A nationwide questionnaire study of post-acute symptoms and health problems after SARS-CoV-2 infection in Denmark

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A nationwide questionnaire study of post-acute symptoms and health problems after SARS-CoV-2 infection in Denmark. / Sørensen, Anna Irene Vedel; Spiliopoulos, Lampros; Bager, Peter; Nielsen, Nete Munk; Hansen, Jørgen Vinsløv; Koch, Anders; Meder, Inger Kristine; Ethelberg, Steen; Hviid, Anders.

In: Nature Communications, Vol. 13, No. 1, 4213, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sørensen, AIV, Spiliopoulos, L, Bager, P, Nielsen, NM, Hansen, JV, Koch, A, Meder, IK, Ethelberg, S & Hviid, A 2022, 'A nationwide questionnaire study of post-acute symptoms and health problems after SARS-CoV-2 infection in Denmark', Nature Communications, vol. 13, no. 1, 4213. https://doi.org/10.1038/s41467-022-31897-x

APA

Sørensen, A. I. V., Spiliopoulos, L., Bager, P., Nielsen, N. M., Hansen, J. V., Koch, A., Meder, I. K., Ethelberg, S., & Hviid, A. (2022). A nationwide questionnaire study of post-acute symptoms and health problems after SARS-CoV-2 infection in Denmark. Nature Communications, 13(1), [4213]. https://doi.org/10.1038/s41467-022-31897-x

Vancouver

Sørensen AIV, Spiliopoulos L, Bager P, Nielsen NM, Hansen JV, Koch A et al. A nationwide questionnaire study of post-acute symptoms and health problems after SARS-CoV-2 infection in Denmark. Nature Communications. 2022;13(1). 4213. https://doi.org/10.1038/s41467-022-31897-x

Author

Sørensen, Anna Irene Vedel ; Spiliopoulos, Lampros ; Bager, Peter ; Nielsen, Nete Munk ; Hansen, Jørgen Vinsløv ; Koch, Anders ; Meder, Inger Kristine ; Ethelberg, Steen ; Hviid, Anders. / A nationwide questionnaire study of post-acute symptoms and health problems after SARS-CoV-2 infection in Denmark. In: Nature Communications. 2022 ; Vol. 13, No. 1.

Bibtex

@article{9fd93270706a470f907d543f67f6336b,
title = "A nationwide questionnaire study of post-acute symptoms and health problems after SARS-CoV-2 infection in Denmark",
abstract = "A considerable number of individuals infected with SARS-CoV-2 continue to experience symptoms after the acute phase. Here, we report findings from a nationwide questionnaire study in Denmark including 61,002 RT-PCR confirmed SARS-CoV-2 cases and 91,878 test-negative controls aged 15-years or older. Six to twelve months after the test, the risks of 18 out of 21 symptoms were elevated among test-positives. The largest adjusted risk differences (RD) were observed for dysosmia (RD = 10.92%, 95% CI 10.68–11.21%), dysgeusia (RD = 8.68%, 95% CI 8.43–8.93%), fatigue/exhaustion (RD = 8.43%, 95%CI 8.14–8.74%), dyspnea (RD = 4.87%, 95% CI 4.65–5.09%) and reduced strength in arms/legs (RD = 4.68%, 95% CI 4.45–4.89%). During the period from the test and until completion of the questionnaire, new diagnoses of anxiety (RD = 1.15%, 95% CI 0.95–1.34%) or depression (RD = 1.00%, 95% CI 0.81–1.19%) were also more common among test-positives. Even in a population where the majority of test-positives were not hospitalized, a considerable proportion experiences symptoms up to 12 months after infection. Being female or middle-aged increases risks.",
author = "S{\o}rensen, {Anna Irene Vedel} and Lampros Spiliopoulos and Peter Bager and Nielsen, {Nete Munk} and Hansen, {J{\o}rgen Vinsl{\o}v} and Anders Koch and Meder, {Inger Kristine} and Steen Ethelberg and Anders Hviid",
note = "Funding Information: The authors would like to thank all EFTER-COVID participants for completing the questionnaire. We also thank, the members of the EFTER-COVID stakeholder group, consisting of representatives from universities, long-term sequelae clinics and other relevant hospital departments or health institutions, for their comments to the questionnaires and input during meetings. No specific funding was received for this work that was conducted as part of the governmental institution Statens Serum Institut{\textquoteright}s advisory tasks for the Danish Ministry of Health. ",
year = "2022",
doi = "10.1038/s41467-022-31897-x",
language = "English",
volume = "13",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - A nationwide questionnaire study of post-acute symptoms and health problems after SARS-CoV-2 infection in Denmark

