Trine Meldgaard Lund

Trine Meldgaard Lund

Associate Professor

ORCID: 0000-0001-8598-2880

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  1. Published

    A Model-Based Approach for Joint Analysis of Pain Intensity and Opioid Consumption in Postoperative Pain

    Juul, R. V., Knøsgaard, K. R., Olesen, A. E., Pedersen, K. V., Kreilgaard, M., Christrup, Lona Louring, Osther, P. J., Drewes, A. M. & Lund, Trine Meldgaard, Jul 2016, In: A A P S Journal. 18, 4, p. 1013-1022 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    A Model-Based Approach for Joint Analysis of Pain Intensity and Opioid Consumption in Postoperative Pain

    Knøsgaard, K., Juul, R. V., Olesen, A. E., Pedersen, K. V., Kreilgaard, M., Christrup, Lona Louring, Osther, P. J. S., Drewes, A. M. & Lund, Trine Meldgaard, Jun 2016.

    Research output: Contribution to conference › Poster › Research

  3. Published

    A pharmacokinetic-pharmacodynamic model of morphine exposure and subsequent morphine consumption in postoperative pain

    Juul, R. V., Nyberg, J., Lund, Trine Meldgaard, Rasmussen, S., Kreilgaard, M., Christrup, Lona Louring & Simonsson, U. S. H., 2016, In: Pharmaceutical Research. 33, 5, p. 1093–1103 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    A review of morphine and morphine-6-glucuronide's pharmacokinetic-pharmacodynamic relationships in experimental and clinical pain

    Sverrisdóttir, E., Lund, Trine Meldgaard, Olesen, A. E., Drewes, A. M., Christrup, Lona Louring & Kreilgaard, M., 7 Apr 2015, In: European Journal of Pharmaceutical Sciences. 74, p. 45–62 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    AMPA receptor agonists, design, synthesis and molecular pharmacology

    Lund, Trine Meldgaard, Christensen, I. T., Madsen, Ulf, Ebert, B., Brehm, L. & Krogsgaard-Larsen, Povl, 1990, In: Neurochemistry International. 16 suppl 1, 51, p. 51 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  6. Published

    AMPA receptor agonists: structural, conformational and stereochemical aspects

    Hansen, J., Jørgensen, Flemming Steen, Lund, Trine Meldgaard, Nielsen, Birgitte, Reinhardt, A., Breum, I., Brehm, L. & Krogsgaard-Larsen, Povl, 1992, Excitatory Amino Acid Receptors. Krogsgaard-Larsen, P. & Hansen, J. J. (eds.). Ellis Horwood: Chichester, 30 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  7. Published

    Analysis of opioid consumption in clinical trials: a simulation based analysis of power of four approaches

    Juul, R. V., Nyberg, J., Kreilgaard, M., Christrup, Lona Louring, Simonsson, U. S. H. & Lund, Trine Meldgaard, Aug 2017, In: Journal of Pharmacokinetics and Pharmacodynamics. 44, 4, p. 325-333 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Appetite stimulation with cannabis-based medicine and methods for assessment of glomerular filtration in older patients with medical illness: A study protocol

    Nielsen, R. L., Bornæs, O., Storgaard, I. K., Kallemose, T., Jørgensen, L. M., Jawad, B. N., Altintas, I., Juul-larsen, H. G., Tavenier, J., Durhuus, J. A., Bengaard, A. K. P., Holst, J. J., Kolko, M., Sonne, D. P., Breindahl, T., Damgaard, M., Porrini, E., Hornum, M., Andersen, O., Pedersen, M. M. & 6 others, Rasmussen, H. H., Munk, T., Lund, Trine Meldgaard, Jensen, A. P. S. L., Andersen, A. L. & Houlind, Morten Baltzer, 2023, In: Basic & Clinical Pharmacology & Toxicology. 133, 3, p. 237-253 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Artificial neural network vs pharmacometric model for population prediction of plasma concentration in real-world data: a case study on valproic acid

