An online GPCR structure analysis platform
Research output: Contribution to journal › Journal article › Research › peer-review
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An online GPCR structure analysis platform. / Kooistra, Albert J.; Munk, Christian; Hauser, Alexander S.; Gloriam, David E.
In: Nature Structural and Molecular Biology, Vol. 28, No. 11, 2021, p. 875-878.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - An online GPCR structure analysis platform
AU - Kooistra, Albert J.
AU - Munk, Christian
AU - Hauser, Alexander S.
AU - Gloriam, David E.
N1 - Funding Information: This work was supported by the Lundbeck Foundation (grant nos R163-2013-16327 and R218-2016-1266), the Novo Nordisk Foundation (grant no NNF18OC0031226) and Independent Research Fund Denmark | Natural Sciences (grant no 8021-00173B) to D.E.G. Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2021
Y1 - 2021
N2 - We present an online, interactive platform for comparative analysis of all available G-protein coupled receptor (GPCR) structures while correlating to functional data. The comprehensive platform encompasses structure similarity, secondary structure, protein backbone packing and movement, residue–residue contact networks, amino acid properties and prospective design of experimental mutagenesis studies. This lets any researcher tap the potential of sophisticated structural analyses enabling a plethora of basic and applied receptor research studies.
AB - We present an online, interactive platform for comparative analysis of all available G-protein coupled receptor (GPCR) structures while correlating to functional data. The comprehensive platform encompasses structure similarity, secondary structure, protein backbone packing and movement, residue–residue contact networks, amino acid properties and prospective design of experimental mutagenesis studies. This lets any researcher tap the potential of sophisticated structural analyses enabling a plethora of basic and applied receptor research studies.
U2 - 10.1038/s41594-021-00675-6
DO - 10.1038/s41594-021-00675-6
M3 - Journal article
C2 - 34759374
AN - SCOPUS:85118897997
VL - 28
SP - 875
EP - 878
JO - Nature Structural and Molecular Biology
JF - Nature Structural and Molecular Biology
SN - 1545-9993
IS - 11
ER -
ID: 285938824