AU - Sørensen, Anna Irene Vedel

AU - Spiliopoulos, Lampros

AU - Bager, Peter

AU - Nielsen, Nete Munk

AU - Hansen, Jørgen Vinsløv

AU - Koch, Anders

AU - Meder, Inger Kristine

AU - Ethelberg, Steen

AU - Hviid, Anders

N1 - Funding Information: The authors would like to thank all EFTER-COVID participants for completing the questionnaire. We also thank, the members of the EFTER-COVID stakeholder group, consisting of representatives from universities, long-term sequelae clinics and other relevant hospital departments or health institutions, for their comments to the questionnaires and input during meetings. No specific funding was received for this work that was conducted as part of the governmental institution Statens Serum Institut’s advisory tasks for the Danish Ministry of Health.

PY - 2022

Y1 - 2022

N2 - A considerable number of individuals infected with SARS-CoV-2 continue to experience symptoms after the acute phase. Here, we report findings from a nationwide questionnaire study in Denmark including 61,002 RT-PCR confirmed SARS-CoV-2 cases and 91,878 test-negative controls aged 15-years or older. Six to twelve months after the test, the risks of 18 out of 21 symptoms were elevated among test-positives. The largest adjusted risk differences (RD) were observed for dysosmia (RD = 10.92%, 95% CI 10.68–11.21%), dysgeusia (RD = 8.68%, 95% CI 8.43–8.93%), fatigue/exhaustion (RD = 8.43%, 95%CI 8.14–8.74%), dyspnea (RD = 4.87%, 95% CI 4.65–5.09%) and reduced strength in arms/legs (RD = 4.68%, 95% CI 4.45–4.89%). During the period from the test and until completion of the questionnaire, new diagnoses of anxiety (RD = 1.15%, 95% CI 0.95–1.34%) or depression (RD = 1.00%, 95% CI 0.81–1.19%) were also more common among test-positives. Even in a population where the majority of test-positives were not hospitalized, a considerable proportion experiences symptoms up to 12 months after infection. Being female or middle-aged increases risks.

AB - A considerable number of individuals infected with SARS-CoV-2 continue to experience symptoms after the acute phase. Here, we report findings from a nationwide questionnaire study in Denmark including 61,002 RT-PCR confirmed SARS-CoV-2 cases and 91,878 test-negative controls aged 15-years or older. Six to twelve months after the test, the risks of 18 out of 21 symptoms were elevated among test-positives. The largest adjusted risk differences (RD) were observed for dysosmia (RD = 10.92%, 95% CI 10.68–11.21%), dysgeusia (RD = 8.68%, 95% CI 8.43–8.93%), fatigue/exhaustion (RD = 8.43%, 95%CI 8.14–8.74%), dyspnea (RD = 4.87%, 95% CI 4.65–5.09%) and reduced strength in arms/legs (RD = 4.68%, 95% CI 4.45–4.89%). During the period from the test and until completion of the questionnaire, new diagnoses of anxiety (RD = 1.15%, 95% CI 0.95–1.34%) or depression (RD = 1.00%, 95% CI 0.81–1.19%) were also more common among test-positives. Even in a population where the majority of test-positives were not hospitalized, a considerable proportion experiences symptoms up to 12 months after infection. Being female or middle-aged increases risks.

U2 - 10.1038/s41467-022-31897-x

DO - 10.1038/s41467-022-31897-x

M3 - Journal article

C2 - 35864108

AN - SCOPUS:85134560202

VL - 13

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 4213

ER -

ID: 315251120