Povl Krogsgaard-Larsen
Professor, emeritus
Medicinal Chemistry
Jagtvej 162
2100 København Ø
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Design, synthesis, and characterisation of selective GABA transport inhibitors
Clausen, Rasmus Prætorius, Moltzen, E., Perregaard, J., Lenz, S., Sanchez, S., Frølund, Bente, Bolvig, T., Sarup, A., Larsson, O., White, H., Schousboe, Arne & Krogsgaard-Larsen, Povl, Aug 2005, In: Journal of Neurochemistry. 94, p. 150-150Research output: Contribution to journal › Conference abstract in journal › Research
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Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties
Jensen, Anders A., Plath, N., Pedersen, M. H. F., Isberg, V., Krall, J., Wellendorph, Petrine, Stensbøl, T. B., Gloriam, David E., Krogsgaard-Larsen, Povl & Frølund, Bente, 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 1211-27 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Detecting protein-protein interactions in living cells: development of a bioluminescence resonance energy transfer assay to evaluate the PSD-95/NMDA receptor interaction
Gottschalk, M., Bach, Anders, Hansen, J. L., Krogsgaard-Larsen, Povl, Kristensen, Anders Skov & Strømgaard, Kristian, 2009, In: Neurochemical Research. 34, 10, p. 1729-1737Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazol (exo-THPO) and its N-substituted analogs on GABA transport in cultured neurons and astrocytes and by the four cloned mouse GABA transporters
sarup, A., Larsson, O. M., Bolvig, T., Frølund, Bente, Krogsgaard-Larsen, Povl & Schousboe, Arne, 2003, In: Neurochemistry International. 43, p. 445–451Research output: Contribution to journal › Journal article › Research › peer-review
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Electrophysiological studies of the GABAA receptor ligand, 4‐PIOL, on cultured hippocampal neurones
Kristiansen, Uffe, Lambert, J. D. C., Falch, E. & Krogsgaard-Larsen, Povl, Sep 1991, In: British Journal of Pharmacology. 104, 1, p. 85-90 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Enantiopharmacology of 1,2,5-thiadiazol-3-ol analogues of glutamic acid and 2-aminoadipic acid
Johansen, T., Clausen, Rasmus Prætorius, Brauner-Osbome, H., Janin, Y., Greenwood, J. & Krogsgaard-Larsen, Povl, Aug 2002, In: Neuropharmacology. 43, 2, p. 290-290Research output: Contribution to journal › Conference abstract in journal › Research
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Enzymatic resolution of AMPA by use of alpha-chymotrypsin
Nielsen, Birgitte, Fisker, H., Ebert, B., Madsen, Ulf, Curtis, D. R., Krogsgaard-Larsen, Povl & Hansen, J. J., 1993, In: Bioorganic & Medicinal Chemistry Letters. 3, 1, p. 107–114 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Equilibrium binding characteristics of [3H]thiomuscimol
Ebert, B., Frølund, Bente, Diemer, N. & Krogsgaard-Larsen, Povl, 1999, In: Neurochemistry International. 34, p. 427–434Research output: Contribution to journal › Journal article › Research › peer-review
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Erratum: Activity of novel 4-PIOL analogues at human α1β2γ2S GABAA receptors - Correlation with hydrophobicity (European Journal of Pharmacology (2000) 451 (125-132))
Mortensen, M., Frølund, Bente, Jorgensen, A. T., Liljefors, T., Krogsgaard-Larsen, Povl & Ebert, B., 25 Oct 2002, In: European Journal of Pharmacology. 453, 2-3, p. 345-346 2 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Erratum: Synthesis and pharmacology of glutamate receptor ligands: New isothiazole analogues of ibotenic acid (Organic and Biomolecular Chemistry (2007) 5 DOI:10.1039/b615162k)
Jørgensen, Charlotte Grube, Clausen, Rasmus Prætorius, Hansen, K. B., Bräuner, Hans, Nielsen, Birgitte, Metzler, B., Kehler, J., Krogsgaard-Larsen, Povl & Madsen, Ulf, 2007, In: Organic and Biomolecular Chemistry. 5, 5, p. 848 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Et bud på fremtidens lægemidler mod epilepsi.
