Paul Robert Hansen
Associate Professor
- 2024
- Published
Antimicrobial peptides grafted onto the surface of N-acetylcysteine-chitosan nanoparticles can revitalize drugs against clinical isolates of Mycobacterium tuberculosis
Primo, L. M. D. G., Roque-Borda, C. A., Carnero Canales, C. S., Caruso, I. P., de Lourenço, I. O., Colturato, V. M. M., Sábio, R. M., de Melo, F. A., Vicente, E. F., Chorilli, M., da Silva Barud, H., Barbugli, P. A., Franzyk, Henrik, Hansen, Paul Robert & Pavan, F. R., 2024, In: Carbohydrate Polymers. 323, 17 p., 121449.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nanogel delivery systems for cationic peptides: More than a ‘One Size Fits All’ solution
Kłodzińska, S. N., Wang, Qiuyue, Molchanova, N., Mahmoudi, N., Vallooran, J. J., Hansen, Paul Robert, Jenssen, H. & Nielsen, Hanne Mørck, 2024, In: Journal of Colloid and Interface Science. 663, p. 449-457Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reflections on a Copenhagen–Minneapolis Axis in Bioorganic Chemistry
Barany, G. & Hansen, Paul Robert, 2024, In: Molecules (Basel, Switzerland). 29, 6, 62 p., 1317.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Antibodies to calnexin and mutated calreticulin are common in human sera
Kyllesbech, C., Trier, N. H., Mughal, F. P., Hansen, Paul Robert, Holmström, M. O., Fassi, Daniel El , Hasselbalch, H., Skov, V., Kjær, L., Andersen, Mads Hald, Ciplys, E., Slibinskas, R., Fredriksen, Jette Lautrup, Højrup, P. & Houen, G., 2023, In: Current Research in Translational Medicine. 71, 2, 103380.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Physiological response in E. coli to YdgR overexpression depends on whether the protein has an intact function
Sajid, Salvia, Salas, L. H., Rafiq, M., Lund, T., Jørgensen, M. G., Honoré, B., Christensen, L. P., Hansen, Paul Robert, Franzyk, Henrik, Mirza, Osman Asghar & Prabhala, B. K., 2023, In: Biochemical and Biophysical Research Communications. 661, p. 42-49Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Substrate space analysis of the bacterial proton-coupled oligopeptide transporter YdgR by cheminformatics
Sajid, Salvia, Nielsen, M. M. K., Khalil, R., Hansen, Paul Robert, Franzyk, Henrik, Jørgensen, M. G., Christensen, L. P., Mirza, Osman Asghar & Prabhala, B. K., 2023, In: FEMS Microbiology Letters. 370, 9 p., fnad052.Research output: Contribution to journal › Journal article › Research › peer-review
- Accepted/In press
The Y-ome Conundrum: Insights into Uncharacterized Genes and Approaches for Functional Annotation
Sajid, Salvia, Mashkoor, M., Jørgensen, M. G., Christensen, L. P., Hansen, Paul Robert, Franzyk, Henrik, Mirza, Osman Asghar & Prabhala, B. K., 2023, (Accepted/In press) In: Molecular and Cellular Biochemistry. 12 p.Research output: Contribution to journal › Review › Research › peer-review
- 2022
- Published
C-locked analogs of the antimicrobial peptide BP214
Andersen, I. K. L., Thomsen, T. T., Rashid, J., Bobak, T. R., Oddo, A., Franzyk, Henrik, Løbner-Olesen, Anders & Hansen, Paul Robert, 2022, In: Antibiotics. 11, 8, 10 p., 1080.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cyclic N-Locked Indolicidin Analogues with Antimicrobial Activity: Effect of Ring Size and Fatty Acid Acylation
Lone, A. B. N., Nielsen, J. E., Thulstrup, Peter Waaben, Lund, R., Hansen, Paul Robert & Jenssen, H., 2022, In: European Journal of Medicinal Chemistry Reports. 6, 7 p., 100080.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Peptide Antibody Reactivity to Homologous Regions in Glutamate Decarboxylase Isoforms and Coxsackievirus B4 P2C
Trier, N. H., Valdarnini, N., Fanelli, I., Rovero, P., Hansen, Paul Robert, Schafer, C., Ciplys, E., Slibinskas, R., Pociot, F., Friis, T. & Houen, G., 2022, In: International Journal of Molecular Sciences. 23, 8, 16 p., 4424.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Production and characterization of peptide antibodies to the C-terminal of frameshifted calreticulin associated with myeloproliferative diseases
Mughal , F. P., Bergmann , A. C., Huynh , H. U. B., Jørgensen, S. H., Mansha , I., Kesmeh , M., Schürch, P. M., Theocharides, A. P. A., Hansen, Paul Robert, Friis , T., Holmeren , M. Ö., Ciplys , E., Slibinskas , R., Højrup, P., Houen, G. & Trier, N. H., 2022, In: International Journal of Molecular Sciences. 23, 12, 21 p., 6803.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reactivity of Rheumatoid Arthritis-Associated Citrulline-Dependent Antibodies to Epstein-Barr Virus Nuclear Antigen1-3
