Trond Ulven

Trond Ulven

Professor

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    ORCID: 0000-0002-8135-1755

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    1. Published

      USE OF FFAR2 AGONISTS FOR THE TREATMENT OF BACTERIAL SUPERINFECTIONS POST-VIRAL INFECTION

      Trottein, F., Ulven, Trond & Sencio, V., 2021, Patent No. WO2021018786, 4 Feb 2021, Priority date 24 Jul 2019, Priority No. EP20190188615 20190726

      Research output: Patent

    2. Treatment with TUG891, a free fatty acid receptor 4 agonist, restores adipose tissue metabolic dysfunction following chronic sleep fragmentation in mice

      Gozal, D., Qiao, Z., Almendros, I., Zheng, J., Khalyfa, A., Shimpukade, B. & Ulven, Trond, 2016, In: International Journal of Obesity. 40, 7, p. 1143-1149 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Treatment of type 2 diabetes by free Fatty Acid receptor agonists

      Watterson, K. R., Hudson, B. D., Ulven, Trond & Milligan, G., 2014, In: Frontiers in Endocrinology. 5

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84

      Mahmud, Z. A., Jenkins, L., Ulven, Trond, Labéguère, F., Gosmini, R., De Vos, S., Hudson, B. D., Tikhonova, I. G. & Milligan, G., 2017, In: Scientific Reports. 7, 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Thiazole- and pyrimidineacetic acid derivatives as CRTH2 receptor ligands, their preparation, pharmaceutical compositions, and use in therapy

      Ulven, Trond, Frimurer, Thomas Michael, Rist, Ø., Kostenis, E., Högberg, T., Receveur, J. & Grimstrup, M., 2007, Patent No. WO 2007/062677 A1

      Research output: Patent

    6. Published

      The therapeutic potential of allosteric ligands for free fatty acid sensitive GPCRs

      Hudson, B. D., Ulven, Trond & Milligan, G., 1 Jan 2013, In: Current Topics in Medicinal Chemistry. 13, 1, p. 14-25 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      The role of the prostaglandin D2 receptor, DP, in eosinophil trafficking

      Schratl, P., Royer, J. F., Kostenis, E., Ulven, Trond, Sturm, E. M., Waldhoer, M., Hoefler, G., Schuligoi, R., Lippe, I. T., Peskar, B. A. & Heinemann, A., 1 Oct 2007, In: Journal of Immunology. 179, 7, p. 4792-4799 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      The oxygen-mediated synthesis of 1,3-butadiynes in continuous flow

      Petersen, T. P., Polyzos, A., O'Brien, M., Ulven, Trond, Baxendale, I. R. & Ley, S. V., 2012, In: ChemSusChem (Print). 5, 2, p. 274-277 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120)

      Hudson, B. D., Shimpukade, B., Milligan, G. & Ulven, Trond, 18 Jul 2014, In: Journal of Biological Chemistry. 289, 29, p. 20345-20358 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity

      Mårtensson, J., Sundqvist, M., Manandhar, Asmita, Ieremias, L., Zhang, L., Ulven, Trond, Xie, X., Björkman, L. & Forsman, H., 2021, In: Journal of Innate Immunity. 13, p. 242–256

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. The Pharmacology of TUG-891, a Potent and Selective Agonist of the Free Fatty Acid Receptor 4 (FFA4/GPR120), Demonstrates Both Potential Opportunity and Possible Challenges to Therapeutic Agonism

      Hudson, B. D., Shimpukade, B., Mackenzie, A. E., Butcher, A. J., Pediani, J. D., Ulven, Elisabeth Rexen, Heathcote, H., Tobin, A. B., Ulven, Trond & Milligan, G., 2013, In: Molecular Pharmacology. 84, 5, p. 710-725 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. The Neutrophil Response Induced by an Agonist for Free Fatty Acid Receptor 2 (GPR43) Is Primed by Tumor Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue Recruitment

      Björkman, L., Mårtensson, J., Winther, M., Gabl, M., Holdfeldt, A., Uhrbom, M., Bylund, J., Højgaard Hansen, A., Pandey, S. K., Ulven, Trond, Forsman, H. & Dahlgren, C., 2016, In: Molecular and Cellular Biology. 36, 20, p. 2583-2595 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat

