabine and ML213 were attenuated by pre-incubation with 10µM XE991 (Kv7.1-7.5 channel blocker) (P",
author = "Julie Sval{\o} and Michala Bille and {Parameswaran Theepakaran}, Neeraja and Majid Sheykhzade and J{\o}rgen Nordling and Pierre Bouchelouche",
note = "Copyright {\textcopyright} 2013. Published by Elsevier B.V.",
year = "2013",
month = may,
day = "21",
doi = "10.1016/j.ejphar.2013.05.005",
language = "English",
volume = "715",
pages = "312--320",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "1-3",

}

RIS

TY - JOUR

T1 - Bladder contractility is modulated by Kv7 channels in pig detrusor

AU - Svalø, Julie

AU - Bille, Michala

AU - Parameswaran Theepakaran, Neeraja

AU - Sheykhzade, Majid

AU - Nordling, Jørgen

AU - Bouchelouche, Pierre

N1 - Copyright © 2013. Published by Elsevier B.V.

PY - 2013/5/21

Y1 - 2013/5/21

N2 - Kv7 channels are involved in smooth muscle relaxation, and accordingly we believe that they constitute potential targets for the treatment of overactive bladder syndrome. We have therefore used myography to examine the function of Kv7 channels in detrusor, i.e. pig bladder, with a view to determining the effects of the following potassium channel activators: ML213 (Kv7.2/Kv7.4 channels) and retigabine (Kv7.2-7.5 channels). Retigabine produced a concentration-dependent relaxation of carbachol- and electric field-induced contractions. The potency was similar in magnitude to that of ML213-induced relaxation, suggesting that Kv7.2 and/or Kv7.4 channels constitute the subtypes that are relevant to bladder contractility. The effects of retigabine and ML213 were attenuated by pre-incubation with 10µM XE991 (Kv7.1-7.5 channel blocker) (P

AB - Kv7 channels are involved in smooth muscle relaxation, and accordingly we believe that they constitute potential targets for the treatment of overactive bladder syndrome. We have therefore used myography to examine the function of Kv7 channels in detrusor, i.e. pig bladder, with a view to determining the effects of the following potassium channel activators: ML213 (Kv7.2/Kv7.4 channels) and retigabine (Kv7.2-7.5 channels). Retigabine produced a concentration-dependent relaxation of carbachol- and electric field-induced contractions. The potency was similar in magnitude to that of ML213-induced relaxation, suggesting that Kv7.2 and/or Kv7.4 channels constitute the subtypes that are relevant to bladder contractility. The effects of retigabine and ML213 were attenuated by pre-incubation with 10µM XE991 (Kv7.1-7.5 channel blocker) (P

U2 - 10.1016/j.ejphar.2013.05.005

DO - 10.1016/j.ejphar.2013.05.005

M3 - Journal article

C2 - 23707187

VL - 715

SP - 312

EP - 320

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1-3

ER -

ID: 45973424