Jette Sandholm Jensen Kastrup
Professor
Structural Biology
Universitetsparken 2
2100 København Ø
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Ionotropic glutamate receptor GluA2 in complex with bicyclic pyrimidinedione-based compounds: when small compound modifications have distinct effects on binding interactions
Frydenvang, Karla Andrea, Pickering, Darryl S, Kshirsagar, G. U., Chemi, G., Gemma, S., Sprogøe, D., Kærn, A. M., Brogi, S., Campiani, G., Butini, S. & Kastrup, Jette Sandholm Jensen, 2020, In: ACS Chemical Neuroscience. 11, 12, p. 1791-1800Research output: Contribution to journal › Journal article › Research › peer-review
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Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine
Frydenvang, Karla Andrea, Lash, L. L., Naur, P., Postila, P. A., Pickering, Darryl S, Smith, C. M., Gajhede, Michael, Sasaki, M., Sakai, R., Pentikäinen, O. T., Swanson, G. T. & Kastrup, Jette Sandholm Jensen, 2009, In: Journal of Biological Chemistry. 284, 21, p. 14219-14229Research output: Contribution to journal › Journal article › Research › peer-review
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At være eller ikke være en antagonist
Frydenvang, Karla Andrea, Naur, P., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2009, In: Lægemiddelforskning. p. 43-45Research output: Contribution to journal › Journal article › Communication
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På jagt efter et virkningssted i hjernen
Frydenvang, Karla Andrea, Juknaite, L. & Kastrup, Jette Sandholm Jensen, 2013, In: Lægemiddelforskning. p. 50-52 3 p.Research output: Contribution to journal › Journal article › Communication
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Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid
Frydenvang, Karla Andrea, Pickering, Darryl S, Greenwood, J. R., Krogsgaard-Larsen, N., Brehm, L., Nielsen, Birgitte, Vogensen, S. B., Hald, H., Kastrup, Jette Sandholm Jensen, Krogsgaard-Larsen, Povl & Clausen, Rasmus Prætorius, 10 Nov 2010, In: Journal of Medicinal Chemistry. 53, 23, p. 8354-8361Research output: Contribution to journal › Journal article › Research › peer-review
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7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency
Goffin, E., Drapier, T., Larsen, A. P., Geubelle, P., Ptak, C. P., Laulumaa, S., Rovinskaja, K., Gilissen, J., Tullio, P. D., Olsen, L., Frydenvang, Karla Andrea, Pirotte, B., Hanson, J., Oswald, R. E., Kastrup, Jette Sandholm Jensen & Francotte, P., Jan 2018, In: Journal of Medicinal Chemistry. 61, 1, p. 251–264Research output: Contribution to journal › Journal article › Research › peer-review
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Peptide nucleic acids (PNA) derived from N-(N-methylamino-ethyl)glycine. Synthesis, hybridization and structural roperties
Haaima, G., Rasmussen, H. B., Schmidt, G., Jensen, D. K., Kastrup, Jette Sandholm Jensen, Stafshede, P. W., Nordén, B., Buchardt, O. & Nielsen, Peter E., 1999, In: New. J. Chem.. 23, p. 833-840 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2
Hald, H., Ahring, P. K., Timmermann, D. B., Liljefors, T., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2009, In: Journal of Molecular Biology. 391, 5, p. 906-917Research output: Contribution to journal › Journal article › Research › peer-review
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Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: Structures of the ligand-bining core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid
Hald, H., Naur, P., Pickering, Darryl S, Sprogøe, D., Madsen, Ulf, Timmermann, D. B., Ahring, P. K., Liljefors, T., Schousboe, Arne, Egebjerg, J., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2007, In: Journal of Biological Chemistry. 282, 35, p. 25726-25736Research output: Contribution to journal › Journal article › Research › peer-review
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Modulation of the dimer interface at ionotropic glutamate-like receptor d2 by D-serine and extracellular calcium
Hansen, K. B., Naur, P., Kurtkaya, N. L., Kristensen, Anders Skov, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Traynelis, S. F., 2009, In: Journal of Neuroscience. 29, 4, p. 907-917Research output: Contribution to journal › Journal article › Research › peer-review
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Computeren viser vejen til et nyt potentielt lægemiddel
