Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes

Research output: Contribution to journal › Journal article › Research › peer-review

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Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes. / Lynagh, Timothy; Mikhaleva, Yana; Colding, Janne M; Glover, Joel C; Pless, Stephan A.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 33, 14.08.2018, p. 8430-8435.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lynagh, T, Mikhaleva, Y, Colding, JM, Glover, JC & Pless, SA 2018, 'Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 33, pp. 8430-8435. https://doi.org/10.1073/pnas.1806614115

APA

Lynagh, T., Mikhaleva, Y., Colding, J. M., Glover, J. C., & Pless, S. A. (2018). Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes. Proceedings of the National Academy of Sciences of the United States of America, 115(33), 8430-8435. https://doi.org/10.1073/pnas.1806614115

Vancouver

Lynagh T, Mikhaleva Y, Colding JM, Glover JC, Pless SA. Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes. Proceedings of the National Academy of Sciences of the United States of America. 2018 Aug 14;115(33):8430-8435. https://doi.org/10.1073/pnas.1806614115

Author

Lynagh, Timothy ; Mikhaleva, Yana ; Colding, Janne M ; Glover, Joel C ; Pless, Stephan A. / Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes. In: Proceedings of the National Academy of Sciences of the United States of America. 2018 ; Vol. 115, No. 33. pp. 8430-8435.

Bibtex

@article{4436b7eb010c411fbb513c6b8d70709e,
title = "Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes",
abstract = "Acid-sensing ion channels (ASICs) are proton-gated ion channels broadly expressed in the vertebrate nervous system, converting decreased extracellular pH into excitatory sodium current. ASICs were previously thought to be a vertebrate-specific branch of the DEG/ENaC family, a broadly conserved but functionally diverse family of channels. Here, we provide phylogenetic and experimental evidence that ASICs are conserved throughout deuterostome animals, showing that ASICs evolved over 600 million years ago. We also provide evidence of ASIC expression in the central nervous system of the tunicate, Oikopleura dioica Furthermore, by comparing broadly related ASICs, we identify key molecular determinants of proton sensitivity and establish that proton sensitivity of the ASIC4 isoform was lost in the mammalian lineage. Taken together, these results suggest that contributions of ASICs to neuronal function may also be conserved broadly in numerous animal phyla.",
author = "Timothy Lynagh and Yana Mikhaleva and Colding, {Janne M} and Glover, {Joel C} and Pless, {Stephan A}",
year = "2018",
month = aug,
day = "14",
doi = "10.1073/pnas.1806614115",
language = "English",
volume = "115",
pages = "8430--8435",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "The National Academy of Sciences of the United States of America",
number = "33",

}

RIS

TY - JOUR

T1 - Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes

AU - Lynagh, Timothy

AU - Mikhaleva, Yana

AU - Colding, Janne M

AU - Glover, Joel C

AU - Pless, Stephan A

PY - 2018/8/14

Y1 - 2018/8/14

N2 - Acid-sensing ion channels (ASICs) are proton-gated ion channels broadly expressed in the vertebrate nervous system, converting decreased extracellular pH into excitatory sodium current. ASICs were previously thought to be a vertebrate-specific branch of the DEG/ENaC family, a broadly conserved but functionally diverse family of channels. Here, we provide phylogenetic and experimental evidence that ASICs are conserved throughout deuterostome animals, showing that ASICs evolved over 600 million years ago. We also provide evidence of ASIC expression in the central nervous system of the tunicate, Oikopleura dioica Furthermore, by comparing broadly related ASICs, we identify key molecular determinants of proton sensitivity and establish that proton sensitivity of the ASIC4 isoform was lost in the mammalian lineage. Taken together, these results suggest that contributions of ASICs to neuronal function may also be conserved broadly in numerous animal phyla.

AB - Acid-sensing ion channels (ASICs) are proton-gated ion channels broadly expressed in the vertebrate nervous system, converting decreased extracellular pH into excitatory sodium current. ASICs were previously thought to be a vertebrate-specific branch of the DEG/ENaC family, a broadly conserved but functionally diverse family of channels. Here, we provide phylogenetic and experimental evidence that ASICs are conserved throughout deuterostome animals, showing that ASICs evolved over 600 million years ago. We also provide evidence of ASIC expression in the central nervous system of the tunicate, Oikopleura dioica Furthermore, by comparing broadly related ASICs, we identify key molecular determinants of proton sensitivity and establish that proton sensitivity of the ASIC4 isoform was lost in the mammalian lineage. Taken together, these results suggest that contributions of ASICs to neuronal function may also be conserved broadly in numerous animal phyla.

U2 - 10.1073/pnas.1806614115

DO - 10.1073/pnas.1806614115

M3 - Journal article

C2 - 30061402

VL - 115

SP - 8430

EP - 8435

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 33

ER -

ID: 200960351