Jesper Langgaard Kristensen

Jesper Langgaard Kristensen

Professor

ORCID: 0000-0002-5613-1267

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  1. Published

    Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors

    Petersen, I. N., Crestey, F., Jensen, Anders A., Indurthi, D. C., Pedersen, H., Andreasen T., Jesper, Balle, T. & Kristensen, Jesper Langgaard, 9 Apr 2015, In: A C S Medicinal Chemistry Letters. 6, 4, p. 472-475 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Tweaking agonist efficacy at N-methyl-D-aspartate receptors by site-directed mutagenesis

    Hansen, K. B., Clausen, Rasmus Prætorius, Bjerrum, E. J., Bechmann, C., Greenwood, J. R., Christensen, C., Kristensen, Jesper Langgaard, Egebjerg, J. & Bräuner, Hans, Dec 2005, In: Molecular Pharmacology. 68, 6, p. 1510-23

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Trans-cyclooctene-functionalized PeptoBrushes with improved reaction kinetics of the tetrazine ligation for pretargeted nuclear imaging: [Meeting Abstract]

    Steen, J., Norregard, K., Johann, K., Jørgensen, Jesper Tranekjær, Svatunek, D., Birke, A., Edem, P., Rossin, R., Seidl, C., Schmid, F., Robillard, M., Mikula, H., Kristensen, Jesper Langgaard, Barz, M., Kjær, Andreas & Herth, Matthias Manfred, May 2019, In: Journal of Labelled Compounds and Radiopharmaceuticals. 62, Supl. 1/SI, p. S109-S110

    Research output: Contribution to journal › Conference abstract in journal › Research

  4. Published

    Trans-Cyclooctene-Functionalized PeptoBrushes with Improved Reaction Kinetics of the Tetrazine Ligation for Pretargeted Nuclear Imaging

    Stéen, E. J. L., Jørgensen, Jesper Tranekjær, Johann, K., Norregaard, K., Sohr, B., Svatunek, D., Birke, A., Shalgunov, Vladimir, Edem, P. E., Rossin, R., Seidl, C., Schmid, F., Robillard, M. S., Kristensen, Jesper Langgaard, Mikula, H., Barz, M., Kjær, Andreas & Herth, Matthias Manfred, 2020, In: ACS Nano. 14, 1, p. 568-584

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Towards the Dual Click F-18-labeling of Antibodies

    Steen, J., Denk, C., Norregaard, K., Jorgensen, J., Rossin, R., Svatunek, D., Edem, P., Robillard, M., Kjær, Andreas, Kristensen, Jesper Langgaard, Mikula, H. & Herth, Matthias Manfred, 1 May 2018.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  6. Published

    Total synthesis of ascididemin via anionic cascade ring closure

    Petersen, I. N., Crestey, F. & Kristensen, Jesper Langgaard, 2012, In: Chemical Communications. 48, 72, p. 9092-9094

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice

    Odland, Anna Ulstein, Kristensen, Jesper Langgaard & Andreasen T., Jesper, 2021, In: Behavioural Pharmacology. 32, 5, p. 448-452

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    The selective 5-HT2A receptor agonist 25CN-NBOH: structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics of [3H]25CN-NBOH

    Jensen, Anders A., Halberstadt, A. L., Marcher, Emil, Odland, Anna Ulstein, Chatha, M., Speth, N., Liebscher, G., Hansen, M., Bräuner, Hans, Palner, M., Andreasen T., Jesper & Kristensen, Jesper Langgaard, 2020, In: Biochemical Pharmacology. 177, 16 p., 113979.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    The importance of small polar radiometabolites in molecular neuroimaging: A PET study with [11C]Cimbi-36 labeled in two positions

    Johansen, A., Hansen, H. D., Svarer, C., Lehel, S., Leth-Petersen, S., Kristensen, Jesper Langgaard, Gillings, N. & Knudsen, Gitte Moos, Apr 2018, In: Journal of Cerebral Blood Flow and Metabolism. 38, 4, p. 659-668

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    The Alkaloids from Lophophora diffusa and Other “False Peyotes”

    Chan, Camilla Bachmand, Poulie, Christian Bernard Matthijs, Wismann, S. S., Soelberg, Jens & Kristensen, Jesper Langgaard, 2021, In: Journal of Natural Products. 84, 8, p. 2398–2407

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    The 5-hydroxytryptamine 2A receptor agonists DOI and 25CN-NBOH decrease marble burying and reverse 8-OH-DPAT-induced deficit in spontaneous alternation

