Activity of L-alpha-amino acids at the promiscuous goldfish odorant receptor 5.24
Research output: Contribution to journal › Journal article › Research › peer-review
The goldfish odorant receptor 5.24 is a member of family C of G protein-coupled receptors and is closely related to the human receptor GPRC6A. Receptor 5.24 has previously been shown to have binding affinity for L-alpha-amino acids, especially the basic amino acids arginine and lysine. Here we report the agonist activities of the 20 proteinogenic L-alpha-amino acids, and L-ornithine and L-citrulline, measured in an intracellular calcium release assay in mammalian tsA cells. The results show that receptor 5.24 is broadly activated by 19 of the tested L-alpha-amino acids and displays a preference for basic amino acids.
Original language | English |
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Journal | European Journal of Pharmacology |
Volume | 536 |
Issue number | 1-2 |
Pages (from-to) | 98-101 |
ISSN | 0014-2999 |
DOIs | |
Publication status | Published - 24 Apr 2006 |
- Amino Acids, Aniline Compounds, Animals, Binding, Competitive, Calcium, Cell Line, Dose-Response Relationship, Drug, Fluorescent Dyes, Gene Expression, Goldfish, Humans, Intracellular Fluid, Receptors, Odorant, Transfection, Xanthenes
Research areas
ID: 45607753