Petrine Wellendorph

Petrine Wellendorph

Professor

ORCID: 0000-0002-5455-8013

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  1. Published

    Unraveling the Molecular Determinants for GABA Transporter Subtype Selectivity

    Kickinger, S., Al-Khawaja, A., Haugaard, A. S., Lie, M. E. K., Bavo, Francesco, Loffler, R., Damgaard, M., Frølund, Bente, Ecker, G. F. & Wellendorph, Petrine, 2020, p. 130A-130A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  2. Published

    Molecular Determinants and Pharmacological Analysis for a Class of Competitive Non-transported Bicyclic Inhibitors of the Betaine/GABA Transporter BGT1

    Kickinger, Stefanie, Lie, M. E. K., Suemasa, A., Al-Khawaja, A., Fujiwara, K., Watanabe, M., Wilhelmsen, K. S., Falk-Petersen, C. B., Frølund, Bente, Shuto, S., Ecker, G. F. & Wellendorph, Petrine, 2021, In: Frontiers in Chemistry. 9, 13 p., 736457.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Structural and molecular aspects of betaine-GABA transporter 1 (BGT1) and its relation to brain function

    Kickinger, S., Hellsberg, E., Frølund, Bente, Schousboe, Arne, Ecker, G. F. & Wellendorph, Petrine, 2019, In: Neuropharmacology. 161, 14 p., 107644.

    Research output: Contribution to journal › Review › Research › peer-review

  4. Published

    Autoradiographic imaging and quantification of the high-affinity GHB binding sites in rodent brain using (3)H-HOCPCA

    Klein, A. B., Bay, T., Villumsen, I. S., Falk-Petersen, C. B., Marek, A., Frølund, Bente, Clausen, Rasmus Prætorius, Hansen, H. D., Knudsen, Gitte Moos & Wellendorph, Petrine, Nov 2016, In: Neurochemistry International. 100, p. 138-145 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Compounds for the treatment of acute brain injury

    Klein, A. B., Leurs, U., Houlton, J., Clausen, Rasmus Prætorius, Frølund, Bente, Clarkson, A. & Wellendorph, Petrine, 2020, Patent No. CN111989094, 24 Nov 2020, Priority date 1 Feb 2019, Priority No. PCT/DK2019/050041

    Research output: Patent

  6. Published

    Demonstration of the dynamic mass redistribution label-free technology as a useful cell-based pharmacological assay for endogenously expressed GABAA receptors

    Klein, A. B., Nittegaard-Nielsen, M., Christensen, J. T., Al-Khawaja, A. & Wellendorph, Petrine, 19 Nov 2015, In: MedChemComm. 7, p. 426-432 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Discovery of 2-(Imidazo[1,2-b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites

    Krall, J., Bavo, Francesco, Falk-Petersen, C. B., Jensen, C. H., Nielsen, J. O., Tian, Yongsong, Anglani, V., Kongstad, Kenneth Thermann, Petersen, Louise Piilgaard, Nielsen, Birgitte, Gloriam, David E., Kehler, J., Jensen, Anders A., Harpsøe, Kasper, Wellendorph, Petrine & Frølund, Bente, 14 Mar 2019, In: Journal of Medicinal Chemistry. 62, 5, p. 2798-2813

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs

    Krall, J., Jensen, C. H., Bavo, F., Falk-Petersen, C. B., Haugaard, A. S., Vogensen, S. B., Tian, Y., Nittegaard-Nielsen, M., Sigurdardóttir, S. B., Kehler, J., Kongstad, Kenneth Thermann, Gloriam, David E., Clausen, Rasmus Prætorius, Harpsøe, Kasper, Wellendorph, Petrine & Frølund, Bente, 2017, In: Journal of Medicinal Chemistry. 60, 21, p. 9022-9039 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Radiosynthesis and characterisation of a potent and selective GPR139 agonist radioligand

    Kuhne, S., Nøhr, A. C., Marek, A., Elbert, T., Klein, A. B., Bräuner, Hans, Wellendorph, Petrine & Pedersen, D. S., 2016, In: RSC Advances. 6, 2, p. 947-952 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Synthesis and Pharmacological Evaluation of [C-11]4-Methoxy-N-[2-(thiophen-2-yl) imidazo[1,2-a] pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the delta-Subunit-Containing gamma-Aminobutyric Acid Type A Receptors

    L'Estrade, E. T., Hansen, H. D., Falk-Petersen, C., Haugaard, A., Griem-Krey, Nane, Jung, S., Lueddens, H., Schirmeister, T., Erlandsson, M., Ohlsson, T., Knudsen, Gitte Moos, Herth, Matthias Manfred, Wellendorph, Petrine & Frølund, Bente, May 2019, In: ACS Omega. 4, 5, p. 8846-8851

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain

    Leurs, U., Klein, A. B., McSpadden, E. D., Griem-Krey, N., Solbak, S. M. Ø., Houlton, J., Villumsen, I. S., Vogensen, S. B., Hamborg, L., Gauger, S. J., Palmelund, L. B., Larsen, A. S. G., Shehata, M. A., Kelstrup, C. D., Olsen, J. V., Bach, A., Burnie, R. O., Kerr, D. S., Gowing, E. K., Teurlings, S. M. W. & 9 others, Chi, C. C., Gee, C. L., Frølund, Bente, Kornum, Birgitte Rahbek, van Woerden, G. M., Clausen, Rasmus Prætorius, Kuriyan, J., Clarkson, A. N. & Wellendorph, Petrine, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 9 p., e2108079118.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Glial GABA Transporters as Modulators of Inhibitory Signalling in Epilepsy and Stroke

