David E. Gloriam

David E. Gloriam

Professor

ORCID: 0000-0002-4299-7561

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  1. Published

    Identification and characterization of small molecular NPR-B receptor antagonists

    Andresen, H., Moltzau, L., Fagerheim, S., Gloriam, David E., Bach, T. & Levy, F., 1 Jan 2015, In: BMC Pharmacology and Toxicology. 16, Suppl 1, p. A70

    Research output: Contribution to journal › Journal article › Communication

  2. Published

    Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs

    Avet, C., Mancini, A., Breton, B., Le Gouill, C., Hauser, Alexander Sebastian, Normand, C., Kobayashi, H., Gross, F., Hogue, M., Lukasheva, V., St-Onge, S., Carrier, M., Héroux, M., Morissette, S., Fauman, E. B., Fortin, J. P., Schann, S., Leroy, X., Gloriam, David E. & Bouvier, M., 2022, In: eLife. 11, 34 p., e74101.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat

    Babbitt, P. C., Bagos, P. G., Bairoch, A., Bateman, A., Chatonnet, A., Chen, M. J., Craik, D. J., Finn, R. D., Gloriam, D., Haft, D. H., Henrissat, B., Holliday, G. L., Isberg, V., Kaas, Q., Landsman, D., Lenfant, N., Manning, G., Nagano, N., Srinivasan, N., O’Donovan, C. & 9 others, Pruitt, K. D., Sowdhamini, R., Rawlings, N. D., Saier, M. H., Sharman, J. L., Spedding, M., Tsirigos, Konstantinos, Vastermark, A. & Vriend, G., 18 May 2015, In: Database: The Journal of Biological Databases and Curation. 2015, p. 1-5 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Targeting the APP-Mint2 Protein-Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation

    Bartling, Christian Reinhard Otto, Jensen, T. M. T., Henry, S. M., Colliander, A. L., Sereikaité, Vita, Wenzler, M., Jain, P., Maric, H. M., Harpsøe, Kasper, Pedersen, S. W., Clemmensen, L. S., Haugaard-Kedström, L. M., Gloriam, David E., Ho, A. & Strømgaard, Kristian, 2021, In: Journal of the American Chemical Society. 143, 2, p. 891-901

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Comprehensive Peptide Cyclization Examination Yields Optimized APP Scaffolds with Improved Affinity toward Mint2

    Bartling, Christian Reinhard Otto, Alexopoulou, Flora, Kuschert, S., Chin, Y. K. Y., Jia, X., Sereikaité, Vita, Özcelik, D., Jensen, T. M., Jain, P., Nygaard, M. M., Harpsøe, Kasper, Gloriam, David E., Mobli, M. & Strømgaard, Kristian, 2023, In: Journal of Medicinal Chemistry. 66, 4, p. 3045-3057

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse

    Bjarnadóttir, T. K., Gloriam, David E., Hellstrand, S. H., Kristiansson, H., Fredriksson, R. & Schiöth, H. B., Sep 2006, In: Genomics. 88, 3, p. 263-73 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors

    Bjarnadóttir, T. K., Fredriksson, R., Höglund, P. J., Gloriam, David E., Lagerström, M. C. & Schiöth, H. B., Jul 2004, In: Genomics. 84, 1, p. 23-33 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Delineation of molecular determinants for FR900359 inhibition of Gq/11 unlocks inhibition of Gαs

    Boesgaard, M. W., Harpsøe, Kasper, Malmberg, M., Underwood, C. R., Inoue, A., Mathiesen, Jesper M., König, G. M., Kostenis, E., Gloriam, David E. & Bräuner, Hans, 2020, In: Journal of Biological Chemistry. 295, 40, p. 13850-13861

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Minimum information about a protein affinity reagent (MIAPAR)

    Bourbeillon, J., Orchard, S., Benhar, I., Borrebaeck, C., de Daruvar, A., Dübel, S., Frank, R., Gibson, F., Gloriam, D. E. I., Haslam, N., Hiltker, T., Humphrey-Smith, I., Hust, M., Juncker, D., Koegl, M., Konthur, Z., Korn, B., Krobitsch, S., Muyldermans, S., Nygren, P-Å. & 14 others, Palcy, S., Polic, B., Rodriguez, H., Sawyer, A., Schlapshy, M., Snyder, M., Stoevesandt, O., Taussig, M. J., Templin, M., Uhlen, M., van der Maarel, S., Wingren, C., Hermjakob, H. & Sherman, D., 2010, In: Nature Biotechnology. 28, 7, p. 650-653

    Research output: Contribution to journal › Journal article › Research

  10. Published

    G protein-coupled receptor pharmacology-The next generation

    Bräuner, Hans, Rosenkilde, Mette, Gether, Ulrik & Gloriam, David E., 2020, In: Basic & Clinical Pharmacology & Toxicology. 126, Supplement 6, p. 3-4 2 p.

