David E. Gloriam

David E. Gloriam

Professor

ORCID: 0000-0002-4299-7561

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  1. Published

    24 Messages on a Sustainable Career in Research at UCPH

    Larsen, K. R. (ed.), Wegener, H. C., Stein, A., Bach, A., Williams, A. R., Gall, C., Gravert, C., Gloriam, D. E., Lorenzen, E., Yvanez, E., Cappellini, E., Poulsen, F., Mortensen, J., Bentzen, J. S., Shik, J. Z., Miskowiak, K. W., Elgaard, K. K. E., Jønsson, K. A., Won, K. J., Nørgaard, L. C. & 9 others, Cantarero Arevalo, Lourdes, Kristiansen, Maria, Lund, Marianne N., Borregaard, Michael Krabbe, Høyland-Kroghsbo, Nina Molin, Iversen, Rune, Viskum, U., Nosch, Marie Louise Bech & Hjorth, Jens, 2020, University of Copenhagen. 31 p.

    Research output: Book/Report › Report › Communication

  2. Published

    3-Substituted 2-phenyl-indoles: Privileged structures for medicinal chemistry

    Johansson, K. H., Jørgensen, T. B., Gloriam, David E., Bräuner, Hans & Pedersen, D. S., 21 Jan 2013, In: R S C Advances. 3, 3, p. 945-960

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

    Peng, Y., McCorvy, J. D., Harpsøe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajsen, L. F., Huang, X., Wu, Y., Shen, L., Bjørn-Yoshimoto, W. E., Ding, K., Wacker, D., Han, G. W., Cheng, J., Katritch, V., Jensen, A. A. & 6 others, Hanson, M. A., Zhao, S., Gloriam, David E., Roth, B. L., Stevens, R. C. & Liu, Z., 2018, In: Cell. 172, 4, p. 719-730 P719-730.E14.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    A Structural Framework for GPCR Chemogenomics: What’s In a Residue Number?

    Vass, M., Kooistra, Albert J., Verhoeven, S., Gloriam, David E., de Esch, I. J. P. & de Graaf, C., 1 Jan 2018, Methods in Molecular Biology. Humana Press, p. 73-113 41 p. (Methods in Molecular Biology, Vol. 1705).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  5. Published

    A community Biased Signaling Atlas

    Caroli, J., Mamyrbekov, A., Harpsøe, Kasper, Gardizi, S., Dörries, L., Ghosh, E., Hauser, Alexander Sebastian, Kooistra, Albert J. & Gloriam, David E., 2023, In: Nature Chemical Biology. 19, p. 531–535

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  6. Published

    A community standard format for the representation of protein affinity reagents

    Gloriam, D. E. I., Orchard, S., Bertinetti, D., Björling, E., Bongcam-Rudloff, E., Borrebaeck, C. A. K., Bourbeillon, J., Bradbury, A. R. M., de Daruvar, A., Dübel, S., Frank, R., Gibson, T. J., Gold, L., Haslam, N., Herberg, F. W., Hiltke, T., Hoheisel, J. D., Kerrien, S., Koegl, M., Konthur, Z. & 16 others, Korn, B., Landegren, U., Montecchi-Palazzi, L., Palcy, S., Rodriguez, H., Schweinsberg, S., Sievert, V., Stoevesandt, O., Taussig, M. J., Ueffing, M., Uhlén, M., van der Maarel, S., Wingren, C., Woollard, P., Sherman, D. J. & Hermjakob, H., 2010, In: Molecular and Cellular Proteomics. 9, 1, p. 1-10

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    A ligand's view of target similarity: chemogenomic binding site-directed techniques for drug discovery

    Garland, S. L. & Gloriam, David E., 2011, In: Current Topics in Medicinal Chemistry. 11, 15, p. 1872-1881

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    A new crystal structure fragment-based pharmacophore method for G protein-coupled receptors

    Fidom, K., Isberg, V., Hauser, Alexander Sebastian, Mordalski, S., Lehto, T., Bojarski, A. J. & Gloriam, David E., Jan 2015, In: Methods. 71, p. 104-112 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    A novel red fluorescence dopamine biosensor selectively detects dopamine in the presence of norepinephrine in vitro

