Stephan Pless

Stephan Pless

Professor


  1. Published

    A Semi-Synthetic Approach to Engineer Ligand- and Voltage-Gated Ion Channels in Live Cells

    Khoo, K. K., Galleano, I. & Pless, Stephan, 2019, p. 274A-274A.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  2. Published

    PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels

    Kim, R. Y., Pless, Stephan & Kurata, H. T., 23 Oct 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 45, p. E9702–E9711

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Atomic basis for therapeutic activation of neuronal potassium channels

    Kim, R. Y., Yau, M. C., Galpin, J. D., Seebohm, G., Ahern, C. A., Pless, Stephan & Kurata, H. T., 2015, In: Nature Communications. 6, p. 1-11 11 p., 8116.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Structure of the human sodium leak channel NALCN

    Kschonsak, M., Chua, H. C., Noland, C. L., wbv551, wbv551, Clairfeuille, T., Bahlke, O. Ø., Ameen, A. O., Li, Z. R., Arthur, C. P., Ciferri, C., Pless, Stephan & Payandeh, J., 2020, In: Nature. 587, p. 313-318

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Structural architecture of the human NALCN channelosome

    Kschonsak, M., Chua, H. C., wbv551, wbv551, Chakouri, N., Noland, C. L., Schott, K., Chang, T., Tam, C., Patel, N., Arthur, C. P., Leitner, A., Ben-Johny, M., Ciferri, C., Pless, Stephan & Payandeh, J., 2022, In: Nature. 603, p. 180–186

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Intermediate state trapping of a voltage sensor

    Lacroix, J. J., Pless, Stephan, Maragliano, L., Campos, F. V., Galpin, J. D., Ahern, C. A., Roux, B. & Bezanilla, F., Dec 2012, In: Journal of General Physiology. 140, 6, p. 635-52 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Inhibitor-Induced Conformational Changes in ASIC1A

    Lund, Camilla, Borg, C. B., Lynagh, T. & Pless, Stephan, 2 Feb 2018, p. 130A-130A.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  8. Published

    Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes

    Lynagh, T., Mikhaleva, Y., Colding, J. M., Glover, J. C. & Pless, Stephan, 14 Aug 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 33, p. 8430-8435

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen

    Lynagh, T., Romero-Rojo, J. L., Lund, Camilla & Pless, Stephan, 12 Oct 2017, In: Journal of Medicinal Chemistry. 60, 19, p. 8192-8200 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    A selectivity filter at the intracellular end of the acid-sensing ion channel pore

    Lynagh, T., Flood, E., Boiteux, C., Wulf, M., Komnatnyy, V. V., Colding, J. M., Allen, T. W. & Pless, Stephan, 12 May 2017, In: eLife. 6, 21 p., 24630.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction

    Lynagh, T., Kiontke, S., Meyhoff-Madsen, M., Gless, B. H., Johannesen, J., Kattelmann, S., Christiansen, A., Dufva, M., Laustsen, A. H., Devkota, K., Olsen, Christian Adam, Kuemmel, D., Pless, Stephan & Lohse, B., 2020, In: Journal of Medicinal Chemistry. 63, 22, p. 13709-13718 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Unique contributions of an arginine side chain to ligand recognition in a glutamate-gated chloride channel

    Lynagh, T., Komnatnyy, V. V. & Pless, Stephan, 17 Jan 2017, In: The Journal of Biological Chemistry. 292, p. 3940-3946

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Determinants of ion selectivity in ASIC1a- and ASIC2a-containing acid-sensing ion channels

    Lynagh, T., Flood, E., Boiteux, C., Sheikh, Zeshan Pervez, Allen, T. W. & Pless, Stephan, 3 Feb 2020, In: The Journal of general physiology. 152, 2

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Principles of agonist recognition in Cys-loop receptors

    Lynagh, T. P. & Pless, Stephan, 2014, In: Frontiers in Physiology. 5, p. 1-12 12 p., 160.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    ATP signaling in pancreatic cancer: the P2X7 receptor

    Magni, Lara, Bouazzi, R., Christensen, Nynne, Tozzi, M., Poulsen, M., Johansen, J., Pless, Stephan & Novak, Ivana, 2022, In: Acta Physiologica. 236, S725, p. 661-661

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  16. Published
  17. Published

    Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel

    Noland, C. L., Chua, H. C., Kschonsak, M., Heusser, Stephanie, Braun, N., Chang, T., Tam, C., Tang, J., Arthur, C. P., Ciferri, C., Pless, Stephan & Payandeh, J., 2022, In: Nature Communications. 13, 1, 10 p., 1416.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    The suitability of high throughput automated patch clamp for physiological applications

    Obergrussberger, A., Rinke-Weiß, I., Goetze, T. A., Rapedius, M., Brinkwirth, N., Becker, N., Rotordam, M. G., Hutchison, L., Madau, P., Pau, D., Dalrymple, D., Braun, N., Friis, S., Pless, Stephan & Fertig, N., 2022, In: Journal of Physiology. 600, 2, p. 277-297

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Introduction: Applying Chemical Biology to Ion Channels

    Pless, Stephan & Ahern, C. A., 2015, Applying Chemical Biology to Ion Channels. Vol. 869. p. 1-4 4 p. (Advances in Experimental Medicine and Biology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  20. Published

    A tale of ligands big and small: An update on how pentameric ligand-gated ion channels interact with agonists and proteins

    Pless, Stephan & Sivilotti, L. G., 1 Apr 2018, In: Current Opinion in Physiology. 2, p. 19-26 8 p.

    Research output: Contribution to journalReviewResearchpeer-review

  21. Published

    Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels

    Pless, Stephan, Galpin, J. D., Niciforovic, A. P., Kurata, H. T. & Ahern, C. A., 2013, In: eLife. 2, p. e01289

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Atom-by-atom engineering of voltage-gated ion channels: Magnified insights into function and pharmacology

    Pless, Stephan, Kim, R. Y., Ahern, C. A. & Kurata, H. T., 30 Jan 2015, In: The Journal of Physiology. 593, 12, p. 2627–2634 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel

    Pless, Stephan, Niciforovic, A. P., Galpin, J. D., Nunez, J., Kurata, H. T. & Ahern, C. A., 2013, In: Nature Communications. 4, p. 1784

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Contributions of conserved residues at the gating interface of glycine receptors

    Pless, Stephan, Leung, A. W. Y., Galpin, J. D. & Ahern, C. A., 7 Oct 2011, In: The Journal of Biological Chemistry. 286, 40, p. 35129-36 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Ligand-specific conformational changes in the alpha1 glycine receptor ligand-binding domain

    Pless, Stephan & Lynch, J. W., 5 Jun 2009, In: The Journal of Biological Chemistry. 284, 23, p. 15847-56 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 93715174