Matthias Manfred Herth
Professor
Medicinal Chemistry
Jagtvej 162
2100 København Ø
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(11)C-labeling and preliminary evaluation of pimavanserin as a 5-HT2A receptor PET-radioligand
Andersen, V. L., Hansen, H. D., Herth, Matthias Manfred, Dyssegaard, A., Knudsen, G. M. & Kristensen, Jesper Langgaard, 20 Jan 2015, In: Bioorganic & Medicinal Chemistry Letters. 25, 5, p. 1053–1056 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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(11)C-labeling and preliminary evaluation of vortioxetine as a PET radioligand
Andersen, V. L., Hansen, H. D., Herth, Matthias Manfred, Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 19 Apr 2014, In: Bioorganic & Medicinal Chemistry Letters. 24, 11, p. 2408-2411 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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11C-imaging: methyl jasmonate moves in both phloem and xylem, promotes transport of jasmonate, and of photoassimilate even after proton transport is decoupled
Thorpe, M. R., Ferrieri, A. P., Herth, Matthias Manfred & Ferrieri, R. A., Jul 2007, In: Planta. 226, 2, p. 541-51 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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18F-Labelling of electron rich iodonium ylides: application to the radiosynthesis of potential 5-HT2A receptor PET ligands
Petersen, I. N., Villadsen, J., Hansen, H. D., Madsen, J., Jensen, Anders A., Gillings, N., Lehel, S., Herth, Matthias Manfred, Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, Apr 2017, In: Organic & Biomolecular Chemistry. 15, p. 4351-4358Research output: Contribution to journal › Journal article › Research › peer-review
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18F-labeling and evaluation of novel MDL 100907 derivatives as potential 5-HT2A antagonists for molecular imaging
Debus, F., Herth, Matthias Manfred, Piel, M., Buchholz, H., Bausbacher, N., Kramer, V., Lüddens, H. & Rösch, F., May 2010, In: Nuclear Medicine and Biology. 37, 4, p. 487-95 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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72/74As-labeling of HPMA based polymers for long-term in vivo PET imaging
Herth, Matthias Manfred, Barz, M., Jahn, M., Zentel, R. & Rösch, F., 15 Sep 2010, In: Bioorganic & Medicinal Chemistry Letters. 20, 18, p. 5454-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A Fluorescent Probe as a Lead Compound for a Selective α-Synuclein PET Tracer: Development of a Library of 2-Styrylbenzothiazoles and Biological Evaluation of [18F]PFSB and [18F]MFSB
Di Nanni, A., Saw, R. S., Battisti, Umberto Maria, Bowden, G. D., Boeckermann, A., Bjerregaard-Andersen, K., Pichler, B. J., Herfert, K., Herth, Matthias Manfred & Maurer, A., 2023, In: ACS Omega. 8, 34, p. 31450–31467Research output: Contribution to journal › Journal article › Research › peer-review
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A SPECT-based method for dynamic imaging of the glymphatic system in rats
Sigurdsson, B., Hauglund, Natalie Linea, Lilius, T. O., Mogensen, F. L. H., Mortensen, K. N., Beschorner, Natalie, Klinger, L., Bærentzen, S. L., Rosenholm, Marko, Shalgunov, Vladimir, Herth, Matthias Manfred, Mori, Yuki & Nedergaard, Maiken, 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43, 7, 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A facile synthesis of precursor for the σ-1 receptor PET radioligand [18F]FTC-146 and its radiofluorination
Marešová, A., Jurášek, M., Drašar, P. B., Dolenský, B., Prokudina, E. A., Shalgunov, Vladimir, Herth, Matthias Manfred, Cumming, P. & Popkov, A., 2024, In: Journal of Labelled Compounds and Radiopharmaceuticals. 67, 2, p. 59-66Research output: Contribution to journal › Journal article › Research › peer-review
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A nanobody recognizes a unique conserved epitope and potently neutralizes SARS-CoV-2 omicron variants
Modhiran, N., Lauer, S. M., Amarilla, A. A., Hewins, P., Lopes van den Broek, S. I., Low, Y. S., Thakur, N., Liang, B., Nieto, G. V., Jung, J., Paramitha, D., Isaacs, A., Sng, J. D. J., Song, D., Jørgensen, J. T., Cheuquemilla, Y., Bürger, J., Andersen, I. V., Himelreichs, J., Jara, R. & 18 others, , 2023, In: iScience. 26, 7, 26 p., 107085.Research output: Contribution to journal › Journal article › Research › peer-review
