Ulf Madsen
Associate Professor emeritus
Medicinal Chemistry
Jagtvej 162
2100 København Ø
- 2005
- Published
GABA and Glutamate Receptor Ligands and Their Therapeutic Potential in CNS Disorders
Madsen, Ulf, Bräuner, Hans, Greenwood, J. R., Johansen, Tommy Nørskov, Krogsgaard-Larsen, Povl, Liljefors, T., Nielsen, M. & Frølund, Bente, 27 Jan 2005, Drug Discovery Handbook. John Wiley & Sons, Inc., p. 797-907 111 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
4-Alkylated homoibotenic acid (HIBO) analogues: versatile pharmacological agents with diverse selectivity profiles towards metabotropic and ionotropic glutamate receptor subtypes
Madsen, Ulf, Pickering, Darryl S, Nielsen, Birgitte & Bräuner, Hans, 2005, In: Neuropharmacology. 49 Suppl 1, p. 114-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABA and Glutamate Receptor Ligands and Therapeutic Potential in CNS Disorders
Madsen, Ulf, Greenwood, J., Johansen, Tommy Nørskov, Krogsgaard-Larsen, Povl, Liljefors, T., Nielsen, M. & Frølund, Bente, 2005, Drug Discovery Handbook. Wiley, p. 797–907Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2004
- Published
Bioisosteric modifications of 2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5
Valgeirsson, J., Nielsen, E. O., Peters, D., Mathiesen, C., Kristensen, Anders Skov & Madsen, Ulf, 30 Dec 2004, In: Journal of Medicinal Chemistry. 47, 27, p. 6948-57 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists
Conti, P., De Amici, M., Grazioso, G., Roda, G., Barberis Negra, F. F., Nielsen, Birgitte, Stensbøl, T. B., Madsen, Ulf, Bräuner, Hans, Frydenvang, Karla Andrea, De Sarro, G., Toma, L. & De Micheli, C., 30 Dec 2004, In: Journal of Medicinal Chemistry. 47, 27, p. 6740-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors
Hermit, M. B., Greenwood, J. R., Nielsen, Birgitte, Bunch, Lennart, Jørgensen, Charlotte Grube, Vestergaard, H. T., Stensbøl, T. B., Sanchez, C., Krogsgaard-Larsen, Povl, Madsen, Ulf & Bräuner, Hans, 23 Feb 2004, In: European Journal of Pharmacology. 486, 3, p. 241-50Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5
Valgeirsson, J., Nielsen, E. Ø., Peters, D., Varming, T., Mathiesen, C., Kristensen, Anders Skov & Madsen, Ulf, 18 Dec 2003, In: Journal of Medicinal Chemistry. 46, 26, p. 5834-43 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design of Cyclopentaisoxazoline Amino Acids as Conformationally Constrained Agonists at Glutamate Receptors
Conti, P., De Amici, M., Grazioso, G., Roda, G., Stensbøl, T. B., Bräuner, Hans, Madsen, Ulf, Toma, L. & De Micheli, C., 14 Nov 2003, In: European Journal of Organic Chemistry. 22, p. 4455-4461 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids
Conti, P., De Amici, M., Joppolo Di Ventimiglia, S., Stensbøl, T. B., Madsen, Ulf, Bräuner, Hans, Russo, E., De Sarro, G., Bruno, G. & De Micheli, C., 3 Jul 2003, In: Journal of Medicinal Chemistry. 46, 14, p. 3102-8Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design of novel conformationally restricted analogues of glutamic acid
Conti, P., De Amici, M., Roda, G., Vistoli, G., Stensbøl, T. B., Bräuner, Hans, Madsen, Ulf, Toma, L. & De Micheli, C., 24 Feb 2003, In: Tetrahedron. 59, 9, p. 1443-1452 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO)
Bjerrum, E. J., Kristensen, Anders Skov, Pickering, D. S., Greenwood, J. R., Nielsen, Birgitte, Liljefors, T., Schousboe, Arne, Bräuner, Hans, Madsen, Ulf & Pickering, Darryl S, 2003, In: Journal of Medicinal Chemistry. 46, 11, p. 2246-9 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rational design, synthesis, and pharmacological evaluation of 2-azanorbornane-3-exo,5-endo-dicarboxylic acid: a novel conformationally restricted glutamic acid analogue
Bunch, Lennart, Liljefors, T., Greenwood, J. R., Frydenvang, Karla Andrea, Bräuner, Hans, Krogsgaard-Larsen, Povl & Madsen, Ulf, 2003, In: Journal of Organic Chemistry. 68, 4, p. 1489-95 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors
Johansen, Tommy Nørskov, Greenwood, J. R., Frydenvang, Karla Andrea, Madsen, Ulf & Krogsgaard-Larsen, Povl, 2003, In: Chirality. 15, 2, p. 167-79 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
