Dan Stærk

Dan Stærk

Head of Department, Visiting professor


  1. 2017
  2. Published

    Potential of Polygonum cuspidatum root as an antidiabetic food: Dual high-resolution α-glucosidase and PTP1B inhibition profiling combined with HPLC-HRMS and NMR for identification of antidiabetic constituents

    Zhao, Yong, Chen, M. X., Kongstad, Kenneth Thermann, Jäger, A. K. & Stærk, Dan, 2017, In: Journal of Agricultural and Food Chemistry. 65, p. 4421-4427

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Synthesis of C-glucosylated octaketide anthraquinones in Nicotiana benthamiana using a multispecies-based biosynthetic pathway

    Andersen-Ranberg, Johan, Kongstad, Kenneth Thermann, Nafisi, M., Stærk, Dan, Okkels, F. T., Mortensen, U. H., Møller, Birger Lindberg, Frandsen, R. J. N. & Kannangara, R. M., 2017, In: ChemBioChem. 18, 19, p. 1893-1897 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Total biosynthesis of the cyclic AMP booster forskolin from Coleus forskohlii

    Pateraki, Irini, Andersen-Ranberg, Johan, Jensen, N. B., Wubshet, S. G., Heskes, A. M., Forman, Victor, Hallström, B., Hamberger, B., Motawie, Mohammed Saddik, Olsen, C. E., Stærk, Dan, Hansen, J., Møller, Birger Lindberg & Hamberger, B. R., 2017, In: eLife. 6, 28 p., e23001.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Xanthones from the twigs of Garcinia oblongifolia and their antidiabetic activity

    Trinh, T. D. B., Quach, T. T. T., Bui, D. N., Stærk, Dan, Nguyen, L. D. & Jäger, A. K., 2017, In: Fitoterapia. 118, p. 126-131

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2018
  7. Published

    Biosynthesis of bioactive diterpenoids in the medicinal plant Vitex agnus-castus

    Heskes, A., Sundram, T. C. M., Boughton, B. A., Bjerg Jensen, N., Hansen, N. L., Crocoll, C., Cozzi, F., Rasmussen, Simon, Hamberger, B., Hamberger, B. R., Stærk, Dan, Møller, Birger Lindberg & Pateraki, Irini, 2018, In: Plant Journal. 93, p. 943-958 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Brazilian insulin plant as a bifunctional food: Dual high-resolution PTP1B and α-glucosidase inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of antidiabetic compounds in Myrcia rubella Cambess

    Lima, R. D. C. L., Kato, L., Kongstad, Kenneth Thermann & Stærk, Dan, 2018, In: Journal of Functional Foods. 45, p. 444-451

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Comparative study of the drug delivery mechanism of L-penetratin and D-penetratin

    Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 2018.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  10. Published

    Heterologous production of the widely used natural food colorant carminic acid in Aspergillus nidulans

    Frandsen, R. J. N., Khorsand-Jamal, P., Kongstad, Kenneth Thermann, Nafisi, M., Kannangara, R. M., Stærk, Dan, Okkels, F. T., Binderup, K., Madsen, B., Møller, Birger Lindberg, Thrane, U. & Mortensen, U. H., 2018, In: Scientific Reports. 8, p. 1-10 10 p., 12853.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    High-resolution PTP1B inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of PTP1B inhibitors from Miconia albicans

    Lima, R. D. C. L., Kongstad, Kenneth Thermann, Kato, L., José das Silva, M., Franzyk, Henrik & Stærk, Dan, 2018, In: Molecules. 23, 7, 13 p., 1755.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Identification and characterization of a new antifungal peptide in fermented milk product containing bioprotective Lactobacillus cultures

    McNair, Laura M., Siedler, S., Vinther, J. M., Hansen, A. M., Neves, A. R., Jäger, A. K., Franzyk, Henrik & Stærk, Dan, 2018, In: F E M S Yeast Research. 18, 9 p., foy094.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    On the biosynthetic origin of carminic acid

    Rasmussen, S. A., Kongstad, Kenneth Thermann, Khorsand-Jamal, P., Kannangara, R. M., Nafisi, M., Van Dam, A., Bennedsen, M., Madsen, B., Okkels, F. T., Gotfredsen, C. H., Stærk, Dan, Thrane, U., Mortensen, U. H., Larsen, T. O. & Frandsen, R. J. N., 2018, In: Insect Biochemistry and Molecular Biology. 96, p. 51-61 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published
  15. Published

    Recreational drug use at a major music festival: trend analysis of anonymised pooled urine