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A new perspective for advanced positron emission tomography–based molecular imaging in neurodegenerative proteinopathies
IMBI Project, I. P., 1 Jan 2019, In: Alzheimer's and Dementia. 15, 8, p. 1081-1103Research output: Contribution to journal › Journal article › Research › peer-review
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A pilot study of cerebral metabolism and serotonin 5-HT2A receptor occupancy in rats treated with the psychedelic tryptamine DMT in conjunction with the MAO inhibitor harmine
Egger, K., Gudmundsen, F., Jessen, N. S., Baun, C., Poetzsch, S. N., Shalgunov, Vladimir, Herth, Matthias Manfred, Quednow, B. B., Martin-Soelch, C., Dornbierer, D., Scheidegger, M., Cumming, P. & Palner, M., 2023, In: Frontiers in Pharmacology. 14, 12 p., 1140656.Research output: Contribution to journal › Journal article › Research › peer-review
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Accelerating preclinical PET-screening: reductive amination with [11C]methoxybenzaldehydes
Herth, Matthias Manfred, Leth-Petersen, S., Lehel, S., Hansen, M., Gillings, N., Madsen, J. & Kristensen, Jesper Langgaard, 2014, In: R S C Advances. 41, p. 21347-21350 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Aliphatic 18F-Radiofluorination: Recent Advances in the Labeling of Base-Sensitive Substrates**
Bratteby, K., Shalgunov, Vladimir & Herth, Matthias Manfred, 2021, In: ChemMedChem. 16, 17, p. 2612-2622Research output: Contribution to journal › Review › Research › peer-review
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Alpha-Synuclein PET tracer development-an overview about current efforts
Korat, Š., Bidesi, N. S. R., Bonanno, F., Di Nanni, A., Hoàng, A. N. N., Herfert, K., Maurer, A., Battisti, Umberto Maria, Bowden, G. D., Thonon, D., Vugts, D., Windhorst, A. D. & Herth, Matthias Manfred, 2021, In: Pharmaceuticals. 14, 9, 45 p., 847.Research output: Contribution to journal › Review › Research › peer-review
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An Improved Radiolabelling Strategy for the 5-HT2A Agonist, [C-11]Cimbi-36
Gillings, N., Lehel, S., Herth, Matthias Manfred, Leth-Petersen, S., Madsen, J., Gabel-Jensen, C. & Kristensen, Jesper Langgaard, 15 May 2015, In: Journal of Labelled Compounds and Radiopharmaceuticals. 58, p. S296-S296 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Application of advanced brain positron emission tomography–based molecular imaging for a biological framework in neurodegenerative proteinopathies
IMBI Brain Imaging Working Group, I. B. I. W. G., 1 Dec 2019, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 327-332 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets
Griem-Krey, Nane, Klein, A. B., Herth, Matthias Manfred & Wellendorph, Petrine, 12 Mar 2019, In: Journal of visualized experiments : JoVE. 145, 11 p., e58879.Research output: Contribution to journal › Journal article › Communication
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Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo
Poulie, Christian Bernard Matthijs, Sporer, E., Hvass, Lars, Jørgensen, Jesper Tranekjær, Kempen, Paul Joseph, Lopes van den Broek, S. I., Shalgunov, Vladimir, Kjær, Andreas, Jensen, A. I. & Herth, Matthias Manfred, 2022, In: Chemistry - A European Journal. 28, 61, 10 p., e202201847.Research output: Contribution to journal › Journal article › Research › peer-review
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Blocking of efflux transporters in rats improves translational validation of brain radioligands
Shalgunov, Vladimir, Xiong, M., L’Estrade, E. T., Raval, N. R., Andersen, Ida Vang, Edgar, F. G., Speth, N. R., Baerentzen, S. L., Hansen, H. D., Donovan, L. L., Nasser, A., Peitersen, S. T., Kjær, Andreas, Knudsen, Gitte Moos, Syvänen, S., Palner, M. & Herth, Matthias Manfred, 2020, In: EJNMMI Research. 10, 1, 11 p., 124.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of the serotonin 2A receptor selective PET tracer (R)-[18F]MH.MZ in the human brain
Kramer, V., Dyssegaard, A., Flores, J., Soza-Ried, C., Rösch, F., Knudsen, Gitte Moos, Amaral, H. & Herth, Matthias Manfred, 2020, In: European Journal of Nuclear Medicine and Molecular Imaging. 47, p. 355-365Research output: Contribution to journal › Journal article › Research › peer-review
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Classics in Neuroimaging: The Serotonergic 2A Receptor System-from Discovery to Modern Molecular Imaging
