Atom-by-atom engineering of voltage-gated ion channels: Magnified insights into function and pharmacology
Research output: Contribution to journal › Journal article › Research › peer-review
Unnatural amino acid incorporation into ion channels has proven to be a valuable approach to interrogate detailed hypotheses arising from atomic resolution structures. In this short review, we provide a brief overview of some of the basic principles and methods for incorporation of unnatural amino acids into proteins. We also review insights into the function and pharmacology of voltage-gated ion channels that have emerged from unnatural amino acid mutagenesis approaches.
Original language | English |
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Journal | The Journal of Physiology |
Volume | 593 |
Issue number | 12 |
Pages (from-to) | 2627–2634 |
Number of pages | 8 |
ISSN | 0022-3751 |
DOIs | |
Publication status | Published - 30 Jan 2015 |
ID: 139031065