    Hoegberg, L., Christiansen, C., Søe, J. L., Telving, R., Andreasen, M. F., Stærk, Dan, Christrup, Lona Louring & Kongstad, Kenneth Thermann, 2018, In: Clinical Toxicology. 56, p. 245-255 1360496.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Athenolide A, a new steroidal lactone from the leaves of Athenaea martiana (Solanacea) determined by means of HPLC-HRMS-SPE-NMR analysis

    Silva, E. L., Almeida-Lafetá, R. C., Borges, R. M. & Stærk, Dan, Jan 2018, In: Chemistry & Biodiversity. 15, 1, 8 p., e1700455.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Investigation of medicinal plants from Madagascar against DPP-IV linked to type 2 diabetes

    Beidokhti, M. N., Lobbens, E. S. B., Rasoavaivo, P., Jäger, A. K. & Stærk, Dan, Mar 2018, In: South African Journal of Botany. 115, p. 113-119

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Stereochemistry as a determining factor for the effect of a cell-penetrating peptide on cellular viability and epithelial integrity

    Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 24 May 2018, In: Biochemical Journal. 475, 10, p. 1773-1788 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. 2019
  20. Published

    2(5H)-Furanone sesquiterpenes from Eremophila bignoniiflora: High-resolution inhibition profiling and PTP1B inhibitory activity

    Zhao, Yong, Kjaerulff, Louise, Kongstad, Kenneth Thermann, Heskes, A. M., Møller, Birger Lindberg & Stærk, Dan, 2019, In: Phytochemistry. 166, p. 1-8 112054.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    19F-substituted amino acids as an alternative to fluorophore labels: monitoring of degradation and cellular uptake of analogues of penetratin by 19F NMR

    Christensen, M. V., Kongstad, Kenneth Thermann, Sondergaard, T. E., Stærk, Dan, Nielsen, Hanne Mørck, Franzyk, Henrik & Wimmer, R., 2019, In: Journal of Biomolecular N M R. 73, p. 167-182

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Antidiabetic constituents of Dendrobium officinale as determined by high-resolution profiling of radical scavenging and α-glucosidase and α-amylase inhibition combined with HPLC-PDA-HRMS-SPE-NMR analysis.

    Chu, C., Li, T., Pedersen, H. A., Kongstad, Kenneth Thermann, Yan, J. & Stærk, Dan, 2019, In: Phytochemistry Letters. 31, p. 47-52

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Assessing specialized metabolite diversity in the cosmopolitan plant genus Euphorbia L.

    Ernst, M., Nothias, L., van der Hooft, J. J. J., da Silva, R. R., Saslis-Lagoudakis, C. H., Grace, O. M., Martinez-Swatson, K. A., Hassemer, G., Funez, L. A., Simonsen, H. T., Medema, M. H., Stærk, Dan, Nilsson, N., Lovato, P., Dorrestein, P. C. & Rønsted, Nina, 2019, In: Frontiers in Plant Science. 10, 15 p., 846.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Combined magnetic ligand fishing and high-resolution inhibition profiling for identification of α-glucosidase inhibitory ligands: A new screening approach based on complementary inhibition and affinity profiles.

    Wubshet, S. G., Liu, B., Kongstad, Kenneth Thermann, Böcker, U., Petersen, M. J., Li, T., Wang, J. & Stærk, Dan, 2019, In: Talanta. 200, p. 279-287

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Detection of Seasonal Variation in Aloe Polysaccharides Using Carbohydrate Detecting Microarrays

    Isager Ahl, Louise, Al-Husseini, N., Al-Helle, S., Stærk, Dan, Grace, O. M., Willats, W. G. T., Mravec, Jozef, Jørgensen, Bodil & Rønsted, Nina, 2019, In: Frontiers in Plant Science. 10, p. 1-14 512.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    High-dose naloxone, an experimental tool uncovering latent sensitisation: pharmacokinetics in humans.