Clausen, Rasmus Prætorius, Larsson, O. M., Greenwood, J. & Krogsgaard-Larsen, Povl, 2001, In: Lægemiddelforskning. p. 20-21Research output: Contribution to journal › Journal article › Communication
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Excitatory Amino acid agonists and parital agonists
Christensen, I. T., Reinhardt, A., Nielsen, Birgitte, Ebert, B., Madsen, Ulf, Nielsen, E. Ø., Brehm, L. & Krogsgaard-Larsen, Povl, 1989, In: drug design and delivery. 5, p. 57-71 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Excitatory Amino acid agonists: Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid
Hansen, J. J., Nielsen, Birgitte, Krogsgaard-Larsen, Povl, Brehm, L., Nielsen, E. Ø. & Curtis, D. R., 1989, In: Journal of Medicinal Chemistry. 32, p. 2254-2260 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Excitatory Amino acid receptor agonists: enantiomeric resolutions by use of enzymes and chiral HPLC
Hansen, J. J., Nielsen, Birgitte, Reinhardt, A. & Krogsgaard-Larsen, Povl, 1990, In: Acta Pharmaceutica Nordica. 2, p. 185-192 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Excitatory amino acid agonists and partial agonists
Christensen, I. T., Reinhardt, A., Nielsen, B., Ebert, B., Madsen, Ulf, Nielsen, E. O., Brehm, L. & Krogsgaard-Larsen, Povl, 1989, In: Drug Design and Delivery. 5, 1, p. 57-71 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Excitatory amino acid receptor antagonists: resolution, absolute stereochemistry, and pharmacology of (S)- and (R)-2-amino-2-(5-tert-butyl-3-hydroxyisoxazol-4-yl)acetic acid (ATAA)
Johansen, Tommy Nørskov, Frydenvang, Karla Andrea, Ebert, B., Madsen, Ulf & Krogsgaard-Larsen, Povl, 1997, In: Chirality. 9, 5-6, p. 529-36 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Excitatory amino acid receptor ligands. Synthesis and biological activity of 3-isoxazolol amino acids structurally related to homoibotenic acid
Christensen, I. T., Ebert, B., Madsen, Ulf, Nielsen, Birgitte, Brehm, L. & Krogsgaard-Larsen, Povl, 18 Sep 1992, In: Journal of Medicinal Chemistry. 35, 19, p. 3512-3519 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid
Johansen, Tommy Nørskov, Ebert, B., Bräuner, Hans, Didriksen, M., Christensen, I. T., Søby, K. K., Madsen, Ulf, Krogsgaard-Larsen, Povl & Brehm, L., 12 Mar 1998, In: Journal of Medicinal Chemistry. 41, 6, p. 930-9Research output: Contribution to journal › Journal article › Research › peer-review
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Excitatory amino acid receptors: multiplicity and structural requirements for activation and blockade
Krogsgaard-Larsen, Povl, Lund, Trine Meldgaard, Jørgensen, Flemming Steen & Brehn, L., 1991, Excitatory amino acids and synaptic function. Wheal, H. & Thomson, A. (eds.). London: Academic Press, p. 1-17 17 p. (Excitatory Amino Acids and Synaptic Transmission, Academic Press, London).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Excitatory amino acid research in Alzheimer´s disease: activation, enhancement and blockade of receptor subtypes
Krogsgaard-Larsen, Povl, Nielsen, Birgitte & Hansen, J. J., 1993, Advances in Neuropharmacology. Ross, F. C. (ed.). London: Smith-Gordon and Company Limited, p. 241-248 8 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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First Demonstration of a Functional Role for CNS Betaine/GABA Transporter (mGAT2) Based on Synergistic Anticonvulsant Action Among Inhibitors of mGAT1 and mGAT2
White, S., Watson, W. P., Hansen, S. L., Slough, S., Perregård, J., Sarup, A., Bolvig, T., Petersen, G., Larsson, O. M., Clausen, Rasmus Prætorius, Frølund, Bente, Falch, E., Krogsgaard-Larsen, Povl & Schousboe, Arne, 2005, In: The Journal of Pharmacology and Experimental Therapeutics. 312, p. 866–874Research output: Contribution to journal › Journal article › Research › peer-review
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Functional and Pharmacological Aspects of GABA Transporters
Madsen, K., White, S. H., Clausen, Rasmus Prætorius, Larsson, O. M., Frølund, Bente, Krogsgaard-Larsen, Povl & Schousboe, Arne, 2006, Handbook of Neurochemistry and Molecular neurobiology. p. 1-17Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Functional and pharmacological aspects of GABA transporters
