Povl Krogsgaard-Larsen
Professor, emeritus
Medicinal Chemistry
Jagtvej 162
2100 København Ø
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gamma-Aminobutyric Acid and Glycine Neurotransmitter Transporters
Wellendorph, Petrine, Jacobsen, Julie, Skovgaard-Petersen, J., Jurik, A., Vogensen, S. B., Ecker, G., Schousboe, Arne, Krogsgaard-Larsen, Povl & Clausen, Rasmus Prætorius, 2017, Transporters As Drug Targets.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Unprecedented migration of N-alkoxycarbonyl groups in protected pyroglutaminol
Bunch, Lennart, Norrby, P., Frydenvang, Karla Andrea, Krogsgaard-Larsen, Povl & Madsen, Ulf, 2001, In: Organic Letters. 3, 3, p. 433-5 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The role of Arg(78) in the metabotropic glutamate receptor mGlu(1) for agonist binding and selectivity
Jensen, Anders A., Sheppard, P. O., O'Hara, P. J., Krogsgaard-Larsen, Povl & Bräuner, Hans, 2000, In: European Journal of Pharmacology. 397, 2-3, p. 247-53 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors
Hoestgaard-Jensen, K., O'Connor, R. M., Dalby, N. O., Simonsen, C., Finger, B. C., Golubeva, A., Hammer, H., Bergmann, M. L., Kristiansen, Uffe, Krogsgaard-Larsen, Povl, Bräuner, Hans, Ebert, B., Frølund, Bente, Cryan, J. F. & Jensen, Anders A., Oct 2013, In: British Journal of Pharmacology. 170, 4, p. 919-32 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization
Clausen, Rasmus Prætorius, Naur, P., Kristensen, Anders Skov, Greenwood, J. R., Strange, M., Bräuner, Hans, Jensen, Anders A., Nielsen, A. S. T., Geneser, U., Ringgaard, L. M., Nielsen, Birgitte, Pickering, Darryl S, Brehm, L., Gajhede, Michael, Krogsgaard-Larsen, Povl & Kastrup, Jette Sandholm Jensen, 2009, In: Journal of Medicinal Chemistry. 52, 15, p. 4911-4922Research output: Contribution to journal › Journal article › Research › peer-review
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The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain
Bräuner, Hans, Jensen, Anders A., Sheppard, P. O., O'Hara, P. & Krogsgaard-Larsen, Povl, 1999, In: Journal of Biological Chemistry. 274, 26, p. 18382-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Textbook of drug design and discovery
Krogsgaard-Larsen, Povl, Strømgaard, Kristian & Madsen, Ulf, 2010, 4 ed. Boca Raton: CRC Press. 460 p.Research output: Book/Report › Book › Education
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Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology
Frølund, Bente, Greenwood, J. R., Holm, M. M., Egebjerg, J., Madsen, Ulf, Nielsen, Birgitte, Bräuner, Hans, Stensbøl, T. B. & Krogsgaard-Larsen, Povl, 15 Sep 2005, In: Bioorganic & Medicinal Chemistry. 13, 18, p. 5391-8Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis, theoretical and structural analyses, and enantiopharmacology of 3-carboxy homologs of AMPA
Brehm, L., Greenwood, J. R., Sløk, F. A., Holm, M. M., Nielsen, Birgitte, Geneser, U., Stensbøl, T. B., Bräuner, Hans, Begtrup, M., Egebjerg, J. & Krogsgaard-Larsen, Povl, Aug 2004, In: Chirality. 16, 7, p. 452-66Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and structure-activity studies on acidic amino acids and related diacids as NMDA receptor ligands
Johansen, Tommy Nørskov, Frydenvang, Karla Andrea, Ebert, B., Krogsgaard-Larsen, Povl & Madsen, Ulf, 1994, In: Journal of Medicinal Chemistry. 37, 20, p. 3252-62 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and receptor binding of 5-amino[3H]2methyl-3-isothiazolol ([3H]thiomuscimol), a specific GABAa agonist photoaffinity label
Frølund, Bente, Ebert, B., Lawrence, L. W., Hurt, S. D. & Krogsgaard-Larsen, Povl, 1995, In: Journal of Labelled Compounds and Radiopharmaceuticals. 36, p. 877–889Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and receptor binding affinity of new selective GluR5 ligands
Bunch, Lennart, Johansen, T. H., Bräuner, Hans, Stensbøl, T. B., Johansen, Tommy Nørskov, Krogsgaard-Larsen, Povl & Madsen, Ulf, Apr 2001, In: Bioorganic & Medicinal Chemistry. 9, 4, p. 875-9Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid
Jørgensen, Charlotte Grube, Clausen, Rasmus Prætorius, Hansen, K. B., Bräuner, Hans, Nielsen, Birgitte, Metzler, B., Kehler, J., Krogsgaard-Larsen, Povl & Madsen, Ulf, 2007, In: Organic & Biomolecular Chemistry. 5, 3, p. 463-471Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors
Madsen, Ulf, Bräuner, Hans, Frydenvang, Karla Andrea, Hvene, L., Johansen, Tommy Nørskov, Nielsen, Birgitte, Sánchez, C., Stensbøl, T. B., Bischoff, F. & Krogsgaard-Larsen, Povl, 2001, In: Journal of Medicinal Chemistry. 44, 7, p. 1051-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and pharmacology of 2-amino-4-(4-hydroxy-1,2,5-thiadiazol-3-yl)butyric acid.