    Research output: Contribution to journal › Editorial › Research

  11. Published

    A community Biased Signaling Atlas

    Caroli, J., Mamyrbekov, A., Harpsøe, Kasper, Gardizi, S., Dörries, L., Ghosh, E., Hauser, Alexander Sebastian, Kooistra, Albert J. & Gloriam, David E., 2023, In: Nature Chemical Biology. 19, p. 531–535

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  12. Published

    Structure-Activity Relationships and Identification of Optmized CC-Chemokine Receptor CCR1, 5, and 8 Metal-Ion Chelators

    Chalikiopoulos, A., Thiele, S., Malmgaard-Clausen, M., Rydberg, P., Isberg, V., Ulven, Trond, Frimurer, Thomas Michael, Rosenkilde, Mette & Gloriam, David E., 25 Nov 2013, In: Journal of Chemical Information and Modeling. 53, 11, p. 2863-73 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Applying label-free dynamic mass redistribution assay for studying endogenous FPR1 receptor signalling in human neutrophils

    Christensen, H. B., Gloriam, David E., Pedersen, D. S., Cowland, J. B., Borregaard, N. & Bräuner, Hans, 15 Jul 2017, In: Journal of Pharmacological and Toxicological Methods. 88, Pt 1, p. 72-78 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Peptide inhibitors as tool compounds targeting GPCR signaling

    Daver, H., Harpsøe, Kasper & Gloriam, David E., 2021, In: European Biophysics Journal. 50, SUPPL 1, p. 161-161 238.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  15. Published

    Present perspectives on the automated classification of the G-protein coupled receptors (GPCRs) at the protein sequence level

    Davies, M. N., Gloriam, David E., Secker, A., Freitas, A. A., Timmis, J. & Flower, D. R., 2011, In: Current Topics in Medicinal Chemistry. 11, 15, p. 1994-2009

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    In silico identification of novel G protein-coupled receptors

    Davies, M. N., Gloriam, David E. & Flower, D. R., 2011, Methods for the discovery and characterization of G protein-coupled receptors. Stevens, C. W. (ed.). New York: Humana Press, Vol. 60. p. 3-18 (Neuromethods, Vol. 60).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  17. Proteomic applications of automated GPCR classification

    Davies, M. N., Gloriam, David E., Secker, A., Freitas, A. A., Mendao, M., Timmis, J. & Flower, D. R., Aug 2007, In: Proteomics. 7, 16, p. 2800-14 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Structure–activity relationship of GPR15L peptide analogues and investigation of their interaction with the GPR15 receptor

    Deng, Y., Perez Almeria, C. V., van Gijzel, L., Schaller, Kay, Vedel, L., Gloriam, David E., Ulven, Trond & Bräuner, Hans, 2023, In: Basic and Clinical Pharmacology and Toxicology. 132, 6, p. 459-471

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide

    Di Giglio, M. G., Muttenthaler, M., Harpsøe, Kasper, Liutkeviciute, Z., Keov, P., Eder, T., Rattei, T., Arrowsmith, S., Wray, S., Marek, A., Elbert, T., Alewood, P. F., Gloriam, David E. & Gruber, C. W., 1 Feb 2017, In: Scientific Reports. 7, 15 p., 41002.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Molecular Determinants underlying Delta Selective Compound 2 (DS2) Activity at δ-Containing GABAA Receptors

    Falk-Petersen, C. B., Rostrup, F., Löffler, R., Buchleihtner, S., Harpsøe, Kasper, Gloriam, David E., Frølund, Bente & Wellendorph, Petrine, 2021, In: Molecular Pharmacology. 100, 1, p. 46-56

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABAA receptors

    Falk-Petersen, C. B., Tsonkov, T. M., Nielsen, M. S., Harpsøe, Kasper, Bundgaard, C., Frølund, Bente, Kristiansen, Uffe, Gloriam, David E. & Wellendorph, Petrine, 22 Jun 2020, In: Scientific Reports. 10, 1, 12 p., 10078.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    A new crystal structure fragment-based pharmacophore method for G protein-coupled receptors

    Fidom, K., Isberg, V., Hauser, Alexander Sebastian, Mordalski, S., Lehto, T., Bojarski, A. J. & Gloriam, David E., Jan 2015, In: Methods. 71, p. 104-112 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Selectivity determinants of GPCR-G-protein binding