Madsen, K., White, H. S., Clausen, Rasmus Prætorius, Frølund, Bente, Larsson, O. M., Krogsgaard-Larsen, Povl & Schousboe, Arne, 2007, Handbook of nerochemistry and molecular neurobiology: Neural membranes and transport. Lajtha, A. & Reith, M. E. A. (eds.). 3rd. ed. Berlin: Springer, Vol. 3. p. 285-304Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Functional importance of the Ala(116)-Pro(136) region in the calcium-sensing receptor. Constitutive activity and inverse agonism in a family C G-protein-coupled receptor
Jensen, Anders A., Spalding, T. A., Burstein, E. S., Sheppard, P. O., O'Hara, P. J., Brann, M. R., Krogsgaard-Larsen, Povl & Bräuner, Hans, 2000, In: Journal of Biological Chemistry. 275, 38, p. 29547-55 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional partial agonism at cloned human muscarinic acetylcholine receptors
Bräuner, Hans, Ebert, B., Brann, M. R., Falch, E. & Krogsgaard-Larsen, Povl, 10 Oct 1996, In: European Journal of Pharmacology. 313, 1-2, p. 145-50Research output: Contribution to journal › Journal article › Research › peer-review
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Functional pharmacology of cloned heterodimeric GABA-B receptors expressed in mammalian cells
Bräuner, Hans & Krogsgaard-Larsen, Povl, Dec 1999, In: British Journal of Pharmacology. 128, 7, p. 1370-4Research output: Contribution to journal › Journal article › Research › peer-review
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GABA A agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic
Krogsgaard-Larsen, Povl, Frølund, Bente, Liljefors, T. & Ebert, B., 15 Oct 2004, In: Biochemical Pharmacology. 68, 8, p. 1573-1580 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GABA and Glutamate Receptor Ligands and Their Therapeutic Potential in CNS Disorders
Madsen, Ulf, Bräuner, Hans, Greenwood, J. R., Johansen, Tommy Nørskov, Krogsgaard-Larsen, Povl, Liljefors, T., Nielsen, M. & Frølund, Bente, 27 Jan 2005, Drug Discovery Handbook. John Wiley & Sons, Inc., p. 797-907 111 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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GABA and Glutamate Receptor Ligands and Therapeutic Potential in CNS Disorders
Madsen, Ulf, Greenwood, J., Johansen, Tommy Nørskov, Krogsgaard-Larsen, Povl, Liljefors, T., Nielsen, M. & Frølund, Bente, 2005, Drug Discovery Handbook. Wiley, p. 797–907Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects
Krogsgaard-Larsen, Povl, Frølund, Bente & Frydenvang, Karla Andrea, 2000, In: Current Pharmaceutical Design. 6, 12, p. 1193-209 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GABA(A) and GABA(B) receptor agonists, partial agonists, antagonists and modulators: Design and therapeutic prospects
Krogsgaard-Larsen, Povl, Frølund, Bente, Kristiansen, Uffe, Frydenvang, Karla Andrea & Ebert, B., Nov 1997, In: European Journal of Pharmaceutical Sciences. 5, 6, p. 355-384 30 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GABA(A) receptor ligands and their therapeutic potentials.
Frølund, Bente, Ebert, B., Kristiansen, Uffe, Liljefors, T. & Krogsgaard-Larsen, Povl, Aug 2002, In: Current Topics in Medicinal Chemistry. 2, 8, p. 817-832 16 p.Research output: Contribution to journal › Review › Research › peer-review
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GABA-A Receptor Agonists, Partial Agonists and Antagonists
Frølund, Bente, Krogsgaard-Larsen, Povl & Ebert, B., 1996, The GABA Receptors. 2nd ed. Humana PressResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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GABA-A and GABA-B receptor Agonists, Partial Agonists and Modulators. design and Therapeutic Prospects
Frølund, Bente, Krogsgaard-Larsen, Povl, Kristiansen, Uffe, Frydenvang, Karla Andrea & Ebert, B., 1997, In: European Journal of Pharmaceutical Sciences. 4, p. 355–384Research output: Contribution to journal › Journal article › Research › peer-review
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GABA-B Antagonists: Enantiopharmacology of 5-Amino-4-hydroxy-2-methylvaleric Acid and X-Ray Structure of the Eutomer
Frydenvang, Karla Andrea, Kristiansen, Uffe, Frølund, Bente, Herdeis, C. & Krogsgaard-Larsen, Povl, 1995, In: Chirality. 7, p. 526–533Research output: Contribution to journal › Journal article › Research › peer-review
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GABAA Agonists and Partial Agonists: THIP (Gaboxadol) as a Non-Opioid Analgesic and a Novel Type of Hypnotic
Krogsgaard-Larsen, Povl, Frølund, Bente, Liljefors, T. & Ebert, B., 2006, GABA. Enna, S. (ed.). p. 53–71 (Advances in Pharmacology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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GABAA Agonists: Resolution and Pharmacology of (+)- and (-)-Isoguvacine Oxide
