Ulf Madsen

Ulf Madsen

Associate Professor emeritus

ORCID: 0000-0002-5171-3065

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  1. Published

    Subtype-selective excitatory amino acid receptor agonists and antagonists derived from ibotenic acid

    Ebert, B., Lund, Trine Meldgaard, Madsen, Ulf, Brehm, L. & Krogsgaard-Larsen, Povl, 1992, New leads and targets in drug research: Alfred Benzon Symposium 33. Krogsgaard-Larsen, P., Christensen, S. B. & Kofod, H. (eds.). Copenhagen, p. 340-351 11 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  2. Published

    Molecular pharmacology of the AMPA agonist, (S)-2-amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid [(S)-APPA] and the AMPA antagonist, (R)-APPA

    Ebert, B., Madsen, Ulf, Lund, Trine Meldgaard, Lenz, S. M. & Krogsgaard-Larsen, Povl, Jun 1994, In: Neurochemistry International. 24, 6, p. 507-15 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Molecular pharmacology of cortical and spinal AMPA receptors

    Ebert, B., Madsen, Ulf, Lund, Trine Meldgaard, Holm, T. & Krogsgaard-Larsen, Povl, 1 Jan 1992, In: Molecular Neuropharmacology. 2, 1, p. 47-49 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology

    Frølund, Bente, Greenwood, J. R., Holm, M. M., Egebjerg, J., Madsen, Ulf, Nielsen, Birgitte, Bräuner, Hans, Stensbøl, T. B. & Krogsgaard-Larsen, Povl, 15 Sep 2005, In: Bioorganic & Medicinal Chemistry. 13, 18, p. 5391-8

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    GABA and glutamic acid receptor ligands

    Frølund, Bente & Madsen, Ulf, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 239-262

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education

  6. Published

    Glutamate receptor ligands: synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs

    Guldbrandt, M., Johansen, Tommy Nørskov, Frydenvang, Karla Andrea, Bräuner, Hans, Stensbøl, T. B., Nielsen, Birgitte, Karla, R., Santi, F., Krogsgaard-Larsen, Povl & Madsen, Ulf, 2002, In: Chirality. 14, 4, p. 351-63 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: Structures of the ligand-bining core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid

    Hald, H., Naur, P., Pickering, Darryl S, Sprogøe, D., Madsen, Ulf, Timmermann, D. B., Ahring, P. K., Liljefors, T., Schousboe, Arne, Egebjerg, J., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2007, In: Journal of Biological Chemistry. 282, 35, p. 25726-25736

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Isoxazole amino acids as glutamic acid receptor agonists: conformational and stereochemical aspects

    Hansen, J. J., Madsen, Ulf, Nielsen, E. Ø., Nielsen, Birgitte, Brehm, L. & Krogsgaard-Larsen, Povl, 1989, New Methods in Drug Research. Makriayannis, A. (ed.). Barcelona: Prous Scientific Publishers, Vol. 3. p. 73-101 29 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  9. Published

    Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors

    Hermit, M. B., Greenwood, J. R., Nielsen, Birgitte, Bunch, Lennart, Jørgensen, Charlotte Grube, Vestergaard, H. T., Stensbøl, T. B., Sanchez, C., Krogsgaard-Larsen, Povl, Madsen, Ulf & Bräuner, Hans, 23 Feb 2004, In: European Journal of Pharmacology. 486, 3, p. 241-50

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid

    Johansen, Tommy Nørskov, Ebert, B., Bräuner, Hans, Didriksen, M., Christensen, I. T., Søby, K. K., Madsen, Ulf, Krogsgaard-Larsen, Povl & Brehm, L., 12 Mar 1998, In: Journal of Medicinal Chemistry. 41, 6, p. 930-9

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Synthesis and structure-activity studies on acidic amino acids and related diacids as NMDA receptor ligands

    Johansen, Tommy Nørskov, Frydenvang, Karla Andrea, Ebert, B., Krogsgaard-Larsen, Povl & Madsen, Ulf, 1994, In: Journal of Medicinal Chemistry. 37, 20, p. 3252-62 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA

    Johansen, Tommy Nørskov, Stensbøl, T. B., Nielsen, Birgitte, Vogensen, S. B., Frydenvang, Karla Andrea, Sløk, F. A., Bräuner, Hans, Madsen, Ulf & Krogsgaard-Larsen, Povl, 2001, In: Chirality. 13, 9, p. 523-32 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Excitatory amino acid receptor antagonists: resolution, absolute stereochemistry, and pharmacology of (S)- and (R)-2-amino-2-(5-tert-butyl-3-hydroxyisoxazol-4-yl)acetic acid (ATAA)

    Johansen, Tommy Nørskov, Frydenvang, Karla Andrea, Ebert, B., Madsen, Ulf & Krogsgaard-Larsen, Povl, 1997, In: Chirality. 9, 5-6, p. 529-36 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid: resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors

    Johansen, Tommy Nørskov, Janin, Y. L., Nielsen, Birgitte, Frydenvang, Karla Andrea, Bräuner, Hans, Stensbøl, T. B., Vogensen, S. B., Madsen, Ulf & Krogsgaard-Larsen, Povl, 2002, In: Bioorganic & Medicinal Chemistry. 10, 7, p. 2259-66 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors

    Johansen, Tommy Nørskov, Greenwood, J. R., Frydenvang, Karla Andrea, Madsen, Ulf & Krogsgaard-Larsen, Povl, 2003, In: Chirality. 15, 2, p. 167-79 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Erratum: Synthesis and pharmacology of glutamate receptor ligands: New isothiazole analogues of ibotenic acid (Organic and Biomolecular Chemistry (2007) 5 DOI:10.1039/b615162k)

    Jørgensen, Charlotte Grube, Clausen, Rasmus Prætorius, Hansen, K. B., Bräuner, Hans, Nielsen, Birgitte, Metzler, B., Kehler, J., Krogsgaard-Larsen, Povl & Madsen, Ulf, 2007, In: Organic and Biomolecular Chemistry. 5, 5, p. 848 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  17. Published

    Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid

    Jørgensen, Charlotte Grube, Clausen, Rasmus Prætorius, Hansen, K. B., Bräuner, Hans, Nielsen, Birgitte, Metzler, B., Kehler, J., Krogsgaard-Larsen, Povl & Madsen, Ulf, 2007, In: Organic & Biomolecular Chemistry. 5, 3, p. 463-471

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors

    Jørgensen, Charlotte Grube, Bräuner, Hans, Nielsen, Birgitte, Kehler, J., Clausen, Rasmus Prætorius, Krogsgaard-Larsen, Povl & Madsen, Ulf, 2007, In: Bioorganic & Medicinal Chemistry. 15, 10, p. 3524-3538

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Analogues of 3-Hydroxyisoxazole-Containing Glutamate Receptor Ligands Based on the 3-Hydroxypyrazole-Moiety: Design, Synthesis and Pharmacological Characterization

    Jørgensen, L., Nielsen, Birgitte, Pickering, Darryl S, Kristensen, Anders Skov, Frydenvang, Karla Andrea, Madsen, Ulf & Clausen, Rasmus Prætorius, 2014, In: Neurochemical Research. 39, 10, p. 1895-1905 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Structure-activity relationships for negative allosteric mGluR5 modulators

    Kaae, B. H., Harpsøe, Kasper, Kvist, T., Mathiesen, Jesper M., Mølck, C., Gloriam, David E., Jimenez, H. N., Uberti, M. A., Nielsen, S. M., Nielsen, Birgitte, Bräuner, Hans, Sauerberg, P., Clausen, Rasmus Prætorius & Madsen, Ulf, 2012, In: ChemMedChem. 7, 3, p. 440-451

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Design and characterization of dimeric ligands cross-linking two identical modulatory AMPA receptor sites

    Kaae, B. H., Harpsøe, Kasper, Sanz, A. C., Pickering, Darryl S, Sauerberg, P., Clausen, Rasmus Prætorius, Kastrup, Jette Sandholm Jensen, Liljefors, T. & Madsen, Ulf, 19 Aug 2007, In: American Chemical Society. Abstracts of Papers (at the National Meeting). 234

    Research output: Contribution to journal › Conference abstract in journal › Research

  22. Published

    Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites

    Kaae, B. H., Harpsøe, Kasper, Kastrup, Jette Sandholm Jensen, Sanz, A. C., Pickering, Darryl S, Metzler, B., Clausen, Rasmus Prætorius, Gajhede, Michael, Sauerberg, P., Liljefors, T. & Madsen, Ulf, 2007, In: Chemistry & Biology. 14, 11, p. 1294-303 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Design of excitatory amino acid receptor agonists, partial agonists and antagonists: Ibotenic acid as a key lead structure

    Krogsgaard-Larsen, Povl, Ebert, B., Lund, Trine Meldgaard, Bräuner, Hans, Sloøk, F. A., Johansen, Tommy Nørskov, Brehm, L. & Madsen, Ulf, 10 Sep 1996, In: European Journal of Medicinal Chemistry. 31, 7-8, p. 515-537 23 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Molecular pharmacology of excitatory amino acid receptors: conformational and stereochemical requirements

    Krogsgaard-Larsen, Povl, Madsen, Ulf, Nielsen, Birgitte, Hansen, J. J., Nielsen, E. Ø., Brehm, L. & Curtis, D. R., 1987, Proceedings of the X'th International Congress of Pharmacology. Rand, M. J. & Raper, C. (eds.). Elsevier, p. 113-116 4 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  25. Published

    Medicinal chemical and pharmacological focus on GABA and glutamic acid receptors in neurodegenerative disorders

    Krogsgaard-Larsen, Povl, Hedegaard, A., Nielsen, L., Nielsen, Birgitte, Madsen, Ulf, Brehm, L., Falch, E., Hjeds, H. & Hansen, J. J., 1989, Trends in Medicinal Chemistry '88. van der Goot, H., Domány, G., Pallos, L. & Timmerman, H. (eds.). Elsevier, Amsterdam, p. 429-452 24 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

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