    Soeorg, H., Sverrisdóttir, E., Andersen, Morten, Lund, Trine Meldgaard & Sessa, Maurizio, 2022, In: Clinical Pharmacology and Therapeutics. 111, 6, p. 1278-1285

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Aspartate-glutamate homeostasis in cerebellar neurons changes when shifting from glucose to beta-hydroxybutyrate as substrate

    Lund, Trine Meldgaard, Clausen, M., Risa, Ø., Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 2009, In: Journal of Neurochemistry. s1, p. 291-291

    Research output: Contribution to journal › Conference abstract in journal › Research

  11. Published

    Astrocyte glycogen metabolism is required for neural activity during aglycemia or intense stimulation in mouse white matter

    Brown, A. M., Sickmann, H. M., Fosgerau, K., Lund, Trine Meldgaard, Schousboe, Arne, Waagepetersen, Helle S. & Ransom, B. R., 2005, In: Journal of Neuroscience Research. 79, 1-2, p. 74-80 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Availability of neurotransmitter glutamate is diminished when beta-hydroxybutyrate replaces glucose in cultured neurons

    Lund, Trine Meldgaard, Risa, Ø., Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 2009, In: Journal of Neurochemistry. 110, 1, p. 80-91 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Body of evidence and approaches applied in the clinical development programme of fixed-dose combinations in the European Union from 2010 to 2016

    Nøhr-Nielsen, A., De Bruin, M. L., Thomsen, M., Pipper, C. B., Lange, Theis, Bjerrum, Ole Jannik & Lund, Trine Meldgaard, 2019, In: British Journal of Clinical Pharmacology. 85, 8, p. 1829-1840 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Bounded Integer Modeling of Symptom Scales Specific to Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia

    Lyauk, Y. K., Jonker, D. M., Hooker, A., Lund, Trine Meldgaard & Karlsson, M. O., 2021, In: The AAPS journal. 23, 2, 14 p., 33.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    COMBINATION OF MORPHINE AND GABAPENTIN LEADS TO SYNERGISTIC EFFECTS IN A RAT MODEL OF POSTOPERATIVE PAIN

    Papathanasiou, T., Juul, R. V., Heegaard, Anne-Marie, Kreilgaard, M. & Lund, Trine Meldgaard, 14 Jan 2015.

    Research output: Contribution to conference › Poster › Research

  16. Published

    Carnitine Levels in Skeletal Muscle, Blood, and Urine in Patients with Primary Carnitine Deficiency During Intermission of L-Carnitine Supplementation

    Rasmussen, J., Thomsen, J. A., Olesen, J. H., Lund, Trine Meldgaard, Mohr, M., Clementsen, J., Nielsen, Olav Wendelboe & Lund, A. M., 10 Feb 2015, JIMD Reports. Zschocke, J., Baumgartner, M., Morava, E., Patterson, M., Rahman, S. & Peters, V. (eds.). Berlin: Springer, Vol. 20. p. 103-111 9 p. (JIMD Reports).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  17. Published

    Changes in brain levels of N-acylethanolamines and 2-arachidonoylglycerol in focal cerebral ischemia in mice

    Degn, M., Lambertsen, K. L., Petersen, G., Meldgaard, M., Artmann, A., Clausen, B. H., Hansen, S. H., Finsen, B., Hansen, Harald S. & Lund, Trine Meldgaard, 2007, In: Journal of Neurochemistry. 103, 5, p. 1907-1916

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Co-administration of morphine and gabapentin leads to dose dependent synergistic effects in a rat model of postoperative pain

    Papathanasiou, T., Juul, R. V., Heegaard, Anne-Marie, Kreilgaard, M. & Lund, Trine Meldgaard, 2016, In: European Journal of Pharmaceutical Sciences. 82, p. 97–105 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Comment on Delanaye et al: Future perspectives regarding kidney function estimates and dose adjustments