      Schilperoort, M., van Dam, A. D., Hoeke, G., Shabalina, I. G., Okolo, A., Hanyaloglu, A. C., Dib, L. H., Mol, I. M., Caengprasath, N., Chan, Y., Damak, S., Miller, A. R., Coskun, T., Shimpukade, B., Ulven, Trond, Kooijman, S., Rensen, P. C. & Christian, M., 17 Jan 2018, In: E M B O Molecular Medicine. 10, 3, 18 p., e8047.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      The C-terminal tail of CRTH2 is a key molecular determinant that constrains GalphaI- and downstream-signaling cascade activation

      Schroeder, R., Merten, N., Mathiesen, Jesper M., Martini, L., Letunic, A. K., Krop, F., Blaukat, A., Fang, Y., Tran, E., Ulven, Trond, Drewke, C., Whistler, J., Pardo, L., Gomeza, J. & Kostenis, E., 2009, In: Journal of Biological Chemistry. 284, 2, p. 1324-1336 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Tetrasubstituted phenanthrolines as highly potent, water-soluble, and selective g-quadruplex ligands

      Larsen, A. F., Nielsen, M. C. & Ulven, Trond, 2012, In: Chemistry: A European Journal. 18, 35, p. 10892-10902 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Targeting the prostaglandin D2 receptors DP1 and CRTH2 for treatment of inflammation

      Ulven, Trond & Kostenis, E., 2010, Frontiers in Medicinal Chemistry. Bentham Science Publishers, Vol. 5.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    17. Published

      Targeting the prostaglandin D2 receptors DP and CRTH2 for treatment of inflammation

      Ulven, Trond & Kostenis, E., 2006, In: Current Topics in Medicinal Chemistry. 6, 13, p. 1427-1444 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Targeting G protein-coupled 7TM receptors in treatment of inflammation

      Ulven, Trond, 2006, In: Current Topics in Medicinal Chemistry. 6, 13, p. 1317-1318 2 p.

      Research output: Contribution to journal › Journal article › Research

    19. Published

      Synthesis of racemic 3,5-O-benzylidene-2-deoxypentoses from 2-phenyl-1,3-dioxan-5-one hydrate

      Ulven, Trond, Sørbye, K. A. & Carlsen, P. H. J., 1997, In: Acta Chemica Scandinavica. 51, 10, p. 1041-1044 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Synthesis of benzylidene-protected dihydroxyacetone

      Carlsen, P. H. J., Sørbye, K. A., Ulven, Trond & Aasbø, K., 1996, In: Acta Chemica Scandinavica. 50, 2, p. 185-187 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Synthesis of all diastereomers of the 2-deoxypentoses and 2,6-dideoxyhexoses from 2-phenyl-1,3-dioxan-5-one hydrate

      Ulven, Trond & Carlsen, P. H. J., 2001, In: European Journal of Organic Chemistry. 17, p. 3367-3374 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Synthesis of Lysophosphatidylcholine and Mixed Phosphatidylcholine

      Papangelis, N. & Ulven, Trond, 2022, In: The Journal of Organic Chemistry. 87, 12, p. 8194–8197

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Synthesis of 1,3-O-benzylidene-2-deoxy-L-riboaldose from 2-phenyl-1,3-dioxan-5-one

      Ulven, Trond & Carlsen, P. H. J., 2000, In: Synthetic Communications. 30, 13, p. 2275-2280 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Synthesis and in vitro evaluation of a selective antagonist and the corresponding radioligand for the prostaglandin D2 receptor CRTH2

      Ulven, Trond, Gallen, M. J., Nielsen, M. C., Merten, N., Schmidt, C., Mohr, K., Tränkle, C. & Kostenis, E., 1 Nov 2007, In: Bioorganic & Medicinal Chemistry Letters. 17, 21, p. 5924-5927 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Synthesis and cellular evaluation of click-chemistry probes to study the biological effects of alpha, beta-unsaturated carbonyls

      Morozzi, C., Sauerland, M., Gamon, Luke Francis, Manandhar, Asmita, Ulven, Trond & Davies, Michael J., 2022, In: Redox Biology. 52, 8 p., 102299.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones

      Nicolaou, K. C., Namoto, K., Li, J., Ritzén, A., Ulven, Trond, Shoji, M., Zaharevitz, D., Gussio, R., Sackett, D. L., Ward, R. D., Hensler, A., Fojo, T. & Giannakakou, P., 8 Jan 2001, In: ChemBioChem. 2, 1, p. 69-75 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Succinct synthesis of saturated hydroxy fatty acids and

