A Danish questionnaire study of acute symptoms of SARS-CoV-2 infection by variant, vaccination status, sex and age

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A Danish questionnaire study of acute symptoms of SARS-CoV-2 infection by variant, vaccination status, sex and age. / Sørensen, Anna Irene Vedel; Spiliopoulos, Lampros; Bager, Peter; Nielsen, Nete Munk; Hansen, Jørgen Vinsløv; Koch, Anders; Meder, Inger Kristine; Hviid, Anders; Ethelberg, Steen.

In: Scientific Reports, Vol. 13, No. 1, 19863, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sørensen, AIV, Spiliopoulos, L, Bager, P, Nielsen, NM, Hansen, JV, Koch, A, Meder, IK, Hviid, A & Ethelberg, S 2023, 'A Danish questionnaire study of acute symptoms of SARS-CoV-2 infection by variant, vaccination status, sex and age', Scientific Reports, vol. 13, no. 1, 19863. https://doi.org/10.1038/s41598-023-47273-8

APA

Sørensen, A. I. V., Spiliopoulos, L., Bager, P., Nielsen, N. M., Hansen, J. V., Koch, A., Meder, I. K., Hviid, A., & Ethelberg, S. (2023). A Danish questionnaire study of acute symptoms of SARS-CoV-2 infection by variant, vaccination status, sex and age. Scientific Reports, 13(1), [19863]. https://doi.org/10.1038/s41598-023-47273-8

Vancouver

Sørensen AIV, Spiliopoulos L, Bager P, Nielsen NM, Hansen JV, Koch A et al. A Danish questionnaire study of acute symptoms of SARS-CoV-2 infection by variant, vaccination status, sex and age. Scientific Reports. 2023;13(1). 19863. https://doi.org/10.1038/s41598-023-47273-8

Author

Sørensen, Anna Irene Vedel ; Spiliopoulos, Lampros ; Bager, Peter ; Nielsen, Nete Munk ; Hansen, Jørgen Vinsløv ; Koch, Anders ; Meder, Inger Kristine ; Hviid, Anders ; Ethelberg, Steen. / A Danish questionnaire study of acute symptoms of SARS-CoV-2 infection by variant, vaccination status, sex and age. In: Scientific Reports. 2023 ; Vol. 13, No. 1.

Bibtex

@article{22ad053fbba9424d91142a469a5fd5ac,
title = "A Danish questionnaire study of acute symptoms of SARS-CoV-2 infection by variant, vaccination status, sex and age",
abstract = "It is not well-described how the acute symptoms of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) differ by variant, vaccination, sex and age. A cross-sectional questionnaire study linked to national testing- and registry data was conducted among 148,874 SARS-CoV-2 first time reverse transcription polymerase chain reaction (RT-PCR) test-positive individuals and corresponding date-matched symptomatic test-negative controls. Major SARS-CoV-2 variants (Index/wild type, Alpha, Delta and Omicron) were defined using periods of predominance. Risk differences (RDs) were estimated for each of 21 predefined acute symptoms comparing: (1) test-positive and -negative individuals, by variant period, (2) vaccinated and unvaccinated test-positives, by variant period, (3) individuals tested positive during the Omicron and Delta periods, by vaccination status, and (4) vaccinated Omicron test-positive and -negative individuals, by age and sex. Compared to pre-Omicron, RDs between test-positive and test-negative individuals during the Omicron period were lower for most symptoms. RDs for altered sense of smell (dysosmia) and taste (dysgeusia) were highest for Delta (RD = 50.8 (49.4–52.0) and RD = 54.7 (53.4–56.0), respectively) and lowest for Omicron (RD = 12.8 (12.1–13.5) and RD = 11.8 (11.1–12.4), respectively). Across variants, vaccinated individuals reported fewer symptoms. During Omicron, females and 30–59 year-old participants reported more symptoms.",
author = "S{\o}rensen, {Anna Irene Vedel} and Lampros Spiliopoulos and Peter Bager and Nielsen, {Nete Munk} and Hansen, {J{\o}rgen Vinsl{\o}v} and Anders Koch and Meder, {Inger Kristine} and Anders Hviid and Steen Ethelberg",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
doi = "10.1038/s41598-023-47273-8",
language = "English",
volume = "13",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - A Danish questionnaire study of acute symptoms of SARS-CoV-2 infection by variant, vaccination status, sex and age

