Povl Krogsgaard-Larsen
Professor, emeritus
Medicinal Chemistry
Jagtvej 162
2100 København Ø
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Novel Class of Potent 4-Arylalkyl Substituted 3-Isoxazolol GABAA Antagonists:Synthesis, Pharmacology, and Molecular Modeling
Frølund, Bente, Jørgensen, A. T., Tagmose, L., Stensbøl, T. B., Vestergaard, H. T., Engblom, C., Kristiansen, Uffe, Sanchez, C., Krogsgaard-Larsen, Povl & Liljefors, T., 2002, In: Journal of Medicinal Chemistry. 45, p. 2454–2468Research output: Contribution to journal › Journal article › Research › peer-review
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Novel class of potent 4-arylalkyl substituted 3-isoxazolol GABAA antagonists: Synthesis, pharmacology, and molecular modeling
Frølund, Bente, Jørgensen, A. T., Tagmose, L., Stensbøl, T. B., Vestergaard, H. T., Engblom, C., Kristiansen, Uffe, Sanchez, C., Krogsgaard-Larsen, Povl & Liljefors, T., 6 Jun 2002, In: Journal of Medicinal Chemistry. 45, 12, p. 2454-2468 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Organic hydroxylamine derivatives. VII. Isoxazolin 5 ones. An investigation of a reaction sequence previously stated to give 3 hydroxyisoxazoles
Krogsgaard-Larsen, Povl, Christensen, Søren Brøgger & Hjeds, H., 1 Jan 1973, In: Acta Chemica Scandinavica. 27, 8, p. 2802-2812 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Organic hydroxylamine derivatives. VIII. Structural analogues of GABA of the isoxazole enol betaine type. Synthesis of 5,6,7,8 tetrahydro 4H isoxazolo[3,4 d]azepin 3 ol zwitterion and some derivatives
Krogsgaard-Larsen, Povl, Hjeds, H. & Christensen, Søren Brøgger, 1 Jan 1973, In: Acta Chemica Scandinavica. 27, 9, p. 3251-3258 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Partial GABAA Receptor Agonists. Synthesis and in Vitro Pharmacology of a Series of Nonannulated Analogs of 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol
Frølund, Bente, Kristiansen, Uffe, Brehm, L., Hansen, A. B., Krogsgaard-Larsen, Povl & Falch, E., 1 Aug 1995, In: Journal of Medicinal Chemistry. 38, 17, p. 3287-3296 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Partial GABAA Receptor agonists. Synthesis and in vitro Pharmacology
Frølund, Bente, Kristiansen, Uffe, Brehm, L., Hansen, A. B., Krogsgaard-Larsen, Povl & Falch, E., 1995, In: Journal of Medicinal Chemistry. 38, p. 3287–3296Research output: Contribution to journal › Journal article › Research › peer-review
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Peptide and protein drug delivery : proceedings of a symposium held at the Royal Danish Academy of Sciences and Letters, August 17-21, 1997: Alfred Benzon Symposium, 43
Frøkjær, Sven, Christrup, Lona Louring, Krogsgaard-Larsen, Povl & Alfred Benzon, F., 1998, Copenhagen: Munksgaard .Research output: Book/Report › Book › Research
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Pharmacological characterization of homobaclofen on wild type and mutant GABA(B)1b receptors coexpressed with the GABA(B)2 receptor
Jensen, Anders A., Madsen, B. E., Krogsgaard-Larsen, Povl & Bräuner, Hans, 2001, In: European Journal of Pharmacology. 417, 3, p. 177-80 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacology of (S)-homoquisqualic acid and (S)-2-amino-5-phosphonopentanoic acid [(S)-AP5] at cloned metabotropic glutamate receptors
Bräuner, Hans & Krogsgaard-Larsen, Povl, Jan 1998, In: British Journal of Pharmacology. 123, 2, p. 269-74Research output: Contribution to journal › Journal article › Research › peer-review
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Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABAC receptor antagonists
Frølund, Bente, Krehan, D., Krogsgaard-Larsen, Povl, Kehler, J., Johnston, G. A. R. & Chebib, M., 2003, In: Neurochemistry International. 42, p. 561–565Research output: Contribution to journal › Journal article › Research › peer-review
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Potent 4-Aryl- or 4-Arylalkyl-Substituted 3-Isoxazolol GABAA Antagonists: Synthesis, Pharmacology, and Molecular Modeling
Frølund, Bente, Jensen, L. S., Guandalini, L., Canillo, C., Vestergaard, H. T., Kristiansen, U., Nielsen, Birgitte, Stensbøl, T. B., Madsen, C., Krogsgaard-Larsen, Povl & Liljefors, T., 2005, In: Journal of Medicinal Chemistry. 48, p. 427–439Research output: Contribution to journal › Journal article › Research › peer-review
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Potent 4-Arylalkyl-Substituted 3-Isothiazolol GABAA Competitive/Noncompetitive Antagonists: Synthesis and Pharmacology
Krehan, D., i Storustovu, S., Liljefors, T., Ebert, B., Nielsen, Birgitte, Krogsgaard-Larsen, Povl & Frølund, Bente, 2006, In: Journal of Medicinal Chemistry. 49, p. 1388–1396Research output: Contribution to journal › Journal article › Research › peer-review
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Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABAA antagonists: Synthesis, pharmacology, and molecular modeling
