Trond Ulven
Professor
- 2020
- Published
Activation of GPR40 induces hypothalamic neurogenesis through p38-and BDNF-dependent mechanisms
Engel, D. F., Bobbo, V. C. D., Solon, C. S., Nogueira, G. A., Moura-Assis, A., Mendes, N. F., Zanesco, A. M., Papangelis, A., Ulven, Trond & Velloso, L. A., 2020, In: Scientific Reports. 10, 1, 12 p., 11047.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Autocrine negative feed-back regulation of lipolysis through sensing of NEFAs by FFAR4/GPR120 in WAT
Husted, Anna Sofie, Ekberg, J. H., Tripp, E., Nissen, T. A. D., Meijnikman, S., O'Brien, S. L., Ulven, Trond, Acherman, Y., Bruin, S. C., Nieuwdorp, M., Gerhart-Hines, Zach, Calebiro, D., Dragsted, Lars Ove & Schwartz, Thue W., 2020, In: Molecular Metabolism. 42, 10 p., 101103.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells
Lorza-Gil, E., Kaiser, G., Ulven, Elisabeth Rexen, Koenig, G. M., Gerst, F., Oquendo, M. B., Birkenfeld, A. L., Haering, H., Kostenis, E., Ulven, Trond & Ullrich, S., 2020, In: Scientific Reports. 10, 1, 11 p., 16497.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel GPR120 agonist TUG891 modulates fat taste perception and preference and activates tongue-brain-gut axis in mice
Murtaza, B., Hichami, A., Khan, A. S., Shimpukade, B., Ulven, Trond, Ozdener, M. H. & Khan, N. A., 2020, In: Journal of Lipid Research. 61, 2, p. 133-142 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pathophysiological regulation of lung function by the free fatty acid receptor FFA4
Prihandoko, R., Kaur, D., Wiegman, C. H., Alvarez-Curto, E., Donovan, C., Chachi, L., Ulven, Trond, Tyas, M. R., Euston, E., Dong, Z., Alharbi, A. G. M., Kim, R. Y., Lowe, J. G., Hansbro, P. M., Chung, K. F., Brightling, C. E., Milligan, G. & Tobin, A. B., 2020, In: Science Translational Medicine. 12, 557, 13 p., 9009.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Preparation of substituted pyrrolo[2,3-c]pyridine-2-carboxamides and thieno[2,3-c]pyridine-2-carboxamides as AMPK inhibitors.
Lanz, J. & Ulven, Trond, 6 Jun 2019, WIPO. World Intellectual Property Organisation, Patent No. WO2019106087A1Research output: Patent
- Published
Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival
Theiler, A., Bärnthaler, T., Platzer, W., Richtig, G., Peinhaupt, M., Rittchen, S., Kargl, J., Ulven, Trond, Marsh, L. M., Marsche, G., Schuligoi, R., Sturm, E. M. & Heinemann, A., 2019, In: The Journal of allergy and clinical immunology. 144, 3, p. 764-776Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Selective Allosteric Modulation of N-Terminally Cleaved, but Not Full Length CCL3 in CCR1
Larsen, Olav, Lückmann, Michael, van der Velden, W. J. C., Oliva-Santiago, M., Brvar, M., Ulven, Trond, Frimurer, Thomas Michael, Karlshøj, S. & Rosenkilde, Mette, 2019, In: ACS Pharmacology & Translational Science. 2, 6, p. 429-441 13 p.Research output: Contribution to journal › Letter › Research › peer-review
- 2018
- Published
Preparation of tetrahydroisoquinoline and tetrahydrobenzoazepine derivatives for use as GPR120 modulators.
