Henrik Franzyk
Associate Professor
Glycopeptide Mimics of Mammalian Man9GlcNAc2. Ligand Binding to Mannan Binding Proteins (MBPs)
Franzyk, Henrik, Meldal, M., Paulsen, H., Thiel, S., Jensenius, J. C. & Bock, K., 1996, In: Bioorganic and Medicinal Chemistry. 4, p. 1881-1899 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Guide til Rapportskrivning i Kurset Biopharmaceuticals: Bioorganisk Kemi 2018
Franzyk, Henrik, 2018, 17 p.Research output: Book/Report › Compendium/lecture notes
Halohydrins and Polyols Derived from Antirrhinoside: Structural Revision of Muralioside and Epimuralioside
Franzyk, Henrik, Jensen, S. R., Thale, Z. & Olsen, C. E., 1999, In: Journal of Natural Products. 62, p. 275-278 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High in vitro antimicrobial activity of ß-peptoid-peptide hybrid oligomers against planktonic and biofilm cultures of Staphylococcus epidermidis
Liu, Y., Knapp, K. M., Yang, L., Molin, S., Franzyk, Henrik & Folkesson, A., 2013, In: International Journal of Antimicrobial Agents. 41, 1, p. 20-27 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High-resolution PTP1B inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of PTP1B inhibitors from Miconia albicans
Lima, R. D. C. L., Kongstad, Kenneth Thermann, Kato, L., José das Silva, M., Franzyk, Henrik & Stærk, Dan, 2018, In: Molecules. 23, 7, 13 p., 1755.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Highly cationic cell-penetrating peptides affect the barrier integrity and facilitates mannitol permeation in a human stem cell-based blood-brain barrier model
Frøslev, Patrick, Franzyk, Henrik, Ozgür, Burak, Larsen, Birger Brodin & Kristensen, Mie, 2022, In: European Journal of Pharmaceutical Sciences. 168, 10 p., 106054.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human plasma potentiates antibacterial effect of peptidomimetics against Gram-negative and Gram-positive pathogenic bacteria
Citterio, L., A, K., K, H., Franzyk, Henrik & Gram, L., 2014.Research output: Contribution to conference › Poster › Research
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Hurtige genveje til nye lægemidler
Olsen, Christian Adam, Franzyk, Henrik & Jaroszewski, J. W., 2003, In: Lægemiddelforskning. 2003, p. 8-9 2 p.Research output: Contribution to journal › Journal article › Communication
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Hyaluronic Acid-Based Nanogels Produced by Microfluidics-Facilitated Self-Assembly Improves the Safety Profile of the Cationic Host Defense Peptide Novicidin
Water, J. J., Kim, Y., Maltesen, M. J., Franzyk, Henrik, Foged, Camilla & Nielsen, Hanne Mørck, Aug 2015, In: Pharmaceutical Research. 32, 8, p. 2727-35 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Håb om at ramme latente bakterier i deres skjul
Bahnsen, J. S., Water, J. J., Foged, Camilla, Franzyk, Henrik & Nielsen, Hanne Mørck, 2012, In: Lægemiddelforskning 2012. 2012, p. 12-14Research output: Contribution to journal › Journal article › Research
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Identification and characterization of a new antifungal peptide in fermented milk product containing bioprotective Lactobacillus cultures
McNair, Laura M., Siedler, S., Vinther, J. M., Hansen, A. M., Neves, A. R., Jäger, A. K., Franzyk, Henrik & Stærk, Dan, 2018, In: F E M S Yeast Research. 18, 9 p., foy094.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of Factors of Importance for Spray Drying of Small Interfering RNA-Loaded Lipidoid-Polymer Hybrid Nanoparticles for Inhalation
Dormenval, C., Lokras, Abhijeet, Cano-Garcia, G., Wadhwa, A., Thanki, K., Rose, F., Thakur, A., Franzyk, Henrik & Foged, Camilla, 2019, In: Pharmaceutical Research. 36, 10, 142.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Iminolactones as Tools for Inversion of the Absolute Configuration of alpha-Amino Acids and as Inhibitors of Cancer Cell Proliferation
Jensen, C. M., Chow, H., Chen, M., Zhai, L., Frydenvang, Karla Andrea, Liu, H., Franzyk, Henrik & Christensen, Søren Brøgger, 2016, In: European Journal of Medicinal Chemistry. 114, p. 118-133 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Immune responses induced by nano-self-assembled lipid adjuvants based on a monomycoloyl glycerol analogue after vaccination with the Chlamydia trachomatis major outer membrane protein