Frølund, Bente, Jeppesen, L., Krogsgaard-Larsen, Povl & Hansen, J. J., 1995, In: Chirality. 7, p. 434–438Research output: Contribution to journal › Journal article › Research › peer-review
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GABAA agonists: Resolution and pharmacology of (+)‐ and (−)‐isoguvacine oxide
Frølund, Bente, Jeppesen, L., Krogsgaard-Larsen, Povl & Hansen, J. J., 1995, In: Chirality. 7, 6, p. 434-438 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GABAA agonists and partial agonists
Krogsgaard-Larsen, Povl, Frølund, Bente & Liljefors, T., 2002, In: The Chemical Record. 2, p. 419–430Research output: Contribution to journal › Journal article › Research › peer-review
GABAA agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of Hypnotic
Krogsgaard-Larsen, Povl, Frølund, B., Liljefors, T. & Ebert, B., 2004, In: Biochemical Pharmacology. 68, p. 1573–1580Research output: Contribution to journal › Journal article › Research › peer-review
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GABAA receptor ligands and their therapeutic potentials
Frølund, Bente, Ebert, B., Kristiansen, Uffe, Liljefors, T. & Krogsgaard-Larsen, Povl, 2002, In: Current Topics in Medicinal Chemistry. 2Research output: Contribution to journal › Journal article › Research › peer-review
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GABAA receptor agonists, partial agonists, and antagonists. Design and therapeutic prospects
Krogsgaard-Larsen, Povl, Frølund, Bente, Jørgensen, Flemming Steen & Schousboe, Arne, 1994, In: Journal of Medicinal Chemistry. 37, 16, p. 2489-505 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GABAA receptor partial agonists and antagonists: structure, binding mode, and pharmacology
Krall, J., Balle, T., Krogsgaard-Larsen, N., Sørensen, T. E., Krogsgaard-Larsen, Povl, Kristiansen, Uffe & Frølund, Bente, 2015, Diversity and functions of GABA receptors: A tribute to Hanns Möhler, Part A. Vol. 72. p. 201-27 27 p. (Advances in Pharmacology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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GABAB antagonists: resolution, absolute stereochemistry, and pharmacology of (R)- and (S)-phaclofen
Frydenvang, Karla Andrea, Hansen, J. J., Krogsgaard-Larsen, Povl, Mitrovic, A., Tran, H., Drew, C. A. & Johnston, G. A., 1994, In: Chirality. 6, 7, p. 583-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glutamate receptor ligands: synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs
Guldbrandt, M., Johansen, Tommy Nørskov, Frydenvang, Karla Andrea, Bräuner, Hans, Stensbøl, T. B., Nielsen, Birgitte, Karla, R., Santi, F., Krogsgaard-Larsen, Povl & Madsen, Ulf, 2002, In: Chirality. 14, 4, p. 351-63 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships
Falch, E., Brehm, L., Mikkelsen, I., Johansen, Tommy Nørskov, Skjærbæk, N., Nielsen, Birgitte, Stensbøl, T. B., Ebert, B. & Krogsgaard-Larsen, Povl, 1998, In: Journal of Medicinal Chemistry. 41, p. 2513-2523 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Heterocyclic muscarinic agonists: Structural and therapeutic aspects
Krogsgaard-Larsen, Povl, Jensen, B., Falch, E. & Jørgensen, Flemming Steen, 1 Jan 1989, In: Drugs of the Future. 14, 6, p. 541-561 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Hydroxylated analogues of 5-aminovaleric acid as 4-aminobutyric acidB receptor antagonists: stereostructure-activity relationships
Kristiansen, Uffe, bjl587, bjl587, Herdeis, C., Lund, Trine Meldgaard, Nielsen, Birgitte, Hansen, J. J., Falch, E., Hjeds, H. & Krogsgaard-Larsen, Povl, Mar 1992, In: Journal of Neurochemistry. 58, 3, p. 1150-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors
Hermit, M. B., Greenwood, J. R., Nielsen, Birgitte, Bunch, Lennart, Jørgensen, Charlotte Grube, Vestergaard, H. T., Stensbøl, T. B., Sanchez, C., Krogsgaard-Larsen, Povl, Madsen, Ulf & Bräuner, Hans, 23 Feb 2004, In: European Journal of Pharmacology. 486, 3, p. 241-50Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electrographic bursting in the medial entorhinal cortex (mEC)
Smith, M. D., Saunders, G. W., Clausen, Rasmus Prætorius, Frølund, Bente, Krogsgaard-Larsen, Povl, Larsson, O. M., Schousboe, Arne, Wilcox, K. S. & White, H. S., 2008, In: Epilepsy Research. 79, 1, p. 6-13Research output: Contribution to journal › Journal article › Research › peer-review
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