    Papathanasiou, T., Springborg, A., Kongstad, Kenneth Thermann, Stærk, Dan, Møller, Kirsten, Taylor, B. K., Lund, Trine Meldgaard & Werner, M. U., 2019, In: British Journal of Anaesthesia. 123, 2, p. e204-e214

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Identification of α-glucosidase inhibitors in Machilus litseifolia by combined use of high-resolution α-glucosidase inhibition profiling and HPLC-PDA-HRMS-SPE-NMR

    Li, T., Kongstad, Kenneth Thermann & Stærk, Dan, 2019, In: Journal of Natural Products. 82, p. 249-258

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Immobilized α-amylase magnetic beads for ligand fishing: Proof of concept and identification of α-amylase inhibitors in Ginkgo biloba

    Petersen, M. J., Lima, R. D. C. L., Kjaerulff, Louise & Stærk, Dan, 2019, In: Phytochemistry. 164, p. 94-101

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin

    Zaharudin, N. B., Stærk, Dan & Dragsted, Lars Ove, 2019, In: Food Chemistry. 270, p. 481-486 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Peptides from chicken processing by-product inhibit DPP-IV and promote cellular glucose uptake: potential ingredients for T2D management

    Lima, R. D. C. L., Berg, R. S., Rønning, S. B., Afseth, N. K., Knutsen, S. H., Stærk, Dan & Wubshet, S. G., 2019, In: Food & Function. 10, p. 1619-1628

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Picraviane A and B: Nortriterpenes with limonoid-like skeletons containing a heptanolide E-ring system from Picramnia glazioviana

    Gimenes, L., Batista Junior, J. M., dos Santos Junior, F. M., Souza, M. D. S., Luna-Dulcey, L., Ellena, J., Cominetti, M. R., da Silva, M. F. D. G. F., Vieira, P. C., Fernandes, J. B. & Stærk, Dan, 2019, In: Phytochemistry. 163, p. 38-45

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Potential of Sorbus berry extracts for management of type 2 diabetes: metabolomics investigation of 1H NMR spectra, α-amylase and α-glucosidase inhibitory activities, and in vivo anti-hyperglycaemic activity of S. norvegica

    Broholm, S. L., Gramsbergen, S., Nyberg, N., Jäger, A. K. & Stærk, Dan, 2019, In: Journal of Ethnopharmacology. 242, 10 p., 112061.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Simultaneous quantification of high-dose naloxone and naloxone-3-β-D-glucuronide in human plasma by UHPLC-MS/MS

    Kongstad, Kenneth Thermann, Papathanasiou, T., Springborg, A., Lund, Trine Meldgaard, Werner, M. U. & Stærk, Dan, 2019, In: Bioanalysis. 11, 03, p. 165-173

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Unraveling the complexity of complex mixtures by combining high-resolution pharmacological, analytical and spectroscopic techniques: Antidiabetic constituents in Chinese medicinal plants

    Zhao, Yong, Kongstad, Kenneth Thermann, Liu, Y., He, C. & Stærk, Dan, 2019, In: Faraday Discussions. 218, p. 202-218

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    High resolution techniques: General discussion

    Adair, E., Afonso, C., Bell, N. G. A., Davies, A. N., Delsuc, M. A., Godfrey, R., Goodacre, R., Hawkes, J. A., Hertkorn, N., Jones, D., Lameiras, P., Le Guennec, A., Lubben, A., Nilsson, M., Paša-Tolić, L., Richards, J., Rodgers, R. P., Rüger, C. P., Schmitt-Kopplin, P., Schoenmakers, P. J. & 8 others, Sidebottom, P., Stærk, Dan, Summerfield, S., Uhrín, D., Van Delft, P., Van Der Hooft, J. J. J., Van Zelst, F. H. M. & Zherebker, A., 1 Jan 2019, In: Faraday Discussions. 218, p. 247-267 21 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  36. 2020
  37. Published

    4-Benzyloxylonchocarpin and muracatanes A-C from Ranunculus muricatus L. and their biological effects

    Hussain, H., Ali, I., Wang, D., Mamadalieva, N. Z., Hussain, W., Csuk, R., Loesche, A., Fischer, L., Stærk, Dan, Anam, S., AlZain, M. N., Mushtaq, M., Ul-Haq, Z., Ullah, R., Noman, O. M., Abbas, G. & Green, I. R., 2020, In: Biomolecules. 10, 11, 15 p., 1562.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Antidiabetic xanthones with α-glucosidase inhibitory activities from an endophytic Penicillium canescens

    Malik, A., Ardalani, H., Anam, S., McNair, Laura M., Kromphardt, K. J. K., Frandsen, R. J. N., Franzyk, Henrik, Stærk, Dan & Kongstad, Kenneth Thermann, 2020, In: Fitoterapia. 142, 8 p., 104522.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Identification of Amaryllidaceae alkaloids in larvae of the ‘lily borer’ moth Brithys crini

    Nair, J. J., Andresen, A. L., Papenfus, H., Stærk, Dan & van Staden, J., 2020, In: South African Journal of Botany. 131, p. 351-359