T L'Estrade, E., Hansen, H. D., Erlandsson, M., Ohlsson, T. G., Knudsen, Gitte Moos & Herth, Matthias Manfred, 20 Jun 2018, In: ACS Chemical Neuroscience. 9, 6, p. 1226-1229 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Clearing and Masking Agents in Pretargeting Strategies
Staudt, Markus & Herth, Matthias Manfred, 2023, In: Pharmaceuticals. 16, 4, 15 p., 497.Research output: Contribution to journal › Review › Research › peer-review
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Comparison of the 5-HT2A PET tracers, [F-18]MH.MZ and [F-18]altanserin
Hansen, H., Herth, Matthias Manfred, Ettrup, A., Dyssegaard, A. & Knudsen, Gitte Moos, May 2013, p. S338-S338.Research output: Contribution to conference › Conference abstract for conference › Research
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Convenient Entry to 18 F-Labeled Amines through the Staudinger Reduction
Stéen, E. J. L., Shalgunov, Vladimir, Denk, C., Mikula, H., Kjær, Andreas, Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 2019, In: European Journal of Organic Chemistry. 2019, 8, p. 1722-1725Research output: Contribution to journal › Journal article › Research › peer-review
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Convenient access to F-18-labeled amines through the Staudinger reduction
Shalgunov, Vladimir, Steen, J., Denk, C., Mikula, H., Kjær, Andreas, Kristensen, Jesper Langgaard & Herth, Matthias Manfred, May 2019, In: Journal of Labelled Compounds and Radiopharmaceuticals. 62, Supl. 1/SI, p. S205-S206 P-050.Research output: Contribution to journal › Conference abstract in journal › Research
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Convergent [18]F-labeling and evaluation of N-benzyl-phenethylamines as 5-HT2A receptor PET ligands
Petersen, I. N., Villadsen, J., Hansen, H. D., Jensen, Anders A., Lehel, S., Gillings, N., Herth, Matthias Manfred, Knudsen, G. M. & Kristensen, Jesper Langgaard, 2016, In: Bioorganic & Medicinal Chemistry. 24, p. 5353-5356 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Covalent core-radiolabeling of polymeric micelles with125I/211At for theranostic radiotherapy
Sporer, E., Poulie, Christian Bernard Matthijs, Bäck, T., Lindegren, S., Jensen, H., Kempen, Paul Joseph, Kjær, Andreas, Herth, Matthias Manfred & Jensen, A. I., 2022, In: Nanotheranostics. 6, 4, p. 388-399Research output: Contribution to journal › Journal article › Research › peer-review
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Cover Feature: Convenient Entry to 18 F-Labeled Amines through the Staudinger Reduction (Eur. J. Org. Chem. 8/2019)
Stéen, E. J. L., Shalgunov, Vladimir, Denk, C., Mikula, H., Kjær, Andreas, Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 28 Feb 2019, In: European Journal of Organic Chemistry. 2019, 8, p. 1686-1686Research output: Contribution to journal › Journal article › Communication
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Current radiosynthesis strategies for 5-HT2A receptor PET tracers
Herth, Matthias Manfred & Knudsen, G. M., 15 Jun 2015, In: Journal of Labelled Compounds and Radiopharmaceuticals. 58, 7, p. 265-73 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT7 receptor
Lacivita, E., Niso, M., Hansen, H. D., Di Pilato, P., Herth, Matthias Manfred, Lehel, S., Ettrup, A., Montenegro, L., Perrone, R., Berardi, F., Colabufo, N. A., Leopoldo, M. & Knudsen, G. M., 1 Mar 2014, In: Bioorganic & Medicinal Chemistry. 22, 5, p. 1736-1750 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Desorption Electrospray Ionization Mass Spectrometry Imaging of Cimbi-36, a 5-HT2A Receptor Agonist, with Direct Comparison to Autoradiography and Positron Emission Tomography
Jacobsen, S. C., Speth, N. R., Xiong, M., Herth, Matthias Manfred, Kristensen, Jesper Langgaard, Palner, M. & Janfelt, Christian, 2021, In: Molecular Imaging and Biology. 23, p. 676–685Research output: Contribution to journal › Journal article › Research › peer-review
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Development and Evaluation of Two Potential 5-HT7 Receptor PET Tracers: [18F]ENL09 and [18F]ENL10
Tampio L'Estrade, E., Xiong, M., Shalgunov, Vladimir, Edgar, F. G., Volk, B., Baerentzen, S. L., Palner, M., Erlandsson, M., Ohlsson, T., Knudsen, Gitte Moos & Herth, Matthias Manfred, 2019, In: ACS Chemical Neuroscience. 10, 9, p. 3961-3968 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Development and Preclinical Evaluation of [211At]PSAt-3-Ga: An Inhibitor for Targeted α-Therapy of Prostate Cancer.