Rodrigues, L., Raftopoulos, K. N., Tandrup Schmidt, S., Schneider, F., Dietz, H., Rades, Thomas, Franzyk, Henrik, Pedersen, Anders Elm, Papadakis, C. M., Christensen, D., Winter, G., Foged, Camilla & Hubert, M., 10 Sep 2018, In: Journal of controlled release : official journal of the Controlled Release Society. 285, p. 12-22 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design
de Groot, A. M., Thanki, K., Gangloff, M., Falkenberg, E., Zeng, X., van Bijnen, D. C. J., van Eden, W., Franzyk, Henrik, Nielsen, Hanne Mørck, Broere, F., Gay, N. J., Foged, Camilla & Sijts, A. J. A. M., 1 Jun 2018, In: Molecular Therapy - Nucleic Acids. 11, p. 159-169 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Improved in vitro evaluation of novel antimicrobials: potential synergy between human plasma and antibacterial peptidomimetics, AMPs, or antibiotics against human pathogenic bacteria
Citterio, L., Franzyk, Henrik, Palarasah, Y., Andersen, T. E., Mateiu, R. V. & Gram, L., Feb 2016, In: Research in Microbiology. 167, 2, p. 72-82 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Improving the safety profile of an antimicrobial peptide: Self-assembly into hydrogel nanoparticles using microfluidics
Water, J. J., Maltesen, M. J., Foged, Camilla, Franzyk, Henrik & Nielsen, Hanne Mørck, 2014.Research output: Contribution to conference › Poster › Research › peer-review
- Published
In vivo Anti-inflammatory Activity of Lipidated Peptidomimetics Pam-(Lys-βNspe)6-NH2 and Lau-(Lys-βNspe)6-NH2 Against PMA-Induced Acute Inflammation
Wu, B. C., Skovbakke, S. L., Masoudi, H., Hancock, R. E. W. & Franzyk, Henrik, 2020, In: Frontiers in Immunology. 11, 11 p., 2102.Research output: Contribution to journal › Journal article › Research › peer-review
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Incorporation of a synthetic mycobacterial monomycoloyl glycerol analogue stabilizes dimethyldioctadecylammonium liposomes and potentiates their adjuvant effect in vivo
Nordly, P. J., Korsholm, K. S., Pedersen, E. A., Khilji, T. S., Franzyk, Henrik, Jørgensen, Lene, Nielsen, Hanne Mørck, Agger, E. M. & Foged, Camilla, 2011, In: European Journal of Pharmaceutics and Biopharmaceutics. 77, 1, p. 89-98Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Incorporation of the Cross Fire Beilstein database in the organic chemistry curriculum at the Royal Danish School of Pharmacy
Christensen, Søren Brøgger, Franzyk, Henrik, Frølund, Bente, Jaroszewski, J. W., Stærk, Dan & Vedsø, P., 2002, In: Journal of Chemical Education. 79, p. 765-768Research output: Contribution to journal › Journal article › Research
- Published
Incorporation of the crossfire Beilstein database into the organic chemistry curriculum at the Royal Danish School of Pharmacy
Christensen, Søren Brøgger, Franzyk, Henrik, Frølund, Bente, Jaroszewski, J. W., Stærk, Dan & Vedsø, P., 1 Jun 2002, In: Journal of Chemical Education. 79, 6, 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Induction of antimicrobial activity against ESBL and NDM-1 producing Escherichia coli by peptide backbone modifications - a comparative study
Jahnsen, R. O., Frimodt-Møller, N. & Franzyk, Henrik, 2012.Research output: Contribution to conference › Poster › Research
- Published
Influence of trehalose 6,6'-diester (TDX) chain length on the physicochemical and immunopotentiating properties of DDA/TDX liposomes
Kallerup, R. S., Madsen, C. M., Schiøth, M. L., Franzyk, Henrik, Rose, F., Christensen, D., Korsholm, K. S. & Foged, Camilla, 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 90, p. 80-89 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhalable Composite Microparticles Containing siRNA-Loaded Lipid-Polymer Hybrid Nanoparticles: Saccharides and Leucine Preserve Aerosol Performance and Long-Term Physical Stability
Xu, You, Turan, E. T., Shi, Z., Franzyk, Henrik, Thakur, A. & Foged, Camilla, 2022, In: Frontiers in Drug Delivery. 2, 15 p., 945459.Research output: Contribution to journal › Journal article › Research › peer-review
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Inoculum effect of antimicrobial peptides
Loffredo, M. R., Savini, F., Bobone, S., Casciaro, B., Franzyk, Henrik, Mangoni, M. L. & Stella, L., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 21, 10 p., e2014364118.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insights into the mechanisms of interaction between inhalable lipid-polymer hybrid nanoparticles and pulmonary surfactant
