72/74As-labeling of HPMA based polymers for long-term in vivo PET imaging
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72/74As-labeling of HPMA based polymers for long-term in vivo PET imaging. / Herth, Matthias M; Barz, Matthias; Jahn, Markus; Zentel, Rudolf; Rösch, Frank.
In: Bioorganic & Medicinal Chemistry Letters, Vol. 20, No. 18, 15.09.2010, p. 5454-8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - 72/74As-labeling of HPMA based polymers for long-term in vivo PET imaging
AU - Herth, Matthias M
AU - Barz, Matthias
AU - Jahn, Markus
AU - Zentel, Rudolf
AU - Rösch, Frank
N1 - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
PY - 2010/9/15
Y1 - 2010/9/15
N2 - In the context of molecular imaging, various polymers based on the clinically approved N-(2-hydroxypropyl)-methacrylamide (HPMA) have been radio-labeled using longer-living positron emitters 72As t1/2=26 h or 74As t1/2=17.8 d. This approach may lead to non-invasive determination of the long-term in vivo fate of polymers by PET (positron emission tomography). Presumably, the radio label itself will not strongly influence the polymer structure due to the fact that the used nuclide binds to already existing thiol moieties within the polymer structure. Thus, the use of additional charges or bulky groups can be avoided.
AB - In the context of molecular imaging, various polymers based on the clinically approved N-(2-hydroxypropyl)-methacrylamide (HPMA) have been radio-labeled using longer-living positron emitters 72As t1/2=26 h or 74As t1/2=17.8 d. This approach may lead to non-invasive determination of the long-term in vivo fate of polymers by PET (positron emission tomography). Presumably, the radio label itself will not strongly influence the polymer structure due to the fact that the used nuclide binds to already existing thiol moieties within the polymer structure. Thus, the use of additional charges or bulky groups can be avoided.
KW - Acrylamides
KW - Arsenic
KW - Positron-Emission Tomography
KW - Radioisotopes
KW - Time Factors
U2 - 10.1016/j.bmcl.2010.07.092
DO - 10.1016/j.bmcl.2010.07.092
M3 - Journal article
C2 - 20709549
VL - 20
SP - 5454
EP - 5458
JO - Bioorganic & Medicinal Chemistry Letters
JF - Bioorganic & Medicinal Chemistry Letters
SN - 0960-894X
IS - 18
ER -
ID: 34205338