Fanelli, I., Rovero, P., Hansen, Paul Robert, Frederiksen, J. L., Houen, G. & Trier, N. H., 2022, In: Antibodies. 11, 1, 15 p., 20.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Dual high-resolution α-glucosidase and PTP1B profiling combined with HPLC-PDA-HRMS-SPE-NMR analysis for the identification of potentially antidiabetic chromene meroterpenoids in Rhododendron capitatum
Liang, Chao, Kjaerulff, Louise, Hansen, Paul Robert, Kongstad, Kenneth Thermann & Stærk, Dan, 2021, In: Journal of Natural Products. 84, p. 2454-2467Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Perfluoro-tert-butanol for selective on-resin detritylation: a mild alternative to traditionally used methods
Wester, A., Hansen, A. M., Hansen, Paul Robert & Franzyk, Henrik, 2021, In: Amino Acids. 53, p. 1455–1466Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Specificity of anti-citrullinated protein antibodies to citrullinated α-enolase peptides as a function of epitope structure and composition
Fanelli, I., Rovero, P., Hansen, Paul Robert, Fredriksen, Jette Lautrup, Houen, G. & Trier, N. H., 2021, In: Antibodies. 10, 3, 12 p., 27.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Structure elucidation of prenyl- and geranyl substituted coumarins in Gerbera piloselloides by NMR spectroscopy, electronic circular dichroism calculations, and single crystal X-ray crystallography
Li, T., Ma, X., Fedotov, D., Kjaerulff, Louise, Frydenvang, Karla Andrea, Coriani, S., Hansen, Paul Robert, Kongstad, Kenneth Thermann & Stærk, Dan, 8 Apr 2020, In: Molecules. 25, 25 p., 1706.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Alternating Cationic-Hydrophobic Peptide/Peptoid Hybrids: Influence of Hydrophobicity on Antibacterial Activity and Cell Selectivity
Frederiksen, N., Hansen, Paul Robert, Zabicka, D., Tomczak, M., Urbas, M., Domraceva, I., Björkling, Fredrik & Franzyk, Henrik, 2020, In: ChemMedChem. 15, 24, p. 2544-2561Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Analogues of a Cyclic Antimicrobial Peptide with a Flexible Linker Show Promising Activity Against Pseudomonas aeruginosa and Staphylococcus aureus
Thomsen, T. T., Mendel, H. C., Al-Mansour, W., Oddo, A., Løbner-Olesen, Anders & Hansen, Paul Robert, 2020, In: Antibiotics. 9, 7, 13 p., 366.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides
Greco, I., Molchanova, N., Holmedal, E., Jenssen, H., Hummel, B. D., Watts, J. L., Håkansson, J., Hansen, Paul Robert & Svenson, J., 2020, In: Scientific Reports. 10, 13 p., 13206.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fluorescent analogues of Human α-Calcitonin Gene-Related Peptide with vasodilator potency
Zhu, J., Pedersen, M. D., Ahmed, L. S., Abdolalizadeh, B., Grell, A., Berg, Jais Oliver, Thulstrup, Peter Waaben, Franzyk, Henrik, Edvinsson, L., Sams, A., Sheykhzade, Majid & Hansen, Paul Robert, 2020, In: International Journal of Molecular Sciences (Online). 21, 4, p. 1-15 15 p., 1343.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Halogenation as a tool to tune antimicrobial activity of peptoids
Molchanova, N., Nielsen, J. E., Sørensen, K. B., Prabhala, B. K., Hansen, Paul Robert, Lund, R., Barron, A. E. & Jenssen, H., 2020, In: Scientific Reports. 10, 10 p., 14805.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel Cyclic Lipopeptide Antibiotics: Effects of Acyl Chain Length and Position
Jensen, S. K., Thomsen, T. T., Oddo, A., Franzyk, Henrik, Løbner-Olesen, Anders & Hansen, Paul Robert, 2020, In: International Journal of Molecular Sciences . 21, 16, 18 p., 5829.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis of Peptoids Containing MultipleNhtrp andNtrp Residues: A Comparative Study of Resin, Cleavage Conditions and Submonomer Protection
Lone, A., Arnous, A., Hansen, Paul Robert, Mojsoska, B. & Jenssen, H., 2020, In: Frontiers in Chemistry. 8, 12 p., 370.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Peptide/Peptoid Hybrid Oligomers: The Influence of Hydrophobicity and Relative Side-Chain Length on Antibacterial Activity and Cell Selectivity
Frederiksen, N., Hansen, Paul Robert, Björkling, Fredrik & Franzyk, Henrik, 4 Dec 2019, In: Molecules (Print Archive Edition). 24, 18 p., 4429.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Peptides, antibodies, peptide antibodies and more