Xu, Y., Parra-Ortiz, E., Wan, F., Cañadas, O., Garcia-Alvarez, B., Thakur, A., Franzyk, Henrik, Pérez-Gil, J., Malmsten, Martin & Foged, Camilla, 2023, In: Journal of Colloid and Interface Science. 633, p. 511-525Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intact penetratin metabolite permeates across Caco-2 monolayers
Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 2015.Research output: Contribution to conference › Poster › Research
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Interaction of peptidomimetics with bilayer membranes: biophysical characterization and cellular uptake
Jing, X., Kasimova, M. R., Simonsen, A. H., Jørgensen, Lene, Malmsten, M., Franzyk, Henrik & Foged, Camilla, 2012, In: Langmuir. 28, 11, p. 5167-5175Research output: Contribution to journal › Journal article › Research › peer-review
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Iridoid Glucosides from Myxopyrum s milacifolium
Franzyk, Henrik, Jensen, S. R. & Olsen, C. E., May 2001, In: Journal of Natural Products.Research output: Contribution to journal › Journal article › Research › peer-review
Iridoid Glucosides from Penstemon secundiflorus and P. grandiflorus: Revised Structure of 10-hydroxy-8-epihastatoside
Franzyk, Henrik, Stermitz, F. R. & Jensen, S. R., 1998, In: Phytochemistry. 49, p. 2025-2030 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Iridoid Glucosides from Phlomis tuberosa L. and Phlomis herba-ventis L
Alipieva, K. I., Jensen, S. R., Franzyk, Henrik, Handjieva, N. V. & Evstatieva, L. N., 2000, In: Zeitschrift für Naturforschung C - A Journal of Biosciences. 55c, p. 137-140 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Iridoid Glucosides from Picconia excelsa
Damtoft, S., Franzyk, Henrik & Jensen, S. R., 1997, In: Phytochemistry. 45, p. 743-750 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Iridoid Glycoside Biosynthesis in Penstemon Secundiflorus. Another H-5,H-9 Trans-Iridoid Glycoside
Krull, R. E., Stermitz, F. R., Franzyk, Henrik & Jensen, S. R., 1998, In: Phytochemistry. 49, p. 1605-1608 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Iridoid glucosides from Myxopyrum smilacifolium
Franzyk, Henrik, Jensen, S. R. & Olsen, C. E., 2001, In: Journal of Natural Products. 64, 5, p. 632-3 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
Iridoids and Verbascosides in Retzia
Damtoft, S., Franzyk, H., Jensen, S. R. & Nielsen B.J., D. S. ,. F. H. ,. J. S. R. &. N. B. J., 1993, In: Phytochemistry. 34, p. 239-243Research output: Contribution to journal › Journal article › Research › peer-review
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Jagten på kongens efterfølger
Franzyk, Henrik, Björkling, Fredrik, Nielsen, J. & Nielsen, Peter E., 2015, In: Lægemiddelforskning. 2015, p. 24-27 4 p.Research output: Contribution to journal › Journal article › Communication
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Kunstige forsvarspeptider
Olsen, Christian Adam, Franzyk, Henrik & Jaroszewski, J. W., 2006, In: Lægemiddelforskning. p. 18-19 2 p.Research output: Contribution to journal › Journal article › Communication
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Lactam hybrid analogues of solonamide B and autoinducing peptides as potent S. aureus AgrC antagonists
Hansen, A. M., Peng, P., Baldry, M., Perez-Gassol, I., Christensen, S. B., Vinther, J. M., Ingmer, Hanne & Franzyk, Henrik, 2018, In: European Journal of Medicinal Chemistry. 152, p. 370-376 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Leucine improves the aerosol performance of dry powder inhaler formulations of siRNA-loaded nanoparticles
Xu, Y., Harinck, L., Lokras, Abhijeet, Gerde, P., Selg, E., Sjöberg, C., Franzyk, Henrik, Thakur, A. & Foged, Camilla, 2022, In: International Journal of Pharmaceutics. 621, 14 p., 121758.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Linking activity and mode of action to length in a novel peptidomimetics library
Hein-Kristensen, L., Franzyk, Henrik & Gram, L., 2010.Research output: Contribution to conference › Poster › Research
- Published
Lipid nanoparticles for local delivery of mRNA to the respiratory tract: Effect of PEG-lipid content and administration route
