Elisabeth Rexen Ulven
Associate Professor
Medicinal Chemistry
Jagtvej 162
2100 København Ø
- 2024
- Published
Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance
Dragano, N. R. V., Milbank, E., Haddad-Tóvolli, R., Garrido-Gil, P., Nóvoa, E., Fondevilla, M. F., Capelli, V., Zanesco, A. M., Solon, C., Morari, J., Pires, L., Estevez-Salguero, Á., Beiroa, D., González-García, I., Barca-Mayo, O., Diéguez, C., Nogueiras, R., Labandeira-García, J. L., Rexen Ulven, E., Ulven, T. & 3 others, , 2024, In: Molecular Metabolism. 79, 13 p., 101840.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-Activity Relationship Studies and Optimization of 4-Hydroxypyridones as GPR84 Agonists
Ieremias, L., Kaspersen, M. H., Manandhar, Asmita, Schultz-Knudsen, Katrine, Vrettou, C. I., Pokhrel, R., Heidtmann, C. V., Jenkins, L., Kanellou, C., Marsango, S., Li, Y., Bräuner, Hans, Ulven, Elisabeth Rexen, Milligan, G. & Ulven, Trond, 2024, In: Journal of Medicinal Chemistry. 67, 5, p. 3542-3570Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Development and Characterization of Potent Succinate Receptor Fluorescent Tracers
Ciba, Marija, Dibnah, B., Hudson, B. D. & Ulven, Elisabeth Rexen, 2023, In: Journal of Medicinal Chemistry. 66, 13, p. 8951–8974Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists
Valentini, Alice, Schultz-Knudsen, Katrine, Hansen, A. H., Tsakoumagkou, A., Jenkins, L., Christensen, H. B., Manandhar, Asmita, Milligan, G., Ulven, Trond & Ulven, Elisabeth Rexen, 2023, In: Journal of Medicinal Chemistry. 66, 9, p. 6105–6121Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucose-stimulated insulin secretion depends on FFA1 and Gq in neonatal mouse islets
Lorza-Gil, E., Kaiser, G., Carlein, C., Hoffmann, M. D. A., König, G. M., Haug, S., Prates Roma, L., Ulven, Elisabeth Rexen, Ulven, Trond, Kostenis, E., Birkenfeld, A. L., Häring, H. U., Ullrich, S. & Gerst, F., 2023, In: Diabetologia. 66, p. 1501–1515Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ligand entry pathways control the chemical space recognized by GPR183
Kjær, Viktoria Madeline Skovgaard, Stępniewski, T. M., Medel-Lacruz, B., Reinmuth, L., Ciba, Marija, Ulven, Elisabeth Rexen, Bonomi, M., Selent, J. & Rosenkilde, Mette, 2023, In: Chemical Science. 14, 39, p. 10671-10683Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Chemogenetics defines a short-chain fatty acid receptor gut-brain axis
Barki, N., Bolognini, D., Börjesson, U., Jenkins, L., Riddell, J., Hughes, D. I., Ulven, Trond, Hudson, B. D., Ulven, Elisabeth Rexen, Dekker, N., Tobin, A. B. & Milligan, G., 2022, In: eLife. 11, 23 p., e73777.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Acute effects of delayed-release hydrolyzed pine nut oil on glucose tolerance, incretins, ghrelin and appetite in healthy humans
Sørensen, K. V., Korfitzen, S. S., Kaspersen, M. H., Ulven, Elisabeth Rexen, Ekberg, J. H., Bauer-Brandl, A., Ulven, Trond & Højlund, K., 2021, In: Clinical Nutrition. 40, 4, p. 2169-2179Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-Activity Relationship Explorations and Discovery of a Potent Antagonist for the Free Fatty Acid Receptor 2
Hansen, A. H., Christensen, H. B., Pandey, S. K., Sergeev, E., Valentini, Alice, Dunlop, J., Dedeo, D., Fratta, S., Hudson, B. D., Milligan, G., Ulven, Trond & Ulven, Elisabeth Rexen, 2021, In: ChemMedChem. 16, 21, p. 3326-3341Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Structure-Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators
Ulven, Elisabeth Rexen, Quon, T., Sergeev, E., Barki, N., Brvar, M., Hudson, B. D., Dutta, P., Hansen, A. H., Bielefeldt, L. Ø., Tobin, A. B., McKenzie, C. J., Milligan, G. & Ulven, Trond, 9 Apr 2020, In: Journal of Medicinal Chemistry. 63, 7, p. 3577-3595 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells
Lorza-Gil, E., Kaiser, G., Ulven, Elisabeth Rexen, Koenig, G. M., Gerst, F., Oquendo, M. B., Birkenfeld, A. L., Haering, H., Kostenis, E., Ulven, Trond & Ullrich, S., 2020, In: Scientific Reports. 10, 1, 11 p., 16497.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Kan fedtsyrer bruges som medicin?