Clausen, Rasmus Prætorius & Krogsgaard-Larsen, Povl, Aug 2001, In: American Chemical Society. Abstracts of Papers (at the National Meeting). 222, p. U660-U660Research output: Contribution to journal › Conference article › Research
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Synthesis and muscarinic receptor pharmacology of a series of 4,5,6,7-tetrahydroisothiazolo[4,5-c]pyridine bioisosteres of arecoline
Pedersen, H., Bräuner, Hans, Ball, R. G., Frydenvang, Karla Andrea, Meier, E., Bøgesø, K. P. & Krogsgaard-Larsen, Povl, 1999, In: Bioorganic & Medicinal Chemistry. 7, 5, p. 795-809 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues
Valgeirsson, J., Christensen, J. K., Kristensen, Anders Skov, Pickering, Darryl S, Nielsen, Birgitte, Fischer, C., Bräuner, Hans, Nielsen, E. Ø., Krogsgaard-Larsen, Povl & Madsen, U., 2003, In: Bioorganic & Medicinal Chemistry. 11, 20, p. 4341-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and Pharmacology of the Baclofen Homologues. 5-Amino-4-(4-chlorophenyl)pentanoic Acid and the R- and S-Enantiomers of 5-Amino-3-(4-chlorophenyl)pentanoic Acid
Karla, R., Ebert, B., Thorkildsen, C., Herdeis, C., Johansen, Tommy Nørskov, Nielsen, Birgitte & Krogsgaard-Larsen, Povl, 1999, In: Journal of Medicinal Chemistry. 42, p. 2053-2059 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synergies within the natural sciences at the University of Copenhagen: an interfaculty evaluation of barriers and opportunities to improve the quality of infrastructure, research and education
Krogsgaard-Larsen, Povl, Møller, Birger Lindberg, Larsen, Erik Hviid, Vestergaard, Bente, Lunde, C., Stæhr, P. A. & Andersen, J. (ed.), 2009, Faculty of Life Sciences: Museum Tusculanum. 43 p.Research output: Book/Report › Book › Research
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Synaptic and extrasynaptic GABA transporters as targets for anti-epileptic drugs
Madsen, K. K., Clausen, Rasmus Prætorius, Larsson, O. M., Krogsgaard-Larsen, Povl, Schousboe, Arne & White, H. S., 2009, In: Journal of Neurochemistry. 109, Suppl. 1, p. 139-44Research output: Contribution to journal › Journal article › Research › peer-review
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Subtype-selective excitatory amino acid receptor agonists and antagonists derived from ibotenic acid
Ebert, B., Lund, Trine Meldgaard, Madsen, Ulf, Brehm, L. & Krogsgaard-Larsen, Povl, 1992, New leads and targets in drug research: Alfred Benzon Symposium 33. Krogsgaard-Larsen, P., Christensen, S. B. & Kofod, H. (eds.). Copenhagen, p. 340-351 11 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Subtype selective kainic acid receptor agonists: discovery and approaches to rational design
Bunch, Lennart & Krogsgaard-Larsen, Povl, 2009, In: Medicinal Research Reviews. 29, 1, p. 3-28Research output: Contribution to journal › Review › Research › peer-review
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Structure–Activity Relationship and Pharmacology of γ‐Aminobutyric Acid Transport Inhibitor
Clausen, Rasmus Prætorius, Madsen, K., Larsson, O. M., Frølund, Bente, Krogsgaard-Larsen, Povl & Schousboe, Arne, 2006, GABA. Enna, S. (ed.). Vol. 54. p. 265–284 (Advances in Pharmacology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Structure-Activity Relationships of Selective GABA Uptake Inhibitors
Høg, S., Greenwood, J., Madsen, K. B., Larsson, O. M., Frølund, Bente, Schousboe, Arne, Krogsgaard-Larsen, Povl & Clausen, Rasmus Prætorius, 2006, In: Current Topics in Medicinal Chemistry. 6, 17, p. 1861–1882Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-Activity Relationship and Pharmacology of γ-Aminobutyric Acid (GABA) Transport Inhibitors
Clausen, Rasmus Prætorius, Madsen, K., Larsson, O. M., Frølund, Bente, Krogsgaard-Larsen, Povl & Schousboe, Arne, 1 Dec 2006, GABA. Enna, S. J. (ed.). p. 265-284 20 p. (Advances in Pharmacology, Vol. 54).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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