Ongun, Melike, Lokras, Abhijeet, Baghel, Saahil Sandeep, Shi, Zhenning, Schmidt, S. T., Franzyk, Henrik, Rades, Thomas, Sebastiani, Federica, Thakur, A. & Foged, Camilla, 2024, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 198, 10 p., 114266.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies
Thanki, K., Thakur, A., de Groot, A. M., Geyer, A., Fraire, J., Falkenberg, E., Van Eygen, H., Putteman, E., Van Bijnen, D. C. J., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, H., Broere, F., van Eden, W., Sijts, A. J. A. M., Ogris, M., Nielsen, H. M., Braeckmans, K. & 1 others, , 2018.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Lipidated α-Peptide/β-Peptoid Hybrids with Potent Anti-inflammatory Activity
Skovbakke, S. L., Larsen, C. J., Heegaard, P. M. H., Moesby, L. & Franzyk, Henrik, 2015, In: Journal of Medicinal Chemistry. 58, 2, p. 801-813 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lipidoid-Polymer Hybrid Nanoparticles Loaded with TNF siRNA Suppress Inflammation after Intra-articular Administration in a Murine Experimental Arthritis Model
Jansen, M. A. A., Klausen, L. H., Thanki, K., Lyngsø, J., Skov Pedersen, J., Franzyk, Henrik, Nielsen, Hanne Mørck, van Eden, W., Dong, M., Broere, F., Foged, Camilla & Zeng, X., 2019, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 142, p. 38-48Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Loading of an antimicrobial peptide into PLGA nanoparticles increases its efficacy against intracellular Staphylococcus aureus infection in the Calu-3 bronchial epithelial cell line
Water, J. J., Foged, Camilla, Franzyk, Henrik & Nielsen, Hanne Mørck, 2013.Research output: Contribution to conference › Poster › Research › peer-review
- Published
Lysine-Based α-peptide/β-peptoid peptidomimetics: Influence of hydrophobicity, fluorination and distribution of cationic charge on antimicrobial activity and cytotoxicity
Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro, Nielsen, Hanne Mørck & Franzyk, Henrik, 2017, In: ChemMedChem. 12, p. 312-318 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lægemidler fra naturstoffer: fortid eller fremtid?
Jaroszewski, J. W., Christensen, Søren Brøgger, Franzyk, Henrik, Stærk, Dan & Ziegler, H., 2008, In: Lægemiddelforskning. p. 4-6Research output: Contribution to journal › Journal article › Communication
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Macrolide Resistance and In Vitro Potentiation by Peptidomimetics in Porcine Clinical Escherichia coli
Ma, Y., Pirolo, Mattia, Subramani, P., Gehring, R., Damborg, Peter Panduro, Franzyk, Henrik & Guardabassi, Luca, 2022, In: mSphere. 7, 5, 10 p., e0040222.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Macrophage phosphoproteome analysis reveals MINCLE-dependent and -independent mycobacterial cord factor signaling
Hansen, M., Peltier, J., Killy, B., Amin, B., Bodendorfer, B., Härtlova, A., Uebel, S., Bosmann, M., Hofmann, J., Büttner, C., Ekici, A. B., Kuttke, M., Franzyk, Henrik, Foged, Camilla, Beer-Hammer, S., Schabbauer, G., Trost, M. & Lang, R., Apr 2019, In: Molecular and Cellular Proteomics. 18, 4, p. 669-685Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration
Thanki, K., van Eetvelde, D., Geyer, A., Fraire, J., Hendrix, R., Van Eygen, H., Putteman, E., Sami, H., de Souza Carvalho-Wodarz, C., Franzyk, Henrik, Nielsen, Hanne Mørck, Braeckmans, K., Lehr, C., Ogris, M. & Foged, Camilla, 2019, In: Journal of controlled release : official journal of the Controlled Release Society. 310, p. 82-93Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1302063
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2002
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Erythrocyte membrane modifying agents and the inhibition of Plasmodium falciparum growth: structure-activity relationships for betulinic acid analogues
Research output: Contribution to journal › Journal article › Research › peer-review
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1600
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Prolonged Shelf Life in Fermented Milk Products Investigated by Bioassay-Guided Chemometrics
Research output: Contribution to conference › Poster › Research
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1278
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Non-natural Amino Acid and Peptoid Building Blocks for Optimization of the Cell-Penetrating (R-X-R)n Motif
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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