    Flock, T., Hauser, Alexander Sebastian, Lund, N., Gloriam, David E., Balaji, S. & Babu, M. M., 18 May 2017, In: Nature. 545, 7654, p. 317-322 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors

    Foster, S. R., Hauser, Alexander Sebastian, Vedel, L., Strachan, R. T., Huang, X., Gavin, A. C., Shah, S. D., Nayak, A. P., Haugaard-Kedström, L. M., Penn, R. B., Roth, B. L., Bräuner, Hans & Gloriam, David E., 31 Oct 2019, In: Cell. 179, 4, p. 895-908

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method

    Frandsen, I. O., Boesgaard, M. W., Fidom, K., Hauser, Alexander Sebastian, Isberg, V., Bräuner, Hans, Wellendorph, Petrine & Gloriam, David E., 6 Jul 2017, In: Scientific Reports. 7, 1, 10 p., 4829.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives

    Fredriksson, R., Höglund, P. J., Gloriam, David E., Lagerström, M. C. & Schiöth, H. B., 20 Nov 2003, In: F E B S Letters. 554, 3, p. 381-8 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini

    Fredriksson, R., Gloriam, David E., Höglund, P. J., Lagerström, M. C. & Schiöth, H. B., 14 Feb 2003, In: Biochemical and Biophysical Research Communications. 301, 3, p. 725-34 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Probing the Existence of a Metastable Binding Site at the β2-Adrenergic Receptor with Homobivalent Bitopic Ligands

    Gaiser, B. I., Danielsen, Mia, Marcher, Emil, Røpke Jørgensen, K., Wróbel, T. M., Frykman, M., Johansson, H., Bräuner, Hans, Gloriam, David E., Mathiesen, Jesper M. & Sejer Pedersen, D., 12 Sep 2019, In: Journal of Medicinal Chemistry. 62, 17, p. 7806-7839 34 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    A ligand's view of target similarity: chemogenomic binding site-directed techniques for drug discovery

    Garland, S. L. & Gloriam, David E., 2011, In: Current Topics in Medicinal Chemistry. 11, 15, p. 1872-1881

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Methods for the successful application of chemogenomics to GPCR drug design

    Garland, S. L. (ed.) & Gloriam, David E. (ed.), 2011, In: Current Topics in Medicinal Chemistry. 11, 15, p. 1870-1871

    Research output: Contribution to journal › Editorial › Research

  31. Published

    Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

    Giraudo, A., Krall, J., Bavo, Francesco, Nielsen, Birgitte, Kongstad, Kenneth Thermann, Rolando, B., De Blasio, R., Gloriam, David E., Löffler, R., Thiesen, L., Harpsøe, Kasper, Frydenvang, Karla Andrea, Boschi, D., Wellendorph, Petrine, Lolli, M. L., Jensen, Anders A. & Frølund, Bente, 27 Jun 2019, In: Journal of Medicinal Chemistry. 62, 12, p. 5797-5809

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Bigger is better in virtual drug screens

    Gloriam, David E., Feb 2019, In: Nature. 566, p. 193-194 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    How can I teach to maximize the learning of “Roberts” (slow/nonambitious) and “Susans” (fast/ambitious)? Improving University Science Teaching and Learning - Pedagogical Projects 2008

    Gloriam, David E., 2008, Improving University Science Teaching and Learning - Pedagogical Projects 2008. Christiansen, F. V., Rump, C. & Degn, L. (eds.). København: Department of Science Education, University of Copenhagen, Denmark, Vol. 1. p. 227-244 18 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education

  34. Published

    Chemogenomics of allosteric binding sites in GPCRs

    Gloriam, David E., 2013, In: Drug Discovery Today: Technologies. 10, 2, p. e307-13

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. High species variation within the repertoire of trace amine receptors

    Gloriam, David E., Bjarnadóttir, T. K., Schiöth, H. B. & Fredriksson, R., Apr 2005, In: Annals of the New York Academy of Sciences. 5 p.