Brown, J., Connolly, S., Hansen, S. V. F., Milne, G., Shimpukade, B., Smyth, D., Thomas, G., Ulven, Trond, Brvar, M. & Rigby, A., 27 Sep 2018, Caldan Therapeutics Limited, UK ., Patent No. WO2018172727A1Research output: Patent
- Published
Dihydropyridine Fluorophores Allow for Specific Detection of Human Antibodies in Serum
Domljanovic, I., Ulven, Elisabeth Rexen, Ulven, Trond, Thomsen, R. P., Okholm, A. H., Kjems, J., Voss, A., Taskova, M. & Astakhova, K., 31 Jul 2018, In: ACS Omega. 3, 7, p. 7580-7586 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat
Schilperoort, M., van Dam, A. D., Hoeke, G., Shabalina, I. G., Okolo, A., Hanyaloglu, A. C., Dib, L. H., Mol, I. M., Caengprasath, N., Chan, Y., Damak, S., Miller, A. R., Coskun, T., Shimpukade, B., Ulven, Trond, Kooijman, S., Rensen, P. C. & Christian, M., 17 Jan 2018, In: E M B O Molecular Medicine. 10, 3, 18 p., e8047.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties
Hansen, A. H., Sergeev, E., Bolognini, D., Sprenger, R. R., Ekberg, J. H., Ejsing, C. S., McKenzie, C. J., Ulven, Elisabeth Rexen, Milligan, G. & Ulven, Trond, 2018, In: Journal of Medicinal Chemistry. 61, 21, p. 9534-9550 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
Complex Pharmacology of Free Fatty Acid Receptors
Milligan, G., Shimpukade, B., Ulven, Trond & Hudson, B. D., 11 Jan 2017, In: Chemical Reviews. 117, 1, p. 67-110 44 p.Research output: Contribution to journal › Journal article › Research › peer-review
A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias
Sergeev, E., Hansen, A. H., Bolognini, D., Kawakami, K., Kishi, T., Aoki, J., Ulven, Trond, Inoue, A., Hudson, B. D. & Milligan, G., 2017, In: Scientific Reports. 7, 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43)
Hansen, A. H., Sergeev, E., Pandey, S. K., Hudson, B. D., Ulven, Elisabeth Rexen, Milligan, G. & Ulven, Trond, 2017, In: Journal of Medicinal Chemistry. 60, 13, p. 5638-5645 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance
Houthuijzen, J. M., Oosterom, I., Hudson, B. D., Hirasawa, A., Daenen, L. G. M., McLean, C. M., Hansen, S. V. F., van Jaarsveld, M. T. M., Peeper, D. S., Jafari Sadatmand, S., Roodhart, J. M. L., van de Lest, C. H. A., Ulven, Trond, Ishihara, K., Milligan, G. & Voest, E., 2017, In: F A S E B Journal. 31, 5, p. 2195-2209 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Pharmacological Tool Compounds for the Free Fatty Acid Receptor 4 (FFA4/GPR120)
Hansen, S. V. F. & Ulven, Trond, 2017, Free Fatty Acid Receptors. Springer Science+Business Media, p. 33-56 24 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation
Dragano, N. R. V., Solon, C., Ramalho, A. F., de Moura, R. F., Razolli, D. S., Ulven, Elisabeth Rexen, Goncalves de Azavedo, C. M. B. P., Ulven, Trond & Velloso, L. A., 2017, In: Journal of Neuroinflammation. 14, 91, 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4
Watterson, K. R., Hansen, S. V. F., Hudson, B. D., Alvarez-Curto, E., Raihan, S. Z., Goncalves de Azavedo, C. M. B. P., Martin, G., Dunlop, J., Yarwood, S. J., Ulven, Trond & Milligan, G., 2017, In: Molecular Pharmacology. 91, 6, p. 630-641 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Succinct synthesis of saturated hydroxy fatty acids and
Kaspersen, M. H., Jenkins, L., Dunlop, J., Milligan, G. & Ulven, Trond, 2017, In: MedChemComm. 8, 6, p. 1360-1365 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84
Mahmud, Z. A., Jenkins, L., Ulven, Trond, Labéguère, F., Gosmini, R., De Vos, S., Hudson, B. D., Tikhonova, I. G. & Milligan, G., 2017, In: Scientific Reports. 7, 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5)
Karlshøj, S., Amarandi, R. M., Larsen, Olav, Daugvilaite, V., Steen, A., Brvar, M., Pui, A., Frimurer, Thomas Michael, Ulven, Trond & Rosenkilde, Mette, 23 Dec 2016, In: Journal of Biological Chemistry. 291, 52, p. 26860-26874Research output: Contribution to journal › Journal article › Research › peer-review
A Molecular Mechanism for Sequential Activation of a G Protein-Coupled Receptor
Grundmann, M., Tikhonova, I. G., Hudson, B. D., Smith, N. J., Mohr, K., Ulven, Trond, Milligan, G., Kenakin, T. & Kostenis, E., 17 Mar 2016, In: Cell Chemical Biology. 23, 3, p. 392-403 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area and Robust in Vivo Efficacy
Hansen, S. V. F., Ulven, Elisabeth Rexen, Urban, C., Hudson, B. D., Stocker, C. J., Due-Hansen, M. E., Wargent, E. T., Shimpukade, B., Almeida, R., Ejsing, C. S., Cawthorne, M. A., Kassack, M. U., Milligan, G. & Ulven, Trond, 1 Mar 2016, In: Journal of Medicinal Chemistry. 59, 6, p. 2841-2846 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
A protocol for amide bond formation with electron deficient amines and sterically hindered substrates
Due-Hansen, M. E., Pandey, S. K., Ulven, Elisabeth Rexen, Andersen, R., Hansen, S. V. F. & Ulven, Trond, 2016, In: Organic & Biomolecular Chemistry. 14, 2, p. 430-433 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 187375453
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Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
109
downloads
Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
109
downloads
Dihydropyridine Fluorophores Allow for Specific Detection of Human Antibodies in Serum
Research output: Contribution to journal › Journal article › Research › peer-review
Published