Addiction and the cerebellum with a focus on actions of opioid receptors
Research output: Contribution to journal › Review › Research › peer-review
Standard
Addiction and the cerebellum with a focus on actions of opioid receptors. / Ranjbar, Hoda; Soti, Monavareh; Banazadeh, Mohammad; Saleki, Kiarash; Kohlmeier, Kristi A.; Shabani, Mohammad.
In: Neuroscience and Biobehavioral Reviews, Vol. 131, 2021, p. 229-247.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Addiction and the cerebellum with a focus on actions of opioid receptors
AU - Ranjbar, Hoda
AU - Soti, Monavareh
AU - Banazadeh, Mohammad
AU - Saleki, Kiarash
AU - Kohlmeier, Kristi A.
AU - Shabani, Mohammad
N1 - Funding Information: The authors are grateful to Shahrnaz Parsania for providing practical comments on the manuscript. Funding for this study was provided by Kerman University of Medical Sciences (The Ethic approval Code: IR.KMU.REC.1400.348) as a grant ( 400000006 ) for the PhD thesis conducted by Hoda Ranjbar. Publisher Copyright: © 2021 Elsevier Ltd
PY - 2021
Y1 - 2021
N2 - Increasing evidence suggests that the cerebellum could play a role in the higher cognitive processes involved in addiction as the cerebellum contains anatomical and functional pathways to circuitry controlling motivation and saliency. In addition, the cerebellum exhibits a widespread presence of receptors, including opioid receptors which are known to play a prominent role in synaptic and circuit mechanisms of plasticity associated with drug use and development of addiction to opioids and other drugs of abuse. Further, the presence of perineural nets (PNNs) in the cerebellum which contain proteins known to alter synaptic plasticity could contribute to addiction. The role the cerebellum plays in processes of addiction is likely complex, and could depend on the particular drug of abuse, the pattern of use, and the stage of the user within the addiction cycle. In this review, we discuss functional and structural modifications shown to be produced in the cerebellum by opioids that exhibit dependency-inducing properties which provide support for the conclusion that the cerebellum plays a role in addiction.
AB - Increasing evidence suggests that the cerebellum could play a role in the higher cognitive processes involved in addiction as the cerebellum contains anatomical and functional pathways to circuitry controlling motivation and saliency. In addition, the cerebellum exhibits a widespread presence of receptors, including opioid receptors which are known to play a prominent role in synaptic and circuit mechanisms of plasticity associated with drug use and development of addiction to opioids and other drugs of abuse. Further, the presence of perineural nets (PNNs) in the cerebellum which contain proteins known to alter synaptic plasticity could contribute to addiction. The role the cerebellum plays in processes of addiction is likely complex, and could depend on the particular drug of abuse, the pattern of use, and the stage of the user within the addiction cycle. In this review, we discuss functional and structural modifications shown to be produced in the cerebellum by opioids that exhibit dependency-inducing properties which provide support for the conclusion that the cerebellum plays a role in addiction.
KW - Addiction
KW - Cerebellum
KW - Endogenous opioid
KW - Learning
KW - Opioid receptor
KW - Perineural nets
U2 - 10.1016/j.neubiorev.2021.09.021
DO - 10.1016/j.neubiorev.2021.09.021
M3 - Review
C2 - 34555385
AN - SCOPUS:85115758700
VL - 131
SP - 229
EP - 247
JO - Neuroscience & Biobehavioral Reviews
JF - Neuroscience & Biobehavioral Reviews
SN - 0149-7634
ER -
ID: 281645181