    Research output: Contribution to journal › Conference article › Research

  36. Published

    The repertoire of trace amine G-protein-coupled receptors: large expansion in zebrafish

    Gloriam, David E., Bjarnadóttir, T. K., Yan, Y., Postlethwait, J. H., Schiöth, H. B. & Fredriksson, R., May 2005, In: Molecular Phylogenetics and Evolution. 35, 2, p. 470-82 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship

    Gloriam, David E., Schiöth, H. B. & Fredriksson, R., 15 Apr 2005, In: BBA General Subjects. 1722, 3, p. 235-46 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. The G protein-coupled receptor subset of the rat genome

    Gloriam, David E., Fredriksson, R. & Schiöth, H. B., 2007, In: B M C Genomics. 8, p. 338

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Chemogenomic discovery of allosteric antagonists at the GPRC6A receptor

    Gloriam, David E., Wellendorph, Petrine, Johansen, L. D., Thomsen, A. R. B., Phonekeo, K., Pedersen, D. S. & Bräuner, Hans, 23 Nov 2011, In: Chemistry & Biology. 18, 11, p. 1489-1498

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Definition of the G protein-coupled receptor transmembrane bundle binding pocket and calculation of receptor similarities for drug design

    Gloriam, David E., Foord, S. M., Blaney, F. E. & Garland, S. L., 2009, In: Journal of Medicinal Chemistry. 52, 14, p. 4429-4442

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Kemogenomik: receptoren set fra lægemiddelstoffets synspunkt

    Gloriam, David E., Wellendorph, Petrine, Johansen, L. D., Pedersen, D. S. & Bräuner, Hans, Dec 2010, In: Lægemiddelforskning. 2010, p. 28-30

    Research output: Contribution to journal › Journal article › Communication

  42. Published

    A community standard format for the representation of protein affinity reagents

    Gloriam, D. E. I., Orchard, S., Bertinetti, D., Björling, E., Bongcam-Rudloff, E., Borrebaeck, C. A. K., Bourbeillon, J., Bradbury, A. R. M., de Daruvar, A., Dübel, S., Frank, R., Gibson, T. J., Gold, L., Haslam, N., Herberg, F. W., Hiltke, T., Hoheisel, J. D., Kerrien, S., Koegl, M., Konthur, Z. & 16 others, Korn, B., Landegren, U., Montecchi-Palazzi, L., Palcy, S., Rodriguez, H., Schweinsberg, S., Sievert, V., Stoevesandt, O., Taussig, M. J., Ueffing, M., Uhlén, M., van der Maarel, S., Wingren, C., Woollard, P., Sherman, D. J. & Hermjakob, H., 2010, In: Molecular and Cellular Proteomics. 9, 1, p. 1-10

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations

    Grätz, L., Kowalski-Jahn, M., Scharf, M. M., Kozielewicz, P., Jahn, M., Bous, J., Lambert, N. A., Gloriam, David E. & Schulte, G., 2023, In: Nature Communications. 14, 1, 17 p., 4573.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. The G protein-coupled receptor subset of the dog genome is more similar to that in humans than rodents

    Haitina, T., Fredriksson, R., Foord, S. M., Schiöth, H. B. & Gloriam, David E., 2009, In: B M C Genomics. 10, p. 24

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Structural insight to mutation effects uncover a common allosteric site in class C GPCRs

    Harpsøe, Kasper, Boesgaard, M. W., Munk, C., Bräuner, Hans & Gloriam, David E., 2017, In: Bioinformatics (Oxford, England). 33, 8, p. 1116-1120 5 p., btw784.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors - A Structural Perspective of Ligands and Mutants

    Harpsøe, Kasper, Isberg, V., Tehan, B. G., Weiss, D., Arsova, A., Marshall, F. H., Bräuner, Hans & Gloriam, David E., 11 Sep 2015, In: Scientific Reports. 5, p. 1-11 11 p., 13869.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    GPCR activation mechanisms across classes and macro/microscales

    Hauser, Alexander Sebastian, Kooistra, Albert J., Munk, C., Heydenreich, F. M., Veprintsev, D. B., Bouvier, M., Babu, M. M. & Gloriam, David E., 2021, In: Nature Structural and Molecular Biology. 28, 11, p. 879-888

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Common coupling map advances GPCR-G protein selectivity

    Hauser, Alexander Sebastian, Avet, C., Normand, C., Mancini, A., Inoue, A., Bouvier, M. & Gloriam, David E., 2022, In: eLife. 11, 22 p., e74107.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Novel approaches leading towards peptide GPCR de-orphanisation

    Hauser, Alexander Sebastian, Gloriam, David E., Bräuner, Hans & Foster, S. R., 1 Mar 2020, In: British Journal of Pharmacology. 177, 5, p. 961-968 8 p.

    Research output: Contribution to journal › Review › Research › peer-review

  50. Published

    Pharmacogenomics of GPCR Drug Targets

    Hauser, Alexander Sebastian, Chavali, S., Masuho, I., Jahn, L., Martemyanov, K., Gloriam, David E. & Babu, M., Jan 2018, In: Cell. 172, p. 41–54

    Research output: Contribution to journal › Journal article › Research › peer-review

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