Ulven, Elisabeth Rexen, Jul 2019, In: Aktuel Naturvidenskab. 2019, 3, p. 19-22Research output: Contribution to journal › Journal article › Communication
- 2018
- Published
Dihydropyridine Fluorophores Allow for Specific Detection of Human Antibodies in Serum
Domljanovic, I., Ulven, Elisabeth Rexen, Ulven, Trond, Thomsen, R. P., Okholm, A. H., Kjems, J., Voss, A., Taskova, M. & Astakhova, K., 31 Jul 2018, In: ACS Omega. 3, 7, p. 7580-7586 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties
Hansen, A. H., Sergeev, E., Bolognini, D., Sprenger, R. R., Ekberg, J. H., Ejsing, C. S., McKenzie, C. J., Ulven, Elisabeth Rexen, Milligan, G. & Ulven, Trond, 2018, In: Journal of Medicinal Chemistry. 61, 21, p. 9534-9550 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1
Ulven, Elisabeth Rexen, Trauelsen, Mette, Brvar, M., Lückmann, Michael, Bielefeldt, L. Ø., Jensen, L. K. I., Schwartz, Thue W. & Frimurer, Thomas Michael, 2018, In: Scientific Reports. 8, 1, p. 1-18 10010.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91
Trauelsen, Mette, Ulven, Elisabeth Rexen, Hjorth, Siv Annegrethe, Brvar, M., Monaco, C., Frimurer, Thomas Michael & Schwartz, Thue W., Dec 2017, In: Molecular Metabolism. 6, 12, p. 1585-1596 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43)
Hansen, A. H., Sergeev, E., Pandey, S. K., Hudson, B. D., Ulven, Elisabeth Rexen, Milligan, G. & Ulven, Trond, 2017, In: Journal of Medicinal Chemistry. 60, 13, p. 5638-5645 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation
Dragano, N. R. V., Solon, C., Ramalho, A. F., de Moura, R. F., Razolli, D. S., Ulven, Elisabeth Rexen, Goncalves de Azavedo, C. M. B. P., Ulven, Trond & Velloso, L. A., 2017, In: Journal of Neuroinflammation. 14, 91, 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-based discovery of novel US28 small molecule ligands with different modes of action
Lückmann, Michael, Amarandi, R., Papargyri, N., Jakobsen, M. H., Ulven, Elisabeth Rexen, Jensen, Lars Juhl, Pui, A., Schwartz, Thue W., Rosenkilde, Mette & Frimurer, Thomas Michael, 2017, In: Chemical Biology & Drug Design. 89, 3, p. 289–296Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area and Robust in Vivo Efficacy
Hansen, S. V. F., Ulven, Elisabeth Rexen, Urban, C., Hudson, B. D., Stocker, C. J., Due-Hansen, M. E., Wargent, E. T., Shimpukade, B., Almeida, R., Ejsing, C. S., Cawthorne, M. A., Kassack, M. U., Milligan, G. & Ulven, Trond, 1 Mar 2016, In: Journal of Medicinal Chemistry. 59, 6, p. 2841-2846 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
A protocol for amide bond formation with electron deficient amines and sterically hindered substrates
Due-Hansen, M. E., Pandey, S. K., Ulven, Elisabeth Rexen, Andersen, R., Hansen, S. V. F. & Ulven, Trond, 2016, In: Organic & Biomolecular Chemistry. 14, 2, p. 430-433 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer
Ulven, Elisabeth Rexen, Hudson, B. D., Hansen, A. H., Milligan, G. & Ulven, Trond, 2016, In: Journal of Medicinal Chemistry. 59, 10, p. 4849-4858 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity
Goncalves de Azavedo, C. M. B. P., Watterson, K. R., Wargent, E. T., Hansen, S. V. F., Hudson, B. D., Kępczyńska, M. A., Dunlop, J., Shimpukade, B., Ulven, Elisabeth Rexen, Milligan, G., Stocker, C. J. & Ulven, Trond, 2016, In: Journal of Medicinal Chemistry. 59, 19, p. 8868-8878 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Dietary Fatty Acids and Their Potential for Controlling Metabolic Diseases Through Activation of FFA4/GPR120
Ulven, Trond & Ulven, Elisabeth Rexen, 17 Jul 2015, In: Annual Review of Nutrition. 35, p. 239-263 25 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases
Ulven, Elisabeth Rexen, Watterson, K. R., Stocker, C. J., Sokol, E., Jenkins, L., Simon, K., Grundmann, M., Petersen, R. K., Wargent, E. T., Hudson, B. D., Kostenis, E., Ejsing, C. S., Cawthorne, M. A., Milligan, G. & Ulven, T., 2015, In: British Journal of Nutrition. 113, 11, p. 1677-1688 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 201719978
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606
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Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
277
downloads
Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
140
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Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1
Research output: Contribution to journal › Journal article › Research › peer-review
Published