    Iversen, E., Hornum, Mads, Lund, Trine Meldgaard & Houlind, Morten Baltzer, 2022, In: British Journal of Clinical Pharmacology. 88, 6, p. 2998-2999

    Research output: Contribution to journal › Letter › Research › peer-review

  20. Published

    Conformational and pharmacological characterization of 4-AHCP, a bicyclic homologue of the excitatory amino acid receptor agonist AMPA

    Lund, Trine Meldgaard, Madsen, Ulf, Ebert, B., Jørgensen, Flemming Steen & Krogsgaard-Larsen, Povl, 1991, In: Med. Chem. Res. 1, p. 136-141 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Demonstrating Contribution of Components of Fixed-Dose Drug Combinations Through Longitudinal Exposure-Response Analysis

    Nøhr-Nielsen, A., Lange, Theis, Forman, Julie Lyng, Papathanasiou, T., Foster, D. J. R., Upton, R. N., Bjerrum, Ole Jannik & Lund, Trine Meldgaard, 2020, In: The AAPS Journal. 22, 2, 32.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Design of excitatory amino acid receptor agonists, partial agonists and antagonists: Ibotenic acid as a key lead structure

    Krogsgaard-Larsen, Povl, Ebert, B., Lund, Trine Meldgaard, Bräuner, Hans, Sloøk, F. A., Johansen, Tommy Nørskov, Brehm, L. & Madsen, Ulf, 10 Sep 1996, In: European Journal of Medicinal Chemistry. 31, 7-8, p. 515-537 23 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Design, synthesis and pharmacology of model compounds for indirect elucidation of the topography of AMPA receptor sites

    Madsen, Ulf, Frølund, Bente, Lund, Trine Meldgaard, Ebert, B. & Krogsgaard-Larsen, Povl, 1993, In: European Journal of Medicinal Chemistry. 28, p. 791–800

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Det glutamaterge system: neurokemisk patologi af Alzheimers syge og medicinalkemiske studier af glutaminsyrereceptorerne

    Lund, Trine Meldgaard, 1992, 138 p. Kbh : Danmarks Farmaceutiske Højskole. Institut for Organisk Kemi.

    Research output: Other contribution › Research

  25. Published

    Determination of gastric emptying and small intestine transit time in dogs by paracetamol and sulfapyridine absorption modelling using nonlinear mixed-effects pharmacokinetics

    Hadji-Popovski, K., Skyggebjerg, R., Ynddal, L., Lund, Trine Meldgaard & Kristensen, K., 14 Jan 2015.

    Research output: Contribution to conference › Poster › Research

  26. Published

    Determination of gastric emptying in dogs by paracetamol absorption test using nonlinear mixed-effects pharmacokinetics

    Hadji-Popovski, K., Vegge, A., Olsen, J., Lund, Trine Meldgaard & Kristensen, K., 14 Jan 2015.

    Research output: Contribution to conference › Poster › Research

  27. Published

    Development of quantitative pharmacology-pharmacometrics in Denmark

    Honoré, P. G. H., Bjerrum, Ole Jannik, Lund, Trine Meldgaard, Angelo, H., Ingwersen, S. H., Thygesen, P., Kristensen, K. & Larsen, F., 2011.

    Research output: Contribution to conference › Poster › Research

  28. Published

    Differential localization of voltage-gated calcium channels in neurites and somata of cultured neocortical neurons.

    Timmermann, D., Lund, Trine Meldgaard, Belhage, B. & Schousboe, Arne, 1999, In: Journal of Neurochemistry. 73, Suppl, p. 127 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  29. Published

    Dose Finding in the Clinical Development of 60 US Food and Drug Administration-Approved Drugs Compared With Learning vs. Confirming Recommendations

    Lyauk, Y. K., Jonker, D. M. & Lund, Trine Meldgaard, 2019, In: Clinical and Translational Science. 12, 5, p. 481-489

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Dose safety and pharmacodynamics of subcutaneous bupivacaine in a novel extended-release microparticle formulation: A phase 1, dose-ascending study in male volunteers