Frølund, Bente, Jensen, L. S., Guandalini, L., Canillo, C., Vestergaard, H. T., Kristiansen, Uffe, Nielsen, Birgitte, Stensbøl, T. B., Madsen, C., Krogsgaard-Larsen, Povl & Liljefors, T., 27 Jan 2005, In: Journal of Medicinal Chemistry. 48, 2, p. 427-439 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Preparations of deuterium labelled guvacine and isoguvacine
Christensen, Søren Brøgger & Krogsgaard-Larsen, Povl, 1 Jan 1980, In: Journal of Labelled Compounds and Radiopharmaceuticals. 17, 2, p. 191-202 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Probing the orthosteric binding site of GABAA receptors with heterocyclic GABA carboxylic acid bioisosteres
Petersen, J. G., Bergmann, R., Krogsgaard-Larsen, Povl, Balle, T. & Frølund, Bente, 21 Dec 2013, In: Neurochemical Research. 39, p. 1005-1015Research output: Contribution to journal › Journal article › Research › peer-review
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Probing α4βδ GABAA Receptor Heterogeneity: Differential Regional Effects of a Functionally Selective α4β1δ/α4β3δ Receptor Agonist on Tonic and Phasic Inhibition in Rat Brain
Hoestgaard-Jensen, K., Dalby, N. O., Krall, J., Hammer, H., Krogsgaard-Larsen, Povl, Frølund, Bente & Jensen, Anders A., 2014, In: Journal of Neuroscience. 34, 49, p. 16256-16272 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rational design, synthesis, and pharmacological evaluation of 2-azanorbornane-3-exo,5-endo-dicarboxylic acid: a novel conformationally restricted glutamic acid analogue
Bunch, Lennart, Liljefors, T., Greenwood, J. R., Frydenvang, Karla Andrea, Bräuner, Hans, Krogsgaard-Larsen, Povl & Madsen, Ulf, 2003, In: Journal of Organic Chemistry. 68, 4, p. 1489-95 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Recent advances in the medicinal chemistry of polyamine toxins
Strømgaard, Kristian, Andersen, K., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., Nov 2001, In: Mini - Reviews in Medicinal Chemistry. 1, 4, p. 317-338 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Regioselective lithiation and functionalization of 3-(benzyloxy)isothiazole: Application to the synthesis of thioibotenic acid
Bunch, Lennart, Krogsgaard-Larsen, Povl & Madsen, Ulf, 5 Apr 2002, In: Journal of Organic Chemistry. 67, 7, p. 2375-2377Research output: Contribution to journal › Journal article › Research › peer-review
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Relationship between structure, conformational flexibility, and biological activity of agonists and antagonists at the N-methyl-D-aspartic acid subtype of excitatory amino acid receptors
Madsen, Ulf, Brehm, L., Schaumburg, K., Jørgensen, Flemming Steen & Krogsgaard-Larsen, Povl, 1990, In: Journal of Medicinal Chemistry. 33, 1, p. 374-80 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA
Johansen, Tommy Nørskov, Stensbøl, T. B., Nielsen, Birgitte, Vogensen, S. B., Frydenvang, Karla Andrea, Sløk, F. A., Bräuner, Hans, Madsen, Ulf & Krogsgaard-Larsen, Povl, 2001, In: Chirality. 13, 9, p. 523-32 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Resolution, configurational assignment, and enantiopharmacology of 2-amino-3-[3-hydroxy-5-(2-methyl-2H- tetrazol-5-yl)isoxazol-4-yl]propionic acid, a potent GluR3- and GluR4-preferring AMPA receptor agonist
Vogensen, S. B., Jensen, H. S., Stensbøl, T. B., Frydenvang, Karla Andrea, Bang-Andersen, B., Johansen, Tommy Nørskov, Egebjerg, J. & Krogsgaard-Larsen, Povl, 2000, In: Chirality. 12, 10, p. 705-13 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Scientific social responsibility: a call to arms
Krogsgaard-Larsen, Povl, Thostrup, P. & Besenbacher, F., 11 Nov 2011, In: Angewandte Chemie International Edition. 50, 46, p. 10738-10740Research output: Contribution to journal › Comment/debate › Research
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Selective GABA transporter inhibitors tiagabine and EF1502 exhibit mechanistic differences in their ability to modulate the ataxia and anticonvulsant action of the extrasynaptic GABA(A) receptor agonist gaboxadol
Madsen, K. K., Ebert, B., Clausen, Rasmus Prætorius, Krogsgaard-Larsen, Povl, Schousboe, Arne & White, H. S., 1 Jul 2011, In: Journal of Pharmacology and Experimental Therapeutics. 338, 1, p. 214-219Research output: Contribution to journal › Journal article › Research › peer-review
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Selective Inhibitors of Glial GABA Uptake: Synthesis, Absolute Stereochemistry, and Pharmacology of the Enantiomers of 3-Hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and Analogues
Falch, E., Frølund, Bente, Perregaard, Sanchez, C., Søkilde, B., Buur, A., Hansen, A., Frydenvang, Karla Andrea, Brehm, L., Bolvig, T., Larsson, O. M., Schousboe, Arne & Krogsgaard-Larsen, Povl, 1999, In: Journal of Medicinal Chemistry. 42, p. 5402–5414Research output: Contribution to journal › Journal article › Research › peer-review
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