Trier, N., Hansen, Paul Robert & Houen, G., 11 Nov 2019, In: International Journal of Molecular Sciences (Online). 20, 22 p., 6289.Research output: Contribution to journal › Review › Research › peer-review
- Published
A Biophysical Study of the Interactions between the Antimicrobial Peptide Indolicidin and Lipid Model Systems
Nielsen, J. E., Lind, T. K., Lone, A., Gerelli, Y., Hansen, Paul Robert, Jenssen, H., Cárdenas, M. & Lund, R., 2019, In: B B A - Biomembranes. 1861, 7, p. 1355-1364Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients
Molchanova, N., Wang, H., Hansen, Paul Robert, Høiby, Niels, Nielsen, Hanne Mørck & Franzyk, Henrik, 2019, In: Frontiers in Microbiology. 10, 9 p., 275.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections
Greco, I., Emborg, A., Jana, B., Molchanova, N., Oddo, A., Damborg, Peter Panduro, Guardabassi, Luca & Hansen, Paul Robert, 2019, In: Scientific Reports. 9, 12 p., 3679.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fine mapping of glutamate decarboxylase 65 epitopes reveals dependency of hydrophobic amino acids for specific interactions
Valdarnini, N., Holm, B., Hansen, Paul Robert, Rovero, P., Houen, G. & Trier, N. H., 2019, In: International Journal of Molecular Sciences (Online). 20, 13 p., 2909.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Specificity of anti-citrullinated protein antibodies in rheumatoid arthritis
Trier, N., Holm, B. E., Hansen, Paul Robert, Slot, O., Locht, H. & Houen, G., 2019, In: Antibodies. 8, 2, 10 p., 37.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-Activity Study of an All-D Antimicrobial Octapeptide D2D
Lone, A., Thomsen, T. T., Nielsen, J. E., Thulstrup, Peter Waaben, Klitgaard, R. N., Løbner-Olesen, Anders, Lund, R., Jenssen, H. & Hansen, Paul Robert, 2019, In: Molecules. 24, 24, 17 p., 4571.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-activity study, characterization and mechanism of action of an antimicrobial peptoid D2 and its D- and L-peptide analogues
Greco, I., Hansen, J. E., Jana, B., Molchanova, N., Oddo, A., Thulstrup, Peter Waaben, Damborg, Peter Panduro, Guardabassi, Luca & Hansen, Paul Robert, 2019, In: Molecules. 24, 6, 16 p., 1121.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Biopolymer nanogels improve antibacterial activity and safety profile of a novel lysine-based α-peptide/β-peptoid peptidomimetic
Kłodzińska, S. N., Molchanova, N., Franzyk, Henrik, Hansen, Paul Robert, Damborg, Peter Panduro & Nielsen, Hanne Mørck, Jul 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 128, p. 1-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In Vitro ADME Properties of Two Novel Antimicrobial Peptoid-Based Compounds as Potential Agents against Canine Pyoderma
Greco, I., Hummel, B. D., Vasir, J., Watts, J. L., Koch, J., Hansen, J. E., Nielsen, Hanne Mørck, Damborg, Peter Panduro & Hansen, Paul Robert, 10 Mar 2018, In: Molecules. 23, 3, 15 p., 630.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fluorinated antimicrobial lysine-based peptidomimetics with activity against methicillin-resistant Staphylococcus pseudintermedius
Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro & Franzyk, Henrik, 2018, In: Journal of Peptide Science. 24, 7, 8 p., e3098.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Linear peptidomimetics as potent antagonists of Staphylococcus aureus agr quorum sensing
Karathanasi, G., Bojer, Martin Saxtorph, Baldry, M., Johannessen, B. A., Wolff, S., Greco, I., Kilstrup, M., Hansen, Paul Robert & Ingmer, Hanne, 2018, In: Scientific Reports. 8, 1, 11 p., 3562.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Review on abyssomicins: Inhibitors of the chorismate pathway and folate biosynthesis
Sadaka, C., Ellsworth, E., Hansen, Paul Robert, Ewin, R., Damborg, Peter Panduro & Watts, J. L., 2018, In: Molecules. 23, 6, 25 p., 1371.Research output: Contribution to journal › Review › Research › peer-review
- Published
The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells
Prabhala, B. K., Aduri, N. G., Sharma, N., Shaheen, A., Sharma, A., Iqbal, M., Hansen, Paul Robert, Brasen, C., Gajhede, Michael, Rahman, M. & Mirza, Osman Asghar, 2018, In: The Journal of Biological Chemistry. 293, p. 1007-1017Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Advances in development of antimicrobial peptidomimetics as potential drugs