      Kaspersen, M. H., Jenkins, L., Dunlop, J., Milligan, G. & Ulven, Trond, 2017, In: MedChemComm. 8, 6, p. 1360-1365 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Substituted thiazoleacetic acids as CRTH2 receptor ligands

      Ulven, Trond, Frimurer, Thomas Michael, Rist, Ø., Kostenis, E., Högberg, T., Receveur, J. & Grimstrup, M., 2005, Patent No. WO 2005/116001 A1

      Research output: Patent

    29. Published

      Structure–activity relationship of GPR15L peptide analogues and investigation of their interaction with the GPR15 receptor

      Deng, Y., Perez Almeria, C. V., van Gijzel, L., Schaller, Kay, Vedel, L., Gloriam, David E., Ulven, Trond & Bräuner, Hans, 2023, In: Basic and Clinical Pharmacology and Toxicology. 132, 6, p. 459-471

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Structure-activity study of dihydrocinnamic acids and discovery of the potent FFA1 (GPR40) agonist TUG-469

      Ulven, Elisabeth Rexen, Due-Hansen, M. E., Urban, C., Merten, N., Pfleiderer, M., Karlsen, K. K., Rasmussen, S. S., Steensgaard, M., Hamacher, A., Schmidt, J., Drewke, C., Petersen, R. K., Kristiansen, Karsten, Ullrich, S., Kostenis, E., Kassack, M. U. & Ulven, Trond, 2010, In: ACS Medicinal Chemistry Letters. 1, 7, p. 345-349 5 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    31. Published

      Structure-Activity Relationships and Identification of Optmized CC-Chemokine Receptor CCR1, 5, and 8 Metal-Ion Chelators

      Chalikiopoulos, A., Thiele, S., Malmgaard-Clausen, M., Rydberg, P., Isberg, V., Ulven, Trond, Frimurer, Thomas Michael, Rosenkilde, Mette & Gloriam, David E., 25 Nov 2013, In: Journal of Chemical Information and Modeling. 53, 11, p. 2863-73 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Structure-Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators

      Ulven, Elisabeth Rexen, Quon, T., Sergeev, E., Barki, N., Brvar, M., Hudson, B. D., Dutta, P., Hansen, A. H., Bielefeldt, L. Ø., Tobin, A. B., McKenzie, C. J., Milligan, G. & Ulven, Trond, 9 Apr 2020, In: Journal of Medicinal Chemistry. 63, 7, p. 3577-3595 19 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Structure-Activity Relationship Studies and Optimization of 4-Hydroxypyridones as GPR84 Agonists

      Ieremias, L., Kaspersen, M. H., Manandhar, Asmita, Schultz-Knudsen, Katrine, Vrettou, C. I., Pokhrel, R., Heidtmann, C. V., Jenkins, L., Kanellou, C., Marsango, S., Li, Y., Bräuner, Hans, Ulven, Elisabeth Rexen, Milligan, G. & Ulven, Trond, 2024, In: Journal of Medicinal Chemistry. 67, 5, p. 3542-3570

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Structure-Activity Relationship Explorations and Discovery of a Potent Antagonist for the Free Fatty Acid Receptor 2

      Hansen, A. H., Christensen, H. B., Pandey, S. K., Sergeev, E., Valentini, Alice, Dunlop, J., Dedeo, D., Fratta, S., Hudson, B. D., Milligan, G., Ulven, Trond & Ulven, Elisabeth Rexen, 2021, In: ChemMedChem. 16, 21, p. 3326-3341

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets

      Ulven, Trond, 2012, In: Frontiers in Endocrinology. 3

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3

      Schmidt, J., Smith, N. J., Ulven, Elisabeth Rexen, Tikhonova, I. G., Grundmann, M., Hudson, B. D., Ward, R. J., Drewke, C., Milligan, G., Kostenis, E. & Ulven, Trond, 10 Jan 2011, In: Journal of Biological Chemistry. 286, 12, p. 10628-10640 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Selective extraction of G-quadruplex ligands from a rationally designed scaffold-based dynamic combinatorial library

      Nielsen, M. C. & Ulven, Trond, 1 Jan 2008, In: Chemistry: A European Journal. 14, 31, p. 9487-9490 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Selective copper catalysed aromatic N-arylation in water

