Anders Bach

Anders Bach

Professor

ORCID: 0000-0003-4305-9910

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  1. Published

    Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery

    Solbak, Sara Marie Øie, Zang, J., Narayanan, Dilip, Høj, L. J., Bucciarelli, S., Softley, C., Meier, S., Langkilde, Annette Eva, Gotfredsen, C. H., Sattler, M. & Bach, Anders, 2020, In: Journal of Medicinal Chemistry. 63, 3, p. 1156-1177

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery

    Narayanan, Dilip, Tran, K. T., Pallesen, J. S., Solbak, S. M. Ø., Qin, Y., Mukminova, E., Luchini, M., Vasilyeva, K. O., González Chichón, D., Goutsiou, G., Poulsen, C., Haapanen, N., Popowicz, G. M., Sattler, M., Olagnier, D., Gajhede, Michael & Bach, Anders, 2022, In: Journal of Medicinal Chemistry. 65, 21, p. 14481-14526

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Effects of dimeric PSD-95 inhibition on excitotoxic cell death and outcome after controlled cortical impact in rats: PSD-95 inhibition in experimental TBI

    Sommer, J. B., Bach, Anders, Rytter, Hana Malá, Gynther, M., Bjerre, A., Gram, M. G., Marschner, L., Strømgaard, Kristian, Mogensen, J. & Pickering, Darryl S, 2017, In: Neurochemical Research. 42, 12, p. 3401-3413 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Effects of the dimeric PSD-95 inhibitor UCCB01-144 in mouse models of pain, cognition and motor function

    Andreasen T., Jesper, Nasser, A., Caballero-Puntiverio, M., Sahlholt, M., Bach, Anders, Gynther, M., Strømgaard, Kristian & Pickering, Darryl S, 5 Jun 2016, In: European Journal of Pharmacology. 780, p. 166-73 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Effects of the dimeric PSD-95 inhibitor UCCB01-144 on functional recovery after fimbria-fornix transection in rats

    Sommer, J. B., Bach, Anders, Rytter, Hana Malá, Strømgaard, Kristian, Mogensen, J. & Pickering, Darryl S, Oct 2017, In: Pharmacology, Biochemistry and Behavior. 161, p. 62-67 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Energetic pathway sampling in a protein interaction domain

    Hultqvist, G., Haq, S. R., Punekar, A. S., Chi, C. N., Engström, A., Bach, Anders, Strømgaard, Kristian, Selmer, M., Gianni, S. & Jemth, P., 25 Jun 2013, In: Structure. 21, 7, p. 1193-1202

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Expedient synthesis of 1,3-substituted benzene peptidomimetics

    Bach, Anders & Strømgaard, Kristian, 8 Feb 2011, In: Synthesis. 2011, 5, p. 807-815

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Fatty acid derivatives of dimeric inhibitors of PSD-95

    Strømgaard, Kristian, Bach, Anders & Nissen, K. B., 4 Jun 2015, IPC No. A61K38/17 , Patent No. WO2015/078477A1, Priority date 1 Dec 2013, Priority No. DK/2013/70735

    Research output: Patent

  9. Published

    GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain

    Leurs, U., Klein, A. B., McSpadden, E. D., Griem-Krey, N., Solbak, S. M. Ø., Houlton, J., Villumsen, I. S., Vogensen, S. B., Hamborg, L., Gauger, S. J., Palmelund, L. B., Larsen, A. S. G., Shehata, M. A., Kelstrup, C. D., Olsen, J. V., Bach, A., Burnie, R. O., Kerr, D. S., Gowing, E. K., Teurlings, S. M. W. & 9 others, Chi, C. C., Gee, C. L., Frølund, Bente, Kornum, Birgitte Rahbek, van Woerden, G. M., Clausen, Rasmus Prætorius, Kuriyan, J., Clarkson, A. N. & Wellendorph, Petrine, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 9 p., e2108079118.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Ghrelin receptor inverse agonists: identification of an active peptide core and its interaction epitopes on the receptor

    Holst, Birgitte, Lang, M., Brandt, E., Bach, Anders, Howard, A., Frimurer, T. M., Beck-Sickinger, A. & Schwartz, Thue W., 2006, In: Molecular Pharmacology. 70, 3, p. 936-46 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Submitted

    High-affinity, dimeric inhibitors of PSD-95 as efficient neuroprotectants against ischemic brain damage and for treatment of pain

    Bach, Anders & Strømgaard, Kristian, 2012, (Submitted) Patent No. WO2012/156308 (Granted: EP2707014B1; US9139615B2)

    Research output: Patent

  12. Published

    Identification and Optimization of Novel Small-Molecule Cas9 Inhibitors by Cell-Based High-Throughput Screening

