Activity of L-alpha-amino acids at the promiscuous goldfish odorant receptor 5.24

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Activity of L-alpha-amino acids at the promiscuous goldfish odorant receptor 5.24. / Christiansen, Bolette; Wellendorph, Petrine; Bräuner-Osborne, Hans.

In: European Journal of Pharmacology, Vol. 536, No. 1-2, 24.04.2006, p. 98-101.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Christiansen, B, Wellendorph, P & Bräuner-Osborne, H 2006, 'Activity of L-alpha-amino acids at the promiscuous goldfish odorant receptor 5.24', European Journal of Pharmacology, vol. 536, no. 1-2, pp. 98-101. https://doi.org/10.1016/j.ejphar.2006.02.015

APA

Christiansen, B., Wellendorph, P., & Bräuner-Osborne, H. (2006). Activity of L-alpha-amino acids at the promiscuous goldfish odorant receptor 5.24. European Journal of Pharmacology, 536(1-2), 98-101. https://doi.org/10.1016/j.ejphar.2006.02.015

Vancouver

Christiansen B, Wellendorph P, Bräuner-Osborne H. Activity of L-alpha-amino acids at the promiscuous goldfish odorant receptor 5.24. European Journal of Pharmacology. 2006 Apr 24;536(1-2):98-101. https://doi.org/10.1016/j.ejphar.2006.02.015

Author

Christiansen, Bolette ; Wellendorph, Petrine ; Bräuner-Osborne, Hans. / Activity of L-alpha-amino acids at the promiscuous goldfish odorant receptor 5.24. In: European Journal of Pharmacology. 2006 ; Vol. 536, No. 1-2. pp. 98-101.

Bibtex

@article{819f268969744307b40bb7fa53cd78a7,
title = "Activity of L-alpha-amino acids at the promiscuous goldfish odorant receptor 5.24",
abstract = "The goldfish odorant receptor 5.24 is a member of family C of G protein-coupled receptors and is closely related to the human receptor GPRC6A. Receptor 5.24 has previously been shown to have binding affinity for L-alpha-amino acids, especially the basic amino acids arginine and lysine. Here we report the agonist activities of the 20 proteinogenic L-alpha-amino acids, and L-ornithine and L-citrulline, measured in an intracellular calcium release assay in mammalian tsA cells. The results show that receptor 5.24 is broadly activated by 19 of the tested L-alpha-amino acids and displays a preference for basic amino acids.",
keywords = "Amino Acids, Aniline Compounds, Animals, Binding, Competitive, Calcium, Cell Line, Dose-Response Relationship, Drug, Fluorescent Dyes, Gene Expression, Goldfish, Humans, Intracellular Fluid, Receptors, Odorant, Transfection, Xanthenes",
author = "Bolette Christiansen and Petrine Wellendorph and Hans Br{\"a}uner-Osborne",
year = "2006",
month = apr,
day = "24",
doi = "10.1016/j.ejphar.2006.02.015",
language = "English",
volume = "536",
pages = "98--101",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Activity of L-alpha-amino acids at the promiscuous goldfish odorant receptor 5.24

AU - Christiansen, Bolette

AU - Wellendorph, Petrine

AU - Bräuner-Osborne, Hans

PY - 2006/4/24

Y1 - 2006/4/24

N2 - The goldfish odorant receptor 5.24 is a member of family C of G protein-coupled receptors and is closely related to the human receptor GPRC6A. Receptor 5.24 has previously been shown to have binding affinity for L-alpha-amino acids, especially the basic amino acids arginine and lysine. Here we report the agonist activities of the 20 proteinogenic L-alpha-amino acids, and L-ornithine and L-citrulline, measured in an intracellular calcium release assay in mammalian tsA cells. The results show that receptor 5.24 is broadly activated by 19 of the tested L-alpha-amino acids and displays a preference for basic amino acids.

AB - The goldfish odorant receptor 5.24 is a member of family C of G protein-coupled receptors and is closely related to the human receptor GPRC6A. Receptor 5.24 has previously been shown to have binding affinity for L-alpha-amino acids, especially the basic amino acids arginine and lysine. Here we report the agonist activities of the 20 proteinogenic L-alpha-amino acids, and L-ornithine and L-citrulline, measured in an intracellular calcium release assay in mammalian tsA cells. The results show that receptor 5.24 is broadly activated by 19 of the tested L-alpha-amino acids and displays a preference for basic amino acids.

KW - Amino Acids

KW - Aniline Compounds

KW - Animals

KW - Binding, Competitive

KW - Calcium

KW - Cell Line

KW - Dose-Response Relationship, Drug

KW - Fluorescent Dyes

KW - Gene Expression

KW - Goldfish

KW - Humans

KW - Intracellular Fluid

KW - Receptors, Odorant

KW - Transfection

KW - Xanthenes

U2 - 10.1016/j.ejphar.2006.02.015

DO - 10.1016/j.ejphar.2006.02.015

M3 - Journal article

C2 - 16546162

VL - 536

SP - 98

EP - 101

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1-2

ER -

ID: 45607753