    Odland, Anna Ulstein, Jessen, L., Kristensen, Jesper Langgaard, Fitzpatrick, C. M. & Andreasen T., Jesper, 2021, In: Neuropharmacology. 183, 9 p., 107838.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Textbook of Drug Design and Discovery: In vivo imaging in drug discovery

    Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 2017, Textbook of Drug Design and Discovery. Fifth edition ed. CRC Press

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  13. Published

    Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors

    Lohse, B., Nielsen, A. L., Kristensen, J. B. L., Helgstrand, C., Cloos, P. A. C., Olsen, L., Gajhede, Michael, Clausen, Rasmus Prætorius & Kristensen, Jesper Langgaard, 19 Sep 2011, In: Angewandte Chemie International Edition. 50, 39, p. 9100-9103

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Synthesis, radiofluorination, and preliminary evaluation of the potential 5-HT2A receptor agonists [18 F]Cimbi-92 and [18 F]Cimbi-150

    Edgar, F. G., Hansen, H. D., Leth-Petersen, S., Ettrup, A., Kristensen, Jesper Langgaard, Knudsen, Gitte Moos & Herth, Matthias Manfred, Oct 2017, In: Journal of Labelled Compounds and Radiopharmaceuticals. 60, 12, p. 586-591 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Synthesis, cross-coupling, and anionic cyclization of ortho-substituted naphthaleneboronic esters

    Lysén, M., Madden, M., Kristensen, Jesper Langgaard, Vedsø, P., Zöllner, C. & Begtrup, M., 17 Oct 2006, In: Synthesis. 20, p. 3478-3484 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Synthesis of tertiary benzamides via Pd-catalyzed coupling of arylboronic esters and carbamoyl chlorides

    Lysén, M., Kelleher, S., Begtrup, M. & Kristensen, Jesper Langgaard, 24 Jun 2005, In: Journal of Organic Chemistry. 70, 13, p. 5342-5343 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Synthesis of substituted 2-cyanoarylboronic esters

    Lysén, M., Hansen, H. M., Begtrup, M. & Kristensen, Jesper Langgaard, 17 Mar 2006, In: Journal of Organic Chemistry. 71, 6, p. 2518-20 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Synthesis of pentacyclic 13-azadibenzo[a,de]anthracenes via anionic cascade ring closure

    Kristensen, Jesper Langgaard, Vedsø, P. & Begtrup, M., 16 May 2003, In: Journal of Organic Chemistry. 68, 10, p. 4091-4092 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Synthesis of ortho substituted arylboronic esters by in situ trapping of unstable lithio intermediates: 2-(5,5-Dimethyl-1,3,2-dioxaborinan-2-YL)Benzoic acid ethyl ester: [Benzoic acid, 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-, ethyl ester]

    Kristensen, Jesper Langgaard, Lysén, M., Vedsø, P. & Begtrup, M., 1 Jan 2005, In: Organic Syntheses. 81, p. 134-139 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Synthesis of novel azaxanthones derived from N-hydroxyazoles

    Kristensen, Jesper Langgaard, Vedsø, P. & Begtrup, M., 18 Mar 2002, In: Tetrahedron. 58, 12, p. 2397-2404 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Synthesis of enantiopure 3-substituted morpholines

    Bornholdt, J., Felding, J. & Kristensen, Jesper Langgaard, 2010, In: Journal of Organic Chemistry. 75, 21, p. 7454-7457

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Synthesis of azaphenanthridines via anionic ring closure

    Hansen, H. M., Lysén, M., Begtrup, M. & Kristensen, Jesper Langgaard, 17 Oct 2005, In: Tetrahedron. 61, 42, p. 9955-9960 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Synthesis of RHPS4 via an anionic ring closing cascade

    Kristensen, Jesper Langgaard, 2008, In: Tetrahedron Letters. 49, 15, p. 2351-2354

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Synthesis of Pyridoacridines through Anionic Cascade Ring Closure

    Petersen, I. N. & Kristensen, Jesper Langgaard, 1 Jan 2014, In: Synthesis. 46, p. 1469-1474 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Synthesis of Ortho Substituted Arylboronic Esters by in Situ Trapping of Unstable Lithio Intermediates

    Kristensen, Jesper Langgaard, Lysén, M., Vedsø, P. & Begtrup, M., 17 May 2001, In: Organic Letters. 3, 10, p. 1435-1437 3 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  26. Published