- Published
Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid
Conti, P., De Amici, M., Bräuner, Hans, Madsen, Ulf, Toma, L. & De Micheli, C., Nov 2002, In: Farmaco. 57, 11, p. 889-95Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regioselective lithiation and functionalization of 3-(benzyloxy)isothiazole: Application to the synthesis of thioibotenic acid
Bunch, Lennart, Krogsgaard-Larsen, Povl & Madsen, Ulf, 5 Apr 2002, In: Journal of Organic Chemistry. 67, 7, p. 2375-2377Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Selective antagonists at group I metabotropic glutamate receptors: synthesis and molecular pharmacology of 4-aryl-3-isoxazolol amino acids
Kromann, H., Sløk, F. A., Stensbøl, T. B., Bräuner, Hans, Madsen, Ulf & Krogsgaard-Larsen, Povl, 14 Feb 2002, In: Journal of Medicinal Chemistry. 45, 4, p. 988-91Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel 1-hydroxyazole bioisosteres of glutamic acid. Synthesis, protolytic properties, and pharmacology
Stensbøl, T. B., Uhlmann, P., Morel, S., Eriksen, B. L., Felding, J., Kromann, H., Hermit, M. B., Greenwood, J. R., Braüner-Osborne, H., Madsen, Ulf, Junager, F., Krogsgaard-Larsen, Povl, Begtrup, M., Vedsø, P. & Bräuner, Hans, 3 Jan 2002, In: Journal of Medicinal Chemistry. 45, 1, p. 19-31Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mixed cyano-gilman cuprates - Advances in conjugate addition to alpha,beta-unsaturated pyroglutaminol
Bunch, Lennart, Krogsgaard-Larsen, Povl & Madsen, Ulf, Jan 2002, In: Synthesis. 1, p. 31-33Research output: Contribution to journal › Journal article › Research › peer-review
- Published
2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid: resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors
Johansen, Tommy Nørskov, Janin, Y. L., Nielsen, Birgitte, Frydenvang, Karla Andrea, Bräuner, Hans, Stensbøl, T. B., Vogensen, S. B., Madsen, Ulf & Krogsgaard-Larsen, Povl, 2002, In: Bioorganic & Medicinal Chemistry. 10, 7, p. 2259-66 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glutamate receptor ligands: synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs
Guldbrandt, M., Johansen, Tommy Nørskov, Frydenvang, Karla Andrea, Bräuner, Hans, Stensbøl, T. B., Nielsen, Birgitte, Karla, R., Santi, F., Krogsgaard-Larsen, Povl & Madsen, Ulf, 2002, In: Chirality. 14, 4, p. 351-63 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
- Published
Synthesis and receptor binding affinity of new selective GluR5 ligands
Bunch, Lennart, Johansen, T. H., Bräuner, Hans, Stensbøl, T. B., Johansen, Tommy Nørskov, Krogsgaard-Larsen, Povl & Madsen, Ulf, Apr 2001, In: Bioorganic & Medicinal Chemistry. 9, 4, p. 875-9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA
Johansen, Tommy Nørskov, Stensbøl, T. B., Nielsen, Birgitte, Vogensen, S. B., Frydenvang, Karla Andrea, Sløk, F. A., Bräuner, Hans, Madsen, Ulf & Krogsgaard-Larsen, Povl, 2001, In: Chirality. 13, 9, p. 523-32 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural and stereochemical requirements for activation and blocade of excitatory amino acid receptors
Sløk, F. A., Bräuner, Hans, Stensbøl, T. B., Johansen, Tommy Nørskov, Ebert, B., Mortensen, M., Nielsen, Birgitte, Madsen, Ulf, Brehm, L., Falch, E. & Krogsgaard-Larsen, Povl, 2001, Medicinal Chemistry into the Millenium. Campbell, M. M. & Blagbrough, I. S. (eds.). UK: Royal Society of Chemistry, p. 52-64 13 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors
Madsen, Ulf, Bräuner, Hans, Frydenvang, Karla Andrea, Hvene, L., Johansen, Tommy Nørskov, Nielsen, Birgitte, Sánchez, C., Stensbøl, T. B., Bischoff, F. & Krogsgaard-Larsen, Povl, 2001, In: Journal of Medicinal Chemistry. 44, 7, p. 1051-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Unprecedented migration of N-alkoxycarbonyl groups in protected pyroglutaminol
Bunch, Lennart, Norrby, P., Frydenvang, Karla Andrea, Krogsgaard-Larsen, Povl & Madsen, Ulf, 2001, In: Organic Letters. 3, 3, p. 433-5 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1300906