    Lee, S., Tran, K. T., Vazquez-Uribe, R., Gotfredsen, C. H., Clausen, M. H., Mendez, B. L., Montoya, Guillermo, Bach, Anders & Sommer, M. O. A., 2022, In: Journal of Medicinal Chemistry. 65, 4, p. 3266–3305

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD

    Thorsen, T. S., Madsen, Kenneth Lindegaard, Rebola, N., Rathje, Mette, Anggono, V., Bach, Anders, Moreira, I. S., Stuhr-Hansen, N., Dyhring, T., Peters, D., Beuming, T., Huganir, R., Weinstein, H., Mulle, C., Strømgaard, Kristian, Rønn, L. C. B. & Gether, Ulrik, 2010, In: Proceedings of the National Academy of Science of the United States of America. 107, 1, p. 413-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Identification of novel fragments binding to the PDZ1-2 domain of PSD-95

    Zang, J., Ye, F., Solbak, Sara Marie Øie, Høj, L. J., Zhang, M. & Bach, Anders, 2021, In: ChemMedChem. 16, 6, p. 949-954

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    In Vitro and In Vivo Evaluation of Pellotine: A Hypnotic Lophophora Alkaloid

    Poulie, C. B. M., Chan, C. B., Parka, A., Lettorp, M., Vos, J., Raaschou, A., Pottie, E., Bundgaard, M. S., Sørensen, L. M. E., Cecchi, C. R., Märcher-Rørsted, E., Bach, A., Herth, M. M., Decker, A., Jensen, A. A., Elfving, B., Kretschmann, A. C., Stove, C. P., Kohlmeier, K. A., Cornett, C. & 3 others, Janfelt, Christian, Kornum, Birgitte Rahbek & Kristensen, Jesper Langgaard, 2023, In: ACS Pharmacology & Translational Science. 6, 10, p. 1492-1507

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy

    Fiorentini, M., Bach, Anders, Strømgaard, Kristian, Kastrup, Jette Sandholm Jensen & Gajhede, Michael, Apr 2013, In: Acta Crystallographica. Section D: Biological Crystallography. 69, Pt 4, p. 587-94 8 p.

    Research output: Contribution to journal › Journal article › Research

  17. Published

    Ligand binding by PDZ domains

    Chi, C. N., Bach, Anders, Strømgaard, Kristian, Gianni, S. & Jemth, P., 2012, In: BioFactors. 38, 5, p. 338-348 (Review) 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Modified peptides as potent inhibitors of the PSD-95/NMDA receptor interaction

    Bach, Anders & Strømgaard, Kristian, 14 Jan 2010, Patent No. WO2010/004003 (Granted: EP2320927B1; US9241967B2)

    Research output: Patent

  19. Published

    Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction

    Bach, Anders, Chi, C. N., Olsen, T. B., Pedersen, S. W., Røder, M. U., Pang, G. F., Clausen, Rasmus Prætorius, Jemth, P. & Strømgaard, Kristian, 2008, In: Journal of Medicinal Chemistry. 51, 20, p. 6450-6459

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Molecular architecture of the Jumonji C family histone demethylase KDM5B

    Dorosz, J., Kristensen, L. H., Aduri, N. G., Mirza, Osman Asghar, Lousen, R., Bucciarelli, S., Mehta, V., Sellés Baiget, Selene, Solbak, Sara Marie Øie, Bach, Anders, Mesa, Pablo, Hernandez, P. A., Montoya, Guillermo, Nguyen, T. T. T. N., Rand, Kasper Dyrberg, Boesen, T. & Gajhede, Michael, 2019, In: Scientific Reports. 9, 13 p., 4019.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases

    Pallesen, J. S., Tran, K. T. & Bach, Anders, 27 Sep 2018, In: Journal of Medicinal Chemistry. 61, 18, p. 8088-8103

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling

    Holst, Birgitte, Brandt, E., Bach, Anders, Heding, A. & Schwartz, Thue W., 2005, In: Molecular Endocrinology. 19, 9, p. 2400-11 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions

    Møller, T. C., Wirth, V. F., Roberts, N. I., Bender, J., Bach, Anders, Jacky, B. P. S., Strømgaard, Kristian, Deussing, J. M., Schwartz, Thue W. & Martinez, Karen Laurence, 2013, In: PLOS ONE. 8, 5, e63352.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    PSD-95 uncoupling from NMDA receptors by Tat-N-dimer ameliorates neuronal depolarization in cortical spreading depression

    Kucharz, Krzysztof, Søndergaard Rasmussen, I., Bach, Anders, Strømgaard, Kristian & Lauritzen, Martin, 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 5, p. 1820-1828

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Protein-protein interaktion: et nyt mål for udvikling af lægemidler

    Bach, Anders, Gottschalk, M., Kristensen, Anders Skov & Strømgaard, Kristian, 2008, In: Lægemiddelforskning. p. 10-12

    Research output: Contribution to journal › Journal article › Communication

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