    Synthesis of N-alkylated amino acids using fluorous-tagged hydroxylamines

    Nielsen, S. D., Smith, G. P., Begtrup, M. & Kristensen, Jesper Langgaard, 22 Jul 2011, In: Tetrahedron. 67, 29, p. 5261-5267

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Synthesis of 4-substituted 1-(benzyloxy)pyrazoles via iodine-magnesium exchange of 1-(benzyloxy)-4-iodopyrazole

    Felding, J., Kristensen, Jesper Langgaard, Bjerregaard, T., Sander, L., Vedsø, P. & Begtrup, M., 28 May 1999, In: Journal of Organic Chemistry. 64, 11, p. 4196-4198 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Synthesis of (R)-(-)-2-fluoronorapomorphine - A precursor for the synthesis of (R)-(-)-2-fluoro-N-[C]propylnorapomorphine for evaluation as a dopamine D agonist ligand for PET investigations

    Søndergaard, K., Kristensen, Jesper Langgaard, Gillings, N. & Begtrup, M., 14 Oct 2005, In: European Journal of Organic Chemistry. 20, p. 4428-4433 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists

    Hansen, M., Phonekeo, K., Paine, J. S., Leth-Petersen, S., Begtrup, M., Bräuner, Hans & Kristensen, Jesper Langgaard, 7 Jan 2014, In: A C S Chemical Neuroscience. 5, 3, p. 243-249 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Synthesis and stability study of a new major metabolite of gamma-hydroxybutyric acid

    Petersen, I. N., Kristensen, Jesper Langgaard, Tortzen, C., Breindahl, T. & Pedersen, D. S., 2013, In: Beilstein Journal of Organic Chemistry. 9, p. 641-646 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists

    Hansen, M., Jacobsen, S. E., Plunkett, S., Liebscher, G. E., McCorvy, J. D., Bräuner, Hans & Kristensen, Jesper Langgaard, 2015, In: Bioorganic & Medicinal Chemistry. 23, 14, p. 3933-3937 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Synthesis and pharmacological evaluation of DHβE analogs as neuronal nicotinic acetylcholine receptor antagonists

    Jepsen, T. H., Jensen, Anders A., Lund, M. H., Glibstrup, E. & Kristensen, Jesper Langgaard, 2014, In: A C S Medicinal Chemistry Letters. 5, 7, p. 766-770 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Synthesis and evaluation of [C-11]CIMBI-712 and [C-11]CIMBI-772

    Andersen, V. L., Herth, Matthias Manfred, Hansen, H. D., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, May 2013, p. S101-S101.

    Research output: Contribution to conference › Conference abstract for conference › Research

  34. Published

    Synthesis and evaluation of [11C]Cimbi-806 as a potential PET ligand for 5-HT7 receptor imaging

    Herth, Matthias Manfred, Hansen, H. D., Ettrup, A. J., Dyssegaard, A., Lehel, S., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, 2012, In: Bioorganic and Medicinal Chemistry. 20, 14, p. 4574-4581 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Synthesis and evaluation of 18F-labeled 5-HT2A receptor agonists as PET ligands

    Herth, Matthias Manfred, Petersen, I. N., Hansen, H. D., Hansen, M., Ettrup, A., Jensen, Anders A., Lehel, S., Dyssegaard, A., Gillings, N., Knudsen, G. M. & Kristensen, Jesper Langgaard, 19 Apr 2016, In: Nuclear Medicine and Biology. 43, 8, p. 455-462 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Synthesis and characterisation of substrate-based peptides as inhibitors of histone demethylase KDM4C

    Nielsen, S. D., Leurs, U., Bergner, M., Barris, S. A., Devkota, K., Meyer, K., Iaria, D., McCaughan, J., Lohse, B., Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 13 Jun 2016, In: Protein and Peptide Letters. 23, 9, p. 772 - 776 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as ¿-aminobutyric acidA receptor agonists

    Petersen, J. G., Bergmann, R., Møller, H. A., Jørgensen, Charlotte Grube, Nielsen, Birgitte, Kehler, J., Frydenvang, Karla Andrea, Kristensen, Jesper Langgaard, Balle, T., Jensen, Anders A., Kristiansen, Uffe & Frølund, Bente, 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 993-1006

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Synthesis and binding studies of 2-arylapomorphines

    Søndergaard, K., Kristensen, Jesper Langgaard, Palner, M., Gillings, N., Knudsen, Gitte Moos, Roth, B. & Begtrup, M., 21 Nov 2005, In: Organic & Biomolecular Chemistry. 3, 22, p. 4077-4081 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Synthesis and application of a new fluorous-tagged ammonia equivalent