    Jensen, E. K., Bøgevig, S., Balchen, T., Springborg, A. H., Royal, M. A., Storgaard, Ida Klitzing, Lund, Trine Meldgaard, Møller, Kirsten & Werner, M. U., 2024, In: Basic & clinical pharmacology & toxicology. 134, 5, p. 657-675

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Effects of taurine depletion on cell migration and NCAM expression in cultures of dissociated mouse cerebellum and N2A cells

    Maar, T. E., Lund, Trine Meldgaard, Gegelashvili, G., Hartmann-Petersen, Rasmus, Moran, M. J., Pasantes-Morales, H., Berezin, V., Bock, E. & Schousboe, Arne, 1998, In: Amino Acids. 15, 1, p. 77-88 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Evaluation of Multi-Frequency Bioelectrical Impedance Analysis against Dual-Energy X-ray Absorptiometry for Estimation of Low Muscle Mass in Older Hospitalized Patients

    Nielsen, R. L., Andersen, A. L., Kallemose, T., Damgaard, Morten, Bornæs, O., Juul-Larsen, H. G., Strejby Christensen, L. W., Jawad, B. N., Andersen, Ove, Rasmussen, H. H., Munk, T., Lund, Trine Meldgaard & Houlind, Morten Baltzer, 2024, In: Journal of Clinical Medicine. 13, 1, 15 p., 196.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Excitatory amino acid receptors: multiplicity and structural requirements for activation and blockade

    Krogsgaard-Larsen, Povl, Lund, Trine Meldgaard, Jørgensen, Flemming Steen & Brehn, L., 1991, Excitatory amino acids and synaptic function. Wheal, H. & Thomson, A. (eds.). London: Academic Press, p. 1-17 17 p. (Excitatory Amino Acids and Synaptic Transmission, Academic Press, London).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  34. Published

    Exploring the relationship between analgesic event rate and pain intensity in kidney stone surgery: A Repeated Time to Event Pilot Study

    Juul, R. V., Pedersen, K. V., Christrup, Lona Louring, Olesen, A. E., Drewes, A., Osther, P. J. S. & Lund, Trine Meldgaard, Jun 2015.

    Research output: Contribution to conference › Poster › Research › peer-review

  35. Published

    Feasibility of Exposure-Response Analyses for Clinical Dose-Ranging Studies of Drug Combinations

    Papathanasiou, T., Strathe, A., Hooker, A. C., Lund, Trine Meldgaard & Overgaard, R. V., May 2018, In: The AAPS Journal. 20, 13 p., 64.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    GABA synthesis from ß-hydroxybutyrate and glucose is differentially affected by neuronal activity in cultured GABAergic neurons

    Lund, Trine Meldgaard, Risa, O., Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 2009, In: Journal of Neurochemistry. s2, p. 95

    Research output: Contribution to journal › Conference abstract in journal › Research

  37. Published

    High-dose naloxone: Effects by late administration on pain and hyperalgesia following a human heat injury model. A randomized, double-blind, placebo-controlled, crossover trial with an enriched enrollment design

    Springborg, A. D., Jensen, E. K., Kreilgaard, M., Petersen, M. A., Papathanasiou, T., Lund, Trine Meldgaard, Taylor, B. K. & Werner, M. U., 2020, In: PLoS ONE. 15, 11, 22 p., e0242169.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    High-dose naloxone, an experimental tool uncovering latent sensitisation: pharmacokinetics in humans.

    Papathanasiou, T., Springborg, A., Kongstad, Kenneth Thermann, Stærk, Dan, Møller, Kirsten, Taylor, B. K., Lund, Trine Meldgaard & Werner, M. U., 2019, In: British Journal of Anaesthesia. 123, 2, p. e204-e214

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    How Repeated Time To Event (RTTE) modelling of opioid requests after surgery may improve future post-operative pain management

    Juul, R. V., Rasmussen, S., Kreilgaard, M., Simonsson, U., Christrup, Lona Louring & Lund, Trine Meldgaard, 5 Aug 2013.

