Karla Andrea Frydenvang

Karla Andrea Frydenvang

Associate Professor

Introductory remarks on publicationslist

See Homepage for complete list of publications (incl. all publications from before 2007)
  1. Published

    GABA-A and GABA-B receptor Agonists, Partial Agonists and Modulators. design and Therapeutic Prospects

    Frølund, Bente, Krogsgaard-Larsen, Povl, Kristiansen, Uffe, Frydenvang, Karla Andrea & Ebert, B., 1997, In: European Journal of Pharmaceutical Sciences. 4, p. 355–384

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

    Giraudo, A., Krall, J., Bavo, Francesco, Nielsen, Birgitte, Kongstad, Kenneth Thermann, Rolando, B., De Blasio, R., Gloriam, David E., Löffler, R., Thiesen, L., Harpsøe, Kasper, Frydenvang, Karla Andrea, Boschi, D., Wellendorph, Petrine, Lolli, M. L., Jensen, Anders A. & Frølund, Bente, 27 Jun 2019, In: Journal of Medicinal Chemistry. 62, 12, p. 5797-5809

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency

    Goffin, E., Drapier, T., Larsen, A. P., Geubelle, P., Ptak, C. P., Laulumaa, S., Rovinskaja, K., Gilissen, J., Tullio, P. D., Olsen, L., Frydenvang, Karla Andrea, Pirotte, B., Hanson, J., Oswald, R. E., Kastrup, Jette Sandholm Jensen & Francotte, P., Jan 2018, In: Journal of Medicinal Chemistry. 61, 1, p. 251–264

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Glutamate receptor ligands: synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs

    Guldbrandt, M., Johansen, Tommy Nørskov, Frydenvang, Karla Andrea, Bräuner, Hans, Stensbøl, T. B., Nielsen, Birgitte, Karla, R., Santi, F., Krogsgaard-Larsen, Povl & Madsen, Ulf, 2002, In: Chirality. 14, 4, p. 351-63 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Crystal structures of a pair of diastereomeric 3-(N,N-dimethylammonium)-1,1-diphenyl-1-butanol O,O′-di-p-toloyl hydrogen tartrates

    Hansen, L. M., Frydenvang, Karla Andrea, Jensen, B. & Liljefors, T., Jul 1998, In: Journal of Chemical Crystallography. 28, 7, p. 545-553 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Crystal structures of a pair of diastereomeric 3-(N,N-dimethylammonium)-1,1-diphenyl-1-butanol hydrogen tartrates

    Hansen, L. M., Frydenvang, Karla Andrea & Jensen, B., Feb 1998, In: Journal of Chemical Crystallography. 28, 2, p. 125-132 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

    Hassan, A. R., El-Kousy, S. M., El-Toumy, S. A., Frydenvang, Karla Andrea, Tung, T. T., Olsen, J., Nielsen, J. & Christensen, Søren Brøgger, 27 Oct 2017, In: Journal of Natural Products. 80, p. 2830-2834 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Advances towards aromatic oligoamide foldamers: synthesis and X-ray structures of dimeric arylopeptoids with conformation-directing side chains

    Hjelmgaard, T., Plesner, M., Dissing, M. M., Andersen, J. M., Frydenvang, Karla Andrea & Nielsen, J., 2014, In: European Journal of Organic Chemistry. 2014, 19, p. 3971-3975 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Novel high-affinity and selective biaromatic 4-substituted ¿-hydroxybutyric acid (GHB) analogues as GHB ligands: design, synthesis, and binding studies

    Høg, S., Wellendorph, Petrine, Nielsen, Birgitte, Frydenvang, Karla Andrea, Dahl, I. F., Bräuner, Hans, Brehm, L., Frølund, Bente & Clausen, Rasmus Prætorius, 2008, In: Journal of Medicinal Chemistry. 51, 24, p. 8088-8095

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Carbamoylcholine homologs: synthesis and pharmacology at nicotinic acetylcholine receptors

    Jensen, Anders A., Mikkelsen, I. B., Frølund, Bente, Frydenvang, Karla Andrea, Brehm, L., Jaroszewski, J. W., Bräuner, Hans, Falch, E. & Krogsgaard-Larsen, Povl, 2004, In: European Journal of Pharmacology. 497, 2, p. 125-37 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Iminolactones as Tools for Inversion of the Absolute Configuration of alpha-Amino Acids and as Inhibitors of Cancer Cell Proliferation