    Nakamoto, C., Goto, Y., Tomizawa, Y., Fukata, Y., Fukata, M., Harpsøe, Kasper, Gloriam, David E., Aoki, K. & Takeuchi, T., 2021, In: Molecular Brain. 14, 1, 14 p., 173.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenges

    Kufareva, I., Katritch, V., Biggin, P., Kim, M., Park, K., Jung, S. W., Cho, A. E., Sands, Z. A., Ostopovici-Halip, L., Bologa, C. G., Norn, C., Brylinski, M., Skolnick, J., Keränen, H., Lenselink, B. E., Van Westen, G., Overington, J. P., De Teráán, H. G., Isberg, V., Fidom, K. M. & 96 others, Lehto, T. M., Gloriam, David E., Ghosh, A., Sonavane, U., Joshi, R., Xia, J., Hsieh, J. H., Zhang, L., Wang, X. S., Vogel, H., Yuan, S., Feng, X., Chen, M., Ambia, J., Barth, P., Gageat, C., Stepniewski, M., Xhaard, H., Kelm, S., Pitt, W. R., Shi, J., Larsen, A., Li, H., Wagner, J., Bhattacharya, S., Vaidehi, N., Kanou, K., Cvicek, V., Kim, S. K., Trzaskowski, B., Goddard, W. A., Abrol, R., Selvam, B., Tikhonova, I. G., Cuzzolin, A., Sabbadin, D., Ciancetta, A., Moro, S., Freyd, T., Gabrielsen, M., Kristiansen, K., Sylte, I., Gaffney, K. J., Petasis, N. A., Latek, D., Bajda, M., Młynarczyk, K., Filipek, S., López, L., Kuiper, M., Beuming, T., Perez-Aguilar, J. M., Wang, R. Y. R., Park, H., Greisen, P., Song, Y., DiMaio, F., Baker, D., Shin, W. H., Heo, L., Lee, G. R., Seok, C., Yang, J., Zhang, Y., Ponassi, M., Rosano, C., Cheremovskiy, G., Grudinin, S., Chaudhari, R., Heim, A. J., Li, Z., Lv, Q., Grigorov, M. G., Hu, X., Sun, H., Shen, M., Southall, N., Jadhav, A., Rodríguez, D., Ranganathan, A., Carlsson, J., Najmanovich, R., Durdagi, S., De March, C., Diharce, J., Golebiowski, J., Antonczak, S., Fiorucci, S., Nguyen, E., Meiler, J., Gutcaits, A., Marti-Solano, M., Pastor, M., Selent, J., Stevens, R. C. & Abagyan, R., 2014, In: Structure. 22, 8, p. 1120-1139 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    An online GPCR structure analysis platform

    Kooistra, Albert J., Munk, C., Hauser, Alexander Sebastian & Gloriam, David E., 2021, In: Nature Structural and Molecular Biology. 28, 11, p. 875-878

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    An online resource for GPCR structure determination and analysis

    Munk, C., Mutt, E., Isberg, V., Nikolajsen, L. F., Bibbe, J. M., Flock, T., Hanson, M. A., Stevens, R. C., Deupi, X. & Gloriam, David E., 2019, In: Nature Methods. 16, 2, p. 151-162

    Research output: Contribution to journal › Review › Research › peer-review

  13. Published

    Applying label-free dynamic mass redistribution assay for studying endogenous FPR1 receptor signalling in human neutrophils

    Christensen, H. B., Gloriam, David E., Pedersen, D. S., Cowland, J. B., Borregaard, N. & Bräuner, Hans, 15 Jul 2017, In: Journal of Pharmacological and Toxicological Methods. 88, Pt 1, p. 72-78 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Bigger is better in virtual drug screens

    Gloriam, David E., Feb 2019, In: Nature. 566, p. 193-194 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Binding Mode of a Novel MPEP-Derived Metabotropic Glutamate Receptor Subtype 5 (mGluR5) NAM, 1,3-Bis(pyridin-2-ylethynyl)Benzene

    Molck, C., Harpsøe, Kasper, Gloriam, David E., Kaae, B. H., Jimenez, H. N., Uberti, M. A., Topiol, S., Clausen, Rasmus Prætorius, Madsen, Ulf, Nielsen, S. M., Mathiesen, Jesper M. & Bräuner, Hans, Sep 2011, In: Current Neuropharmacology. 9, p. 43-43