    Nielsen, S. D., Smith, G., Begtrup, M. & Kristensen, Jesper Langgaard, 2010, In: Chemistry: A European Journal. 16, 15, p. 4557-4566

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Synthesis and SAR study of a novel series of dopamine receptor agonists

    Risgaard, R., Jensen, M., Jørgensen, M., Bang-Andersen, B., Christoffersen, C. T., Jensen, K. G., Kristensen, Jesper Langgaard & Püschl, A., 1 Jan 2014, In: Bioorganic and Medicinal Chemistry. 22, 1, p. 381-392

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Synthesis and In Vitro Evaluation of Oxindole Derivatives as Potential Radioligands for 5-HT7 Receptor Imaging with PET

    Herth, Matthias Manfred, Volk, B., Pallagi, K., Koefoed Bech, L., A. Antoni, F., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 31 Aug 2012, In: ACS Chemical Neuroscience. 3, 12, p. 1002-1007

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C

    Leurs, U., Lohse, B., Rand, Kasper Dyrberg, Ming, S., Riise, E. S., Cole, P. A., Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 11 Jul 2014, In: A C S Chemical Biology. 9, 9, p. 2131-2138 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Structure–Activity Assessment and In-Depth Analysis of Biased Agonism in a Set of Phenylalkylamine 5-HT2A Receptor Agonists

    Pottie, E., Poulie, Christian Bernard Matthijs, Simon, Icaro A, Harpsøe, Kasper, D’Andrea, L., Komarov, I. V., Gloriam, David E., Jensen, Anders A., Kristensen, Jesper Langgaard & Stove, C. P., 2023, In: ACS Chemical Neuroscience. 14, 15, p. 2727–2742

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Structure-activity relationships of constrained phenylethylamine ligands for the serotonin 5-ht2 receptors

    Isberg, V., Paine, J., Leth-Petersen, S., Kristensen, Jesper Langgaard & Gloriam, David E., 2013, In: P L o S One. 8, 11, e78515.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Stereoselective synthesis of highly substituted bicyclic γ-lactones using homoaldol addition of 1-(1-cycloalkenyl)methyl carbamates

    Özlügedik, M., Kristensen, Jesper Langgaard, Reuber, J., Fröhlich, R. & Hoppe, D., 1 Oct 2004, In: Synthesis. 14, p. 2303-2316 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Snegleprotein øger forståelsen af vigtige receptorer i hjernen

    Shahsavar, Azadeh, Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael, Balle, T. & Kastrup, Jette Sandholm Jensen, 2012, In: Lægemiddelforskning. 2012, p. 48-50 3 p.

    Research output: Contribution to journal › Journal article › Communication

  47. Published

    Serotonin 2A receptor agonist binding in the human brain with [C]Cimbi-36

    Ettrup, A., da Cunha-Bang, S., McMahon, B. P., Lehel, S., Dyssegaard, A., Skibsted, A. W., Jørgensen, Louise Møller, Hansen, M., Baandrup, A. O., Bache, S., Svarer, C., Kristensen, Jesper Langgaard, Gillings, N., Madsen, J. & Knudsen, Gitte Moos, 30 Apr 2014, In: Journal of Cerebral Blood Flow and Metabolism. 34, p. 1188-1196 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Ring opening of pymisyl-protected aziridines with organocuprates

    Bornholdt, J., Felding, J., Clausen, Rasmus Prætorius & Kristensen, Jesper Langgaard, 2010, In: Chemistry: A European Journal. 16, 41, p. 12474-12480

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Radiosynthesis and in vivo evaluation of novel radioligands for PET imaging of cerebral 5-HT7 receptors

    Hansen, H. D., Herth, Matthias Manfred, Ettrup, A., Andersen, V. L., Lehel, S., Dyssegaard, A., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, 24 Feb 2014, In: Journal of Nuclear Medicine. 55, 4, p. 640-646

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers

    Ettrup, A., Hansen, M., Santini, M. A., Paine, J. S., Gillings, N., Palner, M., Lehel, S., Herth, Matthias Manfred, Madsen, J., Kristensen, Jesper Langgaard, Begtrup, M. & Knudsen, Gitte Moos, 1 Apr 2011, In: European Journal of Nuclear Medicine and Molecular Imaging. 38, 4, p. 681-693

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 1305029