Arginine-vasopressin stimulates the formation of phosphatidic acid in rat Leydig cells

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Arginine-vasopressin stimulates the formation of phosphatidic acid in rat Leydig cells. / Nielsen, J.R.; Hansen, Harald S.; Jensen, B.

In: F E B S Letters, Vol. 218, No. 1, 01.01.1987, p. 93-96.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, JR, Hansen, HS & Jensen, B 1987, 'Arginine-vasopressin stimulates the formation of phosphatidic acid in rat Leydig cells', F E B S Letters, vol. 218, no. 1, pp. 93-96.

APA

Nielsen, J. R., Hansen, H. S., & Jensen, B. (1987). Arginine-vasopressin stimulates the formation of phosphatidic acid in rat Leydig cells. F E B S Letters, 218(1), 93-96.

Vancouver

Nielsen JR, Hansen HS, Jensen B. Arginine-vasopressin stimulates the formation of phosphatidic acid in rat Leydig cells. F E B S Letters. 1987 Jan 1;218(1):93-96.

Author

Nielsen, J.R. ; Hansen, Harald S. ; Jensen, B. / Arginine-vasopressin stimulates the formation of phosphatidic acid in rat Leydig cells. In: F E B S Letters. 1987 ; Vol. 218, No. 1. pp. 93-96.

Bibtex

@article{67e1f2add9a54c839ed1b58cd9cf228c,
title = "Arginine-vasopressin stimulates the formation of phosphatidic acid in rat Leydig cells",
abstract = "Arginine-vasopressin (AVP) stimulated the formation of labelled phosphatidic acid (PA) in [C]arachidonic acid-prelabelled rat Leydig cells. After addition of 10 M AVP [C]arachidonoylphosphatidic acid reached a maximum within 2 min. The increase was dose-dependent (10-10 M). No change in labelling of other phospholipids and diacylglycerol could be detected. The V antagonist dPTyr(Me)AVP inhibited in a dose-dependent manner the AVP-stimulated accumulation of PA. The V agonist dPVDAVP was without effect. The present results suggest that AVP binds to V receptors in rat Leydig cells resulting in stimulation of PA turnover. We suggest that the AVP-stimulated PA formation is an indication of phosphoinositide turnover.",
author = "J.R. Nielsen and Hansen, {Harald S.} and B. Jensen",
year = "1987",
month = jan,
day = "1",
language = "English",
volume = "218",
pages = "93--96",
journal = "F E B S Letters",
issn = "0014-5793",
publisher = "JohnWiley & Sons Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Arginine-vasopressin stimulates the formation of phosphatidic acid in rat Leydig cells

AU - Nielsen, J.R.

AU - Hansen, Harald S.

AU - Jensen, B.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - Arginine-vasopressin (AVP) stimulated the formation of labelled phosphatidic acid (PA) in [C]arachidonic acid-prelabelled rat Leydig cells. After addition of 10 M AVP [C]arachidonoylphosphatidic acid reached a maximum within 2 min. The increase was dose-dependent (10-10 M). No change in labelling of other phospholipids and diacylglycerol could be detected. The V antagonist dPTyr(Me)AVP inhibited in a dose-dependent manner the AVP-stimulated accumulation of PA. The V agonist dPVDAVP was without effect. The present results suggest that AVP binds to V receptors in rat Leydig cells resulting in stimulation of PA turnover. We suggest that the AVP-stimulated PA formation is an indication of phosphoinositide turnover.

AB - Arginine-vasopressin (AVP) stimulated the formation of labelled phosphatidic acid (PA) in [C]arachidonic acid-prelabelled rat Leydig cells. After addition of 10 M AVP [C]arachidonoylphosphatidic acid reached a maximum within 2 min. The increase was dose-dependent (10-10 M). No change in labelling of other phospholipids and diacylglycerol could be detected. The V antagonist dPTyr(Me)AVP inhibited in a dose-dependent manner the AVP-stimulated accumulation of PA. The V agonist dPVDAVP was without effect. The present results suggest that AVP binds to V receptors in rat Leydig cells resulting in stimulation of PA turnover. We suggest that the AVP-stimulated PA formation is an indication of phosphoinositide turnover.

UR - http://www.scopus.com/inward/record.url?scp=0023179164&partnerID=8YFLogxK

M3 - Journal article

AN - SCOPUS:0023179164

VL - 218

SP - 93

EP - 96

JO - F E B S Letters

JF - F E B S Letters

SN - 0014-5793

IS - 1

ER -

ID: 45562649