    Research output: Contribution to journal › Conference abstract in journal › Research

  16. Published

    Chemogenomic discovery of allosteric antagonists at the GPRC6A receptor

    Gloriam, David E., Wellendorph, Petrine, Johansen, L. D., Thomsen, A. R. B., Phonekeo, K., Pedersen, D. S. & Bräuner, Hans, 23 Nov 2011, In: Chemistry & Biology. 18, 11, p. 1489-1498

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Chemogenomics of allosteric binding sites in GPCRs

    Gloriam, David E., 2013, In: Drug Discovery Today: Technologies. 10, 2, p. e307-13

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Combinatorial expression of GPCR isoforms affects signalling and drug responses

    Marti-Solano, M., Crilly, S. E., Malinverni, D., Munk, C., Harris, M., Pearce, A., Quon, T., Mackenzie, A. E., Wang, X., Peng, J., Tobin, A. B., Ladds, G., Milligan, G., Gloriam, David E., Puthenveedu, M. A. & Babu, M. M., 2020, In: Nature. 587, p. 650-656 28 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Common coupling map advances GPCR-G protein selectivity

    Hauser, Alexander Sebastian, Avet, C., Normand, C., Mancini, A., Inoue, A., Bouvier, M. & Gloriam, David E., 2022, In: eLife. 11, 22 p., e74107.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Community guidelines for GPCR ligand bias: IUPHAR review 32

    Kolb, P., Kenakin, T., Alexander, S. P. H., Bermudez, M., Bohn, L. M., Breinholt, C. S., Bouvier, M., Hill, S. J., Kostenis, E., Martemyanov, K. A., Neubig, R. R., Onaran, H. O., Rajagopal, S., Roth, B. L., Selent, J., Shukla, A. K., Sommer, M. E. & Gloriam, David E., 2022, In: British Journal of Pharmacology. 179, 14, p. 3651-3674

    Research output: Contribution to journal › Review › Research › peer-review

  21. Published

    Comprehensive Peptide Cyclization Examination Yields Optimized APP Scaffolds with Improved Affinity toward Mint2

    Bartling, Christian Reinhard Otto, Alexopoulou, Flora, Kuschert, S., Chin, Y. K. Y., Jia, X., Sereikaité, Vita, Özcelik, D., Jensen, T. M., Jain, P., Nygaard, M. M., Harpsøe, Kasper, Gloriam, David E., Mobli, M. & Strømgaard, Kristian, 2023, In: Journal of Medicinal Chemistry. 66, 4, p. 3045-3057

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Comprehensive comparisons of the current human, mouse, and rat RefSeq, Ensembl, EST, and FANTOM3 datasets: identification of new human genes with specific tissue expression profile

    Nordström, K. J. V., Mirza, M. A. I., Larsson, T. P., Gloriam, David E., Fredriksson, R. & Schiöth, H. B., 29 Sep 2006, In: Biochemical and Biophysical Research Communications. 348, 3, p. 1063-74 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse

    Bjarnadóttir, T. K., Gloriam, David E., Hellstrand, S. H., Kristiansson, H., Fredriksson, R. & Schiöth, H. B., Sep 2006, In: Genomics. 88, 3, p. 263-73 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Computer-aided discovery of aromatic L-α-amino acids as agonists of the orphan G protein-coupled receptor GPR139

    Ísberg, V., Andersen, K. B., Bisig, C., Dietz, G. P., Bräuner, Hans & Gloriam, David E., 14 May 2014, In: Journal of Chemical Information and Modeling. 54, 6, p. 1553-1557 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat

    Babbitt, P. C., Bagos, P. G., Bairoch, A., Bateman, A., Chatonnet, A., Chen, M. J., Craik, D. J., Finn, R. D., Gloriam, D., Haft, D. H., Henrissat, B., Holliday, G. L., Isberg, V., Kaas, Q., Landsman, D., Lenfant, N., Manning, G., Nagano, N., Srinivasan, N., O’Donovan, C. & 9 others, Pruitt, K. D., Sowdhamini, R., Rawlings, N. D., Saier, M. H., Sharman, J. L., Spedding, M., Tsirigos, Konstantinos, Vastermark, A. & Vriend, G., 18 May 2015, In: Database: The Journal of Biological Databases and Curation. 2015, p. 1-5 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 5953796