    Jensen, C. M., Chow, H., Chen, M., Zhai, L., Frydenvang, Karla Andrea, Liu, H., Franzyk, Henrik & Christensen, Søren Brøgger, 2016, In: European Journal of Medicinal Chemistry. 114, p. 118-133 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published
  13. Published

    Synthesis and structure-activity studies on acidic amino acids and related diacids as NMDA receptor ligands

    Johansen, Tommy Nørskov, Frydenvang, Karla Andrea, Ebert, B., Krogsgaard-Larsen, Povl & Madsen, Ulf, 1994, In: Journal of Medicinal Chemistry. 37, 20, p. 3252-62 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA

    Johansen, Tommy Nørskov, Stensbøl, T. B., Nielsen, Birgitte, Vogensen, S. B., Frydenvang, Karla Andrea, Sløk, F. A., Bräuner, Hans, Madsen, Ulf & Krogsgaard-Larsen, Povl, 2001, In: Chirality. 13, 9, p. 523-32 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid: resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors

    Johansen, Tommy Nørskov, Janin, Y. L., Nielsen, Birgitte, Frydenvang, Karla Andrea, Bräuner, Hans, Stensbøl, T. B., Vogensen, S. B., Madsen, Ulf & Krogsgaard-Larsen, Povl, 2002, In: Bioorganic & Medicinal Chemistry. 10, 7, p. 2259-66 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors

    Johansen, Tommy Nørskov, Greenwood, J. R., Frydenvang, Karla Andrea, Madsen, Ulf & Krogsgaard-Larsen, Povl, 2003, In: Chirality. 15, 2, p. 167-79 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization

    Juknaite, L., Sugamata, Y., Tokiwa, K., Ishikawa, Y., Takamizawa, S., Eng, A., Sakai, R., Pickering, Darryl S, Frydenvang, Karla Andrea, Swanson, G. T., Kastrup, Jette Sandholm Jensen & Oikawa, M., 2013, In: Journal of Medicinal Chemistry. 56, 6, p. 2283-2293

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors

    Juknaite, L., Venskutonyte, R., Assaf, Z., Faure, S., Gefflaut, T., Aitken, D. J., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Bunch, Lennart, Frydenvang, Karla Andrea & Pickering, Darryl S, 2012, In: Journal of Structural Biology. 180, 1, p. 39-46

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published
  20. Published

    Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4

    Kasper, C., Frydenvang, Karla Andrea, Naur, P., Gajhede, Michael, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 2008, In: FEBS Letters. 582, 29, p. 4089-4094

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Solid forms of amlodipine besylate: Physiochemical, structural, and thermodynamic characterization

    Koradia, V. S., Lopez de Diego, H., Frydenvang, Karla Andrea, Ringkjøbing-Elema, M., Mullertz, Anette , Bond, A. D. & Rantanen, Jukka, 28 Oct 2010, In: Crystal Growth & Design. 10, 12, p. 5279-5290

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    A perdeuterated cryoprotectant for neutron studies and a demonstration of its use for neutron powder diffraction on L-(--)-ephedrine hemihydrate

    Krebs, F. C., Jørgensen, M., Lebech, B. & Frydenvang, Karla Andrea, 2001, In: Journal of Applied Crystallography. 34, 2, p. 203-207 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain

    Krintel, C., Frydenvang, Karla Andrea, Ceravalls de Rabassa, A., Kaern, A. M., Gajhede, Michael, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 27 Mar 2014, In: F E B S Journal. p. 2422–2430 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2

    Krintel, C., Francotte, P., Pickering, Darryl S, Juknaite, L., Pøhlsgaaard, J., Olsen, L., Frydenvang, Karla Andrea, Goffin, E., Pirotte, B. & Kastrup, Jette Sandholm Jensen, 2016, In: Biophysical Journal. 110, 11, p. 2397-2406 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain

    Krintel, C., Harpsøe, Kasper, Zachariassen, L. G., Peters, D., Frydenvang, Karla Andrea, Pickering, Darryl S, Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2013, In: Acta Crystallographica Section D: Structural Biology. 69, Pt 9, p. 1645-1652 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2