El Fakiri, M., Ayada, N., Müller, Marius, Hvass, Lars, Gamzov, T. H., Clausen, Anne Skovsbo, Geis, N. M., Steinacker, N., Hansson, E., Lindegren, S., Aneheim, E., Jensen, H., Eder, A., Jensen, Andreas, Poulie, Christian Bernard Matthijs, Kjær, Andreas, Eder, M. & Herth, Matthias Manfred, 2024, In: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 65, 4, p. 593-599Research output: Contribution to journal › Journal article › Research › peer-review
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Development and evaluation of an 18F-labeled nanobody to target SARS-CoV-2's spike protein
Lopes van den Broek, S., García-Vázquez, R., Andersen, Ida Vang, Valenzuela-Nieto, G., Shalgunov, Vladimir, Battisti, Umberto Maria, Schwefel, D., Modhiran, N., Kramer, V., Cheuquemilla, Y., Jara, R., Salinas-Varas, C., Amarilla, A. A., Watterson, D., Rojas-Fernandez, A. & Herth, Matthias Manfred, 2022, In: Frontiers in Nuclear Medicine. 2, 1033697.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of 11C-labeled CRANAD-102 for positron emission tomography imaging of soluble Aβ-species
Staudt, Markus, Shalgunov, Vladimir, Nedergaard, Maiken & Herth, Matthias Manfred, 2023, In: Journal of Labelled Compounds and Radiopharmaceuticals. 66, 12, p. 393-399Research output: Contribution to journal › Journal article › Research › peer-review
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Development of C-11-labeled oxindole derivatives for in vivo PET imaging of the 5-HT7 receptor
Herth, Matthias Manfred, Hansen, H., Andersen, V. L., Volk, B., Ettrup, A., Antoni, F., Lehel, S., Dyssegaard, A., Kristensen, Jesper Langgaard & Knudsen, G. M., May 2013, p. S82-S82.Research output: Contribution to conference › Conference abstract for conference › Research
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Development of New PET Radiotracers for In Vivo 5-HT7 Brain Imaging
Herth, Matthias Manfred, Hansen, H., Lehel, S., Ettrup, A., Paine, J., Madsen, J., Gillings, N., Kristensen, Jesper Langgaard & Knudsen, G., 2011, In: Journal of Labelled Compounds and Radiopharmaceuticals. 54, p. S277-S277Research output: Contribution to journal › Journal article › Research › peer-review
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Development of Trans-Cyclooctene Modified Antibodies for Pretargeted Imaging within the Central Nervous System: [Meeting Abstract]
van den Broek, S. L., Shalgunov, Vladimir, Sehlin, D., Syvanen, S. & Herth, Matthias Manfred, 2020, In: Journal of Nuclear Medicine. 61, Supl. 1, 3 p., 196.Research output: Contribution to journal › Conference abstract in journal › Research
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Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation
Herth, Matthias Manfred, Andersen, V. L., Lehel, S., Madsen, J., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 2013, In: Chemical Communications. 49, p. 3805-3807 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of a 99mTc-labeled tetrazine for pretargeted SPECT imaging using an alendronic acid-based bone targeting model
Bohrmann, L., Poulie, Christian Bernard Matthijs, Rodríguez-Rodríguez, C., Karagiozov, S., Saatchi, K., Herth, Matthias Manfred & Häfeli, U. O., 2024, In: PLoS ONE. 19, 4, 18 p., e0300466.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of a simple proton nuclear magnetic resonance-based procedure to estimate the approximate distribution coefficient at physiological pH (logD7.4): Evaluation and comparison to existing practices
Stéen, E. J. L., Nyberg, N., Lehel, S., Andersen, V. L., Di Pilato, P., Knudsen, Gitte Moos, Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 15 Jan 2017, In: Bioorganic & Medicinal Chemistry Letters. 27, 2, p. 319-322 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of an F-18-labelled 5-HT2A receptor agonist PET radioligand