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Integrating pathway elucidation with yeast engineering to produce polpunonic acid the precursor of the anti-obesity agent celastrol

    Hansen, N. L., Miettinen, Karel, Zhao, Yong, Ignea, C., Andreadeli, A., Raadam, Morten Hessellund, Makris, A. M., Møller, Birger Lindberg, Stærk, Dan, Bak, Søren & Kampranis, Sotirios, 2020, In: Microbial Cell Factories. 19, 17 p., 15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Isolation, structure elucidation and PTP1B inhibitory activity of serrulatane diterpenoids from the roots of Myoporum insulare

    Kjaerulff, Louise, Jensen, A. B. J., Ndi, C., Semple, S. J., Møller, Birger Lindberg & Stærk, Dan, 2020, In: Phytochemistry Letters. 39, p. 49-56

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Nerylneryl diphosphate is the precursor of serrulatane, viscidane and cembrane-type diterpenoids in Eremophila species

    Gericke, Oliver, Hansen, N. L., Pedersen, G. B., Kjaerulff, Louise, Luo, Dan, Stærk, Dan, Møller, Birger Lindberg, Pateraki, Irini & Heskes, A., 2020, In: B M C Plant Biology. 20, 15 p., 91.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published
  44. Published

    Structure elucidation and absolute configuration determination of nortriterpenoids from Picramnia glazioviana

    Gimenes, L., Luna-Dulcey, L., Batista Junior, J. M., dos Santos Junior, F. M., Popolin, C. P., Cominetti, M. R., Fernandes, J. B. & Stærk, Dan, 2020, In: Journal of Natural Products. 83, p. 1859-1876

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    PTP1B-inhibiting branched-chain fatty acid dimers from Eremophila oppositifolia subsp. angustifolia identified by high-resolution PTP1B inhibition profiling and HPLC-PDA-HRMS-SPE-NMR analysis

    Pedersen, H. A., Ndi, C., Semple, S. J., Buirchell, B., Møller, Birger Lindberg & Stærk, Dan, 7 Apr 2020, In: Journal of Natural Products. 83, p. 1598-1610

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published
  47. Published

    Evaluation of the antidiabetic potential of Psidium guajava L. (Myrtaceae) using assays for α-glucosidase, α-amylase, muscle glucose uptake, liver glucose production and triglyceride accumulation in adipocytes

    Beidokhti, M. N., Eid, H. M., Villavicencio, M. L. S., Jäger, A. K., Lobbens, E. S., Rasoanaivo, P. R., McNair, Laura M., Haddad, P. S. & Stærk, Dan, 17 Apr 2020, In: Journal of Ethnopharmacology. 257, 8 p., 112877.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. 2021
  49. Published

    A systematic review of possible interactions for herbal medicines and dietary supplements used concomitantly with disease-modifying or symptom-alleviating multiple sclerosis drugs

    Petersen, M. J., Bergien, Sofie Olsgaard & Stærk, Dan, 2021, In: Phytotherapy Research. 35, 7, p. 3610-3631

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    An independent evolutionary origin for insect deterrent cucurbitacins in Iberis amara

    Dong, L., Almeida Robles, A. R., Pollier, J., Khakimov, Bekzod, Bassard, J. A., Miettinen, K., Stærk, Dan, Mehran, R., Olsen, C. E., Motawie, Mohammed Saddik, Goossens, A. & Bak, Søren, 2021, In: Molecular Biology and Evolution. 38, 11, p. 4659-4673 15 p., msab213.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published
  52. Published

    Coupling microplate-based antibacterial assay with liquid chromatography for high-resolution growth inhibition profiling of crude extracts: Validation and proof-of-concept study with Staphylococcus aureus

    Ardalani, H., Anam, S., Kromphardt, K. J. K., Stærk, Dan & Kongstad, Kenneth Thermann, 2021, In: Molecules. 26, 6, 12 p., 1550.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published
  54. Published

    Furolabdane diterpenoids from Pseudodictamnus aucheri (Boiss.) Salmaki & Siadati (Lamiaceae) as chemophenetic markers

    Sadani, S., Sarrafi, Y. & Stærk, Dan, 2021, In: Biochemical Systematics and Ecology. 98, 4 p., 104304.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Isolation and structure elucidation of serrulatane diterpenoids from the roots of Eremophila longifolia

    Rasmussen, L. F., Anton, J., Kjaerulff, Louise & Stærk, Dan, 2021, p. 1.

    Research output: Contribution to conferencePosterResearch

ID: 1299056