Harpsøe, Kasper, Kaae, B. H., Balle, T., Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 2008, In: Lægemiddelforskning. p. 28-30Research output: Contribution to journal › Journal article › Communication
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Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors
Harpsøe, Kasper, Hald, H., Timmermann, D. B., Jensen, M. L., Dyhring, T., Nielsen, E. Ø., Peters, D., Balle, T., Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Ahring, P. K., 25 Jan 2013, In: Journal of Biological Chemistry. 288, 4, p. 2559-2570 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core
Hogner, A., Kastrup, Jette Sandholm Jensen, Jin, R., Liljefors, T., Mayer, M. L., Egebjerg, J., Larsen, I. K. & Gouaux, E., 6 Sep 2002, In: Journal of Molecular Biology. 322, 1, p. 93-109 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX
Hogner, A., Greenwood, J. R., Liljefors, T., Lunn, M., Egebjerg, J., Larsen, I. K., Gouaux, E. & Kastrup, Jette Sandholm Jensen, 16 Jan 2003, In: Journal of Medicinal Chemistry. 46, 2, p. 214-21 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2
Holm, M. M., Lunn, M., Traynelis, S. F., Kastrup, Jette Sandholm Jensen & Egebjerg, J., 23 Aug 2005, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 34, p. 12053-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure and function of the N-linked glycans of HBP/CAP37/azurocidin: crystal structure determination and biological characterization of nonglycosylated HBP
Iversen, L. F., Kastrup, Jette Sandholm Jensen, Bjørn, S. E., Wiberg, F. C., Larsen, I. K., Flodgaard, H. J. & Rasmussen, P. B., Oct 1999, In: Protein Science. 8, 10, p. 2019-26 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystallization and molecular replacement solution of human heparin binding protein
Iversen, L. F., Kastrup, Jette Sandholm Jensen, Larsen, I. K., Bjørn, S. E., Rasmussen, P. B., Wiberg, F. C. & Flodgaard, H. J., 1996, In: Acta Crystallographica. Section D: Biological Crystallography. 52, p. 1222-1223 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of HBP, a multifunctional protein with a serine proteinase fold
Iversen, L. F., Kastrup, Jette Sandholm Jensen, Bjørn, S. E., Wiberg, F. C., Flodgaard, H. J. & Larsen, I. K., 1997, In: Nature Struc. Biology. 4, p. 265-268 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of the allosteric binding pocket of human liver fructose-1,6-bisphosphatase by protein crystallography and inhibitor activity studies
Iversen, L. F., Brzozowski, M., Hastrup, S., Larsen, I. K., Kastrup, Jette Sandholm Jensen, Nærum, L., Nørskov-Lauridsen, L., Rasmussen, P. B., Thim, L., Wiberg, F. C. & Lundgren, K., 1997, In: Protein Sci.. 6, p. 971-982 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of fenpropiomorph picrate
Kastrup, Jette Sandholm Jensen & Jensen, B., 1990, In: Acta Cryst.. C46, p. 779-781 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of [4S,5S,7S,8S]-11-Hydroxy-1(10)-guaien-8-yl-[1S]-(1-phenyl)-ethylcarbamate
Kastrup, Jette Sandholm Jensen, Lemmich, E. & Gajhede, M., 1991, In: Acta Cryst.. C47, p. 1559-1561 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational analysis of the fungicide fenpropimorph by molecular mechanics calculations and NMR spectroscopy
Kastrup, Jette Sandholm Jensen, Jørgensen, Flemming Steen, Klemmensen, P. D., Hacksell, U. & Petersson, I., 1992, In: Journal of Pesticide Science. 36, p. 309-318 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gennembrud i forståelsen af insulinfibrillering
Jensen, M. G., Vestergaard, Bente, Frøkjær, Sven, Gajhede, Michael, Flink, J. M., van de Weert, Marco, Kastrup, Jette Sandholm Jensen & Svergun, D. I., 2007, In: Lægemiddelforskning. p. 10-11Research output: Contribution to journal › Journal article › Communication
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Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity
Johannessen, B. R., Skov, L., Kastrup, Jette Sandholm Jensen, Kristensen, O., Bolwig, C., Larsen, J., Spangfort, M., Lund, K. & Gajhede, Michael, 2005, In: F E B S Letters. 579, 5, p. 1208-12 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization
Juknaite, L., Sugamata, Y., Tokiwa, K., Ishikawa, Y., Takamizawa, S., Eng, A., Sakai, R., Pickering, Darryl S, Frydenvang, Karla Andrea, Swanson, G. T., Kastrup, Jette Sandholm Jensen & Oikawa, M., 2013, In: Journal of Medicinal Chemistry. 56, 6, p. 2283-2293Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of rat acidic fibroblast growth factor at 1.4 A resolution.
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