    Krintel, C., Frydenvang, Karla Andrea, Olsen, L., Kristensen, M. T., de Barrios, O., Naur, P., Francotte, P., Pirotte, B., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 1 Jan 2012, In: Biochemical Journal. 441, 1, p. 173-178

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Structure of a High-Affinity Kainate Receptor: GluK4 Ligand-Binding Domain Crystallized with Kainate

    Kristensen, O., Kristensen, L. B., Møllerud, S., Frydenvang, Karla Andrea, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 2016, In: Structure. 24, 9, p. 1582-1589 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published
  29. Published

    Syntheses of aza-analogous iso-ergoline scaffolds using carbene mediated C-H insertion

    Krogsgaard-Larsen, N., Begtrup, M., Frydenvang, Karla Andrea & Kehler, J., 20 Nov 2010, In: Tetrahedron. 66, 47, p. 9297-9303

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid

    Krogsgaard-Larsen, N., Storgaard, M., Møller, C., Demmer, C. S., Hansen, J., Han, L., Monrad, R. N., Nielsen, Birgitte, Tapken, D., Pickering, Darryl S, Kastrup, Jette Sandholm Jensen, Frydenvang, Karla Andrea & Bunch, Lennart, 2015, In: Journal of Medicinal Chemistry. 58, 15, p. 6131-50 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects

    Krogsgaard-Larsen, Povl, Frølund, Bente & Frydenvang, Karla Andrea, 2000, In: Current Pharmaceutical Design. 6, 12, p. 1193-209 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    GABA(A) and GABA(B) receptor agonists, partial agonists, antagonists and modulators: Design and therapeutic prospects

    Krogsgaard-Larsen, Povl, Frølund, Bente, Kristiansen, Uffe, Frydenvang, Karla Andrea & Ebert, B., Nov 1997, In: European Journal of Pharmaceutical Sciences. 5, 6, p. 355-384 30 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors

    Larsen, A. P., Francotte, P., Frydenvang, Karla Andrea, Tapken, D., Goffin, E., Fraikin, P., Caignard, D., Lestage, P., Danober, L., Pirotte, B. & Kastrup, Jette Sandholm Jensen, 16 Mar 2016, In: A C S Chemical Neuroscience. 7, 3, p. 378-90 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors

    Larsen, A. P., Fièvre, S., Frydenvang, Karla Andrea, Francotte, P., Pirotte, B., Kastrup, Jette Sandholm Jensen & Mulle, C., Jun 2017, In: Molecular Pharmacology. 91, 6, p. 576-585 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    UV-Guided isolation of alantrypinone, a novel Penicillium alkaloid

    Larsen, T. O., Frydenvang, Karla Andrea, Frisvad, J. C. & Christophersen, C., 1998, In: Journal of Natural Products. 61, 9, p. 1154-7 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    A convenient large-scale chiral synthesis of protected 2-substituted 4-oxo-piperidine derivatives

    Lau, J. F., Kruse Hansen, T., Paul Kilburn, J., Frydenvang, Karla Andrea, Holsworth, D. D., Ge, Y., Uyeda, R. T., Judge, L. M. & Sune Andersen, H., 2 Sep 2002, In: Tetrahedron. 58, 36, p. 7339-7344 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor

    Laulumaa, S., Hansen, K. V., Masternak, M., Drapier, T., Francotte, P., Pirotte, B., Frydenvang, Karla Andrea & Kastrup, Jette Sandholm Jensen, 14 Mar 2019, In: ACS Medicinal Chemistry Letters. 10, 3, p. 243-247 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published
  39. Published

    Iminolactones from Schizophyllum commune

    Liu, X., Frydenvang, Karla Andrea, Liu, H., Zhai, L., Chen, M., Olsen, C. E. & Christensen, Søren Brøgger, 2015, In: Journal of Natural Products. 78, 5, p. 1165-1168 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors

    Madsen, Ulf, Bräuner, Hans, Frydenvang, Karla Andrea, Hvene, L., Johansen, Tommy Nørskov, Nielsen, Birgitte, Sánchez, C., Stensbøl, T. B., Bischoff, F. & Krogsgaard-Larsen, Povl, 2001, In: Journal of Medicinal Chemistry. 44, 7, p. 1051-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    N-methyl-D-aspartic acid receptor agonists: resolution, absolute stereochemistry, and pharmacology of the enantiomers of 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid

    Madsen, Ulf, Frydenvang, Karla Andrea, Ebert, B., Johansen, Tommy Nørskov, Brehm, L. & Krogsgaard-Larsen, Povl, 1996, In: Journal of Medicinal Chemistry. 39, 1, p. 183-90 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Lessons from crystal structures of kainate receptors

    Møllerud, S., Frydenvang, Karla Andrea, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 1 Jan 2017, In: Neuropharmacology. 112, Part A, p. 16-28 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    N-(7-(1H-imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)benzamide - a new kainate receptor selective antagonist and analgesic: Synthesis, X-ray crystallography, structure-affinity relationships, in vitro and in vivo pharmacology

    Møllerud, S., Hansen, R. B., Pallesen, J. S., Temperini, Piero, Pasini, D., Bornholdt, J., Nielsen, Birgitte, Mamedova, Esmira, Chalupnik, P., Paternain, A. V., Lerma, J., Del Castillo, M. D., Andreasen T., Jesper, Frydenvang, Karla Andrea, Kastrup, Jette Sandholm Jensen, Johansen, Tommy Nørskov & Pickering, Darryl S, 2019, In: ACS Chemical Neuroscience. 10, p. 4685-4695 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Structure and affinity of two bicyclic glutamate analogues at AMPA and kainate receptors

    Møllerud, S., Pinto, A., Marconi, L., Frydenvang, Karla Andrea, Thorsen, T. S., Laulumaa, S. K., Venskutonyte, R., Winther, Nikolaj Sebastian, Cunado Moral, A. M., Tamborini, L., Conti, P., Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 2017, In: A C S Chemical Neuroscience. 8, 9, p. 2056-2064 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Pharmacology and crystal structure of novel 2,3-quinoxalinediones at kainate receptors

    Møllerud, S., Pallesen, J. S., Pasini, D., Marconi, L., Han, L., Bornholt, J., Johansen, Tommy Nørskov, Kastrup, Jette Sandholm Jensen, Pickering, Darryl S & Frydenvang, Karla Andrea, Aug 2017, In: Journal of Neurochemistry. 142, S1, p. 124 1 p., MTU07-13.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  46. Published

    Assessment of the combined approach of N-alkylation and salt formation to enhance aqueous solubility of tertiary amines using bupivacaine as a model drug

    Nielsen, A. B., Frydenvang, Karla Andrea, Liljefors, T., Buur, A. & Larsen, C., 2005, In: European Journal of Pharmaceutical Sciences. 24, 1, p. 85-93 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    The ribonucleotide reductase R1 inhibitor N-acetyl-N,Ο-di(propylcarbamoyl)hydroxylamine, an analogue of caracemide

    Nielsen, B. B., Frydenvang, Karla Andrea & Larsen, I. K., 15 Feb 1996, In: Acta Crystallographica Section C: Crystal Structure Communications. 52, 2, p. 387-390 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold

    Nørholm, A., Francotte, P., Olsen, L., Krintel, C., Frydenvang, Karla Andrea, Goffin, E., Challal, S., Danober, L., Botez-Pop, I., Lestage, P., Pirotte, B. & Kastrup, Jette Sandholm Jensen, 14 Nov 2013, In: Journal of Medicinal Chemistry. 56, 21, p. 8736-45 10 p.

    Research output: Contribution to journalJournal articleResearch

  49. Published

    Antiprotozoal properties of 16,17-dihydrobrachycalyxolide from Vernonia brachycalyx

    Oketch-Rabah, H. A., Christensen, Søren Brøgger, Frydenvang, Karla Andrea, Dossaji, S. F., Theander, Thor Grundtvig, Cornett, Claus, Watkins, W. M., Kharazmi, A. & Lemmich, E., 1998, In: Planta Medica. 64, 6, p. 559-62 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Antiprotozoal compounds from Asparagus africanus

    Oketch-Rabah, H. A., Dossaji, S. F., Christensen, S. B., Frydenvang, Karla Andrea, Lemmich, E., Cornett, Claus, Olsen, C. E., Chen, M., Kharazmi, A. & Theander, Thor Grundtvig, 1997, In: Journal of Natural Products. 60, 10, p. 1017-22 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 1305625