A tale of ligands big and small: An update on how pentameric ligand-gated ion channels interact with agonists and proteins

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A tale of ligands big and small : An update on how pentameric ligand-gated ion channels interact with agonists and proteins. / Pless, Stephan A.; Sivilotti, Lucia G.

In: Current Opinion in Physiology, Vol. 2, 01.04.2018, p. 19-26.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Pless, SA & Sivilotti, LG 2018, 'A tale of ligands big and small: An update on how pentameric ligand-gated ion channels interact with agonists and proteins', Current Opinion in Physiology, vol. 2, pp. 19-26. https://doi.org/10.1016/j.cophys.2017.12.012

APA

Pless, S. A., & Sivilotti, L. G. (2018). A tale of ligands big and small: An update on how pentameric ligand-gated ion channels interact with agonists and proteins. Current Opinion in Physiology, 2, 19-26. https://doi.org/10.1016/j.cophys.2017.12.012

Vancouver

Pless SA, Sivilotti LG. A tale of ligands big and small: An update on how pentameric ligand-gated ion channels interact with agonists and proteins. Current Opinion in Physiology. 2018 Apr 1;2:19-26. https://doi.org/10.1016/j.cophys.2017.12.012

Author

Pless, Stephan A. ; Sivilotti, Lucia G. / A tale of ligands big and small : An update on how pentameric ligand-gated ion channels interact with agonists and proteins. In: Current Opinion in Physiology. 2018 ; Vol. 2. pp. 19-26.

Bibtex

@article{be337b67fd874effb41617dcc03289ec,
title = "A tale of ligands big and small: An update on how pentameric ligand-gated ion channels interact with agonists and proteins",
abstract = "Pentameric ligand-gated ion channels (pLGICs, also known as Cys-loop receptors) are a large family of ion channels expressed in all Bilateria and in several groups of bacteria and archaea. They are activated by small-molecule neurotransmitters to mediate fast neurotransmission at many central and peripheral synapses and are the target of several drugs and insecticides. Here we review recent advances in the field, focussing on new insights on the structure of the agonist-binding site and on newly discovered protein–protein interactions involving pLGICs.",
author = "Pless, {Stephan A.} and Sivilotti, {Lucia G.}",
note = "Corrigendum to {\textquoteleft}A tale of ligands big and small an update on how pentameric ligand-gated ion channels interact with agonists and proteins{\textquoteright}, [Curr Opin Physiol 2 (2018) 19–26](S2468867317300354) 10.1016/j.cophys.2018.07.005",
year = "2018",
month = apr,
day = "1",
doi = "10.1016/j.cophys.2017.12.012",
language = "English",
volume = "2",
pages = "19--26",
journal = "Current Opinion in Physiology",
issn = "2468-8681",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - A tale of ligands big and small

T2 - An update on how pentameric ligand-gated ion channels interact with agonists and proteins

AU - Pless, Stephan A.

AU - Sivilotti, Lucia G.

N1 - Corrigendum to ‘A tale of ligands big and small an update on how pentameric ligand-gated ion channels interact with agonists and proteins’, [Curr Opin Physiol 2 (2018) 19–26](S2468867317300354) 10.1016/j.cophys.2018.07.005

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Pentameric ligand-gated ion channels (pLGICs, also known as Cys-loop receptors) are a large family of ion channels expressed in all Bilateria and in several groups of bacteria and archaea. They are activated by small-molecule neurotransmitters to mediate fast neurotransmission at many central and peripheral synapses and are the target of several drugs and insecticides. Here we review recent advances in the field, focussing on new insights on the structure of the agonist-binding site and on newly discovered protein–protein interactions involving pLGICs.

AB - Pentameric ligand-gated ion channels (pLGICs, also known as Cys-loop receptors) are a large family of ion channels expressed in all Bilateria and in several groups of bacteria and archaea. They are activated by small-molecule neurotransmitters to mediate fast neurotransmission at many central and peripheral synapses and are the target of several drugs and insecticides. Here we review recent advances in the field, focussing on new insights on the structure of the agonist-binding site and on newly discovered protein–protein interactions involving pLGICs.

U2 - 10.1016/j.cophys.2017.12.012

DO - 10.1016/j.cophys.2017.12.012

M3 - Review

C2 - 31231710

AN - SCOPUS:85051048195

VL - 2

SP - 19

EP - 26

JO - Current Opinion in Physiology

JF - Current Opinion in Physiology

SN - 2468-8681

ER -

ID: 204112384