AU - Sørensen, Anna Irene Vedel

AU - Spiliopoulos, Lampros

AU - Bager, Peter

AU - Nielsen, Nete Munk

AU - Hansen, Jørgen Vinsløv

AU - Koch, Anders

AU - Meder, Inger Kristine

AU - Hviid, Anders

AU - Ethelberg, Steen

N1 - Publisher Copyright: © 2023, The Author(s).

PY - 2023

Y1 - 2023

N2 - It is not well-described how the acute symptoms of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) differ by variant, vaccination, sex and age. A cross-sectional questionnaire study linked to national testing- and registry data was conducted among 148,874 SARS-CoV-2 first time reverse transcription polymerase chain reaction (RT-PCR) test-positive individuals and corresponding date-matched symptomatic test-negative controls. Major SARS-CoV-2 variants (Index/wild type, Alpha, Delta and Omicron) were defined using periods of predominance. Risk differences (RDs) were estimated for each of 21 predefined acute symptoms comparing: (1) test-positive and -negative individuals, by variant period, (2) vaccinated and unvaccinated test-positives, by variant period, (3) individuals tested positive during the Omicron and Delta periods, by vaccination status, and (4) vaccinated Omicron test-positive and -negative individuals, by age and sex. Compared to pre-Omicron, RDs between test-positive and test-negative individuals during the Omicron period were lower for most symptoms. RDs for altered sense of smell (dysosmia) and taste (dysgeusia) were highest for Delta (RD = 50.8 (49.4–52.0) and RD = 54.7 (53.4–56.0), respectively) and lowest for Omicron (RD = 12.8 (12.1–13.5) and RD = 11.8 (11.1–12.4), respectively). Across variants, vaccinated individuals reported fewer symptoms. During Omicron, females and 30–59 year-old participants reported more symptoms.

AB - It is not well-described how the acute symptoms of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) differ by variant, vaccination, sex and age. A cross-sectional questionnaire study linked to national testing- and registry data was conducted among 148,874 SARS-CoV-2 first time reverse transcription polymerase chain reaction (RT-PCR) test-positive individuals and corresponding date-matched symptomatic test-negative controls. Major SARS-CoV-2 variants (Index/wild type, Alpha, Delta and Omicron) were defined using periods of predominance. Risk differences (RDs) were estimated for each of 21 predefined acute symptoms comparing: (1) test-positive and -negative individuals, by variant period, (2) vaccinated and unvaccinated test-positives, by variant period, (3) individuals tested positive during the Omicron and Delta periods, by vaccination status, and (4) vaccinated Omicron test-positive and -negative individuals, by age and sex. Compared to pre-Omicron, RDs between test-positive and test-negative individuals during the Omicron period were lower for most symptoms. RDs for altered sense of smell (dysosmia) and taste (dysgeusia) were highest for Delta (RD = 50.8 (49.4–52.0) and RD = 54.7 (53.4–56.0), respectively) and lowest for Omicron (RD = 12.8 (12.1–13.5) and RD = 11.8 (11.1–12.4), respectively). Across variants, vaccinated individuals reported fewer symptoms. During Omicron, females and 30–59 year-old participants reported more symptoms.

U2 - 10.1038/s41598-023-47273-8

DO - 10.1038/s41598-023-47273-8

M3 - Journal article

C2 - 37964010

AN - SCOPUS:85176424211

VL - 13

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 19863

ER -

ID: 374303569