      Engel-Andreasen, J., Shimpukade, B. & Ulven, Trond, 2013, In: Green Chemistry. 15, 2, p. 336-340 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Selective Allosteric Modulation of N-Terminally Cleaved, but Not Full Length CCL3 in CCR1

      Larsen, Olav, Lückmann, Michael, van der Velden, W. J. C., Oliva-Santiago, M., Brvar, M., Ulven, Trond, Frimurer, Thomas Michael, Karlshøj, S. & Rosenkilde, Mette, 2019, In: ACS Pharmacology & Translational Science. 2, 6, p. 429-441 13 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    40. Reevaluation of Fatty acid receptor 1 (FFAR1/GPR40) as drug target for the stimulation of insulin secretion in humans

      Wagner, R., Kaiser, G., Gerst, F., Ulven, Elisabeth Rexen, Due-Hansen, M. E., Grundmann, M., Machicao, F., Peter, A., Kostenis, E., Ulven, Trond, Fritsche, A., Häring, H. & Ullrich, S., 1 Feb 2013, In: Diabetes. 62, 6, p. 2106-2111 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Quinoline compounds for use in MCH receptor related disorders

      Frimurer, Thomas Michael, Ulven, Trond, Högberg, T., Nørregaard, P. K., Little, P. B. & Receveur, J., 2004, Patent No. WO 2004/052370

      Research output: Patent

    42. Published

      Quinazoline compounds and their use in MCH-related disease

      Frimurer, Thomas Michael, Ulven, Trond, Högberg, T., Nørregaard, P. K., Little, P. B., Receveur, J. & Grimstrup, M., 2005, Patent No. WO 2005/123714

      Research output: Patent

    43. Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4

      Watterson, K. R., Hansen, S. V. F., Hudson, B. D., Alvarez-Curto, E., Raihan, S. Z., Goncalves de Azavedo, C. M. B. P., Martin, G., Dunlop, J., Yarwood, S. J., Ulven, Trond & Milligan, G., 2017, In: Molecular Pharmacology. 91, 6, p. 630-641 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Preparation of tetrahydroisoquinoline and tetrahydrobenzoazepine derivatives for use as GPR120 modulators.

      Brown, J., Connolly, S., Hansen, S. V. F., Milne, G., Shimpukade, B., Smyth, D., Thomas, G., Ulven, Trond, Brvar, M. & Rigby, A., 27 Sep 2018, Caldan Therapeutics Limited, UK ., Patent No. WO2018172727A1

      Research output: Patent

    45. Published

      Preparation of substituted thiazoleacetic acids as CRTH2 receptor ligands

      Ulven, Trond, Frimurer, Thomas Michael, Rist, O., Kostenis, E., Hoegberg, T., Receveur, J. & Grimstrup, M., 2005, Patent No. WO 2005/116001 A1

      Research output: Patent

    46. Published

      Preparation of substituted pyrrolo[2,3-c]pyridine-2-carboxamides and thieno[2,3-c]pyridine-2-carboxamides as AMPK inhibitors.

      Lanz, J. & Ulven, Trond, 6 Jun 2019, WIPO. World Intellectual Property Organisation, Patent No. WO2019106087A1

      Research output: Patent

    47. Published

      Preparation of phenyl benzoyl pyrazoles as CRTH2 receptor ligands

      Ulven, Trond, Frimurer, Thomas Michael, Rist, O., Kostenis, E., Hoegberg, T., Receveur, J. & Grimstrup, M., 2005, Patent No. WO 2005/115382 A1

      Research output: Patent

    48. Published

      Preparation of ortho-fluoro substituted compounds for the treatment of metabolic diseases.

      Ulven, Trond & Christiansen, E., 11 Oct 2012, Patent No. WO 2012/136221A1

      Research output: Patent

    49. Published

      Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding

      Jensen, P. C., Thiele, S., Ulven, Trond, Schwartz, Thue W. & Rosenkilde, Mette, 17 Jun 2008, In: Journal of Biological Chemistry. 283, 34, p. 23121-23128 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation

      Dragano, N. R. V., Solon, C., Ramalho, A. F., de Moura, R. F., Razolli, D. S., Ulven, Elisabeth Rexen, Goncalves de Azavedo, C. M. B. P., Ulven, Trond & Velloso, L. A., 2017, In: Journal of Neuroinflammation. 14, 91, 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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