Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids. / Olsen, Christian A; Christensen, Caspar; Nielsen, Birgitte; Farah, Mohamed M; Mohamed, Farah M; Witt, Matthias; Clausen, Rasmus P; Kristensen, Jesper L; Franzyk, Henrik; Jaroszewski, Jerzy W.

In: Organic Letters, Vol. 8, No. 15, 2006, p. 3371-4.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Olsen, CA, Christensen, C, Nielsen, B, Farah, MM, Mohamed, FM, Witt, M, Clausen, RP, Kristensen, JL, Franzyk, H & Jaroszewski, JW 2006, 'Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids', Organic Letters, vol. 8, no. 15, pp. 3371-4. https://doi.org/10.1021/ol061304e

APA

Olsen, C. A., Christensen, C., Nielsen, B., Farah, M. M., Mohamed, F. M., Witt, M., Clausen, R. P., Kristensen, J. L., Franzyk, H., & Jaroszewski, J. W. (2006). Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids. Organic Letters, 8(15), 3371-4. https://doi.org/10.1021/ol061304e

Vancouver

Olsen CA, Christensen C, Nielsen B, Farah MM, Mohamed FM, Witt M et al. Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids. Organic Letters. 2006;8(15):3371-4. https://doi.org/10.1021/ol061304e

Author

Olsen, Christian A ; Christensen, Caspar ; Nielsen, Birgitte ; Farah, Mohamed M ; Mohamed, Farah M ; Witt, Matthias ; Clausen, Rasmus P ; Kristensen, Jesper L ; Franzyk, Henrik ; Jaroszewski, Jerzy W. / Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids. In: Organic Letters. 2006 ; Vol. 8, No. 15. pp. 3371-4.

Bibtex

@article{77f4589d52924ccd8ab48766725092c6,
title = "Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids",
abstract = "[Structure: see text] Solid-phase synthesis is a rapidly developing area of organic chemistry, of particular importance for medicinal chemistry and chemical biology. Aziridines have previously only rarely been applied in solid-phase synthesis. In the present work, aminolysis of resin-bound, spring-loaded N-nitrobenzenesulfonyl-activated aziridine-2-carboxylic acids has been optimized and employed in the synthesis of a number of open-chain and heterocyclic scaffolds, including enantiopure products.",
keywords = "Amino Alcohols, Aziridines, Carboxylic Acids, Heterocyclic Compounds, Molecular Structure, Stereoisomerism",
author = "Olsen, {Christian A} and Caspar Christensen and Birgitte Nielsen and Farah, {Mohamed M} and Mohamed, {Farah M} and Matthias Witt and Clausen, {Rasmus P} and Kristensen, {Jesper L} and Henrik Franzyk and Jaroszewski, {Jerzy W}",
year = "2006",
doi = "10.1021/ol061304e",
language = "English",
volume = "8",
pages = "3371--4",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "15",

}

RIS

TY - JOUR

T1 - Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids

AU - Olsen, Christian A

AU - Christensen, Caspar

AU - Nielsen, Birgitte

AU - Farah, Mohamed M

AU - Mohamed, Farah M

AU - Witt, Matthias

AU - Clausen, Rasmus P

AU - Kristensen, Jesper L

AU - Franzyk, Henrik

AU - Jaroszewski, Jerzy W

PY - 2006

Y1 - 2006

N2 - [Structure: see text] Solid-phase synthesis is a rapidly developing area of organic chemistry, of particular importance for medicinal chemistry and chemical biology. Aziridines have previously only rarely been applied in solid-phase synthesis. In the present work, aminolysis of resin-bound, spring-loaded N-nitrobenzenesulfonyl-activated aziridine-2-carboxylic acids has been optimized and employed in the synthesis of a number of open-chain and heterocyclic scaffolds, including enantiopure products.

AB - [Structure: see text] Solid-phase synthesis is a rapidly developing area of organic chemistry, of particular importance for medicinal chemistry and chemical biology. Aziridines have previously only rarely been applied in solid-phase synthesis. In the present work, aminolysis of resin-bound, spring-loaded N-nitrobenzenesulfonyl-activated aziridine-2-carboxylic acids has been optimized and employed in the synthesis of a number of open-chain and heterocyclic scaffolds, including enantiopure products.

KW - Amino Alcohols

KW - Aziridines

KW - Carboxylic Acids

KW - Heterocyclic Compounds

KW - Molecular Structure

KW - Stereoisomerism

U2 - 10.1021/ol061304e

DO - 10.1021/ol061304e

M3 - Journal article

C2 - 16836408

VL - 8

SP - 3371

EP - 3374

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 15

ER -

ID: 42352810