Molchanova, N., Hansen, Paul Robert & Franzyk, Henrik, 28 Aug 2017, In: Molecules. 22, 9, 60 p., 1430.Research output: Contribution to journal › Review › Research › peer-review
- Published
Broadening CD4(+) and CD8(+) T Cell Responses against Hepatitis C Virus by Vaccination with NS3 Overlapping Peptide Panels in Cross-Priming Liposomes
Filskov, J., Mikkelsen, M., Hansen, Paul Robert, Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Andersen, P., Bukh, Jens & Agger, E., Jul 2017, In: Journal of Virology. 91, 14, 18 p., e00130-17.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR
Prabhala, B. K., Aduri, N. G., Iqbal, M., Rahman, M., Gajhede, Michael, Hansen, Paul Robert & Mirza, Osman Asghar, 16 Feb 2017, In: Research in Microbiology. 168, 5, p. 443-449Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lysine-Based α-peptide/β-peptoid peptidomimetics: Influence of hydrophobicity, fluorination and distribution of cationic charge on antimicrobial activity and cytotoxicity
Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro, Nielsen, Hanne Mørck & Franzyk, Henrik, 2017, In: ChemMedChem. 12, p. 312-318 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
An amphipathic undecapeptide with all D-amino acids shows promising activity against colistin-resistant strains of Acinetobacter baumannii and a dual mode of action
Oddo, A., Thomsen, T. T., Kjelstrup, S., Gorey, C., Franzyk, Henrik, Frimodt-Møller, N., Løbner-Olesen, Anders & Hansen, Paul Robert, 2016, In: Antimicrobial Agents and Chemotherapy. 60, 1, p. 592-599 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modulation of backbone flexibility for effective dissociation of antibacterial and hemolytic activity in cyclic peptides
Oddo, A., Thomsen, T. T., Britt, H. M., Løbner-Olesen, Anders, Thulstrup, Peter Waaben, Sanderson, J. M. & Hansen, Paul Robert, 2016, In: ACS Medicinal Chemistry Letters. 7, 8, p. 741-745 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Amphibian antimicrobial peptide fallaxin analogue FL9 affects virulence gene expression and DNA replication in Staphylococcus aureus
Gottschalk, S., Gottlieb, C. T., Vestergaard, M., Hansen, Paul Robert, Gram, L., Ingmer, Hanne & Thomsen, Line Elnif, 1 Dec 2015, In: Journal of Medical Microbiology. 64, 12, p. 1504-1513 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antibodies with specificity for native and denatured forms of ovalbumin differ in reactivity between enzyme-linked immunosorbent assays.
Holm, B. E., Bergmann, A. C., Hansen, Paul Robert, Koch, C., Houen, G. & Trier, N. H., 1 Feb 2015, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 123, 2, p. 136–145 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Contribution of peptide backbone to Anti-citrulline-dependent antibody reactivity
Trier, N. H., Dam, C., Olsen, D., Hansen, Paul Robert & Houen, G., 2015, In: P L o S One. p. 1-12 12 p., 0144707.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficient, regioselective ring-opening of activated aziridine-2-carboxylates with [18F]fluoride
Schjøth-Eskesen, C., Hansen, Paul Robert, Kjær, Andreas & Gillings, N., 2015, In: ChemistryOpen. 4, 1, p. 65–71 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Peptide Macrocycles Featuring a Backbone Secondary Amine: A Convenient Strategy for the Synthesis of Lipidated Cyclic and Bicyclic Peptides on Solid Support
Oddo, A., Münzker, L. & Hansen, Paul Robert, 2015, In: Organic Letters. 17, 10, p. 2502-2505 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rational Design of alpha-helical antimicrobial peptides: DOs and DON’Ts
Uggerhøj, L. E., Poulsen, T. J., Munk, J. K., Fredborg, M., Sondergaard, T. E., Frimodt-Møller, N., Hansen, Paul Robert & Wimmer, R., 2015, In: ChemBioChem. 16, 2, p. 242–253 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4237511
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Cyclic peptide inhibitors of the β-sliding clamp in Staphylococcus aureus
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Two novel synthetic peptoids exhibit rapid in vitro killing of methicillin-resistant Staphylococcus pseudintermedius
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Peptoid analogs of the antibacterial peptide anoplin
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