Ulf Madsen
Associate Professor emeritus
Medicinal Chemistry
Jagtvej 162
2100 København Ø
- Published
Relationship between structure, conformational flexibility, and biological activity of agonists and antagonists at the N-methyl-D-aspartic acid subtype of excitatory amino acid receptors
Madsen, Ulf, Brehm, L., Schaumburg, K., Jørgensen, Flemming Steen & Krogsgaard-Larsen, Povl, 1990, In: Journal of Medicinal Chemistry. 33, 1, p. 374-80 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA
Johansen, Tommy Nørskov, Stensbøl, T. B., Nielsen, Birgitte, Vogensen, S. B., Frydenvang, Karla Andrea, Sløk, F. A., Bräuner, Hans, Madsen, Ulf & Krogsgaard-Larsen, Povl, 2001, In: Chirality. 13, 9, p. 523-32 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rigid nonproteinogenic cyclic amino acids as ligands for glutamate receptors: trans-tris(homoglutamic) acids
Meyer, U., Bisel, P., Bräuner, Hans, Madsen, Ulf, Höfner, G., Wanner, K. T. & Frahm, A. W., Feb 2005, In: Chirality. 17, 2, p. 99-107Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Selective antagonists at group I metabotropic glutamate receptors: synthesis and molecular pharmacology of 4-aryl-3-isoxazolol amino acids
Kromann, H., Sløk, F. A., Stensbøl, T. B., Bräuner, Hans, Madsen, Ulf & Krogsgaard-Larsen, Povl, 14 Feb 2002, In: Journal of Medicinal Chemistry. 45, 4, p. 988-91Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors
Johansen, Tommy Nørskov, Greenwood, J. R., Frydenvang, Karla Andrea, Madsen, Ulf & Krogsgaard-Larsen, Povl, 2003, In: Chirality. 15, 2, p. 167-79 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural and stereochemical requirements for activation and blocade of excitatory amino acid receptors
Sløk, F. A., Bräuner, Hans, Stensbøl, T. B., Johansen, Tommy Nørskov, Ebert, B., Mortensen, M., Nielsen, Birgitte, Madsen, Ulf, Brehm, L., Falch, E. & Krogsgaard-Larsen, Povl, 2001, Medicinal Chemistry into the Millenium. Campbell, M. M. & Blagbrough, I. S. (eds.). UK: Royal Society of Chemistry, p. 52-64 13 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Structural and stereochemical requirements for interactions with subtypes of central excitatory amino acid receptors
Brehm, L., Christensen, I. T., Nielsen, Birgitte, Reinhardt, A., Ebert, B., Madsen, Ulf, Jørgensen, Flemming Steen, Hansen, J. J. & Krogsgaard-Larsen, Povl, 1990, Frontiers in Drug Research; Alfred Benzon Symposium 28. Jensen, B., Jørgensen, F. S. & Kofod, H. (eds.). Copenhagen: Munksgaard , p. 92-105 14 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites
Kaae, B. H., Harpsøe, Kasper, Kastrup, Jette Sandholm Jensen, Sanz, A. C., Pickering, Darryl S, Metzler, B., Clausen, Rasmus Prætorius, Gajhede, Michael, Sauerberg, P., Liljefors, T. & Madsen, Ulf, 2007, In: Chemistry & Biology. 14, 11, p. 1294-303 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural, stereochemical and conformational requirements for activation and blockade of central glutamic acid receptors
Krogsgaard-Larsen, Povl, Madsen, Ulf, Brehm, L., Christensen, I. T., Nielsen, Birgitte, Reinhardt, A., Ebert, B. & Hansen, J. J., 1990, Problems and Wonders of Chirale Molecules. Simonyi, M. (ed.). Budapest: Akadémiai Kiadó, p. 205-225 21 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Structure-activity relationships for negative allosteric mGluR5 modulators
Kaae, B. H., Harpsøe, Kasper, Kvist, T., Mathiesen, Jesper M., Mølck, C., Gloriam, David E., Jimenez, H. N., Uberti, M. A., Nielsen, S. M., Nielsen, Birgitte, Bräuner, Hans, Sauerberg, P., Clausen, Rasmus Prætorius & Madsen, Ulf, 2012, In: ChemMedChem. 7, 3, p. 440-451Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Subtype-selective excitatory amino acid receptor agonists and antagonists derived from ibotenic acid
Ebert, B., Lund, Trine Meldgaard, Madsen, Ulf, Brehm, L. & Krogsgaard-Larsen, Povl, 1992, New leads and targets in drug research: Alfred Benzon Symposium 33. Krogsgaard-Larsen, P., Christensen, S. B. & Kofod, H. (eds.). Copenhagen, p. 340-351 11 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids
Conti, P., De Amici, M., Joppolo Di Ventimiglia, S., Stensbøl, T. B., Madsen, Ulf, Bräuner, Hans, Russo, E., De Sarro, G., Bruno, G. & De Micheli, C., 3 Jul 2003, In: Journal of Medicinal Chemistry. 46, 14, p. 3102-8Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and enantiopharmacology of new AMPA-kainate receptor agonists
Conti, P., De Amici, M., De Sarro, G., Rizzo, M., Stensbøl, T. B., Bräuner, Hans, Madsen, Ulf, Toma, L. & De Micheli, C., 7 Oct 1999, In: Journal of Medicinal Chemistry. 42, 20, p. 4099-107Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and pharmacological characterization at glutamate receptors of erythro- and threo-tricholomic acid and homologues thereof
Conti, P., De Amici, M., Roda, G., Pinto, A., Tamborini, L., Madsen, Ulf, Nielsen, Birgitte, Bräuner, Hans & De Micheli, C., 2007, In: Tetrahedron. 63, 10, p. 2249-2256Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid
Pinto, A., Conti, P., De Amici, M., Tamborini, L., Madsen, Ulf, Nielsen, Birgitte, Christesen, T., Bräuner, Hans & De Micheli, C., 2008, In: Journal of Medicinal Chemistry. 51, 7, p. 2311-2315Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and pharmacological evaluation of novel conformationally constrained homologues of glutamic acid
Conti, P., Caligiuri, A., Pinto, A., Roda, G., Tamborini, L., Nielsen, Birgitte, Madsen, Ulf, Frydenvang, Karla Andrea, Colombo, A. & De Micheli, C., 2007, In: European Journal of Medicinal Chemistry. 42, 8, p. 1059-1068Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid
Conti, P., De Amici, M., Bräuner, Hans, Madsen, Ulf, Toma, L. & De Micheli, C., Nov 2002, In: Farmaco. 57, 11, p. 889-95Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors
Madsen, Ulf, Bräuner, Hans, Frydenvang, Karla Andrea, Hvene, L., Johansen, Tommy Nørskov, Nielsen, Birgitte, Sánchez, C., Stensbøl, T. B., Bischoff, F. & Krogsgaard-Larsen, Povl, 2001, In: Journal of Medicinal Chemistry. 44, 7, p. 1051-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and pharmacology of N-alkylated derivatives of the excitotoxin ibotenic acid
Madsen, Ulf, Dumpis, M. A., Bräuner, Hans & Piotrovsky, L. B., 16 Jun 1998, In: Bioorganic & Medicinal Chemistry Letters. 8, 12, p. 1563-8Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and pharmacology of a new AMPA-kainate receptor agonist with potent convulsant activity
Conti, P., De Amici, M., De Sarro, G., Stensbøl, T. B., Bräuner, Hans, Madsen, Ulf & De Micheli, C., 24 Sep 1998, In: Journal of Medicinal Chemistry. 41, 20, p. 3759-62Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid
Jørgensen, Charlotte Grube, Clausen, Rasmus Prætorius, Hansen, K. B., Bräuner, Hans, Nielsen, Birgitte, Metzler, B., Kehler, J., Krogsgaard-Larsen, Povl & Madsen, Ulf, 2007, In: Organic & Biomolecular Chemistry. 5, 3, p. 463-471Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and receptor binding affinity of new selective GluR5 ligands
Bunch, Lennart, Johansen, T. H., Bräuner, Hans, Stensbøl, T. B., Johansen, Tommy Nørskov, Krogsgaard-Larsen, Povl & Madsen, Ulf, Apr 2001, In: Bioorganic & Medicinal Chemistry. 9, 4, p. 875-9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and structure-activity studies on acidic amino acids and related diacids as NMDA receptor ligands
Johansen, Tommy Nørskov, Frydenvang, Karla Andrea, Ebert, B., Krogsgaard-Larsen, Povl & Madsen, Ulf, 1994, In: Journal of Medicinal Chemistry. 37, 20, p. 3252-62 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors
Pinto, A., Conti, P., Grazioso, G., Tamborini, L., Madsen, Ulf, Nielsen, Birgitte & De Micheli, C., 1 Feb 2011, In: European Journal of Medicinal Chemistry. 46, 2, p. 787-793Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis of novel N1-substituted bicyclic pyrazole amino acids and evaluation of their interaction with glutamate receptors
Conti, P., Grazioso, G., di Ventimiglia, S. J., Pinto, A., Roda, G., Madsen, Ulf, Bräuner, Hans, Nielsen, Birgitte, Costagli, C. & Galli, A., Jun 2005, In: Chemistry & Biodiversity. 2, 6, p. 748-57Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1300906