    Lie, M. E. K., Al-Khawaja, A., Damgaard, M., Haugaard, A. S., Schousboe, Arne, Clarkson, A. N. & Wellendorph, Petrine, 2017, Advances in Neurobiology. Vol. 16. p. 137-167 31 p. (Advances in Neurobiology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  13. Published

    Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects

    Lie, M. E. K., Kickinger, S., Skovgaard-Petersen, J., Ecker, G. F., Clausen, Rasmus Prætorius, Schousboe, Arne, White, H. S. & Wellendorph, Petrine, 2020, In: Neurochemical Research. 45, p. 1551–1565

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Inhibition of GABA transporters fails to afford significant protection following focal cerebral ischemia

    Lie, M. E., Gowing, E. K., Clausen, Rasmus Prætorius, Wellendorph, Petrine & Clarkson, A. N., 2018, In: Journal of Cerebral Blood Flow and Metabolism. 38, 1, p. 166-173

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice

    Lie, M. E., Gowing, E. K., Johansen, N. B., Dalby, N. O., Thiesen, L., Wellendorph, Petrine & Clarkson, A. N., 1 Jan 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, 1, p. 74-88 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    GABAA receptor β1-subunit knock-out mice show increased delta power in NREM sleep and decreased theta power in REM sleep

    Lie, M. E. K., Falk-Petersen, C. B., Petersen, Louise Piilgaard, Griem-Krey, Nane, Wellendorph, Petrine & Kornum, Birgitte Rahbek, 2021, In: European Journal of Neuroscience. 54, 2, p. 4445-4455 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Transmembrane transporter proteins: Capturing transport in motion

    Loland, Claus Juul, Wellendorph, Petrine, Pedersen, Stine Helene Falsig & Gether, Ulrik, 2024, In: Basic and Clinical Pharmacology and Toxicology. 134, 2, p. 203-205 3 p.

    Research output: Contribution to journal › Editorial › Research › peer-review

  18. Published

    Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function.Synthesis, ionization constants and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds

    Lolli, M. L., Hansen, S. L., Rolando, B., Nielsen, Birgitte, Wellendorph, Petrine, Madsen, K., Larsen, O. M., Kristiansen, Uffe, Fruttero, R., Gasco, A. & Johansen, Tommy Nørskov, 2006, In: J. Med. Chem.. 49, p. 4442-4446 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Synthesis of gamma-Aminobutyric Acid (GABA) Analogues Conformationally Restricted by Bicyclo[3.1.0]hexane/hexene or [4.1.0]Heptane/heptene Backbones as Potent Betaine/GABA Transporter Inhibitors

    Mitsui, K., Lie, M. E. K., Saito, N., Fujiwara, K., Watanabe, M., Wellendorph, Petrine & Shuto, S., 2022, In: Organic Letters. 24, 23, p. 4151-4154

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Tuning wasp toxin structure for nicotinic receptor antagonism: cyclohexylalanine-containing analogues as potent and voltage-dependent blockers

    Olsen, Christian Adam, Mellor, I. R., Wellendorph, Petrine, Usherwood, P. N. R., Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2006, In: ChemMedChem. 1, 3, p. 303-5 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Development of a medium throughput whole-cell microtiter plate Thr286 autophosphorylation assay for CaMKIIα using ELISA

    Palmelund, L. B., van Woerden, G. M., Bräuner, Hans & Wellendorph, Petrine, 2022, In: Journal of Pharmacological and Toxicological Methods. 118, 8 p., 107226.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    (1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent gamma-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction

    Pan, Y., Gerasimov, M. R., Kvist, T., Wellendorph, Petrine, Madsen, K. K., Pera, E., Lee, H., Schousboe, Arne, Chebib, M., Bräuner, Hans, Craft, C. M., Brodie, J. D., Schiffer, W. K., Dewey, S. L., Miller, S. R. & Silverman, R. B., 1 Jan 2012, In: Journal of Medicinal Chemistry. 55, 1, p. 357-366

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Radioiododestannyllation of novel GHB neuroreceptor ligands

    Pedersen, M. H. F., Høg, S., Wellendorph, Petrine & Martiny, L., 2010, In: Journal of Labelled Compounds and Radiopharmaceuticals. 5-6, p. 318-320

    Research output: Contribution to journal › Conference article › Research › peer-review

  24. Published

    Non-invasive detection of narcolepsy type I phenotypical features and disease progression by continuous home-cage monitoring of activity in two mouse models: the HCRT-KO and DTA model

    Petersen, Louise Piilgaard, Rose, Laura, Justinussen, Jessica, Hviid, C. G., Lemcke, René, Wellendorph, Petrine & Kornum, Birgitte Rahbek, 2023, In: Sleep. 46, 9, 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Functional modulation of a pH-sensitive ion channel by a transporter family

    Poulsen, Mette Homann, Xue, F., Maurya, S. R., Kickinger, Stefanie, Usher, Samuel George, Wellendorph, Petrine, Lundby, Alicia & Pless, Stephan, 2023, In: Biophysical Journal. 122, 3 Suppl. 1, p. 249a

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

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