    Research output: Contribution to conference › Poster › Research

  40. Published

    How Repeated Time To Event (RTTE) modelling of opioid requests after surgery may improve future post-operative pain management

    Juul, R. V., Rasmussen, S., Kreilgaard, M., simonsson, U., Christrup, Lona Louring & Lund, Trine Meldgaard, 11 Jul 2014.

    Research output: Contribution to conference › Poster › Research

  41. Published

    Hydroxylated analogues of 5-aminovaleric acid as 4-aminobutyric acidB receptor antagonists: stereostructure-activity relationships

    Kristiansen, Uffe, bjl587, bjl587, Herdeis, C., Lund, Trine Meldgaard, Nielsen, Birgitte, Hansen, J. J., Falch, E., Hjeds, H. & Krogsgaard-Larsen, Povl, Mar 1992, In: Journal of Neurochemistry. 58, 3, p. 1150-9 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Impact of dose-escalation schemes and drug discontinuation on weight loss outcomes with liraglutide 3.0 mg: A model-based approach

    Papathanasiou, T., Strathe, A., Agersø, H., Lund, Trine Meldgaard & Overgaard, R. V., 2020, In: Diabetes, Obesity and Metabolism. 22, 6, p. 969-977 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Impact of the malate-aspartate shuttle in glutamate neurotransmission

    Waagepetersen, Helle S., Bak, Lasse Kristoffer, Lund, Trine Meldgaard, Walls, A. B., Sonnewald, U. & Schousboe, Arne, 2009, In: Journal of Neurochemistry. s1, p. 9

    Research output: Contribution to journal › Conference abstract in journal › Research

  44. Published

    Integrated Item Response Theory Modeling of Multiple Patient-Reported Outcomes Assessing Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia

    Lyauk, Y. K., Lund, Trine Meldgaard, Hooker, A. C., Karlsson, M. O. & Jonker, D. M., 2020, In: The AAPS Journal. 22, 5, 13 p., 98.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Item Response Theory Modeling of the International Prostate Symptom Score in Patients with Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia

    Lyauk, Y. K., Jonker, D. M., Lund, Trine Meldgaard, Hooker, A. C. & Karlsson, M. O., 2020, In: The AAPS Journal. 22, 5, 15 p., 115.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    KATP channel openers in the trigeminalvascular system

    Ploug, K. B., Amrutkar, D. V., Baun, M., Ramachandran, R., Iversen, A., Lund, Trine Meldgaard, Gupta, S., Hay-Schmidt, A., Olesen, J. & Jansen-Olesen, I., 2012, In: Cephalagia. 32, 1

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Kroppens egne cannabinoider påvirker immunsystemet

    Degn, M., Hansen, Harald S., Lund, Trine Meldgaard & Petersen, G., 1 Jan 2005, In: Lægemiddelforskning. p. 8 9 p., 2.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Localization and pharmacological characterization of voltage dependent calcium channels in cultured neocortical neurons

    Timmermann, D. B., Lund, Trine Meldgaard, Belhage, B. & Schousboe, Arne, 2001, In: International Journal of Developmental Neuroscience. 19, 1, p. 1-10 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Midazolam Pharmacokinetics in Obese and Non-obese Children and Adolescents

    Gade, C., Sverrisdóttir, E., Dalhoff, Kim, Sonne, J., Johansen, M. Ø., Christensen, H. R., Burhenne, J., Mikus, G., Holm, Jens-Christian, Lund, Trine Meldgaard & Holst, H., 2020, In: Clinical Pharmacokinetics. 59, p. 643-654

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Modelling analgesia-concentration relationships for morphine to evaluate experimental pain models

    Sverrisdóttir, E., Foster, D., Upton, R., Olesen, A. E., Lund, Trine Meldgaard, Christrup, Lona Louring & Kreilgaard, M., Jun 2013.

    Research output: Contribution to conference › Poster › Research

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