Ettrup, A., Hansen, M., Gillings, N., Dyssegaard, A., Lehel, S., Hansen, H. D., Herth, Matthias Manfred, Madsen, J., Kristensen, J. & Knudsen, G. M., Aug 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, p. S109-S109Research output: Contribution to journal › Journal article › Research › peer-review
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Development of the First Aliphatic 18F-Labeled Tetrazine Suitable for Pretargeted PET Imaging-Expanding the Bioorthogonal Tool Box
Battisti, Umberto Maria, Bratteby, K., Jørgensen, Jesper Tranekjær, Hvass, Lars, Shalgunov, Vladimir, Mikula, H., Kjær, Andreas & Herth, Matthias Manfred, 2021, In: Journal of Medicinal Chemistry. 64, 20, p. 15297–15312Research output: Contribution to journal › Journal article › Research › peer-review
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Development of the First Tritiated Tetrazine: Facilitating Tritiation of Proteins
Radjani Bidesi, N. S., Battisti, Umberto Maria, Lopes van de Broek, S., Shalgunov, Vladimir, Dall, A., Bøggild Kristensen, J., Sehlin, D., Syvänen, S., Knudsen, Gitte Moos & Herth, Matthias Manfred, 2022, In: ChemBioChem. 23, 23, 7 p., e202200539.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of18F-Labeled Bispyridyl Tetrazines for In Vivo Pretargeted PET Imaging
García-Vázquez, R., Jørgensen, Jesper Tranekjær, Bratteby, K. E., Shalgunov, Vladimir, Hvass, Lars, Herth, Matthias Manfred, Kjær, Andreas & Battisti, Umberto Maria, 2022, In: Pharmaceuticals. 15, 2, 28 p., 245.Research output: Contribution to journal › Journal article › Research › peer-review
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Direct Aromatic F-18-labeling of Tetrazines: A Rapid and Convenient Entry to Tetrazines for Pretargeted PET Imaging [Meeting Abstract]
Vazquez, R. G., Battisti, Umberto Maria, Stares, D. L., Petersen, I. N., Crestey, F., Svatunek, D., Mikula, H., Kristensen, Jesper Langgaard, Kjær, Andreas & Herth, Matthias Manfred, 2020, In: Journal of Nuclear Medicine. 61, Supl. 1, 2 p., 134.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Direct Cu-mediated aromatic18F-labeling of highly reactive tetrazines for pretargeted bioorthogonal PET imaging
García-Vázquez, R., Battisti, Umberto Maria, Jørgensen, Jesper Tranekjær, Shalgunov, Vladimir, Hvass, Lars, Stares, D. L., Petersen, I. N., Crestey, F., Löffler, A., Svatunek, D., Kristensen, Jesper Langgaard, Mikula, H., Kjær, Andreas & Herth, Matthias Manfred, 2021, In: Chemical Science. 12, 35, p. 11668-11675Research output: Contribution to journal › Journal article › Research › peer-review
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Direct comparison of [18F]MH.MZ and [18F]altanserin for 5-HT2A receptor imaging with PET
Hansen, H. D., Ettrup, A., Herth, Matthias Manfred, Dyssegaard, A., Ratner, C., Gillings, N. & Knudsen, G. M., 2013, In: Synapse. 67, 6, p. 328-337 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Direct radiofluorination of [18F]MH.MZ for 5-HT2A receptor molecular imaging with PET
Herth, Matthias Manfred, Kramer, V., Gillings, N., Roesch, F. & Knudsen, G. M., Jul 2012, In: Journal of Labelled Compounds and Radiopharmaceuticals. 55, 9, p. 354-358Research output: Contribution to journal › Journal article › Research › peer-review
ID: 33147568
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SPECT imaging of the glymphatic pathway with In-111-labeled ovalbumin in the rat brain
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Convenient access to F-18-labeled amines through the Staudinger reduction
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363
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Pretargeting in nuclear imaging and radionuclide therapy: Improving efficacy of theranostics and nanomedicines
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