1,4-Benzodioxane, an evergreen, versatile scaffold in medicinal chemistry: A review of its recent applications in drug design

Research output: Contribution to journal › Review › Research › peer-review

Standard

1,4-Benzodioxane, an evergreen, versatile scaffold in medicinal chemistry : A review of its recent applications in drug design. / Bolchi, Cristiano; Bavo, Francesco; Appiani, Rebecca; Roda, Gabriella; Pallavicini, Marco.

In: European Journal of Medicinal Chemistry, Vol. 200, 112419, 15.08.2020.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Bolchi, C, Bavo, F, Appiani, R, Roda, G & Pallavicini, M 2020, '1,4-Benzodioxane, an evergreen, versatile scaffold in medicinal chemistry: A review of its recent applications in drug design', European Journal of Medicinal Chemistry, vol. 200, 112419. https://doi.org/10.1016/j.ejmech.2020.112419

APA

Bolchi, C., Bavo, F., Appiani, R., Roda, G., & Pallavicini, M. (2020). 1,4-Benzodioxane, an evergreen, versatile scaffold in medicinal chemistry: A review of its recent applications in drug design. European Journal of Medicinal Chemistry, 200, [112419]. https://doi.org/10.1016/j.ejmech.2020.112419

Vancouver

Bolchi C, Bavo F, Appiani R, Roda G, Pallavicini M. 1,4-Benzodioxane, an evergreen, versatile scaffold in medicinal chemistry: A review of its recent applications in drug design. European Journal of Medicinal Chemistry. 2020 Aug 15;200. 112419. https://doi.org/10.1016/j.ejmech.2020.112419

Author

Bolchi, Cristiano ; Bavo, Francesco ; Appiani, Rebecca ; Roda, Gabriella ; Pallavicini, Marco. / 1,4-Benzodioxane, an evergreen, versatile scaffold in medicinal chemistry : A review of its recent applications in drug design. In: European Journal of Medicinal Chemistry. 2020 ; Vol. 200.

Bibtex

@article{13a25def18f54ee5ac04594f70b29961,
title = "1,4-Benzodioxane, an evergreen, versatile scaffold in medicinal chemistry: A review of its recent applications in drug design",
abstract = "1,4-Benzodioxane has long been a versatile template widely employed to design molecules endowed with diverse bioactivities. Its use spans the last decades of medicinal chemistry until today concerning many strategies of drug discovery, not excluding the most advanced ones. Here, more than fifty benzodioxane-related lead compounds, selected from recent literature, are presented showing the different approaches with which they have been developed. Agonists and antagonists at neuronal nicotinic, α1 adrenergic and serotoninergic receptor subtypes and antitumor and antibacterial agents form the most representative classes, but a variety of other biological targets are addressed by benzodioxane-containing compounds.",
keywords = "1,4-Benzodioxane, 5-HT, alpha1-AR, Antibacterial, Anticancer, nAChR",
author = "Cristiano Bolchi and Francesco Bavo and Rebecca Appiani and Gabriella Roda and Marco Pallavicini",
year = "2020",
month = aug,
day = "15",
doi = "10.1016/j.ejmech.2020.112419",
language = "English",
volume = "200",
journal = "European Journal of Medicinal Chemistry",
issn = "0223-5234",
publisher = "Elsevier Masson",

}

RIS

TY - JOUR

T1 - 1,4-Benzodioxane, an evergreen, versatile scaffold in medicinal chemistry

T2 - A review of its recent applications in drug design

AU - Bolchi, Cristiano

AU - Bavo, Francesco

AU - Appiani, Rebecca

AU - Roda, Gabriella

AU - Pallavicini, Marco

PY - 2020/8/15

Y1 - 2020/8/15

N2 - 1,4-Benzodioxane has long been a versatile template widely employed to design molecules endowed with diverse bioactivities. Its use spans the last decades of medicinal chemistry until today concerning many strategies of drug discovery, not excluding the most advanced ones. Here, more than fifty benzodioxane-related lead compounds, selected from recent literature, are presented showing the different approaches with which they have been developed. Agonists and antagonists at neuronal nicotinic, α1 adrenergic and serotoninergic receptor subtypes and antitumor and antibacterial agents form the most representative classes, but a variety of other biological targets are addressed by benzodioxane-containing compounds.

AB - 1,4-Benzodioxane has long been a versatile template widely employed to design molecules endowed with diverse bioactivities. Its use spans the last decades of medicinal chemistry until today concerning many strategies of drug discovery, not excluding the most advanced ones. Here, more than fifty benzodioxane-related lead compounds, selected from recent literature, are presented showing the different approaches with which they have been developed. Agonists and antagonists at neuronal nicotinic, α1 adrenergic and serotoninergic receptor subtypes and antitumor and antibacterial agents form the most representative classes, but a variety of other biological targets are addressed by benzodioxane-containing compounds.

KW - 1,4-Benzodioxane

KW - 5-HT

KW - alpha1-AR

KW - Antibacterial

KW - Anticancer

KW - nAChR

U2 - 10.1016/j.ejmech.2020.112419

DO - 10.1016/j.ejmech.2020.112419

M3 - Review

C2 - 32502862

AN - SCOPUS:85085663167

VL - 200

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

SN - 0223-5234

M1 - 112419

ER -

ID: 259878678